-
1
-
-
27144449009
-
Monoclonal antibody therapy of cancer
-
Adams G.P., Weiner L.M., Monoclonal antibody therapy of cancer. Nat Biotechnol, 2005, 23, 1141-1157.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1141-1157
-
-
Adams, G.P.1
Weiner, L.M.2
-
2
-
-
34249080326
-
Identifying and validating novel targets with in vivo disease models: Guidelines for study design
-
Anders H.J., Vielhauer V., Identifying and validating novel targets with in vivo disease models: Guidelines for study design. Drug Discov Today, 2007, 12, 446-451.
-
(2007)
Drug Discov Today
, vol.12
, pp. 446-451
-
-
Anders, H.J.1
Vielhauer, V.2
-
3
-
-
33744919804
-
IL-4 receptor α is an important modulator of IL-4 and IL-13 receptor binding: Implications for the development of therapeutic targets
-
Andrews A.L., Holloway J.W., Holgate S.T., Davies D.E., IL-4 receptor α is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets. J Immunol, 2006, 176, 7456-7461.
-
(2006)
J Immunol
, vol.176
, pp. 7456-7461
-
-
Andrews, A.L.1
Holloway, J.W.2
Holgate, S.T.3
Davies, D.E.4
-
4
-
-
35348832312
-
Affinity selection-mass spectrometry screening techniques for small molecule drug discovery
-
Annis D.A., Nickbarg E., Yang X., Ziebell M.R., Whitehurst C.E., Affinity selection-mass spectrometry screening techniques for small molecule drug discovery. Curr Opin Chem Biol, 2007, 11, 518-526.
-
(2007)
Curr Opin Chem Biol
, vol.11
, pp. 518-526
-
-
Annis, D.A.1
Nickbarg, E.2
Yang, X.3
Ziebell, M.R.4
Whitehurst, C.E.5
-
5
-
-
13644256840
-
Phenotype-first screening for the identification of novel drug targets
-
Austen M., Dohrmann C., Phenotype-first screening for the identification of novel drug targets. Drug Discov Today, 2005, 10, 275-282.
-
(2005)
Drug Discov Today
, vol.10
, pp. 275-282
-
-
Austen, M.1
Dohrmann, C.2
-
7
-
-
77953130174
-
Physiological aspects determining the Pharmacokinetic properties of drugs
-
Wermuth C. (Ed.), Academic Press
-
Boussery K., Belpaire F.M., Van de Voorde J., Physiological aspects determining the Pharmacokinetic properties of drugs. In The practice of Medicinal Chemistry, Wermuth C. (Ed.). Academic Press, 2008, pp. 637-654.
-
(2008)
The Practice of Medicinal Chemistry
, pp. 637-654
-
-
Boussery, K.1
Belpaire, F.M.2
Van De Voorde, J.3
-
8
-
-
36549010477
-
Unfinished business: Target-based drug discovery
-
Brown D., Unfinished business: target-based drug discovery. Drug Discov Today, 2007, 12, 1007-101.
-
(2007)
Drug Discov Today
, vol.12
, pp. 1007-1101
-
-
Brown, D.1
-
9
-
-
20844432908
-
Can cell systems biology rescue drug discovery ?
-
Butcher E.C., Can cell systems biology rescue drug discovery ? Nat Rev, 2005, 4, 461-467.
-
(2005)
Nat Rev
, vol.4
, pp. 461-467
-
-
Butcher, E.C.1
-
10
-
-
45149104960
-
Crossing the valley of death
-
Butler D., Crossing the valley of death. Nature, 2008, 453, 840-842.
-
(2008)
Nature
, vol.453
, pp. 840-842
-
-
Butler, D.1
-
11
-
-
33646352962
-
Potent antibody therapeutics by design
-
Carter P., Potent antibody therapeutics by design. Nat Rev Immunol, 2006, 6, 343-357.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 343-357
-
-
Carter, P.1
-
12
-
-
0031304155
-
The role of innovation in drug development
-
Drews J., Ryser S., The role of innovation in drug development. Nat Biotechnol, 1997, 15, 1318-1319.
