Detection of microbial DNAemia: Does it matter for sepsis management?

Intensive Care Medicine

Volumn 36, Issue 2, 2010, Pages 193-195

  Struelens, Marc J ^a  

^a ERASME HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; FUNGAL DNA; RNA 16S; RNA 23S; TOLL LIKE RECEPTOR; ANTIINFECTIVE AGENT; VIRUS DNA;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; BACTEREMIA; BLOOD CULTURE; DIAGNOSTIC ACCURACY; DNA DETERMINATION; DNA HYBRIDIZATION; DNA MICROARRAY; DNA PROBE; EDITORIAL; GENE TARGETING; HUMAN; INTENSIVE CARE UNIT; MICROORGANISM DETECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PNEUMONIA; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SEPSIS; GENETICS; LUNG MYCOSIS; MICROBIOLOGY; NOTE;

ANTI-INFECTIVE AGENTS; DNA, VIRAL; DRUG RESISTANCE, MICROBIAL; HUMANS; LUNG DISEASES, FUNGAL; SEPSIS;

EID: 77951211142     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-009-1710-2     Document Type: Editorial

References (13)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303-1310
2. Fraser A, Paul M, Almanasreh N, Tacconelli E, Frank U, Cauda R, Borok S, Cohen M, Andreassen S, Nielsen AD, Leibovici L, TREAT Study Group (2006) Benefit of appropriate empirical antibiotic treatment: thirty-day mortality and duration of hospital stay. Am J Med 119:970-976
3. Bochud PY, Bonten M, Marchetti O, Calandra T (2004) Antimicrobial therapy for patients with severe sepsis and septic shock: an evidence-based review. Crit Care Med 32(Suppl 11):S495-S512
4. Rello J, Sa-Borges M, Correa H, Leal SR, Baraibar J (1999) Variations in etiology of ventilator-associated pneumonia across four treatment sites: implications for antimicrobial prescribing practices. Am J Respir Crit Care Med 160:608-613
5. Dark PM, Dean P, Warhurst G (2009) Bench-to-bedside review: the promise of rapid infection diagnosis during sepsis using polymerase chain reactionbased pathogen detection. Crit Care 13:217
6. Seng P, Drancourt M, Gouriet F, La Scola B, Fournier PE, Rolain JM, Raoult D (2009) Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin Infect Dis 49:543-551
7. Francois P, Charbonnier Y, Jacquet J, Utinger D, Bento M, Lew D, Kresbach GM, Ehrat M, Schlegel W, Schrenzel J (2006) Rapid bacterial identification using evanescent-waveguide oligonucleotide microarray classification. J Microbiol Methods 65:390-403
8. Burteau S, Bogaerts P, de Mendonça R, Irenge L, Berhin C, Hiffe J, de San N, Beyne P, Hamels S, Glupczynski Y, Struelens M, Gala JL, Remacle J (2008) Design and validation of a low density array (Nosochip) for the detection and identification of the main pathogenic bacteria and fungi responsible for nosocomial pneumonia. Eur J Clin Microbiol Infect Dis 27:17-27
9. Mancini N, Clerici D, Diotti R, Perotti M, Ghidoli N, De Marco D, Pizzorno B, Emrich T, Burioni R, Ciceri F, Clementi M (2008) Molecular diagnosis of sepsis in neutropenic patients with haematological malignancies. J Med Microbiol 57:601-604
10. Louie RF, Tang Z, Albertson TE, Cohen S, Tran NK, Kost GJ (2008) Multiplex polymerase chain reaction detection enhancement of bacteremia and fungemia. Crit Care Med 36:1487-1492
11. Dierkes C, Ehrenstein B, Siebig S, Linde HJ, Reischl U, Salzberger B (2009) Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis. BMC Infect Dis 9:126
12. Westh H, Lisby G, Breysse F, Böddinghaus B, Chomarat M, Gant V, Goglio A, Raglio A, Schuster H, Stuber F, Wissing H, Hoeft A (2009) Multiplex real-time PCR and blood culture for identification of bloodstream pathogens in patients with suspected sepsis. Clin Microbiol Infect 15:544-551
13. Bloos F, Hinder F, Becker K, Sachse S, Mekonto-Dessap A, Straube E, Cattoir V, Brun-Buisson C, Reinhart K, Peters G, Bauer M (2009) A multicentre trial to compare blood culture with polymerase chain reaction in severe human sepsis. Intensive Care Med. doi: 10.1007/s00134-009-1705-z