Stem cell therapies for ocular surface disease

Drug Discovery Today

Volumn 15, Issue 7-8, 2010, Pages 306-313

  Ahmad, Sajjad ^a   Kolli, Sai ^b   Lako, Majlinda ^a   Figueiredo, Francisco ^a   Daniels, Julie T ^c  

^a North East England Stem Cell Institute ^*  (United Kingdom)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CORNEA; CORNEA EPITHELIUM; EMBRYONIC STEM CELL; EYE DISEASE; HUMAN; LIMBAL STEM CELL TRANSPLANTATION; PLURIPOTENT STEM CELL; REVIEW; STEM CELL TRANSPLANTATION; VISION; VISUAL IMPAIRMENT;

ANIMALS; CELLS, CULTURED; CORNEA; CORNEAL DISEASES; EMBRYONIC STEM CELLS; EPITHELIAL CELLS; EPITHELIUM, CORNEAL; HUMANS; PLURIPOTENT STEM CELLS; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME;

EID: 77950949984     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2010.02.001     Document Type: Review

References (64)

1. Fuchs E., et al. Socializing with the neighbours: stem cells and their niche. Cell 2004, 116:769-778.
2. Davanger M., Evenson A. Role of the pericorneal structure in renewal of corneal epithelium. Nature 1971, 229:560-561.
3. Schermer A., et al. Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. J. Cell Biol. 1986, 103:49-62.
4. Cotsarelis G., et al. Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell 1989, 57:201-209.
5. Lavker R.M., et al. Relative proliferative rates of limbal and corneal epithelia. Implications of corneal epithelial migration, circadian rhythm, and suprabasally located DNA-synthesising keratinocytes. Invest. Ophthalmol. Vis. Sci. 1991, 32:1864-1875.
6. Chen J.J., Tseng S.C. Abnormal corneal epithelial wound healing in partial-thickness removal of limbal epithelium. Invest. Ophthalmol. Vis. Sci. 1991, 32:2219-2233.
7. Kenyon K.R., Tseng S.C. Limbal autograft transplantation for ocular surface disorders. Ophthalmology 1989, 96:709-722.
8. Majo F., et al. Oligopotent stem cells are distributed throughout the entire mammalian ocular surface. Nature 2008, 456:250-254.
9. Bickenbach J.R. Identification and behaviour of label-retaining cells in oral mucosa and skin. J. Dent. Res. 1981, 60:1611-1620.
10. Romano A.C., et al. Different cell sizes in human limbal and central corneal basal epithelia measured by confocal microscopy and flow cytometry. Invest. Ophthalmol. Vis. Sci. 2003, 44:5125-5129.
11. Barrandon Y., Green H. Three clonal types of keratinocyte with different capacities for multiplication. Proc. Natl. Acad. Sci. U. S. A. 1987, 84:2302-2306.
12. Schlotzer-Schrehardt U., Kruse F.E. Identification and characterisation of limbal stem cells. Exp. Eye Res. 2005, 81:247-264.
13. Arpitha P., et al. High expression of p63 combined with a large N/C ratio defines a subset of human limbal epithelial cells: implications on epithelial stem cells. Invest. Ophthalmol. Vis. Sci. 2005, 46:3631-3636.
14. Di Iorio E., et al. Isoforms of DeltaNp63 and the migration of ocular limbal cells in human corneal regeneration. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:9523-9528.
15. Barbaro V., et al. C/EBP delta regulates cell cycle and self-renewal of human limbal stem cells. J. Cell Biol. 2007, 177:1037-1049.
16. Watanabe K., et al. Human limbal epithelium contains side population cells expressing the ATP-binding cassette transporter ABCG2. FEBS Lett. 2004, 565:6-10.
17. Chen Z., et al. Characterisation of putative stem cell phenotype in human limbal epithelia. Stem Cells 2004, 22:355-366.
18. Wolosin J.M., et al. Changes in connexin 43 in early ocular surface development. Curr. Eye Res. 2002, 24:430-438.
19. Dong Y., et al. Differential expression of two gap junctions proteins in corneal epithelium. Eur. J. Cell Biol. 1994, 64:95-100.
20. Schofield R. The stem cell system. Biomed. Pharmacother. 1983, 37:375-380.
21. Watt F.M., Hogan B.L. Out of Eden: stem cells and their niches. Science 2000, 287:1427-1430.
22. Davies S.B., et al. Stem cell activity in the developing human cornea. Stem Cells 2009, 27:2781-2792.
23. Shortt A.J., et al. Characterization of the limbal epithelial stem cell niche: novel imaging techniques permit in vivo observation and targeted biopsy of limbal epithelial stem cells. Stem Cells 2007, 25:1402-1409.
24. Gipson I.K. The epithelial basement membrane zone of the limbus. Eye 1989, 3:132-140.
25. Kolega J., et al. Basement membrane heterogeneity and variation in corneal epithelial differentiation. Differentiation 1989, 42:54-63.
26. Ljubimov A.V., et al. Human corneal basement membrane heterogeneity: topographical differences in the expression of type IV collagen and laminin isoforms. Lab. Invest. 1995, 72:461-473.
27. Ahmad S., et al. Differentiation of human embryonic stem cells into corneal epithelial like cells by in vitro replication of the corneal epithelial stem cell niche. Stem Cells 2007, 25:1145-1155.
28. Sotozono C., et al. Paracrine role of keratinocyte growth factor in rabbit corneal epithelial cell growth. Exp. Eye Res. 1994, 59:385-391.
29. Wilson S.E., et al. Effect of epidermal growth factor, hepatocyte growth factor, keratinocyte growth factor on the motility and differentiation of human corneal epithelial cells. Exp. Eye Res. 1994, 59:665-678.
