Δ9-Tetrahydrocannabinol inhibits gastric motility in the rat through cannabinoid CB1 receptors

European Journal of Pharmacology

Volumn 371, Issue 2-3, 1999, Pages 187-196

  Krowicki, Zbigniew K ^a   Moerschbaecher, Joseph M ^a   Winsauer, Peter J ^a   Digavalli, Sivarao V ^a   Hornby, Pamela J ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

9 Tetrahydrocannabinol; Blood pressure; Brainstem; Cannabidiol; Gastric motility; Heart rate; Intragastric pressure; N (Piperidin 1 yl) 5 (4 chlorophenyl) 1 (2,4 dichlorophenyl) 4 methyl 1H pyrazole 3 carboxamide

Indexed keywords

CANNABIDIOL; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR; DRONABINOL; RIMONABANT; UNCLASSIFIED DRUG; GANGLION BLOCKING AGENT; TETRAHYDROCANNABINOL;

ANIMAL EXPERIMENT; ARTICLE; BRADYCARDIA; BRAIN STEM; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; HEART RATE; HYPOTENSION; INTRACEREBRAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MOTILITY; STOMACH PRESSURE; VAGOTOMY; VAGUS NERVE; ANIMAL; DRUG EFFECT; GASTROINTESTINAL MOTILITY; HEMODYNAMICS; SPINAL CORD INJURY; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN STEM; GANGLIONIC BLOCKERS; GASTROINTESTINAL MOTILITY; HEMODYNAMIC PROCESSES; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; TETRAHYDROCANNABINOL; VAGOTOMY;

EID: 0032586712     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00165-X     Document Type: Article

References (58)

