Novel 1,4-diarylpiperidine-4-methylureas as anti-hyperlipidemic agents: Dual effectors on acyl-CoA:cholesterol O-acyltransferase and low-density lipoprotein receptor expression

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 4, 2009, Pages 1062-1065

  Asano, Shigehiro ^a   Ban, Hitoshi ^a   Kino, Kouichi ^a   Ioriya, Katsuhisa ^a   Muraoka, Masami ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

1,4 Diarylpiperidine 4 methylureas; ACAT inhibitor; Anti hyperlipidemic agent; LDL receptor up regulator

Indexed keywords

ANTILIPEMIC AGENT; AVASIMIBE; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; LOW DENSITY LIPOPROTEIN RECEPTOR; PIPERIDINE 4 METHYLUREA DERIVATIVE; PIPERIDINE DERIVATIVE; SMP 797; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; ATHEROSCLEROSIS; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HEPATOMA CELL; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; LIPID METABOLISM; RECEPTOR UPREGULATION; STRUCTURE ACTIVITY RELATION;

COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; METHYLUREA COMPOUNDS; MOLECULAR STRUCTURE; NAPHTHYRIDINES; PIPERIDINES; RECEPTORS, LDL; STEROL O-ACYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 59649104957     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.020     Document Type: Article

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