-
(1997)
Nat Biotechnol
, vol.15
, pp. 1318-1319
-
-
Drews, J.1
Ryser, S.2
-
13
-
-
27144443099
-
Playing dirty
-
Frantz S., Playing dirty. Nature, 2005, 437, 942-943.
-
(2005)
Nature
, vol.437
, pp. 942-943
-
-
Frantz, S.1
-
14
-
-
33751099302
-
Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy
-
Gorter J.A., van Vliet E.A., Aronica E., Breit T., Rauwerda H., Lopes da Silva F., Wadman W.J., Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy. J Neurosci, 2006, 26, 11083-11110.
-
(2006)
J Neurosci
, vol.26
, pp. 11083-11110
-
-
Gorter, J.A.1
Van Vliet, E.A.2
Aronica, E.3
Breit, T.4
Rauwerda, H.5
Lopes Da Silva, F.6
Wadman, W.J.7
-
16
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J., Selkoe D.J., The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science, 2002, 297, 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
17
-
-
58149165212
-
Insulin analogs: Impact on treatment success, satisfaction, quality of life, and adherence
-
Hartman I., Insulin analogs: impact on treatment success, satisfaction, quality of life, and adherence. Clin Med Res, 2008, 6, 54-67.
-
(2008)
Clin Med Res
, vol.6
, pp. 54-67
-
-
Hartman, I.1
-
18
-
-
62249112106
-
Personalized cancer therapy gets closer
-
Hayden E.C., Personalized cancer therapy gets closer. Nature, 2009, 458, 131-132.
-
(2009)
Nature
, vol.458
, pp. 131-132
-
-
Hayden, E.C.1
-
19
-
-
0036759632
-
Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus
-
He X.P., Minichiello L., Klein R., McNamara J.O., Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus. J Neurosci, 2002, 22, 7502-7508.
-
(2002)
J Neurosci
, vol.22
, pp. 7502-7508
-
-
He, X.P.1
Minichiello, L.2
Klein, R.3
McNamara, J.O.4
-
20
-
-
3242704193
-
Conditional deletion of trkB but not BDNF prevents epileptogenesis in the kindling model
-
He X.P., Kotloski R., Nef S., Luikart B., Parada L.F., McNamara J.O., Conditional deletion of trkB but not BDNF prevents epileptogenesis in the kindling model. Neuron, 2004, 43, 31-42.
-
(2004)
Neuron
, vol.43
, pp. 31-42
-
-
He, X.P.1
Kotloski, R.2
Nef, S.3
Luikart, B.4
Parada, L.F.5
McNamara, J.O.6
-
21
-
-
3242813635
-
Utility of homology models in the drug discovery process
-
Hillish A., Pineda L.F., Hilgenfeld R., Utility of homology models in the drug discovery process. Drug Discov Today, 2004, 9, 659-669.
-
(2004)
Drug Discov Today
, vol.9
, pp. 659-669
-
-
Hillish, A.1
Pineda, L.F.2
Hilgenfeld, R.3
-
22
-
-
27144431943
-
Selecting and Screening Recombinant Antibody Libraries
-
Hoogenboom H.R., Selecting and screening recombinant antibody libraries. Nature Biotechnol, 2005, 23, 1105-1116.
-
(2005)
Nature Biotechnol
, vol.23
, pp. 1105-1116
-
-
Hoogenboom, H.R.1
-
24
-
-
33749234216
-
Drugs, their targets and the nature and number of drug targets
-
Imming P., Sinning C., Meyer A., Drugs, their targets and the nature and number of drug targets. Nature Rev, 2006, 5, 821-834.
