Aerobic exercise acutely improves insulin- and insulin-like growth factor-1-mediated vasorelaxation in hypertensive rats

Experimental Physiology

Volumn 95, Issue 5, 2010, Pages 622-629

  Yang, Ai Lun ^a   Yeh, Chien Kuei ^b   Su, Chia Ting ^c   Lo, Chia Wen ^a   Lin, Ko Long ^d   Lee, Shin Da ^e,f  

^a UNIVERSITY OF TAIPEI   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^d KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f ASIA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; SOMATOMEDIN C; SUPEROXIDE; SUPEROXIDE DISMUTASE;

AEROBIC EXERCISE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; ENDOTHELIUM; HYPERTENSION; NONHUMAN; RANDOMIZATION; RAT; SITTING; SPONTANEOUSLY HYPERTENSIVE RAT; TREADMILL EXERCISE; VASCULAR RING; VASODILATATION; WISTAR KYOTO RAT;

EID: 77951197548     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2009.050146     Document Type: Article

References (36)

1. Bragulat E, de la Sierra A, Antonio MT Coca A (2001). Endothelial dysfunction in salt-sensitive essential hypertension. Hypertension 37, 444 448.
2. Chen HI, Chiang IP Jen CJ (1996). Exercise training increases acetylcholine-stimulated endothelium-derived nitric oxide release in spontaneously hypertensive rats. J Biomed Sci 3, 454 460.
3. Conti E, Carrozza C, Capoluongo E, Volpe M, Crea F, Zuppi C Andreotti F (2004). Insulin-like growth factor-1 as a vascular protective factor. Circulation 110, 2260 2265.
4. Folkow B (1987). Structure and function of the arteries in hypertension. Am Heart J 114, 938 948.
5. Goke B Fehmann HC (1996). Insulin and insulin-like growth factor-I: their role as risk factors in the development of diabetic cardiovascular disease. Diabetes Res Clin Pract 30 (Suppl 93 106. (Pubitemid 126352583)
6. Goto C, Nishioka K, Umemura T, Jitsuiki D, Sakagutchi A, Kawamura M, Chayama K, Yoshizumi M Higashi Y (2007). Acute moderate-intensity exercise induces vasodilation through an increase in nitric oxide bioavailiability in humans. Am J Hypertens 20, 825 830.
7. Graham DA Rush JW (2004). Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats. J Appl Physiol 96, 2088 2096.
8. Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, Schoene N Schuler G (2000). Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 342, 454 460.
9. Hamilton CA, Brosnan MJ, McIntyre M, Graham D Dominiczak AF (2001). Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction. Hypertension 37, 529 534.
10. Haram PM, Adams V, Kemi OJ, Brubakk AO, Hambrecht R, Ellingsen O Wisloff U (2006). Time-course of endothelial adaptation following acute and regular exercise. Eur J Cardiovasc Prev Rehabil 13, 585 591.
11. Hardman AE (1996). Exercise in the prevention of atherosclerotic, metabolic and hypertensive diseases: a review. J Sports Sci 14, 201 218.
12. Higashi Y, Sasaki S, Kurisu S, Yoshimizu A, Sasaki N, Matsuura H, Kajiyama G Oshima T (1999). Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation 100, 1194 1202.
13. Howard MG, DiCarlo SE Stallone JN (1992). Acute exercise attenuates phenylephrine-induced contraction of rabbit isolated aortic rings. Med Sci Sports Exerc 24, 1102 1107.
14. Inoue N, Ramasamy S, Fukai T, Nerem RM Harrison DG (1996). Shear stress modulates expression of Cu/Zn superoxide dismutase in human aortic endothelial cells. Circ Res 79, 32 37.
15. John S Schmieder RE (2000). Impaired endothelial function in arterial hypertension and hypercholesterolemia: potential mechanisms and differences. J Hypertens 18, 363 374.
16. Kerr S, Brosnan MJ, McIntyre M, Reid JL, Dominiczak AF Hamilton CA (1999). Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. Hypertension 33, 1353 1358.