30. Dua H.S., et al. Limbal stem cell deficiency: concept, aetiology, clinical presentation, diagnosis and management. Indian J. Ophthalmol. 2000, 48:83-92.
31. Vemuganti G.K., et al. Limbal stem cells: application in ocular biomedicine. Int. Rev. Cell Mol. Biol. 2009, 275:133-181.
32. Hau S., Barton K. Corneal complications of glaucoma surgery. Curr. Opin. Ophthalmol. 2009, 20:131-136.
33. Ramaesh, T. et al. Mechanisms underlying corneal epithelial dysgenesis in the Pax6+/- mouse model of aniridia. Exp. Eye Res. (in press).
34. Ramaesh K., et al. Evolving concepts on the pathogenic mechanisms of aniridia related keratopathy. Int. J. Biochem. Cell Biol. 2005, 37:547-557.
35. Mackman G., et al. Corneal changes in aniridia. Am. J. Ophthalmol. 1979, 87:497-502.
36. Nishida K., et al. Ocular surface abnormalities in aniridia. Am. J. Ophthalmol. 1995, 120:368-375.
37. Li W., et al. Down-regulation of Pax6 is associated with abnormal differentiation of corneal epithelial surface diseases. J. Pathol. 2008, 214:114-122.
38. Jenkins C., et al. Limbal transplantation in the management of chronic contact lens-associated epitheliopathy. Eye 1993, 7:629-633.
39. Tseng S.C., et al. Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency. Arch. Ophthalmol. 1998, 116:431-441.
40. Coster D.J., et al. Surgical management of ocular surface disorders using conjunctival and stem cell allografts. Br. J. Ophthalmol. 1995, 79:977-982.
41. Pellegrini G., et al. Long-term restoration of damaged corneal surfaces with autologous cultivated human epithelium. Lancet 1997, 349:990-993.
42. Shortt A.J., et al. Transplantation of ex-vivo cultured limbal epithelial stem cells - a review of current techniques and clinical results. Surv. Ophthalmol. 2007, 52:483-502.
43. Tsai R.J-F., et al. Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells. N. Engl. J. Med. 2000, 343:86-93.
44. Osei-Bempong C., et al. Culture conditions for primary human limbal epithelial cells. Regen. Med. 2009, 4:461-470.
45. Kolli, S. et al. Successful clinical implementation of corneal epithelial stem cell therapy for treatment of unilateral limbal stem cell deficiency. Stem Cells [Epub ahead of print].
46. Shortt A.J., et al. Ex vivo expansion and transplantation of limbal epithelial stem cells. Ophthalmology 2008, 115:1989-1997.
47. Schwab I.R. Cultured corneal epithelia for ocular surface disease. Trans. Am. Ophthalmol. Soc. 1999, 97:891-986.
48. Sangwan V.S., et al. Successful reconstruction of damaged ocular outer surface in humans using limbal and conjunctival stem cell cultures methods. Biosci. Rep. 2003, 23:169-174.
49. Daya S.M., et al. Outcomes and DNA analysis of ex vivo expanded stem cell allograft for ocular surface reconstruction. Ophthalmology 2005, 112:470-477.
50. Nakamura M., et al. Transplantation of autologous serum-derived cultivated corneal epithelial equivalents for the treatment of severe ocular surface disease. Ophthalmology 2006, 113:1765-1772.
51. Notara M., et al. A xenobiotic-free culture system for human limbal epithelial stem cells. Regen. Med. 2007, 2:919-927.
52. Kolli S., et al. Loss of corneal epithelial stem cell properties in outgrowths from human limbal explants cultured on intact amniotic membrane. Regen. Med. 2008, 3:329-342.
53. Grueterich M., et al. Connexin 43 expression and proliferation of human limbal epithelium on intact and denuded amniotic membrane. Invest. Ophthalmol. Vis. Sci. 2002, 43:63-71.
54. Shortt A.J., et al. The method of amniotic membrane processing affects its ability to serve as an ex-vivo niche for corneal limbal epithelial stem cells. Biomaterials 2008, 30:1056-1065.
55. Nishida K., et al. Functional bioengineered corneal epithelial sheet grafts from corneal stem cells expanded ex vivo on a temperature-responsive cell culture surface. Transplantation 2004, 77:379-385.
56. Di Girolamo N., et al. A contact lens-based technique for expansion and transplantation of autologous epithelial progenitors for ocular surface reconstruction. Transplantation 2009, 87:1571-1578.
57. Nakamura T., et al. The successful culture and autologous transplantation of rabbit oral mucosal epithelial cells on amniotic membrane. Invest. Ophthalmol. Vis. Sci. 2003, 44:106-116.
58. Inatomi T., et al. Midterm results on ocular surface reconstruction using cultivated autologous oral mucosal epithelial transplantation. Am. J. Ophthalmol. 2006, 141:267-275.
59. Homma R., et al. Induction of epithelial progenitors in vitro from mouse embryonic stem cells and application for reconstruction of damaged cornea in mice. Invest. Ophthalmol. Vis. Sci. 2004, 45:4320-4326.
60. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
61. Takahashi K., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
62. Park I.H., et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008, 451:141-146.
63. Yu J., et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007, 318:1917-1920.
64. Schwab I.R., et al. Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease. Cornea 2000, 19(4):421-426.