Extracellular cAMP inhibits P2X3 receptors in rat sensory neurones through G protein-mediated mechanism

Acta Physiologica

Volumn 199, Issue 2, 2010, Pages 199-204

  Mamenko, M V ^a   Chizhmakov, I V ^a   Volkova, T M ^a   Verkhratsky, A ^b,c   Krishtal, O A ^a  

^a BOGOMOLETZ INSTITUTE OF PHYSIOLOGY   (Ukraine)

^b INSTITUTE OF EXPERIMENTAL BOTANY   (Czech Republic)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

ATP; CAMP; CAMP receptors; G proteins; Purinergic transmission; Sensory neurone

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (2 THIODIPHOSPHATE); GUANOSINE DIPHOSPHATE; PURINERGIC P2X3 RECEPTOR; P2RX3 PROTEIN, RAT; PURINERGIC P2 RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MEMBRANE CURRENT; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SPINAL GANGLION; STEADY STATE; VOLTAGE CLAMP; WHOLE CELL; ANIMAL; CYTOLOGY; DRUG EFFECTS; METABOLISM; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; SECOND MESSENGER; WISTAR RAT;

ANIMALS; CYCLIC AMP; GANGLIA, SPINAL; GTP-BINDING PROTEINS; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2; RECEPTORS, PURINERGIC P2X3; SECOND MESSENGER SYSTEMS; SENSORY RECEPTOR CELLS;

EID: 77951212012     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2010.02088.x     Document Type: Article

References (32)

