Clinical significance of dihydropyrimidine dehydrogenase and thymidylate synthase expression in patients with pancreatic cancer

International Journal of Clinical Oncology

Volumn 15, Issue 1, 2010, Pages 39-45

  Nakahara, Osamu ^a   Takamori, Hiroshi ^a   Tanaka, Hiroshi ^a   Sakamoto, Yasuo ^a   Ikuta, Yoshiaki ^a   Furuhashi, Satoshi ^a   Watanabe, Masayuki ^a   Beppu, Toru ^a   Hirota, Masahiko ^a   Kanemitsu, Keiichiro ^a   Baba, Hideo ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Dihydropyrimidine dehydrogenase; Pancreatic cancer; Thymidylate synthase

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; THYMIDYLATE SYNTHASE;

ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER SURGERY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; PANCREAS CARCINOMA; PANCREAS RESECTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

AGED; DIHYDROURACIL DEHYDROGENASE (NADP); FEMALE; HUMANS; MALE; MIDDLE AGED; PANCREAS; PANCREATIC NEOPLASMS; PROGNOSIS; THYMIDYLATE SYNTHASE;

EID: 77950916102     PISSN: 13419625     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10147-009-0008-2     Document Type: Article

References (32)

1. DT Silverman M Schiffman J Everhart A Goldstein KD Lillemoe GM Swanson, et al. 1999 Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer Br J Cancer 80 1830 1837 10.1038/sj.bjc.6690607 1:STN:280:DyaK1Mzps1ersA%3D%3D 10468306 (Pubitemid 29389642)
2. AC Lockhart ML Rothenberg JD Berlin 2005 Treatment for pancreatic cancer: current therapy and continued progress Gastroenterology 128 1642 1654 10.1053/j.gastro.2005.03.039 1:CAS:528:DC%2BD2MXltlOgtb0%3D 15887156 (Pubitemid 40692557)
3. Ries L, Harkins D, Krapcho M, Mariotto A, Miller BA, Feuer EJ, Clegg L, Eisner MP, Horner MJ, Howlader N, Hayat M, Hankey BF, Edwards BK (eds) (2006) SEER cancer statistics review, 1975-2003. National Cancer Institute, Bethesda (based on November 2005 SEER data submission, posted to the SEER website; cited 21 Nov 2007)
4. SF Sener A Fremgen HR Menck DP Winchester 1999 Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database J Am Coll Surg 189 1 7 10.1016/S1072-7515(99)00075-7 1:STN:280:DyaK1MzivVWlsg%3D%3D 10401733 (Pubitemid 29307735)
5. C Sperti C Pasquali A Piccoli S Pedrazzoli 1997 Recurrence after resection for ductal adenocarcinoma of the pancreas World J Surg 21 195 200 10.1007/s002689900215 1:STN:280:DyaK2s7lt1ensA%3D%3D 8995078 (Pubitemid 27053441)
6. JF Griffin SR Smalley W Jewell JC Paradelo RD Reymond RE Hassanein, et al. 1990 Patterns of failure after curative resection of pancreatic carcinoma Cancer 66 56 61 10.1002/1097-0142(19900701)66:1<56::AID-CNCR2820660112>3. 0.CO;2-6 1:STN:280:DyaK3c3otlyhtg%3D%3D 2354408 (Pubitemid 20197085)
7. J Westerdahl A Andren-Sandberg I Ihse 1993 Recurrence of exocrine pancreatic cancer-local or hepatic? Hepatogastroenterology 40 384 387 1:STN:280:DyaK2c%2FhtVKrsQ%3D%3D 8406311 (Pubitemid 23258561)
8. A Beck MC Etienne S Cheradame JL Fischel P Formento N Renee, et al. 1994 A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil Eur J Cancer 30A 1517 1522 10.1016/0959-8049(94) 00216-R 1:CAS:528:DyaK2MXit1Wls7o%3D 7833111 (Pubitemid 24343014)