1. 9-tetrahydrocannabinol in the rat. J. Pharmacol. Exp. Ther. 196:1976;649-656.
2. Agarwal S.K., Calaresu F.R. Electrical stimulation of nucleus tractus solitarius excites vagal preganglionic cardiomotor neurons of the nucleus ambiguus in rats. Brain Res. 574:1992;320-324.
3. 9-tetrahydrocannabinol and cannabidiol on intestinal motility in mice. J. Pharm. Pharmacol. 26:1974;136-137.
4. Axelrod J., Felder C.C. Cannabinoid receptors and their endogenous agonist, anandamide. Neurochem. Res. 23:1998;575-581.
5. 9-tetrahydrocannabinol in the anesthetized dog. Toxicol. Appl. Pharmacol. 31:1975;100-106.
6. Calignano A., La Rana G., Makriyannis A., Lin S.Y., Beltramo M., Piomelli D. Inhibition of intestinal motility by anadamide, an endogenous cannabinoid. Eur. J. Pharmacol. 340:1997;R7-R8.
7. 9-trans-tetrahydrocannabinol in anesthetized dogs. Eur. J. Pharmacol. 22:1973;263-269.
8. 9-trans-tetrahydrocannabinol on myocardial contractility and venous return in anesthetized dogs. Eur. J. Pharmacol. 29:1974;74-82.
9. Chesher G.B., Dahl C.J., Everingham M., Jackson D.M., Marchant-Williams H., Starmer G.A. The effect of cannabinoids on intestinal motility and their antinociceptive effect in mice. Br. J. Pharmacol. 49:1973;588-594.
10. Colombo G., Agabio R., Lobina C., Reali R., Gessa G.L. Cannabinoid modulation of intestinal propulsion in mice. Eur. J. Pharmacol. 344:1998;67-69.
11. 9-tetrahydrocannabinol-induced responses and apparent agonist activity. J. Pharmacol. Exp. Ther. 277:1996;586-594.
12. De Souza H., Trajano E., de Carvalho F.V., Neto J.P. Effects of acute and long-term cannabis treatment of restraint-induced gastric ulceration in rats. Jpn. J. Pharmacol. 28:1978;507-510.
13. Dewey W.L., Kennedy J.S., Howes J.F. Some autonomic, gastrointestinal and metabolic effects of two constituents of marihuana. Fed. Proc. 29:1970;650.
14. 9-tetrahydrocannabinol in laboratory rodents. Arch. Int. Pharmacodyn. 196:1972;133-145.
15. 9-tetrahydrocannabinol and their interaction with norepinephrine. Life Sci. 41:1987;79-87.
16. Feinle C., Grundy D., Read N.W. Fat increases vection-induced nausea independent of changes in gastric emptying. Physiol. Behav. 58:1995;1159-1165.
17. Felder C.C., Glass M. Cannabinoid receptors and their endogenous agonists. Annu. Rev. Pharmacol. Toxicol. 38:1998;179-200.
18. Felder C.C., Joyce K.E., Briley E.M., Mansouri J., Mackie K., Devane W.A. Comparison of the pharmacology and signal transduction of the human CB1 and CB2 receptors. Mol. Pharmacol. 48:1995;443-450.
19. Glass M., Dragunow M., Faull R.L. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience. 77:1997;299-318.
20. Gonzalez-Rosales F., Walsh D. Intractable nausea and vomiting due to gastrointestinal mucosal metastases relieved by tetrahydrocannabinol (dronabinol). J. Pain Symp. Manage. 14:1997;311-314.
21. Graham J.D., Li D.M. Cardiovascular and respiratory effects of cannabis in cat and rat. Br. J. Pharmacol. 49:1973;1-10.
22. Grundy D., Bagaev V., Hillsley K. Inhibition of gastric mechanoreceptor discharge by cholecystokinin in the rat. Am. J. Physiol. 268:1995;G355-G360.
23. 9-tetrahydrocannabinol in the solitary tract nucleus. Eur. J. Pharmacol. 312:1996;273-279.
24. 9-tetrahydrocannabinol on intestinal motility and on the abdominal constriction response in the mouse. Psychopharmacologia. 47:1976;187-193.
25. 9-tetrahydrocannabinol on pulmonary hemodynamics of anesthetized dogs. Eur. J. Pharmacol. 38:1976;183-187.
26. Krowicki, Z.K., Hornby, P.J., 1995. Hindbrain neuroactive substances controlling gastrointestinal function. In: Gaginella, T.S. (Ed.), Regulatory Mechanisms in Gastrointestinal Function. CRC Press, Boca Raton, FL, pp. 277-319.
27. Krowicki Z.K., Hornby P.J. Contribution of acetylcholine, vasoactive intestinal polypeptide and nitric oxide to CNS-evoked vagal gastric relaxation in the rat. Neurogastroenterol. Motil. 8:1996;307-317.
28. Krowicki Z.K., Nathan N.A., Hornby P.J. Opposing effects of vasoactive intestinal polypeptide on gastric motor function in the dorsal vagal complex and the nucleus raphe obscurus of the rat. J. Pharmacol. Exp. Ther. 282:1997;14-22.
29. 9-tetrahydrocannabinol (THC) on the heart rate (HR) of the dog. Fed. Proc. 31:1972;505.
30. 1-like cannabinoid receptors. J. Pharmacol. Exp. Ther. 281:1997;1030-1037.
