Large conformational changes in the Escherichia coli tryptophan synthase β2 subunit upon pyridoxal 5′-phosphate binding

FEBS Journal

Volumn 277, Issue 9, 2010, Pages 2157-2170

  Nishio, Kazuya ^a   Ogasahara, Kyoko ^a   Morimoto, Yukio ^b,c   Tsukihara, Tomitake ^a,d   Lee, Soo Jae ^e   Yutani, Katsuhide ^c  

^a OSAKA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Harima Institute ^*  (Japan)

^d UNIVERSITY OF HYOGO   (Japan)

^e Chungbuk National University   (South Korea)

Author keywords

Apo and holo forms; Conformational change; PLP binding; Tryptophan synthase 2 subunit; X ray crystal structure

Indexed keywords

APOLIPOPROTEIN B; ASPARTIC ACID; DIMER; INDOLE; PHENYLALANINE; PYRIDOXAL 5 PHOSPHATE; TRYPTOPHAN SYNTHASE; TRYPTOPHAN SYNTHASE BETA2 SUBUNIT; TYROSINE; UNCLASSIFIED DRUG;

ALPHA CHAIN; ARTICLE; BACTERIUM EXAMINATION; BETA CHAIN; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; ENZYME SUBUNIT; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SALMONELLA TYPHIMURIUM; STRUCTURE ANALYSIS; THERMOSTABILITY;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; APOENZYMES; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; ESCHERICHIA COLI; HOLOENZYMES; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN SUBUNITS; PYRIDOXAL PHOSPHATE; SALMONELLA TYPHIMURIUM; SEQUENCE ALIGNMENT; TRYPTOPHAN SYNTHASE;

ESCHERICHIA COLI; SALMONELLA TYPHIMURIUM;

EID: 77951247294     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07631.x     Document Type: Article

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