메뉴 건너뛰기




Volumn 19, Issue 4, 2010, Pages 475-485

Antiphospholipid syndrome treatment beyond anticoagulation: Are we there yet?

Author keywords

Anticardiolipin antibodies; Antiphospholipid antibodies; Endothelial cells; Lupus anticoagulant; Targeted therapies; Thrombosis

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ATORVASTATIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA2 GLYCOPROTEIN 1; BETA2 GLYCOPROTEIN 1 ANTIBODY; CAPTOPRIL; CERIVASTATIN; DEFIBROTIDE; DILAZEP; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPYRIDAMOLE; FIBRINOGEN RECEPTOR; FLUINDOSTATIN; HEPARIN; HYDROXYCHLOROQUINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOMODULATING AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PENTOXIFYLLINE; PHOSPHOLIPID ANTIBODY; PLACEBO; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN; THROMBOPLASTIN; UNINDEXED DRUG; WARFARIN;

EID: 77951229587     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/0961203310361489     Document Type: Review
Times cited : (55)

References (94)
  • 1
    • 33344458573 scopus 로고    scopus 로고
    • International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    • Miyakis S., Lockshin MD, Atsumi T., et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006 ; 4: 295-306.
    • (2006) J Thromb Haemost , vol.4 , pp. 295-306
    • Miyakis, S.1    Lockshin, M.D.2    Atsumi, T.3
  • 2
    • 34547407889 scopus 로고    scopus 로고
    • Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: A randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody-positive individuals
    • DOI 10.1002/art.22663
    • Erkan D., Harrison M., Levy R., et al. Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: a randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody-positive individuals. Arthritis Rheum 2007 ; 56: 2382-2391. (Pubitemid 47173586)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.7 , pp. 2382-2391
    • Erkan, D.1    Harrison, M.J.2    Levy, R.3    Peterson, M.4    Petri, M.5    Sammaritano, L.6    Unalp-Arida, A.7    Vilela, V.8    Yazici, Y.9    Lockshin, M.D.10
  • 4
    • 0033826480 scopus 로고    scopus 로고
    • Endothelia activation of aPL; A potential pathogenic mechanism for the clinical manifestations of the syndrome
    • Meroni PL, Raschi E., Carrera M., et al. Endothelia activation of aPL; a potential pathogenic mechanism for the clinical manifestations of the syndrome. J Autoimmun 2000 ; 15: 237-240.
    • (2000) J Autoimmun , vol.15 , pp. 237-240
    • Meroni, P.L.1    Raschi, E.2    Carrera, M.3
  • 5
    • 0031886679 scopus 로고    scopus 로고
    • The role of the tissue factor pathway in the hypercoagulable state in patients with the antiphospholipid syndrome
    • Amengual O., Atsumi T., Khamashta M., et al. The role of the tissue factor pathway in the hypercoagulable state in patients with the antiphospholipid syndrome. Thromb Haemost 1998 ; 79: 276-281. (Pubitemid 28065869)
    • (1998) Thrombosis and Haemostasis , vol.79 , Issue.2 , pp. 276-281
    • Amengual, O.1    Atsumi, T.2    Khamashta, M.A.3    Hughes, G.R.V.4
  • 7
    • 3242697048 scopus 로고    scopus 로고
    • Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep
    • DOI 10.1182/blood-2004-01-0145
    • Zhou H., Wolberg AS, Roubey AS Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep. Blood 2004 ; 15: 2353-2358. (Pubitemid 39331833)
    • (2004) Blood , vol.104 , Issue.8 , pp. 2353-2358
    • Zhou, H.1    Wolberg, A.S.2    Roubey, R.A.S.3
  • 8
    • 14744275911 scopus 로고    scopus 로고
    • Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprosy related antiphospholipid antibodies
    • Forastiero RR, Martinuzzo ME, de Larranaga GF Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprosy related antiphospholipid antibodies. Lupus 2005 ; 14: 129-136.
    • (2005) Lupus , vol.14 , pp. 129-136
    • Forastiero, R.R.1    Martinuzzo, M.E.2    De Larranaga, G.F.3
  • 9
    • 0142197162 scopus 로고    scopus 로고
    • High titers of autoantibodies to tissue factor pathway inhibitor are associated with the antiphospholipid syndrome
    • Forastiero RR, Martinuzzo ME, Broze GJ High titers of autoantibodies to tissue factor pathway inhibitor are associated with the antiphospholipid syndrome. J Thromb Haemost 2003 ; 1: 718-724.
    • (2003) J Thromb Haemost , vol.1 , pp. 718-724
    • Forastiero, R.R.1    Martinuzzo, M.E.2    Broze, G.J.3
  • 10
    • 0033694198 scopus 로고    scopus 로고
    • Systemic endothelial cell markers in primary antiphospholipid syndrome
    • Williams FMK, Parmar K., Hughes GRV, Hunt BJ Systemic endothelial cell markers in primary antiphospholipid syndrome. J Thromb Haemost 2000 ; 84: 742-746.
