Nonlinear optical microscopy and computational analysis of intrinsic signatures in breast cancer

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Volumn , Issue , 2009, Pages 4077-4080

  Rueden, Curtis T ^a   Conklin, Matthew W ^a   Provenzano, Paolo P ^a   Keely, Patricia J ^a   Eliceiri, Kevin W ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APPLICATION PROGRAMS; DATA VISUALIZATION; DISEASES; FLUORESCENCE; HARMONIC GENERATION; MEDICAL IMAGING; VISUALIZATION;

COMPUTATIONAL ANALYSIS; EXTRACELLULAR MATRICES; FLUORESCENCE LIFETIMES; INTERACTIVE VISUALIZATIONS; INTRINSIC FLUORESCENCE; MULTIPHOTON LASER SCANNING MICROSCOPY; NON-LINEAR OPTICAL METHODS; NONLINEAR OPTICAL MICROSCOPY;

NONLINEAR OPTICS;

EID: 77950973394     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2009.5334523     Document Type: Conference Paper

References (31)

1. Olumi, A.F., G.D. Grossfeld, S.W. Hayward, P.R. Carroll, T.D. Tlsty, and G.R. Cunha, Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res, 1999. 59(19): p. 5002-5011
2. Orimo, A., P.B. Gupta, D.C. Sgroi, F. Arenzana-Seisdedos, T. Delaunay, R. Naeem, V.J. Carey, A.L. Richardson, and R.A. Weinberg, Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell, 2005. 121(3): p. 335-348
3. Kuperwasser, C., T. Chavarria, M. Wu, G. Magrane, J.W. Gray, L. Carey, A. Richardson, and R.A. Weinberg, Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A, 2004. 101(14): p. 4966-4971
4. Boyd, N.F., L.J. Martin, J. Stone, C. Greenberg, S. Minkin, and M.J. Yaffe, Mammographic densities as a marker of human breast cancer risk and their use in chemoprevention. Curr Oncol Rep, 2001. 3(4): p. 314-321
5. Bardeesy, N. and R.A. DePinho, Pancreatic cancer biology and genetics. Nat Rev Cancer, 2002. 2(12): p. 897-909.
6. Kauppila, S., F. Stenback, J. Risteli, A. Jukkola, and L. Risteli, Aberrant type I and type III collagen gene expression in human breast cancer in vivo. J Pathol, 1998. 186(3): p. 262-268
7. Rowley, D.R., What might a stromal response mean to prostate cancer progression? Cancer Metastasis Rev, 1998. 17(4): p. 411-419
8. Wozniak, M.A., R. Desai, P.A. Solski, C.J. Der, and P.J. Keely, ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a threedimensional collagen matrix. J Cell Biol, 2003. 163(3): p. 583-595
9. Wolf, K., I. Mazo, H. Leung, K. Engelke, U.H. von Andrian, E.I. Deryugina, A.Y. Strongin, E.-B. Brocker, and P. Friedl, Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J. Cell Biol., 2003. 160(2): p. 267-277.
10. Provenzano, P.P., K.W. Eliceiri, J.M. Campbell, D.R. Inman, J.G. White, and P.J. Keely, Collagen reorganization at the tumorstromal interface facilitates local invasion. BMC Med, 2006. 4: p. 38.
11. Sahai, E., J. Wyckoff, U. Philippar, J. Segall, F. Gertler, and J. Condeelis, Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy. BMC Biotechnology, 2005. 5(1): p. 14.
12. Ahmed, F., J. Wyckoff, E.Y. Lin, W. Wang, Y. Wang, L. Hennighausen, J. Miyazaki, J. Jones, J.W. Pollard, J.S. Condeelis, and J.E. Segall, GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice. Cancer Res, 2002. 62(24): p. 7166-7169
13. Friedl, P. and E.B. Brocker, The biology of cell locomotion within three-dimensional extracellular matrix. Cell Mol Life Sci, 2000. 57(1): p. 41-64.
14. Chambers, A.F. and L.M. Matrisian, Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst, 1997. 89(17): p. 1260-1270
