메뉴 건너뛰기




Volumn 40, Issue 4, 2010, Pages 1118-1126

The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils

Author keywords

Antimicrobial peptide; Host defense; Innate immunity; Neutrophil

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; LUMINOL; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

EID: 77951044334     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939275     Document Type: Article
Times cited : (122)

References (40)
  • 1
    • 45549110119 scopus 로고    scopus 로고
    • The role of neutrophils in the immune system: An overview
    • Malech, H. L., The role of neutrophils in the immune system: an overview. Methods Mol.Biol. 2007. 412: 3-11.
    • (2007) Methods Mol.Biol. , vol.412 , pp. 3-11
    • Malech, H.L.1
  • 2
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff, M., Antimicrobial peptides of multicellular organisms. Nature 2002. 415: 389-395.
    • (2002) Nature , vol.415 , pp. 389-395
    • Zasloff, M.1
  • 3
    • 2542480000 scopus 로고    scopus 로고
    • Multiple Roles of Antimicrobial Defensins, Cathelicidins, and Eosinophil-Derived Neurotoxin in Host Defense
    • Yang, D., Biragyn, A., Hoover, D. M., Lubkowski, J., and Oppenheim, J. J., Multiple Roles of Antimicrobial Defensins, Cathelicidins, and Eosinophil-Derived Neurotoxin in Host Defense. Annu Rev Immunol 2004. 22: 181-215.
    • (2004) Annu Rev Immunol , vol.22 , pp. 181-215
    • Yang, D.1    Biragyn, A.2    Hoover, D.M.3    Lubkowski, J.4    Oppenheim, J.J.5
  • 4
    • 22944458199 scopus 로고    scopus 로고
    • The role of cathelicidins in the innate host defenses of mammals
    • Zanetti, M., The role of cathelicidins in the innate host defenses of mammals. Curr. Issues Mol. Biol. 2005. 7: 179-196.
    • (2005) Curr. Issues Mol. Biol. , vol.7 , pp. 179-196
    • Zanetti, M.1
  • 5
    • 33744986714 scopus 로고    scopus 로고
    • The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection
    • Chromek, M., Slamova, Z., Bergman, P., Kovacs, L., Podracka, L., Ehren, I., Hokfelt, T. et al., The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat. Med. 2006. 12: 636-641.
    • (2006) Nat. Med. , vol.12 , pp. 636-641
    • Chromek, M.1    Slamova, Z.2    Bergman, P.3    Kovacs, L.4    Podracka, L.5    Ehren, I.6    Hokfelt, T.7
  • 8
    • 0037335205 scopus 로고    scopus 로고
    • The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium
    • DOI 10.1046/j.1523-1747.2003.12069.x
    • Heilborn, J. D., Nilsson, M. F., Kratz, G., Weber, G., Sorensen, O., Borregaard, N., and Stahle-Backdahl, M., The cathelicidin anti-microbial peptide LL-37 is involved in re- epithelialization of human skin wounds and is lacking in chronic ulcer epithelium. J Invest Dermatol. 2003. 120: 379-389. (Pubitemid 36298423)
    • (2003) Journal of Investigative Dermatology , vol.120 , Issue.3 , pp. 379-389
    • Heilborn, J.D.1    Frohm Nilsson, M.2    Kratz, G.3    Weber, G.4    Sorensen, O.5    Borregaard, N.6    Stahle-Backdahl, M.7
  • 9
    • 0034596945 scopus 로고    scopus 로고
    • LL-37, the neutrophil granule- And epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T-cells
    • Yang, D., Chen, Q., Schmidt, A. P., Anderson, G. M., Wang, J. M.,Wooters, J., Oppenheim, J. J., and Chertov, O., LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T-cells. J Exp Med 2000. 192: 1069-1074.
    • (2000) J Exp Med , vol.192 , pp. 1069-1074
    • Yang, D.1    Chen, Q.2    Schmidt, A.P.3    Anderson, G.M.4    Wang, J.M.5    Wooters, J.6    Oppenheim, J.J.7    Chertov, O.8
  • 10
    • 0346996865 scopus 로고    scopus 로고
    • The Antimicrobial Peptide LL-37 Activates Innate Immunity at the Airway Epithelial Surface by Transactivation of the Epidermal Growth Factor Receptor
