Elevated blood concentrations of calcineurin inhibitors during diarrheal episode in pediatric liver transplant recipients: Involvement of the suppression of intestinal cytochrome P450 3A and P-glycoprotein

Pediatric Transplantation

Volumn 9, Issue 3, 2005, Pages 315-323

  Maezono, Sachiko ^a,b   Sugimoto, Koh Ichi ^a   Sakamoto, Koh Ichi ^a   Ohmori, Masami ^a   Hishikawa, Shuji ^a   Mizuta, Koichi ^a   Kawarasaki, Hideo ^a   Watanabe, Yoshiteru ^b   Fujimura, Akio ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cyclosporine; Cytochrome P450 3A; Diarrhea; Enteritis; P glycoprotein; Tacrolimus

Indexed keywords

CALCINEURIN INHIBITOR; CEFOTAXIME; CYCLOSPORIN A; CYTOCHROME P450 3A; DIGOXIN; GENTAMICIN; GLYCOPROTEIN P; LIPOPOLYSACCHARIDE; METHYLPREDNISOLONE; NIFEDIPINE; TACROLIMUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASE REPORT; CHILD; CHOLANGITIS; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG OXIDATION; ENTERITIS; ENZYME ACTIVITY; FEMALE; HUMAN; IMMUNOASSAY; INTESTINE EPITHELIUM; INTESTINE INJURY; INTESTINE PERFUSION; JEJUNUM; LIVER TRANSPLANTATION; LIVING DONOR; MALE; NONHUMAN; RAT;

ANIMALS; CALCINEURIN; CHILD, PRESCHOOL; CYCLOSPORINE; CYTOCHROME P-450 ENZYME SYSTEM; DIARRHEA, INFANTILE; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; LIPOPOLYSACCHARIDES; LIVER TRANSPLANTATION; LIVING DONORS; MALE; P-GLYCOPROTEIN; RATS; TACROLIMUS;

EID: 20344383283     PISSN: 13973142     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2005.00315.x     Document Type: Article

References (27)

