Estrogen prevents sustained COLO-205 human colon cancer cell growth by inducing apoptosis, decreasing c-myb protein, and decreasing transcription of the anti-apoptotic protein bcl-2

Tumor Biology

Volumn 31, Issue 1, 2010, Pages 16-22

  Wilkins, Heather R ^a   Doucet, Kristin ^a   Duke, Victoria ^a   Morra, Amber ^a   Johnson, Nicole ^a  

^a ASSUMPTION COLLEGE   (United States)

Author keywords

Apoptosis; Bcl 2; C myb; COLO 205; Estrogen

Indexed keywords

ACRIDINE ORANGE; ESTRADIOL; PROPIDIUM IODIDE; PROTEIN BCL 2; PROTEIN C MYB; RNA; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL LABELING; COLON CANCER; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG MECHANISM; GEL ELECTROPHORESIS; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTION TERMINATION;

EID: 77951025716     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-009-0003-2     Document Type: Article

References (45)

1. Jagani Z, Khosravi-Far R. Cancer stem cells and impaired apoptosis. Adv Exp Med Biol. 2008;615:331-344
2. Aggarwal BB, Ichikawa H. Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle. 2005;4:1201-1215
3. Lechner D, Kallay E, Cross HS. Phytoestrogens and colorectal cancer prevention. Vitam Horm. 2005;70:169-198
4. Liu X, Lazenby AJ, Siegal GP. Signal transduction cross-talk during colorectal tumorigenesis. Adv Anat Pathol. 2006;13:270-274
5. Jakowlew SB. Transforming growth factor-beta in cancer and metastasis. Cancer Metastasis Rev. 2006;25:435-457
6. Ramocki NM, Wilkins HR, Magness ST, Simmons JG, Scull BP, Lee GH, et al. Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits apcmin/+ tumors, and regulates sox9. Endocrinology. 2008;149: 261-267
7. Torelli G, Venturelli D, Colo A, Zanni C, Selleri L, Moretti L, et al. Expression of c-myb protooncogene and other cell cyclerelated genes in normal and neoplastic human colonic mucosa. Cancer Res. 1987;47:5266-5269
8. Greco C, Alvino S, Buglioni S, Assisi D, Lapenta R, Grassi A, et al. Activation of c-myc and c-myb proto-oncogenes is associated with decreased apoptosis in tumor colon progression. Anticancer Res. 2001;21:3185-3192
9. Funato T, Satou J, Kozawa K, Fujimaki S, Miura T, Kaku M. Use of c-myb antisense oligonucleotides to increase the sensitivity of human colon cancer cells to cisplatin. Oncol Rep. 2001;8:807-810
10. Frampton J, Ramqvist T, Graf T. V-myb of e26 leukemia virus upregulates bcl-2 and suppresses apoptosis in myeloid cells. Genes Dev. 1996;10:2720-2731
11. Taylor D, Badiani P, Weston K. A dominant interfering myb mutant causes apoptosis in t cells. Genes Dev. 1996;10:2732-2744
12. Gupta S, Kass GE, Szegezdi E, Joseph B The mitochondrial death pathway: A promising therapeutic target in diseases. J Cell Mol Med. 2009 (in press)
13. Kim R, Emi M, Tanabe K. Role of mitochondria as the gardens of cell death. Cancer Chemother Pharmacol. 2006;57:545-553 (Pubitemid 43237837)
14. Gonda TJ, Leo P, Ramsay RG. Estrogen and myb in breast cancer: potential for new therapies. Expert Opin Biol Ther. 2008;8:713-717
15. Drabsch Y, Hugo H, Zhang R, Dowhan DH, Miao YR, Gewirtz AM, et al. Mechanism of and requirement for estrogen-regulated myb expression in estrogen receptor-positive breast cancer cells. Proc Natl Acad Sci U S A. 2007;104:13762-13767
16. Gudas JM, Klein RC, Oka M, Cowan KH. Posttranscriptional regulation of the c-myb proto-oncogene in estrogen receptorpositive breast cancer cells. Clin Cancer Res. 1995;1:235-243
17. Humphries KH, Gill S. Risks and benefits of hormone replacement therapy: the evidence speaks. Cmaj. 2003;168:1001-1010
18. Lemay A. The relevance of the women's health initiative results on combined hormone replacement therapy in clinical practice. J Obstet Gynaecol Can. 2002;24:711-715
19. Grodstein F, Newcomb PA, Stampfer MJ. Postmenopausal hormone therapy and the risk of colorectal cancer: a review and meta-analysis. Am J Med. 1999;106:574-582 (Pubitemid 29231110)
20. Hsu HH, Cheng SF, Wu CC, Chu CH, Weng YJ, Lin CS, et al. Apoptotic effects of over-expressed estrogen receptor-beta on lovo colon cancer cell is mediated by p53 signalings in a liganddependent manner. Chin J Physiol. 2006;49:110-116
