Comparative study of the influence of thy1 deficiency and dietary iron deficiency on dopaminergic profiles in the mouse striatum

Journal of Neuroscience Research

Volumn 86, Issue 14, 2008, Pages 3194-3202

  Connor, James R ^a,c   Wang, Xin Sheng ^a   Neely, Elizabeth B ^a   Ponnuru, Padmavathi ^a   Morita, Hokuto ^a   Beard, John ^b  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Dopamine; GABA; Iron; Neurotransmitters; Restless legs syndrome; Synaptic function

Indexed keywords

DOPAMINE; DOPAMINE TRANSPORTER; HYDROLASE; MONOAMINE; THY 1 ANTIGEN; TYROSINE HYDROLASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DOPAMINERGIC SYSTEM; FEMALE; IRON DEFICIENCY; KNOCKOUT MOUSE; MALE; MOUSE; MUTANT; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX DIFFERENCE; SYNAPTOSOME;

ANIMALS; ANTIGENS, THY-1; CORPUS STRIATUM; DIET; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; IMMUNOBLOTTING; IRON; MALE; MICE; MICE, KNOCKOUT; NEURONS; SEX FACTORS;

EID: 57049160900     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21758     Document Type: Article

References (42)

1. Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ. 2001. MRI measurement of brain iron in patients with restless legs syndrome. Neurology 56:263-265.
2. Beard J. 2003. Iron deficiency alters brain development and functioning. J Nutr 133(Suppl 1):1468S-1472S.
3. Beard JL, Connor JR. 2003. Iron status and neural functioning. Annu Rev Nutr 23:41-58.
4. Beard JL, Chen Q, Connor J, Jones BC. 1994. Altered monamine metabolism in caudate-putamen of iron-deficient rats. Pharmacol Biochem Behav 48:621-624.
5. Beard JL, Unger EL, Bianco LE, Paul T, Rundle SE, Jones BC. 2007. Early postnatal iron repletion overcomes lasting effects of gestational iron deficiency in rats. J Nutr 137:1176-1182.
6. Binder EB, Kinkead B, Owens MJ, Nemeroff CB. 2001. Neurotensin and dopamine interactions. Pharmacol Rev 53:453-486.
7. Chen Q, Beard JL, Jones BC. 1995. Abnormal rat brain monoamine metabolism in iron deficiency anemia. J Nutr Biochem 6:486-493.
8. Connor JR, Boyer PJ, Menzies SL, Dellinger B, Allen RP, Ondo WG, Earley CJ. 2003. Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology 61:304-309.
9. Connor JR, Wang XS, Patton SM, Menzies SL, Troncoso JC, Earley CJ, Allen RP. 2004. Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Neurology 62:1563-1567.
10. Earley CJ, Yaffee JB, Allen RP. 1998. Randomized, double-blind, placebo-controlled trial of pergolide in restless legs syndrome. Neurology 51:1599-1602.
11. Earley CJ, Heckler D, Allen RP. 2001. IV iron treatment for the restless legs syndrome (RLS). Sleep 24:A359.
12. Erikson KM, Aschner M. 2003. Manganese neurotoxicity and glutamate-GABA interaction. Neurochem Int 43:475-480.
13. Erikson KM, Jones BC, Beard JL. 2000. Iron deficiency alters dopamine transporter functioning in rat striatum. J Nutr 130:2831-2837.
14. Erikson KM, Shihabi ZK, Aschner JL, Aschner M. 2002. Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations. Biol Trace Elem Res 87:143-156.
15. Fitsanakis VA, Au C, Erikson KM, Aschner M. 2006. The effects of manganese on glutamate, dopamine and gamma-amino butyric acid regulation. Neurochem Int 48:426-433.
16. Haavik J, Andersson KK, Petersson L, Flatmark T. 1988. Soluble tyrosine hydroxylase (tyrosine 3-monooxygenase) from bovine adrenal medulla: large-scale purification and physicochemical properties. Biochim Biophys Acta 953:142-156.
17. Haavik J, Martinez A, Flatmark T. 1990. pH-dependent release of catecholamines from tyrosine hydroxylase and the effect of phosphorylation of Ser-40. FEBS Lett 262:363-365.
18. Haavik J, Le Bourdelles B, Martinez A, Flatmark T, Mallet J. 1991. Recombinant human tyrosine hydroxylase isozymes. Reconstitution with iron and inhibitory effect of other metal ions. Eur J Biochem 199:371-378.
19. 1H-NMR spectroscopy. Eur J Biochem 210:23-31.