    • (2000) J Thromb Haemost , vol.84 , pp. 742-746
    • Williams, F.M.K.1    Parmar, K.2    Hughes, G.R.V.3    Hunt, B.J.4
  • 11
    • 0029551586 scopus 로고
    • Pentoxifylline: A potential treatment for thrombosis associated with abnormal tissue factor expression by monocytes and endothelial cells
    • de Prost D. Pentoxifylline: a potential treatment for thrombosis associated with abnormal tissue factor expression by monocytes and endothelial cells. J Cardiovasc Pharmacol 1995 ; 25 (Suppl 2). S114 - S118. (Pubitemid 26086258)
    • (1995) Journal of Cardiovascular Pharmacology , vol.25 , Issue.SUPPL. 2
    • De Prost, D.1
  • 12
    • 0036732005 scopus 로고    scopus 로고
    • Treatment of catastrophic antiphospholipid syndrome with defibrotide, a proposed vascular endothelial cell modulator
    • Burcoglu-ORal A., Erkan D., Asherson RA Treatment of catastrophic antiphospholipid syndrome with defibrotide, a proposed vascular endothelial cell modulator. J Rheumatol 2002 ; 29: 2006-2011. (Pubitemid 34988713)
    • (2002) Journal of Rheumatology , vol.29 , Issue.9 , pp. 2006-2011
    • Burcoglu-O'Ral, A.1    Erkan, D.2    Asherson, R.3
  • 13
    • 0033960710 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors downregulate tissue factor synthesis in monocytes
    • Napoleone E., Di Santo A., Camera M., et al. Angiotensin-converting enzyme inhibitors downregulate tissue factor synthesis in monocytes. Circ Res 2000 ; 86: 139-143. (Pubitemid 30086173)
    • (2000) Circulation Research , vol.86 , Issue.2 , pp. 139-143
    • Napoleone, E.1    Di Santo, A.2    Camera, M.3    Tremoli, E.4    Lorenzet, R.5
  • 14
    • 0142166253 scopus 로고    scopus 로고
    • E-Selectin mediates pathogenic effects of antiphospholipid antibodies
    • Espinola RG, Liu X., Colden-Stanfield M., et al. E-Selectin mediates pathogenic effects of antiphospholipid antibodies. J Thromb Haemost 2003 ; 1: 843-848.
    • (2003) J Thromb Haemost , vol.1 , pp. 843-848
    • Espinola, R.G.1    Liu, X.2    Colden-Stanfield, M.3
  • 17
    • 4444273214 scopus 로고    scopus 로고
    • Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin
    • Vega-Ostertag ME, Harris EN, Pierangeli SS Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin. Arthritis Rheum 2004 ; 50: 2911-2919.
    • (2004) Arthritis Rheum , vol.50 , pp. 2911-2919
    • Vega-Ostertag, M.E.1    Harris, E.N.2    Pierangeli, S.S.3
  • 18
    • 18644361988 scopus 로고    scopus 로고
    • Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies
    • DOI 10.1002/art.21009
    • Vega-Ostertag ME, Carper K., Swerlick R., et al. Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies. Arthritis Rheum 2005 ; 52: 1545-1554. (Pubitemid 40663946)
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.5 , pp. 1545-1554
    • Vega-Ostertag, M.1    Casper, K.2    Swerlick, R.3    Ferrara, D.4    Harris, E.N.5    Pierangeli, S.S.6
  • 19
    • 17644365392 scopus 로고    scopus 로고
    • Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome
    • DOI 10.1093/intimm/dxh229
    • Simoncini S., Sapet C., Camoin-Jau L., et al. Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome. Int Immunol 2004 ; 17: 489-500. (Pubitemid 40568124)
    • (2005) International Immunology , vol.17 , Issue.4 , pp. 489-500
    • Simoncini, S.1    Sapet, C.2    Camoin-Jau, L.3    Bardin, N.4    Harle, J.-R.5    Sampol, J.6    Dignat-George, F.7    Anfosso, F.8
  • 22
    • 0036123462 scopus 로고    scopus 로고
    • Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies
    • Espinola RG, Pierangeli SS, Gharavi AE, Harris EN Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies. Thromb Haemost 2002 ; 87: 518-522.