21. Qiu Y, Langman MJ, Eggo MC. Targets of 17beta-oestradiolinduced apoptosis in colon cancer cells: a mechanism for the protective effects of hormone replacement therapy? J Endocrinol. 2004;181:327-337
22. Qiu Y, Waters CE, Lewis AE, Langman MJ, Eggo MC. Oestrogen-induced apoptosis in colonocytes expressing oestrogen receptor beta. J Endocrinol. 2002;174:369-377
23. Motylewska E, Lawnicka H, Melen-Mucha G. Oestradiol and tamoxifen inhibit murine colon 38 cancer growth and increase the cytotoxic effect of fluorouracil. Endokrynol Pol. 2007;58:426-434
24. Thompson MA, Rosenthal MA, Ellis SL, Friend AJ, Zorbas MI, Whitehead RH, et al. C-myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased bcl-2 expression. Cancer Res. 1998;58:5168-5175
25. Wolff L, Schmidt M, Koller R, Haviernik P, Watson R, Bies J, et al. Three genes with different functions in transformation are regulated by c-myb in myeloid cells. Blood Cells Mol Dis. 2001;27:483-488
26. Blick M, Westin E, Gutterman J, Wong-Staal F, Gallo R, McCredie K, et al. Oncogene expression in human leukemia. Blood. 1984;64:1234-1239
27. Gonda TJ. The c-myb oncoprotein. Int J Biochem Cell Biol. 1998;30:547-551
28. Liang W. Age, sex and the risk of grade-specific second primary colorectal cancer: evidence for the protective effect of female hormone. Eur J Cancer. 2007;43:1856-1861
29. Yu Z, Li W, Liu F. Inhibition of proliferation and induction of apoptosis by genistein in colon cancer ht-29 cells. Cancer Lett. 2004;215:159-166
30. Couse JF, Lindzey J, Grandien K, Gustafsson JA, Korach KS. Tissue distribution and quantitative analysis of estrogen receptoralpha (eralpha) and estrogen receptor-beta (erbeta) messenger ribonucleic acid in the wild-type and eralpha-knockout mouse. Endocrinology. 1997;138:4613-4621
31. Kennelly R, Kavanagh DO, Hogan AM, Winter DC. Oestrogen and the colon: potential mechanisms for cancer prevention. Lancet Oncol. 2008;9:385-391
32. Kuiper GG, Shughrue PJ, Merchenthaler I, Gustafsson JA. The estrogen receptor beta subtype: a novel mediator of estrogen action in neuroendocrine systems. Front Neuroendocrinol. 1998;19:253-286
33. Ellem SJ, Risbridger GP. The dual, opposing roles of estrogen in the prostate. Ann N Y Acad Sci. 2009;1155:174-186
34. Thornton MJ. The biological actions of estrogens on skin. Exp Dermatol. 2002;11:487-502.
35. Dechering K, Boersma C, Mosselman S. Estrogen receptors alpha and beta: two receptors of a kind? Curr Med Chem. 2000;7:561-576
36. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci U S A. 1996;93:5925-5930
37. Tremblay GB, Tremblay A, Copeland NG, Gilbert DJ, Jenkins NA, Labrie F, et al. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol Endocrinol. 1997;11:353-365
38. Mosselman S, Polman J, Dijkema R. Er beta: Identification and characterization of a novel human estrogen receptor. FEBS Lett. 1996;392:49-53.
39. Girdler F, Brotherick I. The oestrogen receptors (er alpha and er beta) and their role in breast cancer: a review. Breast. 2000;9:194-200.
40. Strobl JS,Wonderlin WF, Flynn DC. Mitogenic signal transduction in human breast cancer cells. Gen Pharmacol. 1995;26:1643-1649
41. Verdier-Sevrain S, Yaar M, Cantatore J, Traish A, Gilchrest BA. Estradiol induces proliferation of keratinocytes via a receptormediated mechanism. Faseb J. 2004;18:1252-1254
42. Qi X, Borowicz S, Pramanik R, Schultz RM, Han J, Chen G. Estrogen receptor inhibits c-jun-dependent stress-induced cell death by binding and modifying c-jun activity in human breast cancer cells. J Biol Chem. 2004;279:6769-6777
43. Ramsay RG, Gonda TJ. Myb function in normal and cancer cells. Nat Rev Cancer. 2008;8:523-534
44. Thompson MA, Flegg R, Westin EH, Ramsay RG. Microsatellite deletions in the c-myb transcriptional attenuator region associated with over-expression in colon tumour cell lines. Oncogene. 1997;14:1715-1723
45. Jakacka M, Ito M, Weiss J, Chien PY, Gehm BD, Jameson JL. Estrogen receptor binding to DNA is not required for its activity through the nonclassical ap1 pathway. J Biol Chem. 2001;276: 13615-13621 (Pubitemid 33657375)