The serotonergic projection from the median raphe nucleus to the ventral hippocampus is involved in the retrieval of fear memory through the corticotropin-releasing factor type 2 receptor

Neuropsychopharmacology

Volumn 35, Issue 6, 2010, Pages 1271-1278

  Ohmura, Yu ^a,b   Izumi, Takeshi ^a   Yamaguchi, Taku ^a   Tsutsui Kimura, Iku ^a   Yoshida, Takayuki ^a   Yoshioka, Mitsuhiro ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

5 HT; Corticotropin releasing hormone; Fear; Hippocampus; Median raphe nucleus; Memory

Indexed keywords

ANTALARMIN; ASTRESSIN; ASTRESSIN 2B; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; EXPLORATORY BEHAVIOR; FEAR; HIPPOCAMPUS; IN VIVO STUDY; MALE; MAZE TEST; MEDIAN RAPHE NUCLEUS; MEMORY; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEROTONINERGIC NERVE CELL;

ANIMALS; CORTICOTROPIN-RELEASING HORMONE; FEAR; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY; NEURAL PATHWAYS; NEUROPROTECTIVE AGENTS; NEUROPSYCHOLOGICAL TESTS; PEPTIDE FRAGMENTS; RAPHE NUCLEI; RATS; RATS, WISTAR; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SEROTONIN;

EID: 77951101967     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2009.229     Document Type: Article

References (40)