9. D Ota M Kusama H Kaise S Nakayama T Misaka A Tsuchida, et al. 2004 Evaluation of sensitivity to 5-FU on the basis of thymidylate synthase (TS)/dihydropyrimidine dehydrogenase (DPD) activity and chromosomal analysis in micro tissue specimens of breast cancer Breast Cancer (Tokyo, Japan) 11 356 366
10. W Ichikawa T Takahashi K Suto T Yamashita Z Nihei Y Shirota, et al. 2004 Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer Br J Cancer 91 1245 1250 10.1038/sj.bjc.6602139 1:CAS:528:DC%2BD2cXnvFCgtbs%3D 15354215 (Pubitemid 39424782)
11. D Vallbohmer DY Yang H Kuramochi D Shimizu KD Danenberg J Lindebjerg, et al. 2007 DPD is a molecular determinant of capecitabine efficacy in colorectal cancer Int J Oncol 31 413 418 17611699
12. H Kobayashi T Koike A Nakatsuka H Kurita J Sagara S Taniguchi, et al. 2005 Dihydropyrimidine dehydrogenase expression predicts survival outcome and chemosensitivity to 5-fluorouracil in patients with oral squamous cell carcinoma Oral Oncol 41 38 47 10.1016/j.oraloncology.2004.06.003 1:CAS:528: DC%2BD2cXhtVKrtb7N 15598584 (Pubitemid 39647118)
13. T Tsuji T Sawai H Takeshita T Nakagoe S Hidaka H Yamaguchi, et al. 2004 Tumor dihydropyrimidine dehydrogenase expression is a useful marker in adjuvant therapy with oral fluoropyrimidines after curative resection of colorectal cancer Cancer Chemother Pharmacol 54 531 536 10.1007/s00280-004-0802-5 1:CAS:528:DC%2BD2cXpt1WqsLk%3D 15309506 (Pubitemid 40022249)
14. Japan Pancreas Society (2003) Classification of pancreatic cancer, 2nd English edn. Kanehara & Co. Ltd., Tokyo, pp 4-12
15. CP Spears AH Shahinian RG Moran C Heidelberger TH Corbett 1982 In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas Cancer Res 42 450 456 1:CAS:528:DyaL38XhtlGntrs%3D 6173112
16. FN Naguib MH el Kouni S Cha 1985 Enzymes of uracil catabolism in normal and neoplastic human tissues Cancer Res 45 5405 5412 1:CAS:528:DyaL28XktFSg 3931905 (Pubitemid 16200794)
17. T Takechi A Fujioka E Matsushima M Fukushima 2002 Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2, 4-dihydroxypyridine (CDHP) in human tumour cells Eur J Cancer 38 1271 1277 10.1016/S0959-8049(02)00048-5 1:CAS:528:DC%2BD38XktVeitLY%3D 12044515 (Pubitemid 34603489)
18. JG Maring HJ Groen FM Wachters DR Uges EG de Vries 2005 Genetic factors influencing pyrimidine-antagonist chemotherapy Pharmacogenomics J 5 226 243 10.1038/sj.tpj.6500320 1:CAS:528:DC%2BD2MXmsVyjs7g%3D 16041392 (Pubitemid 41131715)
19. H Kuramochi K Hayashi K Uchida G Nakajima T Hatori KD Danenberg, et al. 2008 High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1 Cancer Chemother Pharmacol 63 85 89 10.1007/s00280-008-0714-x 1:CAS:528:DC%2BD1cXhtF2kur%2FE 18309485
20. S Kamoshida K Shiogama R Shimomura K Inada Y Sakurai M Ochiai, et al. 2005 Immunohistochemical demonstration of fluoropyrimidine-metabolizing enzymes in various types of cancer Oncol Rep 14 5 1223 1230 1:CAS:528:DC%2BD2MXhtF2mtrrK 16211289
21. M Fukushima M Morita K Ikeda S Nagayama 2003 Population study of expression of thymidylate synthase and dihydropyrimidine dehydrogenase in patients with solid tumors Int J Mol Med 12 839 844 1:CAS:528: DC%2BD3sXpvFansLs%3D 14612954