-
(2006)
Nature Rev
, vol.5
, pp. 821-834
-
-
Imming, P.1
Sinning, C.2
Meyer, A.3
-
25
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates
-
Kola I., Landis J., Can the pharmaceutical industry reduce attrition rates. Nat Rev Drug Discov, 2004, 3, 711-715.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
26
-
-
0043069489
-
Drug research: Myths, hype and reality
-
Kubinyi H., Drug research: myths, hype and reality. Nat Rev Drug Discov, 2003, 2, 665-668.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 665-668
-
-
Kubinyi, H.1
-
27
-
-
77956310827
-
Biology oriented synthesis and diversity oriented synthesis in compound collection development
-
Wermuth C. (Ed.), Academic Press
-
Kumar K.,Wetzel, S.,Waldmann H., Biology oriented synthesis and diversity oriented synthesis in compound collection development. In« The practice of Medicinal Chemistry»,Wermuth C. (Ed.). Academic Press, 2008, pp. 187-209.
-
(2008)
The Practice of Medicinal Chemistry
, pp. 187-209
-
-
Kumar, K.1
Wetzel, S.2
Waldmann, H.3
-
28
-
-
38649120829
-
Drugs and their molecular targets: An updated overview
-
Landry Y., Gies, J.P., Drugs and their molecular targets : an updated overview. Fundam Clin Pharmacol, 2008, 22, 1-18.
-
(2008)
Fundam Clin Pharmacol
, vol.22
, pp. 1-18
-
-
Landry, Y.1
Gies, J.P.2
-
29
-
-
70349419169
-
In silico screening: Hit finding from database mining
-
Wermuth C. (Ed.), Academic Press
-
Langer T., Bryant S.D., In silico screening: hit finding from database mining. In« The practice of Medicinal Chemistry»,Wermuth C. (Ed.). Academic Press, 2008, pp. 210-227.
-
(2008)
The Practice of Medicinal Chemistry
, pp. 210-227
-
-
Langer, T.1
Bryant, S.D.2
-
30
-
-
37649013428
-
Alternative drug discovery approaches for orphan GPCRs
-
Levoye A., Jockers R., Alternative drug discovery approaches for orphan GPCRs. Drug Discov Today, 2008, 12, 52-58.
-
(2008)
Drug Discov Today
, vol.12
, pp. 52-58
-
-
Levoye, A.1
Jockers, R.2
-
31
-
-
27144532832
-
Human antibodies from transgenic animals
-
Lonberg N., Human antibodies from transgenic animals. Nat Biotechnol, 2005, 23, 1117-1125.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1117-1125
-
-
Lonberg, N.1
-
32
-
-
33645887230
-
Critical review of the role of HTS in drug discovery
-
Macarron R., Critical review of the role of HTS in drug discovery. Drug Discov Today, 2006, 11, 277-279.
-
(2006)
Drug Discov Today
, vol.11
, pp. 277-279
-
-
MacArron, R.1
-
33
-
-
65249147834
-
Relevance of transgenic mouse models to human Alzheimer disease
-
Morrissette D.A., Parachikova A., Green K.N., La Ferla, F.M., Relevance of transgenic mouse models to human Alzheimer disease. J Biol Chem, 2009, 284, 6033-6037.
-
(2009)
J Biol Chem
, vol.284
, pp. 6033-6037
-
-
Morrissette, D.A.1
Parachikova, A.2
Green, K.N.3
La Ferla, F.M.4
-
34
-
-
84882530319
-
Natural products as pharmaceuticals and sources for lead structures
-
Wermuth C. (Ed.), Academic Press
-
Newman D.J., Craag G.M., Kingston D., Natural products as pharmaceuticals and sources for lead structures. In« The practice of Medicinal Chemistry», Wermuth C. (Ed.). Academic Press, 2008, pp. 159-186.
-
(2008)
The Practice of Medicinal Chemistry
, pp. 159-186
-
-
Newman, D.J.1
Craag, G.M.2
Kingston, D.3
-
35
-
-
77956320461
-
Measurement and expression of drug effects
-
Wermuth, C. (Ed.), Academic Press
-
Nowicki J.P., Scatton B., Measurement and expression of drug effects. In« The practice of Medicinal Chemistry»,Wermuth C. (Ed.). Academic Press, 2008, pp. 73-84.
