Judging a plethora of p-Values: How to contend with the problem of multiple testing part 10 of a series on evaluation of scientific publications;Übersichtsarbeit Wie bewertet man die p-Wert-Flut?: Hinweise zum umgang mit dem multiplen testen teil 10 der serie zur bewertung wissenschaftlicher publikationen

Deutsches Arzteblatt

Volumn 107, Issue 4, 2010, Pages 50-56

  Victor, Anja ^a   Elsäßer, Amelie ^a   Hommel, Gerhard ^a   Blettner, Maria ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MEDICAL RESEARCH; NULL HYPOTHESIS; PUBLICATION; REVIEW; STATISTICAL SIGNIFICANCE;

CLINICAL TRIALS AS TOPIC; CONFIDENCE INTERVALS; DATA INTERPRETATION, STATISTICAL; ENDPOINT DETERMINATION; EVIDENCE-BASED MEDICINE; PERIODICALS AS TOPIC;

EID: 77950942207     PISSN: 00121207     EISSN: None     Source Type: Journal    
DOI: 10.3238/arztebl.2010.0050     Document Type: Review

References (13)

1. Sladek R, Rocheleau G, Rung J, et al.: A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007; 454: 881-5. (Pubitemid 46309843)
2. Samani NJ, Erdmann J, Hall AS, et al.: Genome-wide association analysis of coronary artery disease. NEJM 2007; 357: 443-53. (Pubitemid 47204873)
3. The Wellcome Trust Case Control Consortium: A genome-wide association study of 14 000 cases of seven common diseases and 3000 shared controls. Nature 2007; 447: 661-78.
4. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG: Replication validity of genetic association studies. Nature Genetics 2001; 29: 306-9. (Pubitemid 33096456)
5. Lohmüller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN: Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nature Genetics 2003; 33: 177-82. (Pubitemid 36177070)
6. Horn M, Vollandt R: Multiple Tests und Auswahlverfahren. Stuttgart 1995: Gustav Fischer Verlag.
7. Simes RJ: An improved Bonferroni procedure for multiple tests of significance. Biometrika 1986; 73: 751-4.
8. Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistic Society 1995; 57: 298-300.
9. EMEA: Points to consider on multiplicity issues in clinical trials, www.emea.europa.eu/pdfs/human/ewp/090899en.pdf
10. Prel JB du, Röhrig B, Blettner M: Kritisches Lesen wissenschaftlicher Artikel: Teil 1 der Serie zur Bewertung wissenschaftlicher Publikationen. Dtsch Arztebl Int 2009; 106(7): 100-5.
11. Cardon LR, Bell JI: Association study designs for complex diseases. Nature Reviews Genetics 2001; 2: 91-9. (Pubitemid 33674000)
12. Risch N: Searching for genetic determinants in the new millenium. Nature 2000; 405: 847-56. (Pubitemid 30407863)
13. Traunecker KB: Assoziation der genetischen Polymorphismen am Beispiel von SULT1A1 und COMT mit Brustkrebs. Promotionsschrift am Fachbereich Medizin der Universitätsmedizin der Johannes- Gutenberg Universität Mainz.