1. Almada RC, Borelli KG, Albrechet-Souza L, Brandão ML (2009). Serotonergic mechanisms of the median raphe nucleus-dorsal hippocampus in conditioned fear: output circuit involves the prefrontal cortex and amygdala. Behav Brain Res 203: 279-287.
2. Andrade TG, Graeff FG (2001). Effect of electrolytic and neurotoxic lesions of the median raphe nucleus on anxiety and stress. Pharmacol Biochem Behav 70: 1-14. (Pubitemid 32786962)
3. Andrade TG, Macedo CE, Zangrossi Jr H, Graeff FG (2004). Anxiolytic-like effects of median raphe nucleus lesion in the elevated T-maze. Behav Brain Res 153: 55-60.
4. Avanzi V, Castilho VM, de Andrade TGCS, Brandao ML (1998). Regulation of contextual conditioning by the median raphe nucleus. Brain Res 790: 178-184. (Pubitemid 28234501)
5. Azmitia EC, Segal M (1978). An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J Comp Neurol 179: 641-667. (Pubitemid 8372646)
6. Baker DG, West SA, Nicholson WE, Ekhator NN, Kasckow JW, Hill KK et al. (1999). Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder. Am J Psychiatry 156: 585-588.
7. Bittencourt JC, Vaughan J, Arias C, Rissman RA, Vale WW, Sawchenko PE (1999). Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors. J Comp Neurol 415: 285-312.
8. Bittencourt JC, Sawchenko PE (2000). Do centrally administered neuropeptides access cognate receptors? An analysis in the central corticotropin-releasing factor system. J Neurosci 20: 1142-1156.
9. Borelli KG, Gárgaro AC, dos Santos JM, Brandão ML (2005). Effects of inactivation of serotonergic neurons of the median raphe nucleus on learning and performance of contextual fear conditioning. Neurosci Lett 387: 105-110.
10. Burman MA, Starr MJ, Gewirtz JC (2006). Dissociable effects of hippocampus lesions on expression of fear and trace fear conditioning memories in rats. Hippocampus 16: 103-113.
11. De Oca BM, DeCola JP, Maren S, Fanselow MS (1998). Distinct regions of the periaqueductal gray are involved in the acquisition and expression of defensive responses. J Neurosci 18: 3426-3432. (Pubitemid 28186033)
12. Fanselow MS (1980). Conditioned and unconditional components of post-shock freezing. Pavlov J Biol Sci 15: 177-182.
13. Hammack SE, Richey KJ, Schmid MJ, LoPresti ML, Watkins LR, Maier SF (2002). The role of corticotropin-releasing hormone in the dorsal raphe nucleus in mediating the behavioral consequences of uncontrollable stress. J Neurosci 22: 1020-1026.
14. Hammack SE, Schmid MJ, LoPresti ML, Der-Avakian A, Pellymounter MA, Foster AC et al. (2003). Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress. J Neurosci 23: 1019-1025. (Pubitemid 36206194)
15. Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM (2003). International union of pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands. Pharmacol Rev 55: 21-26.
16. Henry B, Vale W, Markou A (2006). The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci 26: 9142-9152. (Pubitemid 44359841)
17. Hobin JA, Ji J, Maren S (2006). Ventral hippocampal muscimol disrupts context-specific fear memory retrieval after extinction in rats. Hippocampus 16: 174-182.
18. Holt W, Maren S (1999). Muscimol inactivation of the dorsal hippocampus impairs contextual retrieval of fear memory. J Neurosci 19: 9054-9062.
19. Irons J (2005). Fluvoxamine in the treatment of anxiety disorders. Neuropsychiatr Dis Treat 1: 289-299.
20. LeDoux JE (2000). Emotion circuits in the brain. Annu Rev Neurosci 23: 155-184.
21. Lukkes JL, Forster GL, Renner KJ, Summers CH (2008). Corticotropin- releasing factor 1 and 2 receptors in the dorsal raphe differentially affect serotonin release in the nucleus accumbens. Eur J Pharmacol 578: 185-193.
22. Matsumoto M, Togashi H, Kaku A, Kanno M, Tahara K, Yoshioka M (2005). Cortical GABAergic regulation of dopaminergic responses to psychological stress in the rat dorsolateral striatum. Synapse 56: 117-121. (Pubitemid 40389563)
23. Matsumoto M, Shikanai H, Togashi H, Izumi T, Kitta T, Hirata R et al. (2008). Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats. Brain Res 1195: 50-55.
24. Matsuo M, Kataoka Y, Mataki S, Kato Y, Oi K (1996). Conflict situation increases serotonin release in rat dorsal hippocampus: in vivo study with microdialysis and Vogel test. Neurosci Lett 215: 197-200. (Pubitemid 26323460)
25. Muchimapura S, Fulford AJ, Mason R, Marsden CA (2002). Isolation rearing in the rat disrupts the hippocampal response to stress. Neuroscience 112: 697-705. (Pubitemid 34634163)
26. Nemeroff CB, Widerlöv E, Bissette G, Walléus H, Karlsson I, Eklund K et al. (1984). Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in de-pressed patients. Science 226: 1342-1344.
27. Ohmura Y, Yamaguchi T, Izumi T, Matsumoto M, Yoshioka M (2008). Corticotropin releasing factor in the median raphe nucleus is involved in the retrieval of fear memory in rats. Eur J Pharmacol 584: 357-360.
28. Pan W, Kastin AJ (2008). Urocortin and the brain. Prog Neurobiol 84: 148-156.
29. Paxinos G, Watson C (2004). The Rat Brain in Stereotaxic Coordinates 5th edn Academic Press: San Diego.
30. Robert S, Hamner MB, Ulmer HG, Lorberbaum JP, Durkalski VL (2006). Open-label trial of escitalopram in the treatment of posttraumatic stress disorder. J Clin Psychiatry 67: 1522-1526.
31. Sajdyk TJ, Gehlert DR (2000). Astressin, a corticotropin releasing factor antagonist, reverses the anxiogenic effects of urocortin when administered into the basolateral amygdala. Brain Res 877: 226-234.
32. Treit D, Menard J, Royan C (1993). Anxiogenic stimuli in the elevated plus-maze. Pharmacol Biochem Behav 44: 463-469.
33. Trivedi MA, Coover GD (2004). Lesions of the ventral hippocam-pus, but not the dorsal hippocampus, impair conditioned fear expression and inhibitory avoidance on the elevated T-maze. Neurobiol Learn Mem 81: 172-184.
34. Umegaki H, Munoz J, Meyer RC, Spangler EL, Yoshimura J, Ikari H et al. (2001). Involvement of dopamine D(2) receptors in complex maze learning and acetylcholine release in ventral hippocampus of rats. Neuroscience 103: 27-33.
35. Vale W, Spiess J, Rivier C, Rivier J (1981). Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213: 1394-1397.
36. Vianna DM, Graeff FG, Landeira-Fernandez J, Brandão ML (2001). Lesion of the ventral periaqueductal gray reduces conditioned fear but does not change freezing induced by stimulation of the dorsal periaqueductal gray. Learn Mem 8: 164-169.
37. Wilkerson A, Levin ED (1999). Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats. Neuro-science 89: 743-749.
38. Wilkinson LS, Humby T, Killcross S, Robbins TW, Everitt BJ (1996). Dissociations in hippocampal 5-hydroxytryptamine release in the rat following Pavlovian aversive conditioning to discrete and contextual stimuli. Eur J Neurosci 8: 1479-1487.
39. Yoshioka M, Matsumoto M, Togashi H, Saito H (1995). Effects of conditioned fear stress on 5-HT release in the rat prefrontal cortex. Pharmacol Biochem Behav 51: 515-519.
40. Zohar J, Westenberg HG (2000). Anxiety disorders: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors. Acta Psychiatr Scand 403: 39-49.