15. Squirrell, J.M., D.L. Wokosin, J.G. White, and B.D. Bavister, Longterm two-photon fluorescence imaging of mammalian embryos without compromising viability. Nature Biotechnology, 1999. 17(8): p. 763-767
16. Denk, W., J.H. Strickler, and W.W. Webb, Two-photon laser scanning fluorescence microscopy. Science, 1990. 248(4951): p. 73-76
17. Lakowicz, J.R., Principals of Fluorescence Spectroscopy. 1999, New York: Academic Press.
18. Eliceiri, K.W., C.H. Fan, G.E. Lyons, and J.G. White, Analysis of histology specimens using lifetime multiphoton microscopy. J Biomed Opt, 2003. 8(3): p. 376-380
19. Dong, C.Y., T. French, P.T. So, C. Buehler, K.M. Berland, and E. Gratton, Fluorescence-lifetime imaging techniques for microscopy. Methods Cell Biol, 2003. 72: p. 431-464
20. Ulrich, V., P. Fischer, I. Riemann, and K. Konigt, Compact multiphoton/single photon laser scanning microscope for spectral imaging and fluorescence lifetime imaging. Scanning, 2004. 26(5): p. 217-225
21. Thaler, C., S.V. Koushik, P.S. Blank, and S.S. Vogel, Quantitative multiphoton spectral imaging and its use for measuring resonance energy transfer. Biophys J, 2005. 89(4): p. 2736-2749
22. Campagnola, P.J., M.D. Wei, A. Lewis, and L.M. Loew, High-resolution nonlinear optical imaging of live cells by second harmonic generation. Biophys J, 1999. 77(6): p. 3341-3349
23. Provenzano, P.P., K.W. Eliceiri, and P.J. Keely, Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment. Clin Exp Metastasis, 2009. 26(4): p. 357-370
24. Provenzano, P.P., K.W. Eliceiri, L. Yan, A. Ada-Nguema, M.W. Conklin, D.R. Inman, and P.J. Keely, Nonlinear optical imaging of cellular processes in breast cancer. Microsc Microanal, 2008. 14(6): p. 532-548
25. Chance, B., B. Schoener, R. Oshino, F. Itshak, and Y. Nakase, Oxidation-reduction ratio studies of mitochondria in freeze-trapped samples. NADH and flavoprotein fluorescence signals. J Biol Chem, 1979. 254(11): p. 4764-4771
26. Gulledge, C.J. and M.W. Dewhirst, Tumor oxygenation: a matter of supply and demand. Anticancer Res, 1996. 16(2): p. 741-749
27. Bird, D.K., L. Yan, K.M. Vrotsos, K.W. Eliceiri, E.M. Vaughan, P.J. Keely, J.G. White, and N. Ramanujam, Metabolic mapping of MCF10A human breast cells via multiphoton fluorescence lifetime imaging of the coenzyme NADH. Cancer Res, 2005. 65(19): p. 8766-8773
28. Conklin, M.W., P.P. Provenzano, K.W. Eliceiri, R. Sullivan, and P.J. Keely, Fluorescence lifetime imaging of endogenous fluorophores in histopathology sections reveals differences between normal and tumor epithelium in carcinoma in situ of the breast. Cell Biochem Biophys, 2009. 53(3): p. 145-157
29. Wokosin, D.L., J.M. Squirrell, K.W. Eliceiri, and J.G. White, An optical workstation with concurrent, independent multiphoton imaging and experimental laser microbeam capabilities. Rev Sci Instrum, 2003. 74(1).
30. Bird, D.K., K.W. Eliceiri, C.H. Fan, and J.G. White, Simultaneous two-photon spectral and lifetime fluorescence microscopy. Appl Opt, 2004. 43(27): p. 5173-5182
31. Provenzano, P.P., C.T. Rueden, S.M. Trier, L. Yan, S.M. Ponik, D.R. Inman, P.J. Keely, and K.W. Eliceiri, Nonlinear optical imaging and spectral-lifetime computational analysis of endogenous and exogenous fluorophores in breast cancer. J Biomed Opt, 2008. 13(3): p. 031220.