22. H Takamori K Kanemitsu T Tsuji H Tanaka A Chikamoto O Nakahara, et al. 2005 5-fluorouracil intra-arterial infusion combined with systemic gemcitabine for unresectable pancreatic cancer Pancreas 30 223 226 10.1097/01.mpa. 0000158025.46172.ae 1:CAS:528:DC%2BD2MXjsVyit70%3D 15782098 (Pubitemid 40397372)
23. T Shimizu Y Yamada H Yasui K Shirao M Fukuoka 2005 Clinical application of immunoreactivity of dihydropyrimidine dehydrogenase (DPD) in gastric scirrhous carcinoma treated with S-1, a new DPD inhibitory fluoropyrimidine Anticancer Res 25 2997 3001 1:CAS:528:DC%2BD2MXpt1WrtLw%3D 16080558 (Pubitemid 41044693)
24. Y Mizutani H Wada M Fukushima O Yoshida O Ukimura A Kawauchi, et al. 2001 The significance of dihydropyrimidine dehydrogenase (DPD) activity in bladder cancer Eur J Cancer 37 569 575 10.1016/S0959-8049(00)00440-8 1:CAS:528:DC%2BD3MXisVSqtrc%3D 11290431 (Pubitemid 32261013)
25. K Miyake S Imura T Yoshizumi T Ikemoto Y Morine M Shimada 2007 Role of thymidine phosphorylase and orotate phosphoribosyltransferase mRNA expression and its ratio to dihydropyrimidine dehydrogenase in the prognosis and clinicopathological features of patients with pancreatic cancer Int J Clin Oncol 12 2 111 119 10.1007/s10147-006-0634-x 1:CAS:528:DC%2BD2sXktlOgsrs%3D 17443278 (Pubitemid 46632459)
26. D Edler U Kressner P Ragnhammar PG Johnston I Magnusson B Glimelius, et al. 2000 Immunohistochemically detected thymidylate synthase in colorectal cancer: an independent prognostic factor of survival Clin Cancer Res 6 488 492 1:STN:280:DC%2BD3c7lsFWiug%3D%3D 10690528 (Pubitemid 30111468)
27. HJ Lenz CG Leichman KD Danenberg PV Danenberg S Groshen H Cohen, et al. 1996 Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival J Clin Oncol 14 176 182 1:STN:280:DyaK287ktVaqtQ%3D%3D 8558194 (Pubitemid 26020011)
28. DH Harpole Jr MB Moore JE Herndon 2nd T Aloia TA D'Amico T Sporn, et al. 2001 The prognostic value of molecular marker analysis in patients treated with trimodality therapy for esophageal cancer Clin Cancer Res 7 562 569 11297249 (Pubitemid 32707979)
29. S Romain F Spyratos F Descotes A Daver B Rostaing-Puissant P Bougnoux, et al. 2000 Prognostic of DNA-synthesizing enzyme activities (thymidine kinase and thymidylate synthase) in 908 T1-T2, N0-N1, M0 breast cancers: a retrospective multicenter study Int J Cancer 87 860 868 10.1002/1097-0215(20000915)87: 6<860::AID-IJC16>3.0.CO;2-Y 1:CAS:528:DC%2BD3cXmsVOgsb0%3D 10956398 (Pubitemid 30660567)
30. K Harada Y Kawashima H Yoshida M Sato 2006 Thymidylate synthase expression in oral squamous cell carcinoma predicts response to S-1 Oncol Rep 15 1417 1423 1:CAS:528:DC%2BD28XlvVOisrg%3D 16685374
31. YC Hu RA Komorowski S Graewin G Hostetter OP Kallioniemi HA Pitt, et al. 2003 Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer Clin Cancer Res 9 4165 4171 1:CAS:528:DC%2BD3sXns1Ojtbs%3D 14519641 (Pubitemid 37204035)
32. A Formentini S Sander S Denzer J Straeter D Henne-Bruns M Kornmann 2007 Thymidylate synthase expression in resectable and unresectable pancreatic cancer: role as predictive or prognostic marker? Int J Colorectal Dis 22 49 55 10.1007/s00384-006-0111-z 16538493 (Pubitemid 44742339)