-
(2008)
The Practice of Medicinal Chemistry
, pp. 73-84
-
-
Nowicki, J.P.1
Scatton, B.2
-
36
-
-
33947593210
-
2006 drug approvals: Finding the niche
-
Owens J., 2006 drug approvals: finding the niche. Nat Rev, 2007, 6, 99-101.
-
(2007)
Nat Rev
, vol.6
, pp. 99-101
-
-
Owens, J.1
-
37
-
-
50049132424
-
Beyond the era of NPH insulin-long-acting insulin analogs: Chemistry, comparative pharmacology, and clinical application
-
Owens, D.R., Biol F.I., Bolli G.B., Beyond the era of NPH insulin-long-acting insulin analogs: chemistry, comparative pharmacology, and clinical application. Diabetes Technol Ther, 2008, 10, 333-349.
-
(2008)
Diabetes Technol Ther
, vol.10
, pp. 333-349
-
-
Owens, D.R.1
Biol, F.I.2
Bolli, G.B.3
-
38
-
-
34347403252
-
Drug development for CNS disorders: Strategies for balancing risk and reducing attrition
-
Pangalos M.N., Schechter L.E., Hurko O., Drug development for CNS disorders: Strategies for balancing risk and reducing attrition. Nat Rev Drug Discov, 2007, 6, 521-532.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 521-532
-
-
Pangalos, M.N.1
Schechter, L.E.2
Hurko, O.3
-
39
-
-
77956299850
-
High-throughput screening and drug discovery
-
Wermuth C. (Ed.), Academic Press
-
Proudfoot J.R., High-throughput screening and drug discovery. In "The practice of Medicinal Chemistry", Wermuth C. (Ed.). Academic Press, 2008, pp. 144-158.
-
(2008)
The Practice of Medicinal Chemistry
, pp. 144-158
-
-
Proudfoot, J.R.1
-
40
-
-
27144457667
-
Monoclonal antibody successes in the clinic
-
Reichert J.M., Rosensweig C.J., Faden L.B., Dewitz M.C., Monoclonal antibody successes in the clinic. Nat Biotechnol, 2005, 23, 1073-1078.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1073-1078
-
-
Reichert, J.M.1
Rosensweig, C.J.2
Faden, L.B.3
Dewitz, M.C.4
-
41
-
-
77956304898
-
Protein crystallography and drug discovery
-
Wermuth, C. (Ed.), Academic Press
-
Rondeau J.M., Schreuder H., Protein crystallography and drug discovery. In« The practice of Medicinal Chemistry»,Wermuth C. (Ed.). Academic Press, 2008, pp. 605-634.
-
(2008)
The Practice of Medicinal Chemistry
, pp. 605-634
-
-
Rondeau, J.M.1
Schreuder, H.2
-
42
-
-
13844276627
-
Target-based drug discovery: Is something wrong ?
-
Sams-Dodd F., Target-based drug discovery: is something wrong ? Drug Discov Today, 2005, 10, 139-147.
-
(2005)
Drug Discov Today
, vol.10
, pp. 139-147
-
-
Sams-Dodd, F.1
-
43
-
-
54449101252
-
3-adrenoceptor agonist 4-[[(hexylamino) carbonyl] amino]-N-[4-[2-[[(2S)-2-hydroxy-3(4-hydroxyphenoxy) propyl]amino]ethyl]-phenyl]- benzenesulfonamide( L755507)
-
3-adrenoceptor
-
3-adrenoceptor. Mol Pharmacol, 2008, 74, 1417-1428.
-
(2008)
Mol Pharmacol
, vol.74
, pp. 1417-1428
-
-
Sato, M.1
Hutchinson, D.2
Evans, B.3
Summers, R.4
-
44
-
-
0043162099
-
The genetics of human epilepsy
-
Scheffer I.E., Berkovic S.F., The genetics of human epilepsy. TIPS, 2003, 24, 428-433.