17. McCallum RW, Hamilton CA, Graham D, Jardine E, Connell JM Dominiczak AF (2005). Vascular responses to IGF-I and insulin are impaired in aortae of hypertensive rats. J Hypertens 23, 351 358.
18. Maiorana A, O'Driscoll G, Taylor R Green D (2003). Exercise and the nitric oxide vasodilator system. Sports Med 33, 1013 1035.
19. Melo RM, Martinho E Jr. Michelini LC (2003). Training-induced, pressure-lowering effect in SHR: wide effects on circulatory profile of exercised and nonexercised muscles. Hypertension 42, 851 857.
20. Oparil S, Zaman MA Calhoun DA (2003). Pathogenesis of hypertension. Ann Intern Med 139, 761 776.
21. Panza JA, Garcia CE, Kilcoyne CM, Quyyumi AA Cannon RO 3rd. (1995). Impaired endothelium-dependent vasodilation in patients with essential hypertension. Evidence that nitric oxide abnormality is not localized to a single signal transduction pathway. Circulation 91, 1732 1738.
22. Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA Ray CA American College of Sports Medicine (2004). American College of Sports Medicine position stand. Exercise and hypertension. Med Sci Sports Exerc 36, 533 553.
23. Ross R (1999). Atherosclerosis - an inflammatory disease. N Engl J Med 340, 115 126.
24. Rush JW, Turk JR Laughlin MH (2003). Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium. Am J Physiol Heart Circ Physiol 284, H1378 H1387.
25. Simon G (2004). Pathogenesis of structural vascular changes in hypertension. J Hypertens 22, 3 10.
26. Sowers JR (1997). Insulin and insulin-like growth factor in normal and pathological cardiovascular physiology. Hypertension 29, 691 699.
27. Sun MW, Qian FL, Wang J, Tao T, Guo J, Wang L, Lu AY Chen H (2008). Low-intensity voluntary running lowers blood pressure with simultaneous improvement in endothelium-dependent vasodilatation and insulin sensitivity in aged spontaneously hypertensive rats. Hypertens Res 31, 543 552.
28. Thompson PD, Crouse SF, Goodpaster B, Kelley D, Moyna N Pescatello L (2001). The acute versus the chronic response to exercise. Med Sci Sports Exerc 33, S438 S445.
29. Vecchione C, Colella S, Fratta L, Gentile MT, Selvetella G, Frati G, Trimarco B Lembo G (2001). Impaired insulin-like growth factor I vasorelaxant effects in hypertension. Hypertension 37, 1480 1485.
30. Walsh MF, Barazi M, Pete G, Muniyappa R, Dunbar JC Sowers JR (1996). Insulin-like growth factor I diminishes in vivo and in vitro vascular contractility: role of vascular nitric oxide. Endocrinology 137, 1798 1803.
31. Yamashita N, Hoshida S, Otsu K, Asahi M, Kuzuya T Hori M (1999). Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation. J Exp Med 89, 1699 1706.
32. Yang AL, Chao JI Lee SD (2007). Altered insulin-mediated and insulin-like growth factor-1-mediated vasorelaxation in aortas of obese Zucker rats. Int J Obes (Lond) 31, 72 77.
33. Yang AL, Jen CJ Chen HI (2003). Effects of high-cholesterol diet and parallel exercise training on the vascular function of rabbit aortas: a time course study. J Appl Physiol 95, 1194 1200.
34. Yang AL, Su CT, Lin KL, Chao JI, You HP Lee SD (2006). Exercise training improves insulin-induced and insulin-like growth factor-1-induced vasorelaxation in rat aortas. Life Sci 79, 2017 2021.
35. Yang AL, Su CT, Lin KL Lee SD (2008). Enhancement of vascular function mediated by insulin and insulin-like growth factor-1 following single exercise session. Chin J Physiol 51, 71 77.
36. Zeng G, Nystrom FH, Ravichandran LV, Cong LN, Kirby M, Mostowski H Quon MJ (2000). Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation 101, 1539 1545.