UV and X-ray structural studies of a 101-residue long Tat protein from a HIV-1 primary isolate and of its mutated, detoxified, vaccine candidate

Proteins: Structure, Function and Bioinformatics

Volumn 78, Issue 6, 2010, Pages 1441-1456

  Foucault, Marine ^a   Mayol, Katia ^a,e   Receveur Bréchot, Véronique ^b   Bussat, Marie Claire ^c   Klinguer Hamour, Christine ^c   Verrier, Bernard ^d   Beck, Alain ^c   Haser, Richard ^a   Gouet, Patrice ^a   Guillon, Christophe ^a  

^a INSTITUT DE BIOLOGIE ET CHIMIE DES PROTÉINES   (France)

^b IMR   (France)

^c Centre d'Immunologie Pierre Fabre   (France)

^d INSTITUT DE BIOLOGIE ET CHIMIE DES PROTÉINES   (France)

^e CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

HIV 1; Induced folding; Natively unfolded protein; Protein chemical synthesis; SAXS; Tat; Trifluoroethanol; Vaccine candidate

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; MUTANT PROTEIN; TRANSACTIVATOR PROTEIN; VIRUS PROTEIN;

ANTIBODY PRODUCTION; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CRYSTALLIZATION; FLUORESCENCE ANALYSIS; GEL FILTRATION; HUMAN IMMUNODEFICIENCY VIRUS 1; LIGHT SCATTERING; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; STRUCTURE ANALYSIS; TRANSACTIVATION; ULTRAVIOLET RADIATION; VALIDATION PROCESS; VIRUS ISOLATION; WILD TYPE; X RAY ANALYSIS; X RAY CRYSTALLOGRAPHY;

AIDS VACCINES; AMINO ACID SEQUENCE; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; HIV-1; HYDROPHOBICITY; IMMUNOGLOBULIN FRAGMENTS; LIGHT; METHYLAMINES; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PROTEIN FOLDING; SCATTERING, RADIATION; SCATTERING, SMALL ANGLE; SPECTROPHOTOMETRY, ULTRAVIOLET; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TRIFLUOROETHANOL; WATER;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77951221951     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22661     Document Type: Article

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