    • (2002) Thromb Haemost , vol.87 , pp. 518-522
    • Espinola, R.G.1    Pierangeli, S.S.2    Gharavi, A.E.3    Harris, E.N.4
  • 23
    • 36348973956 scopus 로고    scopus 로고
    • New targeted therapies for treatment of thrombosis in antiphospholipid syndrome
    • DOI 10.1017/S1462399407000506, PII S1462399407000506
    • Pierangeli SS, Vega-Ostertag M., Gonzalez EB New targeted therapies for treatment of thrombosis in antiphospholipid syndrome. Expert Rev Mol Med 2007 ; 9: 1-15. (Pubitemid 350154117)
    • (2007) Expert Reviews in Molecular Medicine , vol.9 , Issue.30 , pp. 1-15
    • Pierangeli, S.S.1    Vega-Ostertag, M.E.2    Gonzalez, E.B.3
  • 24
    • 0035895319 scopus 로고    scopus 로고
    • An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro
    • Aikawa M., Rabkin E., Sugiyama S., et al. An HMG-CoA inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro. Circulation 2001 ; 103: 276-283. (Pubitemid 32095415)
    • (2001) Circulation , vol.103 , Issue.2 , pp. 276-283
    • Aikawa, M.1    Rabkin, E.2    Sugiyama, S.3    Voglic, S.J.4    Fukumoto, Y.5    Furukawa, Y.6    Shiomi, M.7    Schoen, F.J.8    Libby, P.9
  • 25
    • 45149103015 scopus 로고    scopus 로고
    • Double heterozygosity polymorphisms for platelet glycoproteins Ia/IIa and IIb/IIIa increases arterial thrombosis and arteriosclerosis in patients with the antiphospholipid syndrome or with systemic lupus erythematosus
    • DOI 10.1136/ard.2007.077321
    • Jiménez S., Tassies D., Espinosa G., et al. Double heterozygosity polymorphisms for platelet glycoproteins Ia/IIa and IIb/IIIa increases arterial thrombosis and arteriosclerosis in patients with the antiphospholipid syndrome or with systemic lupus erythematosus. Ann Rheum Dis 2008 ; 67: 835-840. (Pubitemid 351829385)
    • (2008) Annals of the Rheumatic Diseases , vol.67 , Issue.6 , pp. 835-840
    • Jimenez, S.1    Tassies, D.2    Espinosa, G.3    Garcia-Criado, A.4    Plaza, J.5    Monteagudo, J.6    Cervera, R.7    Reverter, J.C.8
  • 26
    • 15744396553 scopus 로고    scopus 로고
    • The GP IIb/IIIa inhibitor abciximab (ReoPro®) decreases activation and interaction of platelets and leukocytes during in vitro cardiopulmonary bypass simulation
    • DOI 10.1016/j.ejcts.2004.12.005
    • Straub A., Wendel HP, Azevedo R., Ziemer G. The GP IIb/IIIa inhibitor abciximab (ReoPro) decreases activation and interaction of platelets and leukocytes during in vitro cardiopulmonary bypass simulation. Eur J Cardiothorac Surg 2005 ; 27: 617-621. (Pubitemid 40409733)
    • (2005) European Journal of Cardio-thoracic Surgery , vol.27 , Issue.4 , pp. 617-621
    • Straub, A.1    Wendel, H.P.2    Azevedo, R.3    Ziemer, G.4
  • 27
    • 0028260945 scopus 로고
    • On the inhibitory effect of chloroquine on blood platelet aggregation
    • DOI 10.1016/0049-3848(94)90270-4
    • Jancinova V., Nosal R., Petrikova M. On the inhibitory effect of chloroquine on blood platelet aggregation. Thromb Res 1994 ; 74: 495-504. (Pubitemid 24173331)
    • (1994) Thrombosis Research , vol.74 , Issue.5 , pp. 495-504
    • Jancinova, V.1    Nosal, R.2    Petrikova, M.3
  • 28
    • 0027144394 scopus 로고
    • Inhibition by chloroquine of the class II major histocompatibility complex-restricted presentation of endogenous antigens varies according to the cellular origin of the antigen-presenting cells, the nature of the T-cell epitope, and the responding T cell
    • Lombard-Platlet S., Bertolino P., Deng H., Gerlier D., Rabourdin-Combe C. Inhibition by chloroquine of the class II major histocompatibility complex-restricted presentation of endogenous antigens varies according to the cellular origin of the antigen-presenting cells, the nature of the T-cell epitope, and the responding T cell. Immunology 1993 ; 80: 566-573. (Pubitemid 24010116)
    • (1993) Immunology , vol.80 , Issue.4 , pp. 566-573
    • Lombard-Platlet, S.1    Bertolino, P.2    Deng, H.3    Gerlier, D.4    Rabourdin-Combe, C.5
  • 29
    • 0034210661 scopus 로고    scopus 로고
    • Hydroxychloroquine inhibits calcium signals in T cells: A new mechanism to explain its immunomodulatory properties
    • Goldman FD, Gilman AL, Hollenback C., et al. Hydroxychloroquine inhibits calcium signals in T cells: a new mechanism to explain its immunomodulatory properties. Blood 2000 ; 95: 3460-3466. (Pubitemid 30428477)
    • (2000) Blood , vol.95 , Issue.11 , pp. 3460-3466
    • Goldman, F.D.1    Gilman, A.L.2    Hollenback, C.3    Kato, R.M.4    Premack, B.A.5    Rawlings, D.J.6
  • 30
    • 7244242660 scopus 로고    scopus 로고
    • Intracellular signaling triggered by antiphospholipid antibodies in platelets and endothelial cells: A pathway to targeted therapies
    • DOI 10.1016/j.thromres.2004.06.031, PII S0049384804003408
    • Pierangeli SS, Vega-Ostertag M., Harris EN Intracellular signaling triggered by antiphospholipid antibodies in platelets and endothelial cells: a pathway to targeted therapies. Thromb Res 2004 ; 114: 467-476. (Pubitemid 39429425)
    • (2004) Thrombosis Research , vol.114 , Issue.SPEC. ISS. , pp. 467-476
    • Pierangeli, S.S.1    Vega-Ostertag, M.2    Nigel Harris, E.3
  • 31
    • 48749104624 scopus 로고    scopus 로고
    • Hydroxychloroquine directly reduces the binding of antiphospholipid antibody-beta2-glycoprotein i complexes to phospholipid bilayers
    • Rand JH, Wu XX, Quinn AS, et al. Hydroxychloroquine directly reduces the binding of antiphospholipid antibody-beta2-glycoprotein I complexes to phospholipid bilayers. Blood 2008 ; 112: 1687-1695.
