Physico-chemical characterisation of PLGA nanoparticles after freeze-drying and storage

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 72, Issue 2, 2009, Pages 428-437

  Holzer, Melisande ^a   Vogel, Vitali ^a   Mäntele, Werner ^a   Schwartz, Daniel ^b   Haase, Winfried ^c   Langer, Klaus ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Merck Serono GmbH   (Germany)

^c MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

Author keywords

Analytical ultracentrifugation; DSC; Dynamic light scattering; Electron microscopy; Freeze drying; Moisture content; Poly(d,l lactic co glycolic acid) (PLGA) nanoparticles; Storage stability

Indexed keywords

ARGININE; MANNITOL; NANOPARTICLE; POLYGLACTIN; SUCROSE; TREHALOSE;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DETERMINATION; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; DRUG SYNTHESIS; EVAPORATION; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; LIGHT SCATTERING; MOISTURE; TITRIMETRY; TRANSMISSION ELECTRON MICROSCOPY; ULTRACENTRIFUGATION;

CALORIMETRY, DIFFERENTIAL SCANNING; FREEZE DRYING; LACTIC ACID; LIGHT; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; PARTICLE SIZE; POLYGLYCOLIC ACID; SCATTERING, RADIATION; ULTRACENTRIFUGATION;

EID: 67349119561     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2009.02.002     Document Type: Article

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