    • Tjabringa, G. S., Aarbiou, J., Ninaber, D. K., Drijfhout, J. W., Sorensen, O. E., Borregaard, N., Rabe, K. F., and Hiemstra, P. S., The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor. J Immunol 2003. 171: 6690-6696. (Pubitemid 37532101)
    • (2003) Journal of Immunology , vol.171 , Issue.12 , pp. 6690-6696
    • Tjabringaf, G.S.1    Aarbiou, J.2    Ninaber, D.K.3    Drijfhout, J.W.4    Sorensen, O.E.5    Borregaard, N.6    Rabe, K.F.7    Hiemstra, P.S.8
  • 11
    • 1542564787 scopus 로고    scopus 로고
    • The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization
    • Davidson, D. J., Currie, A. J., Reid, G. S., Bowdish, D. M., MacDonald, K. L., Ma, R. C., Hancock, R. E., and Speert, D. P., The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization. J Immunol 2004. 172: 1146-1156.
    • (2004) J Immunol , vol.172 , pp. 1146-1156
    • Davidson, D.J.1    Currie, A.J.2    Reid, G.S.3    Bowdish, D.M.4    MacDonald, K.L.5    Ma, R.C.6    Hancock, R.E.7    Speert, D.P.8
  • 12
    • 33845364149 scopus 로고    scopus 로고
    • The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands
    • DOI 10.1093/intimm/dxl107
    • Kandler, K., Shaykhiev, R., Kleemann, P., Klescz, F., Lohoff, M., Vogelmeier, C., and Bals, R., The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands. Int. Immunol 2006. 18: 1729-1736. (Pubitemid 44884035)
    • (2006) International Immunology , vol.18 , Issue.12 , pp. 1729-1736
    • Kandler, K.1    Shaykhiev, R.2    Kleemann, P.3    Klescz, F.4    Lohoff, M.5    Vogelmeier, C.6    Bals, R.7
  • 13
    • 0036785559 scopus 로고    scopus 로고
    • The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses
    • Scott, M. G., Davidson, D. J., Gold, M. R., Bowdish, D., and Hancock, R. E., The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol 2002. 169: 3883-3891.
    • (2002) J Immunol , vol.169 , pp. 3883-3891
    • Scott, M.G.1    Davidson, D.J.2    Gold, M.R.3    Bowdish, D.4    Hancock, R.E.5
  • 15
    • 36148980891 scopus 로고    scopus 로고
    • Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils
    • Zheng, Y., Niyonsaba, F., Ushio, H., Nagaoka, I., Ikeda, S., Okumura, K., and Ogawa, H., Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils. Br. J. Dermatol. 2007. 157: 1124-1131.
    • (2007) Br. J. Dermatol. , vol.157 , pp. 1124-1131
    • Zheng, Y.1    Niyonsaba, F.2    Ushio, H.3    Nagaoka, I.4    Ikeda, S.5    Okumura, K.6    Ogawa, H.7
  • 17
    • 33644511380 scopus 로고    scopus 로고
    • 7
    • Nagaoka, I., Tamura, H., and Hirata, M., An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7. J. Immunol. 2006. 176: 3044-3052. (Pubitemid 43306966)
    • (2006) Journal of Immunology , vol.176 , Issue.5 , pp. 3044-3052
    • Nagaoka, I.1    Tamura, H.2    Hirata, M.3
  • 18
    • 50849112078 scopus 로고    scopus 로고
    • Neutrophil secondary necrosis is induced by LL-37 derived from cathelicidin
    • Zhang, Z., Cherryholmes, G., and Shively, J. E., Neutrophil secondary necrosis is induced by LL-37 derived from cathelicidin. J. Leukoc. Biol. 2008. 84: 780-788.
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 780-788
    • Zhang, Z.1    Cherryholmes, G.2    Shively, J.E.3
  • 19
    • 0141705297 scopus 로고    scopus 로고
    • Toll-like receptors stimulate human neutrophil function
    • DOI 10.1182/blood-2003-04-1078
    • Hayashi, F., Means, T. K., and Luster, A. D., Toll-like receptors stimulate human neutrophil function. Blood 2003. 102: 2660-2669. (Pubitemid 37193610)
    • (2003) Blood , vol.102 , Issue.7 , pp. 2660-2669
    • Hayashi, F.1    Means, T.K.2    Luster, A.D.3
  • 20
    • 62549156641 scopus 로고    scopus 로고
    • Fungal and bacterial killing by neutrophils
    • Ermert, D., Zychlinsky, A., and Urban, C., Fungal and bacterial killing by neutrophils. Methods Mol.Biol. 2009. 470: 293-312.
