Polymeric micelles as a drug delivery system enhance cytotoxicity of vinorelbine through more intercellular accumulation

Drug Delivery

Volumn 17, Issue 4, 2010, Pages 255-262

  Lu, Xiaoyan ^a,b   Zhang, Fayun ^a   Qin, Lei ^a   Xiao, Fengying ^a   Liang, Wei ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Apoptosis; Cell cytotoxicity; Drug accumulation; Polymeric micelles; Vinorelbine

Indexed keywords

DRUG CARRIER; GLYCOL; NAVELBINE; PHOSPHATIDYLETHANOLAMINE; POLYMER;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; MICELLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL;

ANIMALS; CELL DEATH; CELL LINE, TUMOR; CYTOTOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; EXTRACELLULAR FLUID; MICE; MICELLES; POLYMERS; VINBLASTINE;

EID: 77951448502     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717541003702769     Document Type: Article

References (29)

1. Abraham, J., Edgerly, M., Wilson, R., Chen, C., Rutt, A., Bakke, S., Robey, R., Dwyer, A., Goldspiel, B., Balis, F., Van Tellingen, O., Bates, S.E., Fojo, T. (2009). A phase I study of the P-glycoprotein antagonist tariquidar in combination with vinorelbine. Clin Cancer Res. 15:3574-3582
2. Binet, S., Chaineau, E., Fellous, A., Lataste, H., Krikorian, A., Couzinier, J.P., Meininger, V. (1990). Immunofluorescence study of the action of navelbine, vincristine and vinblastine on mitotic and axonal microtubules. Int J Cancer. 46:262-266
3. Chen, Y.C., Lu, P.H., Pan, S.L., Teng, C.M., Kuo, S.C., Lin, T.P., Ho, Y.F., Huang, Y.C., Guh, J.H. (2007). Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways. Biochem Pharmacol. 74:10-19.
4. Dhamodharan, R., Jordan, M.A., Thrower, D., Wilson, L., Wadsworth, P. (1995). Vinblastine suppresses dynamics of individual microtubules in living interphase cells. Mol Biol Cell 6:1215-1229
5. Gou, M., Zheng, X., Men, K., Zhang, J., Wang, B., Lv, L., Wang, X., Zhao, Y., Luo, F., Chen, L., Zhao, X., Wei, Y., Qian, Z. (2009a). Selfassembled hydrophobic honokiol loaded MPEG-PCL diblock copolymer micelles. Pharm Res. 26:2164-2173
6. Gou, M., Zheng, X., Men, K., Zhang, J., Zheng, L., Wang, X., Luo, F., Zhao, Y., Zhao, X., Wei, Y., Qian, Z. (2009b). Poly(epsiloncaprolactone)/ poly(ethylene glycol)/poly(epsilon-caprolactone) nanoparticles: preparation, characterization, and application in doxorubicin delivery. J Phys Chem B. 113:12928-12933
7. Groth-Pedersen, L., Ostenfeld, M.S., Hoyer-Hansen, M., Nylandsted, J., Jaattela, M. (2007). Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine. Cancer Res. 67:2217-2225
8. Hayakawa, A., Kawamoto, Y., Nakajima, H., Sakai, J., Takasawa, R., Nakashima, I., Magae, J., Tanuma, S. (2008). Bid truncation mediated by caspases-3 and -9 in vinorelbine-induced apoptosis. Apoptosis. 13:523-530
9. Jordan, M.A., Himes, R.H., Wilson, L. (1985). Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45:2741-2747
10. Jordan, M.A., Thrower, D., Wilson, L. (1991). Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer Res. 51:2212-2222
11. Jordan, M.A., Wilson, L. (1998). Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr Opin Cell Biol. 10:123-130
12. Krikorian, A., Breillout, F. (1991). Vinorelbine (Navelbine). A new semisynthetic vinca alkaloid. Onkologie. 14:7-12.
13. Kuo, C.C., Hsieh, H.P., Pan, W.Y., Chen, C.P., Liou, J.P., Lee, S.J., Chang, Y.L., Chen, L.T., Chen, C.T., Chang, J.Y. (2004). BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo. Cancer Res. 64:4621-4628
14. Ling, H., Lu, X., Tang, N., Liang, W. (2006). [VCR encapsulated in phospholipid micelles to improve effect of growth inhibition on MCF-7 cells]. Prog Biochem Biophys. 33:769-774
15. Lobert, S., Vulevic, B., Correia, J.J. (1996). Interaction of vinca alkaloids with tubulin: a comparison of vinblastine, vincristine, and vinorelbine. Biochemistry. 35:6806-6814
16. Morris, P.G., Fornier, M.N. (2008). Microtubule active agents: beyond the taxane frontier. Clin Cancer Res. 14:7167-7172
17. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Meth. 65:55-63.
18. Ngan, V.K., Bellman, K., Hill, B.T., Wilson, L., Jordan, M.A. (2001). Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol. 60:225-232
19. Owellen, R.J., Hartke, C.A., Dickerson, R.M., Hains, F.O. (1976). Inhibition of tubulin-microtubule polymerization by drugs of the Vinca alkaloid class. Cancer Res. 36:1499-1502
20. Owellen, R.J., Owens, A.H., Jr., Donigian, D.W. (1972). The binding of vincristine, vinblastine and colchicine to tubulin. Biochem Biophys Res Commun. 47:685-691
21. Pastan, I., Gottesman, M.M. (1991). Multidrug resistance. Annu Rev Med. 42:277-286
22. Pourroy, B., Carre, M., Honore, S., Bourgarel-Rey, V., Kruczynski, A., Briand, C., Braguer, D. (2004). Low concentrations of vinflunine induce apoptosis in human SK-N-SH neuroblastoma cells through a postmitotic G1 arrest and a mitochondrial pathway. Mol Pharmacol. 66:580-591
23. Rai, S.S., Wolff, J. (1996). Localization of the vinblastine-binding site on beta-tubulin. J Biol Chem. 271:14707-14711
24. Tang, N., Du, G., Wang, N., Liu, C., Hang, H., Liang, W. (2007). Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin. J Natl Cancer Inst. 99:1004-1015
25. Vijayaraghavalu, S., Raghavan, D., Labhasetwar, V. (2007). Nanoparticles for delivery of chemotherapeutic agents to tumors. Curr Opin Investig Drugs. 8:477-484
26. Wang, L.G., Liu, X.M., Kreis, W., Budman, D.R. (1999). The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review. Cancer Chemother Pharmacol. 44:355-361
27. Wei, X., Gong, C., Gou, M., Fu, S., Guo, Q., Shi, S., Luo, F., Guo, G., Qiu, L., Qian, Z. (2009a). Biodegradable poly(epsiloncaprolactone)-poly(ethylene glycol) copolymers as drug delivery system. Int J Pharm. 381:1-18.
28. Wei, X., Gong, C., Shi, S., Fu, S., Men, K., Zeng, S., Zheng, X., Gou, M., Chen, L., Qiu, L., Qian, Z. (2009b). Self-assembled honokiol loaded micelles based on poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon- caprolactone) copolymer. Int J Pharm. 369:170-175
29. Wu-Wong, J.R., Alder, J.D., Alder, L., Burns, D.J., Han, E.K., Credo, B., Tahir, S.K., Dayton, B.D., Ewing, P.J., Chiou, W.J. (2001). Identification and characterization of A-105972, an antineoplastic agent. Cancer Res. 61:1486-1492