-
(2003)
TIPS
, vol.24
, pp. 428-433
-
-
Scheffer, I.E.1
Berkovic, S.F.2
-
45
-
-
33645056478
-
Antibody targeted drugs as cancer therapeutics
-
Schrama D., Reisfeld R.A., Becker J.C., Antibody targeted drugs as cancer therapeutics. Nat Rev Drug Discov, 2006, 5, 147-159.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 147-159
-
-
Schrama, D.1
Reisfeld, R.A.2
Becker, J.C.3
-
46
-
-
17744390180
-
An overview of SSR149415, a selective nonpeptide vasopressin V1b receptor antagonist for the treatment of stress-related disorders
-
Serradeil-Le Gal, C., Wagnon J., Tonnerre B., Roux R., Garcia G., Griebel G., Aulombard A., An overview of SSR149415, a selective nonpeptide vasopressin V1b receptor antagonist for the treatment of stress-related disorders. CNS Drug Rev, 2005, 11, 53-68.
-
(2005)
CNS Drug Rev
, vol.11
, pp. 53-68
-
-
Serradeil-Le Gal, C.1
Wagnon, J.2
Tonnerre, B.3
Roux, R.4
Garcia, G.5
Griebel, G.6
Aulombard, A.7
-
47
-
-
42149094530
-
Gemtuzumab ozogamicin: An anti-CD33 immunoconjugate for the treatment of acute myeloid leukaemia
-
Stasi R., Gemtuzumab ozogamicin: an anti-CD33 immunoconjugate for the treatment of acute myeloid leukaemia. Expert Opin Biol Ther, 2008, 8, 527-540.
-
(2008)
Expert Opin Biol Ther
, vol.8
, pp. 527-540
-
-
Stasi, R.1
-
48
-
-
33747024041
-
The adult rat hippocampal slice revisited with multi-electrode arrays
-
Steidl E.M., Neveu E., Bertrand D., Buisson B., The adult rat hippocampal slice revisited with multi-electrode arrays. Brain Res, 2006, 1096, 70-84.
-
(2006)
Brain Res
, vol.1096
, pp. 70-84
-
-
Steidl, E.M.1
Neveu, E.2
Bertrand, D.3
Buisson, B.4
-
49
-
-
35748983210
-
Target deconvolution strategies in drug discovery
-
Terstappen G.C., Schlüpen C., Raggiaschi R., Gaviraghi G., Target deconvolution strategies in drug discovery. Nat Rev, 2007, 6, 891-903.
-
(2007)
Nat Rev
, vol.6
, pp. 891-903
-
-
Terstappen, G.C.1
Schlüpen, C.2
Raggiaschi, R.3
Gaviraghi, G.4
-
50
-
-
63149148789
-
Intracerebroventricular amyloid-β antibodies reduce cerebral amyloidangiopathy and associated microhemorrhages in aged Tg2576 mice
-
Thakker D., Weatherspoon M., Harrison J., Keene T., Lane D., Kaemerrer W., Stewart G., Schafer L., Intracerebroventricular amyloid-β antibodies reduce cerebral amyloidangiopathy and associated microhemorrhages in aged Tg2576 mice. PNAS, 2009, 106, 4501-4506.
-
(2009)
PNAS
, vol.106
, pp. 4501-4506
-
-
Thakker, D.1
Weatherspoon, M.2
Harrison, J.3
Keene, T.4
Lane, D.5
Kaemerrer, W.6
Stewart, G.7
Schafer, L.8
-
51
-
-
36048994993
-
From laboratory to phase I/II cancer trials with recombinant biotherapeutics
-
Tolner B., Smith L., Hillyer T., Bathia J., Beckett P., Robson L., Sharma S.K., Griffin N., Vervecken W., Contreras R., Pedley R.B., Begent R.H.J., Chester K.A., From laboratory to phase I/II cancer trials with recombinant biotherapeutics. Europ J Cancer, 2007, 43, 2515-2522.
