L-arginine does not affect renal morphology and cell survival in ischemic acute renal failure in rats

Nephron - Physiology

Volumn 101, Issue 3, 2005, Pages

  Raff, Ulrike ^a   Schneider, Reinhard ^a   Gambaryan, Stepan ^a   Seibold, Stefan ^a   Reber, Mark ^a   Vornberger, Nicole ^a   Freund, Ralf ^a   Schramm, Lothar ^a   Wanner, Christoph ^a   Galle, Jan ^a,b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Acute renal failure; L Arginine; Nitric oxide synthases

Indexed keywords

ARGININE; CASPASE 3; CYCLINE; PROTEIN BAX; PROTEIN BCL 2; TOLONIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERY CLAMP; ARTICLE; CELL DEATH; CELL INFILTRATION; CELL PROLIFERATION; CELL REGENERATION; CELL STRUCTURE; CELL SURVIVAL; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; FOLLOW UP; HEMODYNAMICS; IMMUNOHISTOCHEMISTRY; KIDNEY CORTEX; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY MEDULLA; MORPHOLOGY; NECROSIS; NONHUMAN; PERFUSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RENAL ARTERY; STAINING; TISSUE HOMOGENATE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; ARGININE; BCL-2-ASSOCIATED X PROTEIN; BLOOD PRESSURE; CASPASE 3; CASPASES; CELL DIVISION; CELL SURVIVAL; FEMALE; ISCHEMIA; KIDNEY CORTEX; KIDNEY FAILURE, ACUTE; KIDNEY MEDULLA; KIDNEY TUBULES, PROXIMAL; MACROPHAGES; MONOCYTES; NECROSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY;

EID: 27544487650     PISSN: 16602137     EISSN: None     Source Type: Journal    
DOI: 10.1159/000086647     Document Type: Article

References (24)

1. Liano F, Pascual J: Epidemiology of acute renal failure: A prospective, multicenter, community-based study. Madrid Acute Renal Failure Study Group. Kidney Int 1996;50: 811-818.
2. Kelly KJ, Molitoris BA: Acute renal failure in the new millennium: Time to consider combination therapy. Semin Nephrol 2000;20:4-19.
3. Wilcox CS, Welch WJ, Murad F, Gross SS, Taylor G, Levi R, Schmidt HHHW: Nitric oxide synthase in macula densa regulates glomerular capillary pressure. Proc Natl Acad Sci USA 1992;89:11993-11997.
4. Gabbai FB, Blantz RC: Role of nitric oxide in renal hemodynamics. Semin Nephrol 1999;19: 242-250.
5. Klahr S: Can L-arginine manipulation reduce renal disease? Semin Nephrol 1999;19:304-309.
6. Schramm L, La M, Heidbreder E, Hecker M, Beckman JS, Lopau K, Zimmermann J, Rendl J, Reiners C, Winderl S, Wanner C, Schmidt HHHW: L-Arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation. Kidney Int 2002;61:1423-1432.
7. Schneider R, Raff U, Vornberger N, Schmidt M, Freund R, Reber M, Schramm L, Gambaryan S, Wanner C, Schmidt HHHW, Galle J: L-Arginine counteracts nitric oxide deficiency and improves the recovery phase of ischemic acute renal failure in rats. Kidney Int 2003;64:216-225.
8. Jerkic M, Varagic J, Jovovic D, Radujkovic KG, Nastic MD, Adanja GG, Markovic LJ, Dimitrijevic J, Miloradovic Z, Vojvodic SB: L-Arginine reduces tubular cell injury in acute post-ischaemic renal failure. Nephrol Dial Transplant 1999;14:1398-1407.
9. Caramelo C, Espinosa G, Manzarbeitia F, Cernadas MR, Tejerizo GP, Tan D, Mosquera JR, Digiuni E, Monton M, Millas I, Hernando L, Casado S, LopezFarre A: Role of endothelium-related mechanisms in the pathophysiology of renal ischemia/reperfusion in normal rabbits. Circ Res 1996;79:1031-1038.
10. Reyes AA, Porras BH, Chasalow FI, Klahr S: L-Arginine decreases the infiltration of the kidney by macrophages in obstructive nephropathy and puromycin-induced nephrosis. Kidney Int 1994;45:1346-1354.
11. Boivin V, Jahns R, Gambaryan S, Ness W, Boege F, Lohse MJ: Immunofluorescent imaging of beta 1- and beta 2-adrenergjc receptors in rat kidney. Kidney Int 2001;59:515-531.
12. Bradford MM: Rapid and sensitive method for quantitation of microgram quantities of protein utilizing principle of protein-dye binding. Anal Biochem 1976;72:248-254.
13. Venkatachalam MA, Bernard DB, Donohoe JF, Levinsky NG: Ischemic damage and repair in rat proximal tubule: Differences among S1, S2, and S3 segments. Kidney Int 1978;14:31-49.
14. Hanley MJ: Isolated nephron segments in a rabbit model of ischemic acute renal failure. Am J Physiol 1980;239:F17-F23.
15. Schumer M, Colombel MC, Sawczuk IS, Gobe G, Connor J, Otoole KM, Olsson CA, Wise GJ, Buttyan R: Morphological, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol 1992;140:831-838.
16. Nakajima T, Miyaji T, Kato A, Ikegaya N, Yamamoto T, Hishida A: Uninephrectomy reduces apoptotic cell death and enhances renal tubular cell regeneration in ischemic ARF in rats. Am J Physiol Ren Physiol 1996;40:F846-F853.
17. Raafat AM, Murray MT, McGuire T, DeFrain M, Franko AP, Zafar RS, Palmer K, Diebel L, Dulchavsky SA: Calcium blockade reduces renal apoptosis during ischemia reperfusion. Shock 1997;8:186-192.
18. Stahelin BJ, Marti U, Solioz L, Zimmermann H, Reichen J: False positive staining in the TUNEL assay to detect apoptosis in liver and intestine is caused by endogenous nucleases and inhibited by diethyl pyrocarbonate. Mol Pathol 1998;51:204-208.
19. Ueda N, Shah SV: Tubular cell damage in acute renal failure - Apoptosis, necrosis, or both. Nephrol Dial Transplant 2000;15:318-323.
20. Basile DP, Donohoe DL, Roethe K, Mattson DL: Chronic renal hypoxia after acute ischemic injury: Effects of L-arginine on hypoxia and secondary damage. Am J Physiol Renal Physiol 2003;284:F338-F348.
21. Schwartz IF, Schwartz D, Traskonov M, Chernichovsky T, Wollman Y, Gnessin E, Topilsky I, Levo Y, Iaina A: L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats. Kidney Int 2002;62:1700-1706.
22. Edelstein CL, Ling H, Schrier RW: The nature of renal cell injury. Kidney Int 1997;51:1341-1351.
23. Racusen LC, Fivush BA, Li YL, Slatnik I, Solez K, Zapata A, Monckton E, Peteya D, Atkins P: Dissociation of tubular cell detachment and tubular cell death in clinical and experimental 'acute tubular-necrosis'. Lab Invest 1991;64:546-556.
24. Liu RS, Pittner J, Persson AEG: Changes of cell volume and nitric oxide concentration in macula densa cells caused by changes in luminal NaCl concentration. J Am Soc Nephrol 2002;13:2688-2696.