Effect of human immunodeficiency virus type 1 protease inhibitor therapy and subtype on development of resistance in subtypes B and G

Infection, Genetics and Evolution

Volumn 10, Issue 3, 2010, Pages 373-379

  Palma, Ana Carolina ^a,b   Abecasis, Ana Barroso ^a,b   Vercauteren, Jurgen ^b   Carvalho, Ana Patricia ^a   Cabanas, Joaquim ^a   Vandamme, Anne Mieke ^b   Camacho, Ricardo Jorge ^a,c  

^a HOSPITAL EGAS MONIZ   (Portugal)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

Author keywords

Drug resistance mutations; HIV 1; Protease; Subtype G

Indexed keywords

AMPRENAVIR; ATAZANAVIR; INDINAVIR; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; NELFINAVIR; PROTEINASE; PROTEINASE INHIBITOR; SAQUINAVIR;

ALGORITHM; AMINO ACID SUBSTITUTION; ANTIVIRAL RESISTANCE; ARTICLE; DRUG EXPOSURE; EUROPE; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; PRIORITY JOURNAL; TREATMENT RESPONSE; VIRUS MUTATION; VIRUS RESISTANCE;

AMINO ACID SUBSTITUTION; DRUG RESISTANCE, VIRAL; GENETIC VARIATION; HIV INFECTIONS; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; INDINAVIR; PHYLOGENY; PYRIMIDINONES; SELECTION, GENETIC; SEQUENCE ANALYSIS, PROTEIN;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77951094151     PISSN: 15671348     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.meegid.2009.06.019     Document Type: Article

References (27)

