Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy

Physiological Genomics

Volumn 41, Issue 2, 2010, Pages 137-145

  Molojavyi, Andrei ^a   Lindecke, Antje ^a   Raupach, Annika ^a   Moellendorf, Sarah ^a   Köhrer, Karl ^a   Gödecke, Axel ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Conductance manometry; Heart; Microarray

Indexed keywords

ISOPRENALINE; MYOGLOBIN;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE INDUCTION; HEART FAILURE; HEART STRESS; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; LUNG EDEMA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CLUSTER ANALYSIS; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENOTYPE; HYPERTROPHY, LEFT VENTRICULAR; ISOPROTERENOL; MICE; MICE, KNOCKOUT; MYOCARDIUM; MYOGLOBIN; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; STROKE VOLUME; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE; VENTRICULAR REMODELING;

MUS;

EID: 77951152823     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.90297.2008     Document Type: Article

References (27)

1. Berdeaux R, Goebel N, Banaszynski L, Takemori H, Wandless T, Shelton GD, Montminy M. SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat Med 13: 597-603, 2007.
2. Campbell PH, Hunt DL, Jones Y, Harwood F, Amiel D, Omens JH, McCulloch AD. Effects of biglycan deficiency on myocardial infarct structure and mechanics. Mol Cell Biomech 5: 27-35, 2008.
3. Chugh SS, Whitesel S, Turner M, Roberts CT Jr, Nagalla SR. Genetic basis for chamber-specific ventricular phenotypes in the rat infarct model. Cardiovasc Res 57: 477-485, 2003.
4. Diwan A, Dorn GW. Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets. Physiology (Bethesda) 22: 56-64, 2007.
5. Dorn GW. The fuzzy logic of physiological cardiac hypertrophy. Hypertension 49: 962-970, 2007.
6. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95: 14863-14868, 1998.
7. Flögel U, Jacoby C, Gödecke A, Schrader J. In vivo 2D mapping of impaired murine cardiac energetics in NO-induced heart failure. Magn Reson Med 57: 50-58, 2007.
8. Flögel U, Laussmann T, Gödecke A, Abanador N, Schafers M, Fingas CD, Metzger S, Levkau B, Jacoby C, Schrader J. Lack of myoglobin causes a switch in cardiac substrate selection. Circ Res 96: e68-e75, 2005.
9. Flögel U, Merx MW, Gödecke A, Decking UK, Schrader J. Myoglobin: a scavenger of bioactive NO. Proc Natl Acad Sci USA 98: 735-740, 2001.
10. Gaussin V, Tomlinson JE, Depre C, Engelhardt S, Antos CL, Takagi G, Hein L, Topper JN, Liggett SB, Olson EN, Lohse MJ, Vatner SF, Vatner DE. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation 108: 2926-2933, 2003.
11. Georgakopoulos D, Kass DA. Estimation of parallel conductance by dual-frequency conductance catheter in mice. Am J Physiol Heart Circ Physiol 279: H443-H450, 2000.
12. Gödecke A, Flögel U, Zanger K, Ding Z, Hirchenhain J, Decking UK, Schrader J. Disruption of myoglobin in mice induces multiple compensatory mechanisms. Proc Natl Acad Sci USA 96: 10495-10500, 1999.
13. Gödecke A, Molojavyi A, Heger J, Flögel U, Ding Z, Jacoby C, Schrader J. Myoglobin protects the heart from inducible nitric-oxide synthase (iNOS)-mediated nitrosative stress. J Biol Chem 278: 21761-21766, 2003.
14. Gödecke A, Schrader J. Adaptive mechanisms of the cardiovascular system in transgenic mice: lessons from eNOS and myoglobin knockout mice. Basic Res Cardiol 95: 492-498, 2000.
15. Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet 31: 25-32, 2002.
16. Meeson AP, Radford N, Shelton JM, Mammen PPA, Dimaio JM, Hutcheson K, Kong YF, Elterman J, Williams RS, Garry DJ. Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circ Res 88: 713-720, 2001.
17. Merx MW, Gödecke A, Flögel U, Schrader J. Oxygen supply and nitric oxide scavenging by myoglobin contribute to exercise endurance and cardiac function. FASEB J 19: 1015-1017, 2005.
18. Osadchii OE. Cardiac hypertrophy induced by sustained beta-adrenoreceptor activation: pathophysiological aspects. Heart Fail Rev 12: 66-86, 2007.
19. Oshima Y, Ouchi N, Sato K, Izumiya Y, Pimentel DR, Walsh K. Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart. Circulation 117: 3099-3108, 2008.
20. Phan D, Rasmussen TL, Nakagawa O, McAnally J, Gottlieb PD, Tucker PW, Richardson JA, Bassel-Duby R, Olson EN. BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart. Development 132: 2669-2678, 2005.
21. Popivanova BK, Li YY, Zheng H, Omura K, Fujii C, Tsuneyama K, Mukaida N. Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis. Cancer Sci 98: 321-328, 2007.
22. Schlieper G, Kim JH, Molojavyi A, Jacoby C, Laussmann T, Flögel U, Gödecke A, Schrader J. Adaptation of the myoglobin knockout mouse to hypoxic stress. Am J Physiol Regul Integr Comp Physiol 286: R786-R792, 2004.
23. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article 3, 2004.
24. Smyth GK, Speed T. Normalization of cDNA microarray data. Methods 31: 265-273, 2003.
25. Taegtmeyer H, Razeghi P, Young ME. Mitochondrial proteins in hypertrophy and atrophy: a transcript analysis in rat heart. Clin Exp Pharmacol Physiol 29: 346-350, 2002.
26. Teichholz LE, Kreulen T, Herman MV, Gorlin R. Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy. Am J Cardiol 37: 7-11, 1976.
27. Westermann D, Mersmann J, Melchior A, Freudenberger T, Petrik C, Schaefer L, Lullmann-Rauch R, Lettau O, Jacoby C, Schrader J, Brand-Herrmann SM, Young MF, Schultheiss HP, Levkau B, Baba HA, Unger T, Zacharowski K, Tschope C, Fischer JW. Biglycan is required for adaptive remodeling after myocardial infarction. Circulation 117: 1269-1276, 2008.