-
(2007)
Europ J Cancer
, vol.43
, pp. 2515-2522
-
-
Tolner, B.1
Smith, L.2
Hillyer, T.3
Bathia, J.4
Beckett, P.5
Robson, L.6
Sharma, S.K.7
Griffin, N.8
Vervecken, W.9
Contreras, R.10
Pedley, R.B.11
Begent, R.H.J.12
Chester, K.A.13
-
52
-
-
27744550777
-
TrkB partial agonists: Potential treatment strategy for epilepsy, mania and autism
-
Tsai S.J., TrkB partial agonists: Potential treatment strategy for epilepsy, mania and autism. Medical Hypotheses, 2006, 66, 173-175.
-
(2006)
Medical Hypotheses
, vol.66
, pp. 173-175
-
-
Tsai, S.J.1
-
53
-
-
54849434942
-
Efficacy of biologicals in the treatment of rheumatoid arthritis
-
Venkateshan S.P., Sidhu S., Malhotra S., Pandhi P., Efficacy of biologicals in the treatment of rheumatoid arthritis. Pharmacology, 2009, 83, 1-9.
-
(2009)
Pharmacology
, vol.83
, pp. 1-9
-
-
Venkateshan, S.P.1
Sidhu, S.2
Malhotra, S.3
Pandhi, P.4
-
54
-
-
0036282457
-
Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H3 receptor
-
Wellendorph P., Goodman M., Burstein E.S., Nash N.R., Brann M.R., Weiner D.M., Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H3 receptor. Neuropharmacology, 2002, 42, 929-940.
-
(2002)
Neuropharmacology
, vol.42
, pp. 929-940
-
-
Wellendorph, P.1
Goodman, M.2
Burstein, E.S.3
Nash, N.R.4
Brann, M.R.5
Weiner, D.M.6
-
55
-
-
77956326412
-
Strategies in the search for new lead compounds or original working hypotheses
-
Wermuth C. (Ed.), Academic Press
-
Wermuth C.G., Strategies in the search for new lead compounds or original working hypotheses. In "The Practice of Medicinal chemistry", Wermuth C. (Ed.). Academic Press, 2008, pp. 125-143.
-
(2008)
The Practice of Medicinal Chemistry
, pp. 125-143
-
-
Wermuth, C.G.1
-
56
-
-
0036906312
-
Potassium channels as anti-epileptic drug targets
-
Wickenden A.D., Potassium channels as anti-epileptic drug targets. Neuropharmacology, 2002, 43, 1055-1060.
-
(2002)
Neuropharmacology
, vol.43
, pp. 1055-1060
-
-
Wickenden, A.D.1
-
57
-
-
27144550160
-
Arming antibodies: Prospects and challenges for immunoconjugates
-
Wu A.M., Senter P.D., Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol, 2005, 23, 1137-1146.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1137-1146
-
-
Wu, A.M.1
Senter, P.D.2
-
58
-
-
77956304479
-
Drug targets, target identification, validation and screening
-
Wermuth C. (Ed.), Academic Press
-
Zavitz K.H., Bartel P.L., Hobden A.N., Drug targets, target identification, validation and screening. In« The Practice of Medicinal chemistry», Wermuth C. (Ed.). Academic Press, 2008, pp. 106-122.
-
(2008)
The Practice of Medicinal Chemistry
, pp. 106-122
-
-
Zavitz, K.H.1
Bartel, P.L.2
Hobden, A.N.3
-
59
-
-
53349178722
-
In vivo reprogramming of adult pancreatic exocrine cells to β cells
-
Zhou Q., Brown J., Kanarek A., Rajagopal J., Melton D.A., In vivo reprogramming of adult pancreatic exocrine cells to β cells. Nature, 2008, 455, 627-632.
-
(2008)
Nature
, vol.455
, pp. 627-632
-
-
Zhou, Q.1
Brown, J.2
Kanarek, A.3
Rajagopal, J.4
Melton, D.A.5
|