A small molecule that inhibits the interaction of paxillin and α4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation

Journal of Biological Chemistry

Volumn 285, Issue 13, 2010, Pages 9462-9469

  Kummer, Christiane ^a   Petrich, Brian G ^a   Rose, David M ^a   Ginsberg, Mark H ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; CELLS; CYTOLOGY; DIAGNOSIS; DIGITAL LIBRARIES; DISEASE CONTROL; MOLECULES; PATHOLOGY; T-CELLS; TOXICITY;

CHEMICAL LIBRARIES; EFFECTIVE THERAPY; INFLAMMATORY DISEASE; MONONUCLEAR LEUKOCYTES; PHARMACOLOGICAL REDUCTION; PROOF OF PRINCIPLES; SMALL MOLECULE INHIBITOR; SMALL MOLECULES;

CELL SIGNALING;

ALPHA4 INTEGRIN; ANTIINFLAMMATORY AGENT; COMPOUND 6 B234TTQ; COMPOUND 6 B345TTQ; PAXILLIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL MIGRATION; CELL SPREADING; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SPECIFICITY; DRUG STRUCTURE; GENE DISRUPTION; GENE MUTATION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LEUKEMIA CELL LINE; LEUKOCYTE MIGRATION INHIBITION; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL MOTION; CHO CELL; CRICETULUS; HAMSTER; INFLAMMATION; METABOLISM; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; CELL MOVEMENT; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; INFLAMMATION; INTEGRIN ALPHA4; JURKAT CELLS; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; PAXILLIN; SIGNAL TRANSDUCTION;

EID: 77951211557     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.066993     Document Type: Article

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