    • (2008) Blood , vol.112 , pp. 1687-1695
    • Rand, J.H.1    Wu, X.X.2    Quinn, A.S.3
  • 32
    • 77951230993 scopus 로고    scopus 로고
    • Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: Evidence for a novel effect for an old antimalarial drug
    • Rand JH, Wu XX, Quinn AS, et al. Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug. Blood 2009 ; ([Epub ahead of print]).
    • (2009) Blood
    • Rand, J.H.1    Wu, X.X.2    Quinn, A.S.3
  • 33
    • 0018526284 scopus 로고
    • Hydroxychloroquine in prophylaxis of pulmonary embolism following hip arthroplasty
    • Johnson R., Charnley J. Hydroxychloroquine in prophylaxis of pulmonary embolism following hip arthroplasty. Clin Orthop Relat Res 1979 ; 144: 174-177.
    • (1979) Clin Orthop Relat Res , vol.144 , pp. 174-177
    • Johnson, R.1    Charnley, J.2
  • 34
    • 0023515407 scopus 로고    scopus 로고
    • Does hydroxychloroquine protect against clot formation in systemic lupus erythematosus?
    • Wallace DJ Does hydroxychloroquine protect against clot formation in systemic lupus erythematosus? Arthritis Rheum 1997 ; 30: 1435-1436.
    • (1997) Arthritis Rheum , vol.30 , pp. 1435-1436
    • Wallace, D.J.1
  • 35
    • 30644480957 scopus 로고    scopus 로고
    • Lupus in Baltimore: Evidence-based 'clinical pearls' from the Hopkins Lupus Cohort
    • DOI 10.1191/0961203305lu2230xx
    • Petri M. Lupus in Baltimore: evidence-based clinical pearls from the Hopkins Lupus Cohort. Lupus 2005 ; 14: 970-973. (Pubitemid 43088273)
    • (2005) Lupus , vol.14 , Issue.12 , pp. 970-973
    • Petri, M.1
  • 36
    • 58849159669 scopus 로고    scopus 로고
    • Risk and protective factors for thrombosis in systemic lupus erythematosus: Results from a large, multi-ethnic cohort
    • Kaiser R., Cleveland CM, Criswell LA Risk and protective factors for thrombosis in systemic lupus erythematosus: results from a large, multi-ethnic cohort. Ann Rheum Dis 2009 ; 68: 238-241.
    • (2009) Ann Rheum Dis , vol.68 , pp. 238-241
    • Kaiser, R.1    Cleveland, C.M.2    Criswell, L.A.3
  • 37
    • 58349097555 scopus 로고    scopus 로고
    • Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies
    • Tektonidou MG, Laskari K., Panagiotakos DB, Moutsopoulos HM Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies. Arthritis Rheum 2009 ; 61: 29-36.
    • (2009) Arthritis Rheum , vol.61 , pp. 29-36
    • Tektonidou, M.G.1    Laskari, K.2    Panagiotakos, D.B.3    Moutsopoulos, H.M.4
  • 38
    • 27144483360 scopus 로고    scopus 로고
    • Systemic lupus erythematosus in a multiethnic cohort (LUMINA): XXVIII. Factors predictive of thrombotic events
    • Oxford)
    • Ho KT, Ahn CW, Alarcon GS, et al. Systemic lupus erythematosus in a multiethnic cohort (LUMINA): XXVIII. Factors predictive of thrombotic events. Rheumatology (Oxford) 2005 ; 44: 1303-1307.
    • (2005) Rheumatology , vol.44 , pp. 1303-1307
    • Ho, K.T.1    Ahn, C.W.2    Alarcon, G.S.3
  • 40
    • 0036045796 scopus 로고    scopus 로고
    • A cross-sectional study of clinical thrombotic risk factors and preventive treatments in antiphospholipid syndrome
    • Oxford)
    • Erkan D., Yazici Y., Peterson MG, et al. A cross-sectional study of clinical thrombotic risk factors and preventive treatments in antiphospholipid syndrome. Rheumatology (Oxford) 2002 ; 41: 924-929.
    • (2002) Rheumatology , vol.41 , pp. 924-929
    • Erkan, D.1    Yazici, Y.2    Peterson, M.G.3
  • 41
    • 23944497318 scopus 로고    scopus 로고
    • Use of hydroxychloroquine in antiphospholipid antibody syndrome at three academic rheumatology units over two years: Improvement in antibody titer and symptom management
    • McCarty GA, Cason TE Use of hydroxychloroquine in antiphospholipid antibody syndrome at three academic rheumatology units over two years: improvement in antibody titer and symptom management. 7th International Congress on SLE and related conditions abstract book 2004 ; M17A (abstract).
