Synthesis and structure-activity relationships of N-(4-amino-2,6-diisopropylphenyl)-N'-(1,4-diarylpiperidine-4-yl)methylureas as anti-hyperlipidemic agents

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4636-4646

  Asano, Shigehiro ^a   Ban, Hitoshi ^a   Kino, Koichi ^a   Ioriya, Katsuhisa ^a   Muraoka, Masami ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

1,4 Diarylpiperidine 4 methylureas; ACAT inhibitor; Antihyperlipidemic agent; LDL receptor up regulator; Solubility

Indexed keywords

ANTILIPEMIC AGENT; AVASIMIBE; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; LOW DENSITY LIPOPROTEIN RECEPTOR; METHYLUREA; N (4 AMINO 2,6 DIISOPROPYLPHENYL) N' [[1 [2 (3 HYDROXYPROPOXY)PHENYL] 4 (3 METHOXYPHENYL)PIPERIDIN 4 YL]METHYL]UREA; PIPERIDINE DERIVATIVE; SMP 797; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG MECHANISM; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PROTEIN EXPRESSION; RAT; STRUCTURE ACTIVITY RELATION; UPREGULATION;

ANIMALS; ANTILIPEMIC AGENTS; CELL LINE, TUMOR; HUMANS; LIVER; MACROPHAGES; PHENYLUREA COMPOUNDS; PIPERIDINES; RATS; RECEPTORS, LDL; STEROL O-ACYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP; UP-REGULATION;

EID: 66449122310     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.059     Document Type: Article

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