1. HEBERT MF. Contributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug delivery. Adv Drug Deliv Rev 1997: 27: 201-214.
2. MATSUI A, ARAKAWA Y, MOMOYA T, SASAKI N, KAWASAKI S, TANAKA K. Apparently increased trough levels of tacrolimus caused by acute infantile diarrhea in two infants with biliary atresia after liver transplantation. Acta Paediatr Jpn 1996: 38: 699-701.
3. EADES SK, BOINEAU FG, CHRISTENSEN ML. Increased tacrolimus levels in a pediatric renal transplant patient attributed to chronic diarrhea. Pediatr Transplant 2000: 4: 63-66.
4. FRÜHWIRTH M, FISCHER H, SIMMA B, HOCHLEITNER B, KÖNIGSRAINER A, MARGREITER R, ELLEMUNTER H. Rotavirus infection as cause of tacrolimus elevation in solid-organ-transplanted children. Pediatr Transplant 2001: 5: 88-92.
5. ZYLBER-KATZ E, GRANOT E. Abrupt increase of tacrolimus blood levels during an episode of Shigella infection in a child after liver transplantation. Ther Drug Monit 2001: 23: 647-649.
6. ZHANG Y, BENET LZ. The gut as a barrier to drug absorption. Combined role of cytochrome P450 3A and P-glycoprotein. Clin Pharmacokinet 2001: 40: 159-168.
7. GHEZZI P, SACCARDO B, VILLA P, ROSSI V, BIANCHI M, DINARELLO CA. Role of interleukin-1 in the depression of liver drug metabolism by endotoxin. Infect Immun 1986:54: 837-840.
8. GHEZZI P, SACCARDO B, BIANCHI M. Recombinant tumor necrosis factor depresses cytochrome P450-dependent microsomal drug metabolism in mice. Biochem Biophys Res Commun 1986: 136: 316-321.
9. SHEDLOFSKY SI, SWIM AT, ROBINSON JM, GALLICCHIO VS, COHEN DA, MCCLAIN CJ. Interleukin-1 (IL-1) depresses cytochrome P450 levels and activities in mice. Life Sci 1987: 40: 2331-2336.
10. BERTINI R, BIANCHI M, VILLA P, GHEZZI P. Depression of liver drug metabolism and increase in plasma fibrinogen by interleukin 1 and tumor necrosis factor. A comparison with lymphotoxin and interferon. Int J Immunopharmac 1988: 10: 525-530.
11. MORGAN ET. Down-regulation of multiple cytochrome P450 gene products by inflammatory mediators in vivo. Independence from the hypothalamo-pituitary mediators in vitro. Biochem Pharmacol 1993: 45: 415-419.
12. MORGAN ET. Suppression of constitutive cytochrome P-450 gene expression in livers of rats undergoing an acute phase response to endotoxin. Mol Pharmacol 1989: 36: 699-707.
13. WEISER MM. Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. J Biol Chem 1973: 248: 2536-2541.
14. BONKOVSKY HL, HAURI H-P, MARTI U, GASSER R, MEYER UA. Cytochrome P450 of small intestinal epithelial cells. Immunochemical characterization of the increase in cytochrome P450 caused by pentobarbital. Gastroenterology 1985: 88: 458-467.
15. GUENGERICH FP, MARTIN MV, BEAUNE PH, KREMERS P, WOLFF T, WAXMAN DJ. Characterization of rat and human liver microsome cytochrome P-450 forms involved in nifedipine oxidation, a prototype of genetic polymorphism in oxidative drug metabolism. J Biol Chem 1986: 261: 5051-5060.
16. BOURRIÉ M, NEUNIER V, BERGER Y, FABRE G. Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reaction catalyzed by human liver microsomes. J Pharmacol Exp Ther 1996: 277: 321-332.
17. MERCER DW, SMITH GS, CROSS JM, RUSSELL DH, CHANG L, CACIOPPO J. Effects of lipopolysaccharide on intestinal injury: Potential role of nitric oxide and lipid peroxidation. J Surg Res 1996: 63: 185-192.
18. ATKINSON K, BIGGS JC, BRITTON K, SHORT R, MRONGOVIUS R, CONCANNON A, DODDS A. Oral administration of cyclosporin A for recipients of allogeneic marrow transplants: implications of clinical gut dysfunction. Br J Haematol 1984: 56: 223-231.
19. CHARLES BG, SHEPHERD RW. Gross malabsorption of oral cyclosporin in panenteropathy. Am J Gastroenterol 1988: 83: 890-891.
20. WRIGHT K, MORGAN ET. Regulation of cytochrome P450IIC12 expression by interleukin-1a, interleukin-6, and dexamethasone. Mol Pharmacol 1991: 39: 468-474.
21. CHEN YL, FLORENTIN I, BATT AM, FERRARI L, GIROUD JP, CHAUVELOT-MOACHON L. Effects of interleukin-6 on cytochrome P450-dependent mixed-function oxidases in the rat. Biochem Pharmacol 1992: 44: 137-148.
22. GOMEZ DY, WACHER VJ, TOMLANOVICH MF, HEBERT MF, BENET LZ. The effect of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clin Pharmacol Ther 1995: 58: 15-19.
23. FLOREN LC, BEKERSKY I, BENET LZ, MEKKI Q, DRESSLER D, LEE JW, ROBERTS JP, HEBERT MF. Tacrolimus oral bioavailability doubles with coadministration of ketoconazole. Clin Pharmacol Ther 1997: 62: 41-49.
24. MATHAN VI, PENNY GR, MATHAN MM, ROWLEY D. Bacterial lipopolysaccharide- induced intestinal microvascular lesions leading to acute diarrhea. J Clin Invest 1988: 82: 1714-1721.
25. BOUGHTON-SMITH NK, HUTCHENSON I, WHITTLE BJR. Relationship between Paf-acether and thromboxane A2 biosynthesis in endotoxin-induced intestinal damage in the rat. Prostaglandins 1989: 38: 319-333.
26. CUZZOLIN L, ADAMI A, CRIVELLENTE F, BENONI G. Role of endogenous and exogenous nitric oxide on intestinal mucosa and microflora in the rat. Inflammation 1997: 21: 443-450.
27. SALVEMINI D, RILEY DP, LENNON PJ, WANG Z-Q, CURRIE MG, MACARTHUR H, MISKO TP. Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage. Br J Pharmacol 1999: 127: 685-692.