20. Jeng CJ, McCarroll SA, Martin TF, Floor E, Adams J, Krantz D, Butz S, Edwards R, Schweitzer ES. 1998. Thy-1 is a component common to multiple populations of synaptic vesicles. J Cell Biol 140:685-698.
21. Kabbani N, Negyessy L, Lin R, Goldman-Rakic P, Levenson R. 2002. Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor. J Neurosci 22:8476-8486.
22. Kollias G, Spanopoulou E, Grosveld F, Ritter M, Beech J, Morris R. 1987. Differential regulation of a Thy-1 gene in transgenic mice. Proc Natl Acad Sci U S A 84:1492-1496.
23. Kumer SC, Vrana KE. 1996. Intricate regulation of tyrosine hydroxylase activity and gene expression. J Neurochem 67:443-462.
24. Kwik-Uribe CL, Golub MS, Keen CL. 1999. Behavioral consequences of marginal iron deficiency during development in a murine model. Neurotoxicol Teratol 21:661-672.
25. Li D. 1998. Effects of iron deficiency on iron distribution and gamma-aminobutyric acid (GABA) metabolism in young rat brain tissues. Hokkaido Igaku Zasshi 73:215-225.
26. Lisanti MP, Caras IW, Davitz MA, Rodriguez-Boulan E. 1989. A glyco-phospholipid membrane anchor acts as an apical targeting signal in polarized epithelial cells. J Cell Biol 109:2145-2156.
27. Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. 2006. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev 64:S34-S43; discussion S72-S91.
28. McMahon HT, Foran P, Dolly JO, Verhage M, Wiegant VM, Nicholls DG. 1992. Tetanus toxin and botulinum toxins type A and B inhibit glutamate, gamma-aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes. Clues to the locus of action. J Biol Chem 267:21338-21343.
29. Morris R. 1985. Thy-1 in developing nervous tissue. Dev Neurosci 7:133-160.
30. Morris RJ, Barber PC, Beech J, Raisman G. 1983. The distribution of Thy-1 antigen in the P.N.S. of the adult rat. J Neurocytol 12:1017-1039.
31. Morse A, Beard JL, Jones B. 1999. Sex and genetics are important cofactors in assessing the impact of iron deficiency on the developing rat brain. Nutritional Neuroscience 2:323-335.
32. Nelson C, Erikson K, Pinero DJ, Beard JL. 1997. In vivo dopamine metabolism is altered in iron-deficient anemic rats. J Nutr 127:2282-2288.
33. Nosten-Bertrand M, Errington ML, Murphy KP, Tokugawa Y, Barboni E, Kozlova E, Michalovich D, Morris RG, Silver J, Stewart CL, Bliss TV, Morris RJ. 1996. Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1. Nature 379:826-829.
34. Rao R, Tkac I, Townsend EL, Gruetter R, Georgieff MK. 2003. Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus. J Nutr 133:3215-3221.
35. Rege TA, Hagood JS. 2006. Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer and fibrosis. FASEB J 20:1045-1054.
36. Rothman RB, Partilla JS, Baumann MH, Dersch CM, Carroll FI, Rice KC. 2000. Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse. Synapse 35:222-227.
37. Shukla A, Agarwal KN, Shukla GS. 1989. Latent iron deficiency alters gamma-aminobutyric acid and glutamate metabolism in rat brain. Experientia 45:343-345.
38. Stohl W, Gonatas NK. 1977. Distribution of the thy-1 antigen in cellular and subcellular fractions of adult mouse brain. J Immunol 119:422-427.
39. Unger EL, Paul T, Murray-Kolb LE, Felt B, Jones BC, Beard JL. 2007. Early iron deficiency alters sensorimotor development and brain monoamines in rats. J Nutr 137:118-124.
40. Wang X, Wiesinger J, Beard J, Felt B, Menzies S, Earley C, Allen R, Connor J. 2004. Thy1 expression in the brain is affected by iron and is decreased in restless legs syndrome. J Neurol Sci 220:59-66.
41. Wiesinger JA, Buwen JP, Cifelli CJ, Unger EL, Jones BC, Beard JL. 2007. Down-regulation of dopamine transporter by iron chelation in vitro is mediated by altered trafficking, not synthesis. J Neurochem 100:167-179.
42. Ye Z, Connor JR. 2000. Identification of iron responsive genes by screening cDNA libraries from suppression subtractive hybridization with antisense probes from three iron conditions. Nucleic Acids Res 28:1802-1807.