    • 7th International Congress on SLE and Related Conditions Abstract Book 2004
    • McCarty, G.A.1    Cason, T.E.2
  • 45
    • 0036117985 scopus 로고    scopus 로고
    • Fluvastatin reduces tissue factor expression and macrophage accumulation in carotid lesions of cholesterol-fed rabbits in the absence of lipid lowering
    • DOI 10.1161/01.ATV.0000012802.69414.A8
    • Baetta R., Camera M., Comparato C., et al. Fluvastatin reduces tissue factor expression and macrophage accumulation in carotid lesions of cholesterol-fed rabbits in absence of lipid lowering. Arterioscler Thromb Vasc Biol 2002 ; 22: 692-698. (Pubitemid 34408755)
    • (2002) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.22 , Issue.4 , pp. 692-698
    • Baetta, R.1    Camera, M.2    Comparato, C.3    Altana, C.4    Ezekowitz, M.D.5    Tremoli, E.6
  • 47
    • 63649095045 scopus 로고    scopus 로고
    • JUPITER Trial Study Group. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial
    • Ridker PM, Danielson E., Fonseca FA, et al. JUPITER Trial Study Group. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet 2009 ; 373: 1175-1182.
    • (2009) Lancet , vol.373 , pp. 1175-1182
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.3
  • 48
    • 65449138698 scopus 로고    scopus 로고
    • A randomized trial of rosuvastatin in the prevention of venous thromboembolism
    • Glynn RJ, Danielson E., Fonseca FA, et al. A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med 2009 ; 360: 1851-1861.
    • (2009) N Engl J Med , vol.360 , pp. 1851-1861
    • Glynn, R.J.1    Danielson, E.2    Fonseca, F.A.3
  • 50
    • 0242721975 scopus 로고    scopus 로고
    • Inhibition of the Thrombogenic and Inflammatory Properties of Antiphospholipid Antibodies by Fluvastatin in an In Vivo Animal Model
    • DOI 10.1002/art.11449
    • Ferrara DE, Liu X., Espinola RG, et al. Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model. Arthritis Rheum 2003 ; 48: 3272-3279. (Pubitemid 37409342)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.11 , pp. 3272-3279
    • Ferrara, D.E.1    Liu, X.2    Espinola, R.G.3    Meroni, P.L.4    Abukhalaf, I.5    Harris, E.N.6    Pierangeli, S.S.7
  • 52
    • 62849125725 scopus 로고    scopus 로고
    • Effect of rosuvastatin on VCAM-1 expression by HUVEC exposed to APS serum in an in vitro model
    • Martínez-Martínez LA, Amigo MC, Orozco A., et al. Effect of rosuvastatin on VCAM-1 expression by HUVEC exposed to APS serum in an in vitro model. Clin Exp Rheumatol 2007 ; 25: 18-19.
    • (2007) Clin Exp Rheumatol , vol.25 , pp. 18-19
    • Martínez-Martínez, L.A.1    Amigo, M.C.2    Orozco, A.3
  • 53
    • 77953423421 scopus 로고    scopus 로고
    • Pravastatin prevents miscarriages in antiphospholipid antibody-treated mice
    • Girardi G. Pravastatin prevents miscarriages in antiphospholipid antibody-treated mice. J Reprod Immunol 2009 ; 82: 126-131.
    • (2009) J Reprod Immunol , vol.82 , pp. 126-131
    • Girardi, G.1
  • 54
    • 62849122114 scopus 로고    scopus 로고
    • Effects of fluvastatin on prothrombotic/proinflammatory markers in patients with Antiphospholipid Syndrome
    • (abstract)
    • Kumar SS, Papalardo E., Jajoria P., et al. Effects of fluvastatin on prothrombotic/proinflammatory markers in patients with Antiphospholipid Syndrome. Arthritis Rheum 2008 ; 58: S172 (abstract).
    • (2008) Arthritis Rheum , vol.58 , pp. 172
    • Kumar, S.S.1    Papalardo, E.2    Jajoria, P.3
  • 55
    • 62849106161 scopus 로고    scopus 로고
    • Changes operated in protein pattern of monocytes from patients with antiphospholipid syndrome treated with statins
    • (abstract)
    • Cuadrado MJ, Lopez-Pedrera C., Aguirre A., et al. Changes operated in protein pattern of monocytes from patients with antiphospholipid syndrome treated with statins. Arthritis Rheum 2007 ; 56: S782 (abstract).
    • (2007) Arthritis Rheum , vol.56 , pp. 782
    • Cuadrado, M.J.1    Lopez-Pedrera, C.2    Aguirre, A.3
  • 57
    • 33745861703 scopus 로고    scopus 로고
    • A peptide that mimics the Vth region of β2-glycoprotein i reverses antiphospholipid-mediated thrombosis in mice
    • Ostertag MV, Liu X., Henderson V., Pierangeli SS A peptide that mimics the Vth region of β2-glycoprotein I reverses antiphospholipid-mediated thrombosis in mice. Lupus 2006 ; 15: 358-365.