31. Landsman R.S., Burkey T.H., Consroe P., Roeske W.R., Yamamura H.I. SR141716A is an inverse agonist at the human cannabinoid CB1 receptor. Eur. J. Pharmacol. 334:1997;R1-R2.
32. Lopez-Redondo F., Lees G.M., Pertwee R.G. Effects of cannabinoid receptor ligands on electrophysiological properties of myenteric neurones of the guinea-pig ileum. Br. J. Pharmacol. 122:1997;330-334.
33. 2 receptors. Br. J. Pharmacol. 124:1998;619-622.
34. Mailleux P., Vanderhaegen J.-J. Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry. Neuroscience. 48:1992;655-668.
35. Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 346:1990;561-564.
36. Matsuda L.A., Bonner T.I., Lolait S.J. Localization of cannabinoid receptor mRNA in rat brain. J. Comp. Neurol. 327:1993;535-550.
37. Mattes R.D., Shaw L.M., Edling-Owens J., Engelman K., Elsohly M.A. Bypassing the first-pass effect for the therapeutic use of cannabinoids. Pharmacol. Biochem. Behav. 44:1993;745-747.
38. Miselis, R.R., Rinaman, L., Altschuler, S.M., Bao, X., Lynn, R.B., 1991. Medullary viscerotopic representation of the alimentary canal innervation in rat. In: Tache, Y., Wingate, D. (Eds.), Brain-Gut Interactions. CRC Press, Boca Raton, FL, pp. 3-21.
39. Munro S., Thomas K.L., Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature. 365:1993;61-65.
40. Ormsbee H.S. III, Bass P. Gastroduodenal gradients in the dog after pyloroplasty. Am. J. Physiol. 230:1976;389-397.
41. Pertwee R.G., Fernando S.R., Nash J.E., Coutts A.A. Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine. Br. J. Pharmacol. 118:1996;2199-2205.
42. Rinaldi-Carmona M., Barth F., Heaulme M., Alonso R., Shire D., Congy C., Soubrie P., Breliere J.C., Le Fur G. Biochemical and pharmacological characterization of SR141716A, the first potent and selective brain cannabinoid receptor antagonist. Life Sci. 56:1995;23-24.
43. Rinaldi-Carmona M., Calandra B., Shire D., Bouaboula M., Oustric D., Barth F., Casellas P., Ferrara P., Le Fur G. Characterization of two cloned human CB1 cannabinoid receptor isoforms. J. Pharmacol. Exp. Ther. 278:1996;871-878.
44. 3H ] SR141716A, a selective brain (CB1) cannabinoid receptor antagonist, in rodent brain Life Sci. 58:1996;1239-1247.
45. 9-tetrahydrocannabinol in rat isolated stomach. Eur. J. Pharmacol. 65:1980;317-318.
46. Shire D., Carillon C., Kaghad M., Calandra B., Rinaldi-Carmona M., Le Fur G., Caput D., Ferrara P. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. J. Biol. Chem. 270:1995;3726-3731.
47. Shook J.E., Burks T.F. Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents. J. Pharmacol. Exp. Ther. 249:1989;444-449.
48. Shook J.E., Dewey W.L., Burks T.F. The central and peripheral effects of delta-9-tetrahydrocannabinol on gastrointestinal transit in mice. NIDA Res. Monogr. 67:1986;222-227.
49. Showalter V.M., Compton D.R., Martin B.R., Abood M.E. Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptors (CB2): identification of cannabinoid receptor subtype selective ligands. J. Pharmacol. Exp. Ther. 278:1996;989-999.
50. 9-tetrahydrocannabinol on the rat blood pressure. Eur. J. Pharmacol. 58:1979;351-357.
51. Sridhar K., Ricci D., Lange R., McCallum R.W. Effect of tetrahydrocannabinol on gastric emptying in humans. Gastroenterology. 86:1984;1265.
52. Terranova J.P., Storme J.J., Lafon N., Perio A., Rinaldi-Carmona M., Le Fur G., Soubrie P. Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist, SR141716. Psychopharmacology. 126:1996;165-172.
53. Tsou K., Brown S., Sanudo-Pena M.C., Mackie K., Walker J.M. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience. 83:1998;393-411.
54. Varga K., Lake K., Martin B.R., Kunos G. Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamide. Eur. J. Pharmacol. 278:1995;279-283.
55. Vivian J.A., Kishioka S., Butelman E.R., Broadbear J., Lee K.O., Woods J.H. Analgesic, respiratory and heart rate effects of cannabinoid and opioid agonists in Rhesus monkeys: antagonist effects of SR141716A. J. Pharmacol. Exp. Ther. 286:1998;697-703.
56. 9-trans-tetrahydrocannabinol. J. Pharm. Pharmacol. 26:1974;186-192.
57. Walsh J.W., Hasler W.L., Nugent C.E., Owyang C. Progesterone and estrogen are potential mediators of gastric slow-wave dysrhythmias in nausea of pregnancy. Am. J. Physiol. 270:1996;G506-G514.
58. Welch S.P., Huffman J.W., Lowe J. Differential blockade of the antinociceptive effects of centrally administered cannabinoids by SR141716A. J. Pharmacol. Exp. Ther. 286:1998;1301-1308.