1. Abecasis A.B., Deforche K., Bacheler L.T., McKenna P., Carvalho A.P., Gomes P., Vandamme A.M., Camacho R.J. Investigation of baseline susceptibility to protease inhibitors in HIV-1 subtypes C, F, G and CRF02_AG. Antivir. Ther. 2006, 11:581-589.
2. Abecasis A.B., Deforche K., Snoeck J., Bacheler L.T., McKenna P., Carvalho A.P., Gomes P., Camacho R.J., Vandamme A.M. Protease mutation M89I/V is linked to therapy failure in patients infected with the HIV-1 non-B subtypes C, F or G. AIDS 2005, 19:1799-1806.
3. Bannister W.P., Ruiz L., Loveday C., Vella S., Zilmer K., Kjaer J., Knysz B., Phillips A.N., Mocroft A. HIV-1 subtypes and response to combination antiretroviral therapy in Europe. Antivir. Ther. 2006, 11:707-715.
4. Baxter J.D., Schapiro J.M., Boucher C.A., Kohlbrenner V.M., Hall D.B., Scherer J.R., Mayers D.L. Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J. Virol. 2006, 80:10794-10801.
5. Bennett, D.E., Camacho, R.J., Otelea, D., Kuritzkes, D.R., Fleury, H., Kiuchi, M., Heneine, W., Kantor, R., Jordan, M.R., Schapiro, J.M., Vandamme, A.M., Sandstrom, P., Boucher, C.A., van de Vijver, D., Rhee, S.Y., Liu, T.F., Pillay, D., Shafer, R.W., 2009. Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update. PLoS. ONE. 4: e4724.
6. Camacho R., Deforche K., Valadas M.E., Van Laethem K., Águas M.J., Vera J., Rosado L., Batista T., Bezerra V., Soares I., Branco T., Mouzinho A., Teófilo E., Faria T., Abecasis A., Gomes P., Carvalho A.P., Vandamme A.-M. Nelfinavir resistance in HIV-1 subtype B and G infected patients: evidence for different pathways and novel mutations associated with failure of nelfinavir based regimens. Antivir. Ther. 2004, 9:S1-S182.
7. Camacho, R., Godinho, A.R., Gomes, P., Abecasis, A., Vandamme, A.-M., Palma, A.C., Carvalho, A.P., Cabanas, J., Gonçalves, J., 2005. Different substitutions under drug pressure at protease codon 82 in HIV-1 subtype G compared to subtype B infected individuals including a novel I82M resistance mutation. XIV International HIV Drug Resistance Workshop: Basic Principles and Clinical Implications.
8. Camacho R., Vandamme A.-M. Antiretroviral resistance in different HIV-1 subtypes: impact on therapy outcomes and resistance testing interpretation. Curr. Opin. HIV AIDS 2007, 2:123-129.
9. Cane P.A., Green H., Fearnhill E., Dunn D. Identification of accessory mutations associated with high-level resistance in HIV-1 reverse transcriptase. AIDS 2007, 21:447-455.
10. Chenna R., Sugawara H., Koike T., Lopez R., Gibson T.J., Higgins D.G., Thompson J.D. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 2003, 31:3497-3500.
11. de Oliveira T., Deforche K., Cassol S., Salminen M., Paraskevis D., Seebregts C., Snoeck J., van Rensburg E.J., Wensing A.M., van de Vijver D.A., Boucher C.A., Camacho R., Vandamme A.M. An automated genotyping system for analysis of HIV-1 and other microbial sequences. Bioinformatics 2005, 21:3797-3800.
12. Deforche K., Camacho R., Grossman Z., Silander T., Soares M.A., Moreau Y., Shafer R.W., Van Laethem K., Carvalho A.P., Wynhoven B., Cane P., Snoeck J., Clarke J., Sirivichayakul S., Ariyoshi K., Holguin A., Rudich H., Rodrigues R., Bouzas M.B., Cahn P., Brigido L.F., Soriano V., Sugiura W., Phanuphak P., Morris L., Weber J., Pillay D., Tanuri A., Harrigan P.R., Shapiro J.M., Katzenstein D.A., Kantor R., Vandamme A.M. Bayesian network analysis of resistance pathways against HIV-1 protease inhibitors. Infect. Genet. Evol. 2006, 7:382-390.
13. Deforche K., Silander T., Camacho R., Grossman Z., Soares M., Van Laethem K., Kantor R., Moreau Y., Vandamme A.M. Analysis of HIV-1 pol sequences using Bayesian networks: implications for drug resistance. Bioinformatics 2006.
14. Dumans A.T., Barreto C.C., Santos A.F., Arruda M., Sousa T.M., Machado E.S., Sabino E.C., Brindeiro R.M., Tanuri A., Duarte A.J., Soares M.A. Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. Infect. Genet. Evol. 2009, 9:62-70.
15. Gomes, P., Diogo, I., Goncalves, M.F., Carvalho, P., Cabanas, J., Lobo, M.C., Camacho, R., 2002. Different pathways to nelfinavir genotypic resistance in HIV-1 subtypes B and G. 9th Conference on Retroviruses and Opportunistic Infections, Seattle, abstract no. 46.
16. Gonzalez L.M., Santos A.F., Abecasis A.B., Van Laethem K., Soares E.A., Deforche K., Tanuri A., Camacho R., Vandamme A.M., Soares M.A. Impact of HIV-1 protease mutations A71V/T and T74S on M89I/V-mediated protease inhibitor resistance in subtype G isolates. J. Antimicrob. Chemother. 2008, 61:1201-1204.
17. Grossman Z., Paxinos E.E., Averbuch D., Maayan S., Parkin N.T., Engelhard D., Lorber M., Istomin V., Shaked Y., Mendelson E., Ram D., Petropoulos C.J., Schapiro J.M. Mutation D30N is not preferentially selected by human immunodeficiency virus type 1 subtype C in the development of resistance to nelfinavir. Antimicrob. Agents Chemother. 2004, 48:2159-2165.
18. Hall T.A. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl. Acids. Symp. Ser. 1999, 95-98.
19. Hoffman N.G., Schiffer C.A., Swanstrom R. Covariation of amino acid positions in HIV-1 protease. Virology 2003, 314:536-548.
20. Holguin A., Sune C., Hamy F., Soriano V., Klimkait T. Natural polymorphisms in the protease gene modulate the replicative capacity of non-B HIV-1 variants in the absence of drug pressure. J. Clin. Virol. 2006, 36:264-271.
21. Johnson V.A., Brun-Vezinet F., Clotet B., Gunthard H.F., Kuritzkes D.R., Pillay D., Schapiro J.M., Richman D.D. Update of the drug resistance mutations in HIV-1: Spring 2008. Top. HIV. Med. 2008, 16:62-68.
22. Kantor R., Katzenstein D.A., Efron B., Carvalho A.P., Wynhoven B., Cane P., Clarke J., Sirivichayakul S., Soares M.A., Snoeck J., Pillay C., Rudich H., Rodrigues R., Holguin A., Ariyoshi K., Bouzas M.B., Cahn P., Sugiura W., Soriano V., Brigido L.F., Grossman Z., Morris L., Vandamme A.M., Tanuri A., Phanuphak P., Weber J.N., Pillay D., Harrigan P.R., Camacho R., Schapiro J.M., Shafer R.W. Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration. PLoS Med. 2005, 2:e112.
23. Katzenstein D.A., Camacho R.J., Abecasis A.B., Vandamme A.-M., Shafer R.W. Authors Reply to: Role for geographical location and founder effects in describing HIV-1 subtype-specific polymorphisms. PLoS Med 2006, for the HIV-1 Non-Subtype B Working Group.
24. Lole K.S., Bollinger R.C., Paranjape R.S., Gadkari D., Kulkarni S.S., Novak N.G., Ingersoll R., Sheppard H.W., Ray S.C. Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J. Virol. 1999, 73:152-160.
25. Soares E.A., Santos A.F., Sousa T.M., Sprinz E., Martinez A.M., Silveira J., Tanuri A., Soares M.A. Differential drug resistance acquisition in HIV-1 of subtypes B and C. PLoS One 2007, 2:e730.
26. Sune C., Brennan L., Stover D.R., Klimkait T. Effect of polymorphisms on the replicative capacity of protease inhibitor-resistant HIV-1 variants under drug pressure. Clin. Microbiol. Infect. 2004, 10:119-126.
27. Svicher V., Sing T., Santoro M.M., Forbici F., Rodriguez-Barrios F., Bertoli A., Beerenwinkel N., Bellocchi M.C., Gago F., d'Arminio M.A., Antinori A., Lengauer T., Ceccherini-Silberstein F., Perno C.F. Involvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors. J. Virol. 2006, 80:7186-7198.