    • (2006) Lupus , vol.15 , pp. 358-365
    • Ostertag, M.V.1    Liu, X.2    Henderson, V.3    Pierangeli, S.S.4
  • 59
    • 14944367961 scopus 로고    scopus 로고
    • 2 glycoprotein I antibodies
    • DOI 10.1182/blood-2004-05-1708
    • Zhang J., McCrae KR Annexin A2 mediates endothelial cell activation by antiphospholipid/β2glycoprotein I antibodies. Blood 2005 ; 105: 1964-1969. (Pubitemid 40731779)
    • (2005) Blood , vol.105 , Issue.5 , pp. 1964-1969
    • Zhang, J.1    McCrae, K.R.2
  • 60
    • 70449509134 scopus 로고    scopus 로고
    • Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo
    • Romay-Penabad Z., Montiel-Manzano MG, Shilagard T., et al. Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo. Blood 2009 ; 114: 3074-3083.
    • (2009) Blood , vol.114 , pp. 3074-3083
    • Romay-Penabad, Z.1    Montiel-Manzano, M.G.2    Shilagard, T.3
  • 61
    • 0037528699 scopus 로고    scopus 로고
    • Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies
    • DOI 10.1182/blood-2002-08-2349
    • Raschi E., Testoni C., Bosisio D., et al. Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. Blood 2003 ; 101: 3495-3500. (Pubitemid 36857933)
    • (2003) Blood , vol.101 , Issue.9 , pp. 3495-3500
    • Raschi, E.1    Testoni, C.2    Bosisio, D.3    Borghi, M.O.4    Koike, T.5    Mantovani, A.6    Meroni, P.L.7
  • 62
    • 27644589321 scopus 로고    scopus 로고
    • Activation of endothelial cells by β2glycoprotein i (β2GPI) antibodies is mediated by annexin II cross linking and may involve TLR4
    • (abstract)
    • Zhang J., Lieske K., McCrae B., McCrae K. Activation of endothelial cells by β2glycoprotein I (β2GPI) antibodies is mediated by annexin II cross linking and may involve TLR4. Blood 2004 ; 104: 83 (abstract).
    • (2004) Blood , vol.104 , pp. 83
    • Zhang, J.1    Lieske, K.2    McCrae, B.3    McCrae, K.4
  • 64
    • 34250721890 scopus 로고    scopus 로고
    • Toll like receptor-4 is involved in antiphospholipid-mediated thrombosis: In vivo studies
    • Pierangeli SS, Vega-Ostertag ME, Raschi E., et al. Toll like receptor-4 is involved in antiphospholipid-mediated thrombosis: in vivo studies. Ann Rheum Dis 2007 ; 66: 1327-1333.
    • (2007) Ann Rheum Dis , vol.66 , pp. 1327-1333
    • Pierangeli, S.S.1    Vega-Ostertag, M.E.2    Raschi, E.3
  • 65
    • 0041571482 scopus 로고    scopus 로고
    • Differential binding of ligands to the apolipoprotein E receptor 2
    • DOI 10.1021/bi034475p
    • Andersen OM, Benhayon D., Curran T., Willnow TE Differential binding of ligands to the apolipoprotein E receptor 2. Biochemistry 2003 ; 42: 9355-9364. (Pubitemid 36959243)
    • (2003) Biochemistry , vol.42 , Issue.31 , pp. 9355-9364
    • Andersen, O.M.1    Benhayon, D.2    Curran, T.3    Willnow, T.E.4
  • 66
    • 0034727078 scopus 로고    scopus 로고
    • An LDL-receptor-related protein mediates Wnt signaling in mice
    • Pinson KI, Brennan J., Monkley S., et al. An LDL-receptor-related protein mediates Wnt signaling in mice. Nature 2000 ; 407: 535-538.
    • (2000) Nature , vol.407 , pp. 535-538
    • Pinson, K.I.1    Brennan, J.2    Monkley, S.3
  • 67
    • 33847059481 scopus 로고    scopus 로고
    • The binding site of β2glycoprotein i for apoER2 on platelets is located in Domain v
    • Van Lummel M., Pennings MTT, Derksen RHWM, et al. The binding site of β2glycoprotein I for apoER2 on platelets is located in Domain V. J Biol Chem 2005 ; 280: 36279-36736.
    • (2005) J Biol Chem , vol.280 , pp. 36279-36736
    • Van Lummel, M.1    Pennings, M.T.T.2    Rhwm, D.3
  • 68
    • 0141445991 scopus 로고    scopus 로고
    • Dimers of β2glycoprotein i increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein e receptor 2
    • Lutters BCH, Derksen Rhwm, Tekelenburg WL, et al. Dimers of β2glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2. J Biol Chem 2003 ; 278: 33831-33838.
    • (2003) J Biol Chem , vol.278 , pp. 33831-33838
    • Lutters, B.C.H.1    Rhwm, D.2    Tekelenburg, W.L.3
  • 69
    • 13544276197 scopus 로고    scopus 로고
    • IgG antibodies that recognize epitope Gly40-Arg 43 in domain i of β2glycoprotein i cause LAC, and their presence correlates strongly with thrombosis
    • DeLaat B., Derksen RH, Urbanus RT, deGroot PG IgG antibodies that recognize epitope Gly40-Arg 43 in domain I of β2glycoprotein I cause LAC, and their presence correlates strongly with thrombosis. Blood 2005 ; 105: 1540-1545.