    • (2009) Methods Mol.Biol. , vol.470 , pp. 293-312
    • Ermert, D.1    Zychlinsky, A.2    Urban, C.3
  • 21
    • 14844346145 scopus 로고    scopus 로고
    • Burkholderia cenocepacia induces neutrophil necrosis in chronic granulomatous disease
    • Bylund, J., Campsall, P. A., Ma, R. C., Conway, B. A., and Speert, D. P., Burkholderia cenocepacia induces neutrophil necrosis in chronic granulomatous disease. J. Immunol. 2005. 174. 3562-3569. (Pubitemid 40354065)
    • (2005) Journal of Immunology , vol.174 , Issue.6 , pp. 3562-3569
    • Bylund, J.1    Campsall, P.A.2    Ma, R.C.3    Conway, B.-A.D.4    Speert, D.P.5
  • 22
    • 0031009432 scopus 로고    scopus 로고
    • Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse
    • Gallo, R. L., Kim, K. J., Bernfield, M., Kozak, C. A., Zanetti, M., Merluzzi, L., and Gennaro, R., Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. J. Biol. Chem. 1997. 272: 13088-13093.
    • (1997) J. Biol. Chem. , vol.272 , pp. 13088-13093
    • Gallo, R.L.1    Kim, K.J.2    Bernfield, M.3    Kozak, C.A.4    Zanetti, M.5    Merluzzi, L.6    Gennaro, R.7
  • 23
    • 0032708355 scopus 로고    scopus 로고
    • Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide
    • Bals, R., Weiner, D. J., Moscioni, A. D., Meegalla, R. L., and Wilson, J. M., Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide. Infect Immun 1999. 67: 6084-6089. (Pubitemid 29508140)
    • (1999) Infection and Immunity , vol.67 , Issue.11 , pp. 6084-6089
    • Bals, R.1    Weiner, D.J.2    Moscioni, A.D.3    Meegalla, R.L.4    Wilson, J.M.5
  • 25
    • 34548209277 scopus 로고    scopus 로고
    • Effects of the antimicrobial peptide LL-37 and hyperthermic preconditioning in septic rats
    • DOI 10.1097/01.anes.0000278906.86815.eb, PII 0000054220070900000014
    • Torossian, A., Gurschi, E., Bals, R., Vassiliou, T.,Wulf, H. F., and Bauhofer, A., Effects of the antimicrobial peptide LL-37 and hyperthermic preconditioning in septic rats. Anesthesiology 2007. 107: 437-441. (Pubitemid 47329542)
    • (2007) Anesthesiology , vol.107 , Issue.3 , pp. 437-441
    • Torossian, A.1    Gurschi, E.2    Bals, R.3    Vassiliou, T.4    Wulf, H.F.5    Bauhofer, A.6
  • 26
    • 0031925180 scopus 로고    scopus 로고
    • Protective effects of a human 18-kilodalton cationic antimicrobial protein (CAP18)-derived peptide against murine endotoxemia
    • Kirikae, T., Hirata, M., Yamasu, H., Kirikae, F., Tamura, H., Kayama, F., Nakatsuka, K. et al., Protective effects of a human 18-kilodalton cationic antimicrobial protein (CAP18)-derived peptide against murine endotoxemia. Infect Immun 1998. 66: 1861-1868.
    • (1998) Infect Immun , vol.66 , pp. 1861-1868
    • Kirikae, T.1    Hirata, M.2    Yamasu, H.3    Kirikae, F.4    Tamura, H.5    Kayama, F.6    Nakatsuka, K.7
  • 29
    • 70449363613 scopus 로고    scopus 로고
    • Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils
    • Zhang, Z., Cherryholmes, G., Chang, F., Rose, D. M., Schraufstatter, I., and Shively, J. E., Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils. Eur.J Immunol. 2009. 39: 3181-3194.
    • (2009) Eur.J Immunol. , vol.39 , pp. 3181-3194
    • Zhang, Z.1    Cherryholmes, G.2    Chang, F.3    Rose, D.M.4    Schraufstatter, I.5    Shively, J.E.6
  • 30
    • 23844523180 scopus 로고    scopus 로고
    • Antimicrobial peptides and endotoxin inhibit cytokine and nitric oxide release but amplify respiratory burst response in human and murine macrophages
    • Zughaier, S. M., Shafer, W. M., and Stephens, D. S., Antimicrobial peptides and endotoxin inhibit cytokine and nitric oxide release but amplify respiratory burst response in human and murine macrophages. Cell Microbiol. 2005. 7: 1251-1262.
    • (2005) Cell Microbiol. , vol.7 , pp. 1251-1262
