Control of steroid 21-oic acid synthesis by peroxisome proliferator- activated receptor α and role of the hypothalamic-pituitary-adrenal axis

Journal of Biological Chemistry

Volumn 285, Issue 10, 2010, Pages 7670-7685

  Wang, Ting ^a,d   Shah, Yatrik M ^a,e   Matsubara, Tsutomu ^a   Zhen, Yueying ^a   Tanabe, Tomotaka ^a,f   Nagano, Tomokazu ^a,g   Fotso, Serge ^b   Krausz, Kristopher W ^a   Zabriskie, T Mark ^b   Idle, Jeffrey R ^a,c   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b OREGON STATE UNIVERSITY   (United States)

^c CHARLES UNIVERSITY   (Czech Republic)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^f MATSUYAMA UNIVERSITY   (Japan)

^g DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENAL CORTEX; AGOUTI-RELATED PROTEINS; ALDEHYDE DEHYDROGENASE; CYTOCHROMES P450; END-PRODUCTS; ENERGY HOMEOSTASIS; HYDROXYSTEROID DEHYDROGENASE; HYPOTHALAMIC-PITUITARY-ADRENAL AXIS; IN-VITRO; IN-VIVO; METABOLIC PATHWAYS; METABOLOMICS; MOLECULAR MECHANISM; MOUSE LIVER; NEUROPEPTIDE Y; OXIDATIVE PATHWAYS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; SEQUENTIAL OXIDATION; SPECIFIC TIME; TARGET GENES;

ALDEHYDES; BIOLOGICAL RADIATION EFFECTS; BIOMARKERS; CARBOXYLIC ACIDS; CYTOLOGY; GENES; MASS SPECTROMETRY; ORGANIC ACIDS;

METABOLISM;

11BETA HYDROXY 3,20 DIOXOPREGN 4 EN 21 OIC ACID; 11BETA,20 DIHYDROXY 3,20 PREGN 4 EN 21 OIC ACID; 21 HYDROXYSTEROID DEHYDROGENASE; AGOUTI RELATED PROTEIN; ALDEHYDE DEHYDROGENASE; BIOLOGICAL MARKER; CARBOXYLIC ACID DERIVATIVE; CORTICOSTERONE; CYTOCHROME P450; HYDROXYSTEROID DEHYDROGENASE; MESSENGER RNA; NEUROPEPTIDE Y; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIRINIXIC ACID; UNCLASSIFIED DRUG;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATROPHY; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CUSHING SYNDROME; HORMONE SYNTHESIS; HYPERCORTISOLISM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IN VITRO STUDY; IN VIVO STUDY; MALE; MASS SPECTROMETRY; METABOLOMICS; MICROARRAY ANALYSIS; MOLECULAR MECHANICS; MOUSE; NERVE CELL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA ANALYSIS; SPLEEN DISEASE;

ADRENAL CORTEX HORMONES; ADRENALECTOMY; ALCOHOL OXIDOREDUCTASES; ALDEHYDE OXIDOREDUCTASES; ANIMALS; BIOLOGICAL MARKERS; FASTING; HYDROXYPROGESTERONES; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LIVER; MALE; MASS SPECTROMETRY; METABOLOMICS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR STRUCTURE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATION-REDUCTION; PEROXISOME PROLIFERATORS; PITUITARY-ADRENAL SYSTEM; PPAR ALPHA; PROGESTINS; PYRIMIDINES; URINE;

AGOUTI; MUS;

EID: 77951243562     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.090175     Document Type: Article

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