A novel class of antihyperlipidemic agents with low density lipoprotein receptor up-regulation via the adaptor protein autosomal recessive hypercholesterolemia

Journal of Medicinal Chemistry

Volumn 53, Issue 8, 2010, Pages 3284-3295

  Asano, Shigehiro ^a   Ban, Hitoshi ^a   Tsuboya, Norie ^a   Uno, Shinsaku ^a   Kino, Kouichi ^a   Ioriya, Katsuhisa ^a   Kitano, Masafumi ^a   Ueno, Yoshihide ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 DIISOPROPYLPHENYL [[4 (3 METHOXYPHENYL) 1 PYRIMIDIN 2 YLPIPERIDIN 4 YL]CARBONYL]SULFAMATE; ADAPTOR PROTEIN; ANTILIPEMIC AGENT; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; HAMSTER; HYPERCHOLESTEROLEMIA; MALE; NONHUMAN; RECEPTOR UPREGULATION; RNA INTERFERENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTILIPEMIC AGENTS; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; CHOLESTEROL, LDL; CRICETINAE; HUMANS; HYPERLIPIDEMIAS; MALE; PYRIMIDINES; RECEPTORS, LDL; RNA INTERFERENCE; STEROL O-ACYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS; TRIGLYCERIDES; UP-REGULATION;

EID: 77951133543     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901909p     Document Type: Article

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