    • (2005) Blood , vol.105 , pp. 1540-1545
    • Delaat, B.1    Derksen, R.H.2    Urbanus, R.T.3    Degroot, P.G.4
  • 70
    • 33644951517 scopus 로고    scopus 로고
    • A novel expression system of domain i of human b2glycoprotein i in Escherichia coli
    • Ioannou Y., Giles I., Lambrianides A., et al. A novel expression system of domain I of human b2glycoprotein I in Escherichia coli. BMC Biotechnol 2006 ; 6: 8.
    • (2006) BMC Biotechnol , vol.6 , pp. 8
    • Ioannou, Y.1    Giles, I.2    Lambrianides, A.3
  • 71
    • 33846236309 scopus 로고    scopus 로고
    • 2-glycoprotein I: Mutation studies including residues R39 to R43
    • DOI 10.1002/art.22306
    • Ioannou Y., Pericleous C., Giles I., et al. Binding of Antiphospholipid antibodies to discontinuous epitopes on domain I of human b2glycoprotein I. Mutation studies including residues R39 to R43. Arthritis Rheum 2007 ; 56: 280-290. (Pubitemid 46106202)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.1 , pp. 280-290
    • Ioannou, Y.1    Pericleous, C.2    Giles, I.3    Latchman, D.S.4    Isenberg, D.A.5    Rahman, A.6
  • 72
    • 65349188214 scopus 로고    scopus 로고
    • In vivo inhibition of antibody-induced pathogenicity utilizing the antigenic target peptide domain i of β2glycoprotein I: Proof of concept
    • Ioannou Y., Romay-Penabad Z., Periclerous C., et al. In vivo inhibition of antibody-induced pathogenicity utilizing the antigenic target peptide domain I of β2glycoprotein I: proof of concept. J Thromb Haemost 2009 ; 7: 833-842.
    • (2009) J Thromb Haemost , vol.7 , pp. 833-842
    • Ioannou, Y.1    Romay-Penabad, Z.2    Periclerous, C.3
  • 74
    • 0036839070 scopus 로고    scopus 로고
    • Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis
    • Salmon JE, Girardi G., Holers VM Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis. Ann Rheum Dis 2002 ; 61: 46-50. (Pubitemid 35221713)
    • (2002) Annals of the Rheumatic Diseases , vol.61 , Issue.SUPPL. 2
    • Salmon, J.E.1    Girardi, G.2    Holers, V.M.3
  • 75
    • 22244485396 scopus 로고    scopus 로고
    • Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia
    • DOI 10.1002/art.21157
    • Pierangeli SS, Girardi G., Vega-Ostertag ME, et al. Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia. Arthritis Rheum 2005 ; 52: 2120-2124. (Pubitemid 40994335)
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.7 , pp. 2120-2124
    • Pierangeli, S.S.1    Girardi, G.2    Vega-Ostertag, M.3    Liu, X.4    Espinola, R.G.5    Salmon, J.6
  • 76
    • 34948885608 scopus 로고    scopus 로고
    • C5a receptor-deficient mice are protected from thrombophilia and endothelial cell activation induced by some antiphospholipid antibodies
    • DOI 10.1196/annals.1422.058, Autoimmunity, Part D: Autoimmune Disease, Annus Mirabilis
    • Romay-Penabad Z., Liu X., Montiel-Manzano G., et al. C5a receptor-deficient mice are protected from thrombophilia and endothelial cell activation induced by some antiphospholipid antibodies. NY Acad Sci 2007 ; 1108: 554-566. (Pubitemid 47528769)
    • (2007) Annals of the New York Academy of Sciences , vol.1108 , pp. 554-566
    • Romay-Penabad, Z.1    Liu X, X.2    Montiel-Manzano, G.3    De Martinez, E.P.4    Pierangeli, S.S.5
  • 77
    • 36048937343 scopus 로고    scopus 로고
    • Complement-targeted therapies
    • Ricklin D., Lambris J. Complement-targeted therapies. Nat Biotechnol 2007 ; 25: 1265-1275.
    • (2007) Nat Biotechnol , vol.25 , pp. 1265-1275
    • Ricklin, D.1    Lambris, J.2
  • 78
    • 77951245298 scopus 로고    scopus 로고
    • A C5a receptor antagonist ameliorates in vivo effects of antiphospholipid antibodies
    • (abstract)
    • Carrera-Marín AL, Romay-Penabad Z., Qu HC, et al. A C5a receptor antagonist ameliorates in vivo effects of antiphospholipid antibodies. Arthritis Rheum 2009 ; 60: s767 (abstract).
