Cardioprotection by metformin is abolished by a nitric oxide synthase inhibitor in ischemic rabbit hearts

Hypertension Research

Volumn 26, Issue 1, 2003, Pages 107-110

  Kawabata, Hitoshi ^a   Ishikawa, Kinji ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cardioprotection; Ischemia; Metformin; Nitric Oxide

Indexed keywords

ADENOSINE TRIPHOSPHATE; BIGUANIDE; CHLORPROPAMIDE; GLIBENCLAMIDE; HEPARIN; METFORMIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHORUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DRUG EFFECT; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART PROTECTION; ISOLATED HEART; MALE; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; RABBIT;

EID: 0037275650     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.26.107     Document Type: Article

References (22)

1. United Kingdom Prospective Diabetes Study (UKPDS) Group: Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352: 854-865.
2. Diabetes Prevention Program Research Group: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403.
3. Verma S, McNeill JH: Metformin improves cardiac function in isolated streptozotocin-diabetic rat hearts. Am J Physiol 1994; 266: H714-H719.
4. 2+]. J Hypertens 1997; 15: 269-274.
5. 2+ transients in adult rat ventricular myocytes. Diabetes 1999; 48: 2059-2065.
6. Charlon V, Boucher F, Mouhieddine S, Leiris JD: Reduction of myocardial infarct size by metformin in rats submitted to permanent left coronary artery ligation. Diabetes Metab 1988; 14: 591-595.
7. Bhalla RC, Toth KF, Tan E, Bhatty RA, Mathias BE, Sharma RV: Vascular effects of metformin: possible mechanisms for its antihypertensive action in the spontaneously hypertensive rat. Am J Hypertens 1996; 9: 570-576.
8. Marfella R, Acampora R, Verrazzo G, et al: Metformin improves hemodynamic and rheological responses to L-arginine in NIDDM patients. Diabetes Care 1996; 19: 934-939.
9. Katakam PVG, Ujhelyi MR, Hoenig M, Miller AW: Metformin improves vascular function in insulin-resistant rats. Hypertension 2000; 35: 108-112.
10. + channels induced by HMG CoA reductase inhibitor in ischemic rabbit heart. Hypertens Res 2001; 24: 573-577.
11. Kawabata H, Nakagawa K, Ishikawa K: Effects of an HMG-CoA reductase inhibitor in combination with an ACE inhibitor or angiotensin II type 1 receptor antagonist on myocardial metabolism in ischemic rabbit hearts. Hypertens Res 2002; 25: 203-210.
12. 31P nuclear magnetic resonance analysis of metabolite concentrations in Langendorff-perfused rabbit hearts. Biophys J 1985; 48: 803-813.
13. Opie LH: The Heart Physiology, Metabolism, Pharmacology and Therapy. London, Grune & Stratton, 1984; pp 351-371.
14. Kawabata H, Nakagawa K, Ishikawa K: A novel cardioprotective agent, JTV-519, is abolished by nitric oxide synthase inhibitor on myocardial metabolism in ischemia-reperfused rabbit hearts. Hypertens Res 2002; 25: 303-309.
15. Jennings RB, Reimer KA: Lethal myocardial ischemic injury. Am J Pathol 1981; 102: 241-255.
16. Kawabata H, Ryomoto T, Ishikawa K: Effect of beta-blocker on metabolism and contraction of doxorubicin-induced cardiotoxicity in the isolated perfused rabbit heart. Angiology 2000; 21: 405-413.
17. Nakanishi K, Vinten-Johansen J, Lefer DJ, et al: Intracoronary L-arginine during reperfusion improves endothelial function and reduces infarct size. Am J Physiol 1992; 263: H1650-H1658.
18. Benjamin IJ, McMillan DR: Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease. Circ Res 1998; 83: 117-132.
19. Vegh A, Szekeres L, Parratt J: Preconditioning of the ischaemic myocardium: involvement of the L-arginine nitric oxide pathway. Br J Pharmacol 1992; 107: 648-652.
20. Sasaki N, Sato T, Ohler A, O'Rourke B, Marban E: Activation of mitochondrial ATP-dependent potassium channels by nitric oxide. Circulation 2000; 101: 439-445.
21. Gross GJ, Auchanpach JA: Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res 1992; 70: 223-233.
22. 1 receptors. Circulation 1992; 86: 1310-1316.