Severe elevations of FK506 blood concentration due to diarrhea in renal transplant recipients

Clinical Transplantation

Volumn 18, Issue 5, 2004, Pages 585-590

  Sato, Koichiro ^a,d   Amada, Noritoshi ^b   Sato, Takaomi ^b   Miura, Shunji ^b   Ohashi, Yoichi ^c   Sekiguchi, Satoshi ^a   Satomi, Susumu ^a   Okazaki, Hajime ^c  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Sendai Shakaihoken Hospital   (Japan)

^c Katta General Hospital   (Japan)

^d NONE   (Japan)

Author keywords

Area under the concentration time curve; Diarrhea; FK506; Trough level

Indexed keywords

ALBUMIN TANNATE; AZATHIOPRINE; LOPERAMIDE; MIZORIBINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; SILICATE; TACROLIMUS;

AREA UNDER THE CURVE; ARTICLE; BIFIDOBACTERIUM; CLINICAL ARTICLE; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG METABOLISM; HUMAN; KIDNEY TRANSPLANTATION; MAXIMUM ALLOWABLE CONCENTRATION; PRIORITY JOURNAL; RECIPIENT;

ADMINISTRATION, ORAL; AREA UNDER CURVE; CIRCADIAN RHYTHM; CREATININE; DIARRHEA; FOLLOW-UP STUDIES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL ABSORPTION; KIDNEY TRANSPLANTATION; TACROLIMUS;

EID: 4644281980     PISSN: 09020063     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2004.00232.x     Document Type: Article

References (18)

1. Undre N. Prograf-Clinical Parmacokinetics of Tacrolimus, 2nd edn. Fujisawa.
2. Matsui A, Arakawa Y, Momoya T et al. Apparently increased trough levels of tacrolimus apparently caused by acute infantile diarrhea in two infants with biliary atresia after liver transplantation. Acta Pediatr Japonica 1996: 38: 699.
3. Eades SK, Boineau FG, Christensen ML. Increased tacrolimus level in a pediatric renal transplant patient attributed to chronic diarrhea. Pediatr Transplant 2000: 4: 63.
4. Lampen A, Christians U, Gonschior A et al. Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the using chamber. Br J Phamacol 1996: 117: 1730.
5. Venkataramanan R, Swaminathan A, Prasad T et al. Clinical pharmacokinetics of tacrolimus. Clin Pharmacokinet 1995: 29: 404.
6. Kaplan B, Lown K, Craig R et al. Low bioavailability of cyclosporine microemulsion and tacrolimus in a small bowel transplant recipient. Transplantation 1999: 67: 333.
7. Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T. Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem 1993: 268: 6077.
8. Shapiro R, Venkataramanan R, Warty VS et al. FK506 interaction with danazol. Lancet 1993: 341: 1344.
9. Jensen C, Jordan M, Shapiro R et al. Interaction between tacrolimus and erythromycin. Lancet 1994: 344: 825.
10. Wolter K, Wagner K, Philipp T, Fritschka E. Interaction between FK506 and clarithromycin in renal transplant recipients. Eur J Clin Pharmacol 1994: 47: 207.
11. Mieles L, Venkataramanan R, Yokoyama I. Warty VJ, Starzl TE. Interaction between FK506 and clotrimazole in liver transplant recipients. Transplantation 1991: 52: 1086.
12. Manez R, Martin M. Venkataramanan R et al. Fluconazole therapy in transplant recipients receiving FK506. Transplantation 1994: 57: 1521.
13. Seifeldin R, Maecds-Alvarez A, Lewis WD, Gordon FD, Jenkins RL. Effect of nifedipine on renal function in liver transplant recipients receiving tacrolimus. Clin Ther 1996: 18: 491.
14. Sano N, Nio M, Shimaoka S et al. High trough level of oral FK506 induced by loss of small intestine. Pediatr Transplant 2001: 5: 434.
15. Min DI, Chen HY, Fabrega A et al. Circadian variation of tacrolimus disposition in liver allograft recipients. Transplantation 1996: 62: 1190.
16. Takahara S, Miki T, Hatori M, Kokado Y, Wang J, Okuyama A. A comparative study of FK506 granules and capsules in renal transplant recipient. Transpl Int 1998: 11: 181.
17. Bekersky I, Dressler D, Mkki Q. Effect of time of meal consumption on bioavailability of a single oral 5 mg tacrolimus dose. J Clin Pharmacol 2001: 41: 289.
18. Kimikawa M, Kamoya K, Toma H, Teraoka S. Effective oral administration of tacrolimus in renal transplant recipients. Clin Transplant 2001: 15: 324.