Tacrolimus nephrotoxicity: Beware of the association of diarrhea, drug interaction and pharmacogenetics

Pediatric Nephrology

Volumn 25, Issue 5, 2010, Pages 965-969

  Leroy, Sandrine ^a   Isapof, Arnaud ^a   Fargue, Sonia ^b,c   Fakhoury, May ^d   Bensman, Albert ^a   Deschênes, Georges ^d   Jacqz Aigrain, Evelyne ^d   Ulinski, Tim ^a,e  

^a ARMAND TROUSSEAU HOSPITAL   (France)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITÉ DE LYON   (France)

^d HÔPITAL ROBERT DEBRÉ   (France)

^e CENTRE DE RECHERCHE SAINT ANTOINE   (France)

Author keywords

Calcium channel blocker; Cytochrome P450; Diarrhoea; P glycoprotein; Polymorphisms; Renal transplant; Tacrolimus

Indexed keywords

AMLODIPINE; AZATHIOPRINE; CALCIUM CHANNEL BLOCKING AGENT; CYTOCHROME P450 3A; GLYCOPROTEIN P; STEROID; TACROLIMUS;

ADOLESCENT; ARTICLE; CASE REPORT; CELL DAMAGE; CHILD; CHRONIC GRAFT REJECTION; COMPETITIVE INHIBITION; DIARRHEA; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; ENZYME ACTIVITY; GENOTYPE; GRAFT RECIPIENT; HUMAN; HYPERTENSION; INTESTINE CELL; KIDNEY BIOPSY; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; LOW DRUG DOSE; MALE; NEPHROTOXICITY; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN POLYMORPHISM;

ADOLESCENT; CALCIUM CHANNEL BLOCKERS; CYTOCHROME P-450 ENZYME SYSTEM; DIARRHEA; DRUG INTERACTIONS; DRUG MONITORING; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY FAILURE, ACUTE; KIDNEY TRANSPLANTATION; MALE; P-GLYCOPROTEIN; PHARMACOGENETICS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TACROLIMUS;

EID: 77951256438     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-009-1402-8     Document Type: Article

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