1. Abbracchio, M.P., Burnstock, G., Verkhratsky, A. Zimmermann, H. 2009. Purinergic signalling in the nervous system: an overview. Trends Neurosci 32, 19 29.
2. Bankir, L., Ahloulay, M., Devreotes, P.N. Parent, C.A. 2002. Extracellular cAMP inhibits proximal reabsorption: are plasma membrane cAMP receptors involved? Am J Physiol Renal Physiol 282, F376 F392. (Pubitemid 34654526)
3. Borst, P., de Wolf, C. van de Wetering, K. 2007. Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch 453, 661 673. (Pubitemid 46192537)
4. Burnstock, G. 2007a. Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 87, 659 797. (Pubitemid 47084682)
5. Burnstock, G. 2007b. Purine and pyrimidine receptors. Cell Mol Life Sci 64, 1471 1483. (Pubitemid 46954150)
6. Burnstock, G. 2009a. Purinergic receptors and pain. Curr Pharm Des 15, 1717 1735.
7. Burnstock, G. 2009b. Purines and sensory nerves. Handb Exp Pharmacol 194, 333 392.
8. Burnstock, G. Verkhratsky, A. 2009. Evolutionary origins of the purinergic signalling system. Acta Physiol (Oxf) 195, 415 447.
9. Chizhmakov, I., Yudin, Y., Mamenko, N., Prudnikov, I., Tamarova, Z. Krishtal, O. 2005. Opioids inhibit purinergic nociceptors in the sensory neurons and fibres of rat via a G protein-dependent mechanism. Neuropharmacology 48, 639 647. (Pubitemid 40462404)
10. Devreotes, P. 1989. Cell-cell interactions in Dictyostelium development. Trends Genet 5, 242 245.
11. Firtel, R.A., van Haastert, P.J., Kimmel, A.R. Devreotes, P.N. 1989. G protein linked signal transduction pathways in development: dictyostelium as an experimental system. Cell 58, 235 239.
12. Fredholm, B.B., IJzerman, A.P., Jacobson, K.A., Klotz, K.N. Linden, J. 2001. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53, 527 552. (Pubitemid 33136237)
13. Gerevich, Z., Zadori, Z., Muller, C., Wirkner, K., Schroder, W., Rubini, P. Illes, P. 2007. Metabotropic P2Y receptors inhibit P2X3 receptor-channels via G protein-dependent facilitation of their desensitization. Br J Pharmacol 151, 226 236. (Pubitemid 46763042)
14. Godecke, A. 2008. cAMP: fuel for extracellular adenosine formation? Br J Pharmacol 153, 1087 1089. (Pubitemid 351415516)
15. Gourine, A.V., Wood, J.D. Burnstock, G. 2009. Purinergic signalling in autonomic control. Trends Neurosci 32, 241 248.
16. Kaupp, U.B. Seifert, R. 2002. Cyclic nucleotide-gated ion channels. Physiol Rev 82, 769 824. (Pubitemid 34743338)
17. Khmyz, V., Maximyuk, O., Teslenko, V., Verkhratsky, A. Krishtal, O. 2008. P2X3 receptor gating near normal body temperature. Pflugers Arch 456, 339 347.
18. Klein, P., Vaughan, R., Borleis, J. Devreotes, P. 1987. The surface cyclic AMP receptor in Dictyostelium. Levels of ligand-induced phosphorylation, solubilization, identification of primary transcript, and developmental regulation of expression. J Biol Chem 262, 358 364. (Pubitemid 17000029)
19. Krishtal, O.A. Pidoplichko, V.I. 1980. A receptor for protons in the nerve cell membrane. Neuroscience 5, 2325 2327.
20. North, R.A. Verkhratsky, A. 2006. Purinergic transmission in the central nervous system. Pflugers Arch 452, 479 485. (Pubitemid 44015085)
21. Pankratov, Y., Lalo, U., Krishtal, O. Verkhratsky, A. 2002. Ionotropic P2X purinoreceptors mediate synaptic transmission in rat pyramidal neurones of layer II/III of somato-sensory cortex. J Physiol 542, 529 536. (Pubitemid 35190312)
22. Pankratov, Y., Lalo, U., Krishtal, O. Verkhratsky, A. 2003. P2X receptor-mediated excitatory synaptic currents in somatosensory cortex. Mol Cell Neurosci 24, 842 849. (Pubitemid 37506024)
23. Pankratov, Y., Lalo, U., Krishtal, O.A. Verkhratsky, A. 2009. P2X receptors and synaptic plasticity. Neuroscience 158, 137 148.
24. Paukert, M., Osteroth, R., Geisler, H.S., Brandle, U., Glowatzki, E., Ruppersberg, J.P. Grunder, S. 2001. Inflammatory mediators potentiate ATP-gated channels through the P2X3 subunit. J Biol Chem 276, 21077 21082. (Pubitemid 37413092)
25. Pratt, E.B., Brink, T.S., Bergson, P., Voigt, M.M. Cook, S.P. 2005. Use-dependent inhibition of P2X3 receptors by nanomolar agonist. J Neurosci 25, 7359 7365. (Pubitemid 41129808)
26. Ritter, C.A., Jedlitschky, G., Meyer zu Schwabedissen, H., Grube, M., Kock, K. Kroemer, H.K. 2005. Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev 37, 253 278. (Pubitemid 40250291)
27. Roberts, J.A., Vial, C., Digby, H.R., Agboh, K.C., Wen, H., Atterbury-Thomas, A. Evans, R.J. 2006. Molecular properties of P2X receptors. Pflugers Arch 452, 486 500. (Pubitemid 44015086)
28. Sokolova, E., Nistri, A. Giniatullin, R. 2003. The ATP-mediated fast current of rat dorsal root ganglion neurons is a novel effector for GABA B receptor activation. Neurosci Lett 338, 181 184. (Pubitemid 36173743)
29. Sorbera, L.A. Morad, M. 1991. Modulation of cardiac sodium channels by cAMP receptors on the myocyte surface. Science 253, 1286 1289. (Pubitemid 21917280)
30. Sutherland, E.W. Rall, T.W. 1958. Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles. J Biol Chem 232, 1077 1091.
31. Van Haastert, P.J., Wang, M., Bominaar, A.A., Devreotes, P.N. Schaap, P. 1992. cAMP-induced desensitization of surface cAMP receptors in Dictyostelium: different second messengers mediate receptor phosphorylation, loss of ligand binding, degradation of receptor, and reduction of receptor mRNA levels. Mol Biol Cell 3, 603 612. (Pubitemid 23098260)
32. Verkhratsky, A., Krishtal, O.A. Burnstock, G. 2009. Purinoceptors on neuroglia. Mol Neurobiol 39, 190 208.