    • (2009) Arthritis Rheum , vol.60 , pp. 767
    • Carrera-Marín, A.L.1    Romay-Penabad, Z.2    Qu, H.C.3
  • 79
    • 9144243607 scopus 로고    scopus 로고
    • Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation
    • DOI 10.1038/nm1121
    • Girardi G., Redecha P., Salmon JE Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med 2004 ; 10: 1222-1226. (Pubitemid 39540439)
    • (2004) Nature Medicine , vol.10 , Issue.11 , pp. 1222-1226
    • Girardi, G.1    Redecha, P.2    Salmon, J.E.3
  • 81
    • 67449159236 scopus 로고    scopus 로고
    • Complement activation in patients with primary antiphospholipid syndrome
    • Oku K., Atsumi T., Bohgaki M., et al. Complement activation in patients with primary antiphospholipid syndrome. Ann Rheum Dis 2008 ; 68: 1030-1035.
    • (2008) Ann Rheum Dis , vol.68 , pp. 1030-1035
    • Oku, K.1    Atsumi, T.2    Bohgaki, M.3
  • 82
    • 0026706529 scopus 로고
    • Antiphospholipid antibodies and complement activation in patients with cerebral ischemia
    • Davis WD, Brey RL Antiphospholipid antibodies and complement activation in patients with cerebral ischemia. Clin Exp Immunol 1992 ; 10: 455-460.
    • (1992) Clin Exp Immunol , vol.10 , pp. 455-460
    • Davis, W.D.1    Brey, R.L.2
  • 83
    • 7044239120 scopus 로고    scopus 로고
    • The antiphospholipid syndrome as a model for B cell-induced autoimmune diseases
    • DOI 10.1016/j.thromres.2004.06.019, PII S0049384804003263
    • Youinou P., Reneaudineau Y. The antiphospholipid syndrome as a model for B-cell-induced autoimmune diseases. Thromb Res 2004 ; 114: 363-369. (Pubitemid 39422568)
    • (2004) Thrombosis Research , vol.114 , Issue.SPEC. ISS. , pp. 363-369
    • Youinou, P.1    Renaudineau, Y.2
  • 84
    • 51849128320 scopus 로고    scopus 로고
    • Prevention of murine antiphospholipid syndrome by BAFF blockade
    • Kahn P., Ramanujman M., Bethunaickan R., et al. Prevention of murine antiphospholipid syndrome by BAFF blockade. Arthritis Rheum 2008 ; 58: 2824-2283.
    • (2008) Arthritis Rheum , vol.58 , pp. 2824-2283
    • Kahn, P.1    Ramanujman, M.2    Bethunaickan, R.3
  • 86
    • 41749105516 scopus 로고    scopus 로고
    • Effect of rituximab on clinical and laboratory features of antiphospholipid syndrome: A case report and a review of literature
    • DOI 10.1177/0961203307085251
    • Erre GL, Pardini S., Faedda R., et al. Effect of rituximab on clinical and laboratory features of antiphospholipid syndrome: a case report and a review of literature. Lupus 2008 ; 17: 50-55. (Pubitemid 351487020)
    • (2008) Lupus , vol.17 , Issue.1 , pp. 50-55
    • Erre, G.L.1    Pardini, S.2    Faedda, R.3    Passiu, G.4
  • 87
    • 33750328654 scopus 로고    scopus 로고
    • Rituximab in the primary antiphospholipid antibody syndrome
    • (abstract)
    • Tenedios F., Erkan D., Lockshin MD Rituximab in the primary antiphospholipid antibody syndrome. Arthritis Rheum 2005 ; 52: 4078 (abstract).
    • (2005) Arthritis Rheum , vol.52 , pp. 4078
    • Tenedios, F.1    Erkan, D.2    Lockshin, M.D.3
  • 88
    • 24044470858 scopus 로고    scopus 로고
    • Sustained response to rituximab of autoimmune hemolytic anemia associated with antiphospholipid syndrome
    • (abstract)
    • Erdozain JG, Ruiz-Irastorza G., Egurbide MV, et al. Sustained response to rituximab of autoimmune hemolytic anemia associated with antiphospholipid syndrome. Haematologica 2004 ; 89: ECR34 (abstract).
    • (2004) Haematologica , vol.89 , pp. 34
    • Erdozain, J.G.1    Ruiz-Irastorza, G.2    Egurbide, M.V.3
  • 90
    • 0029830113 scopus 로고    scopus 로고
    • Elevated levels of interleukin-6 in unstable angina
    • Biasucci LM, Vitelli A., Liuzzo G., et al. Elevated levels of interleukin-6 in unstable angina. Circulation 1996 ; 94: 874-877.
    • (1996) Circulation , vol.94 , pp. 874-877
    • Biasucci, L.M.1    Vitelli, A.2    Liuzzo, G.3
  • 94
    • 15944374376 scopus 로고    scopus 로고
    • Interleukin-6 and antiphospholipid antibodies in women with contraceptive-related thromboembolic disease
    • DOI 10.1097/01.AOG.0000136083.13544.02
    • Salobir B., Sabovic M. Interleukin-6 and antiphospholipid antibodies in women with contraceptive-related thromboembolic disease. Obstet Gynecol 2004 ; 104: 564-570. (Pubitemid 40458846)
    • (2004) Obstetrics and Gynecology , vol.104 , Issue.3 , pp. 564-570
    • Salobir, B.1    Sabovic, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.