    • Zughaier, S.M.1    Shafer, W.M.2    Stephens, D.S.3
  • 31
    • 0033396672 scopus 로고    scopus 로고
    • Respiratory burst in human neutrophils
    • Dahlgren, C. and Karlsson, A., Respiratory burst in human neutrophils. J.Immunol.Methods 1999. 232: 3-14.
    • (1999) J.Immunol.Methods , vol.232 , pp. 3-14
    • Dahlgren, C.1    Karlsson, A.2
  • 32
    • 0032482980 scopus 로고    scopus 로고
    • The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface
    • DOI 10.1073/pnas.95.16.9541
    • Bals, R., Wang, X., Zasloff, M., and Wilson, J. M., The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc Natl Acad Sci USA 1998. 95: 9541-9546. (Pubitemid 28506267)
    • (1998) Proceedings of the National Academy of Sciences of the United States of America , vol.95 , Issue.16 , pp. 9541-9546
    • Bals, R.1    Wang, X.2    Zasloff, M.3    Wilson, J.M.4
  • 33
    • 0034332193 scopus 로고    scopus 로고
    • The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations
    • Agerberth, B., Charo, J., Werr, J., Olsson, B., Idali, F., Lindbom, L., Kiessling, R. et al., The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 2000. 96: 3086-3093.
    • (2000) Blood , vol.96 , pp. 3086-3093
    • Agerberth, B.1    Charo, J.2    Werr, J.3    Olsson, B.4    Idali, F.5    Lindbom, L.6    Kiessling, R.7
  • 35
    • 33644978944 scopus 로고    scopus 로고
    • Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides: Peptide properties and plausible modes of action
    • DOI 10.1074/jbc.M504327200
    • Rosenfeld, Y., Papo, N., and Shai, Y., Endotoxin (Lipopolysaccharide) Neutralization by Innate Immunity Host-Defense Peptides: PEPTIDE PROPERTIES AND PLAUSIBLE MODES OF ACTION. J Biol.Chem. 2006. %20;281: 1636-1643. (Pubitemid 43752480)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.3 , pp. 1636-1643
    • Rosenfeld, Y.1    Papo, N.2    Shai, Y.3
  • 36
    • 1842581655 scopus 로고    scopus 로고
    • 7 Receptor Activator, the Human Cathelicidin-Derived Peptide LL37, Induces IL-1beta Processing and Release
    • Elssner, A., Duncan, M., Gavrilin, M., and Wewers, M. D., A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. J.Immunol. 2004. 172: 4987-4994. (Pubitemid 38456425)
    • (2004) Journal of Immunology , vol.172 , Issue.8 , pp. 4987-4994
    • Elssner, A.1    Duncan, M.2    Gavrilin, M.3    Wewers, M.D.4
  • 37
  • 38
    • 0029893253 scopus 로고    scopus 로고
    • The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes
    • Gudmundsson, G. H., Agerberth, B., Odeberg, J., Bergman, T., Olsson, B., and Salcedo, R., The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur J Biochem 1996. 238: 325-332. (Pubitemid 26188246)
    • (1996) European Journal of Biochemistry , vol.238 , Issue.2 , pp. 325-332
    • Gudmundsson, G.H.1    Agerberth, B.2    Odeberg, J.3    Bergman, T.4    Olsson, B.5    Salcedo, R.6
  • 39
    • 0035058454 scopus 로고    scopus 로고
    • Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells
    • Niyonsaba, F., Someya, A., Hirata, M., Ogawa, H., and Nagaoka, I., Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. Eur J Immunol 2001. 31: 1066-1075.
    • (2001) Eur J Immunol , Issue.31 , pp. 1066-1075
    • Niyonsaba, F.1    Someya, A.2    Hirata, M.3    Ogawa, H.4    Nagaoka, I.5
  • 40
    • 34547660319 scopus 로고    scopus 로고
    • Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
    • Yamasaki, K., Di, N. A., Bardan, A., Murakami, M., Ohtake, T., Coda, A., Dorschner, R. A. et al., Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat. Med. 2007. 13: 975-980.
    • (2007) Nat. Med. , vol.13 , pp. 975-980
    • Yamasaki, K.1    Di, N.A.2    Bardan, A.3    Murakami, M.4    Ohtake, T.5    Coda, A.6    Dorschner, R.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.