메뉴 건너뛰기




Volumn 28, Issue 1, 2010, Pages 13-19

The clinical relevance of Wilms Tumour 1 (WT1) gene mutations in acute leukaemia

Author keywords

Acute myeloid leukaemia; Mutation; Prognosis; WT1

Indexed keywords

ACUTE LEUKEMIA; CANCER RELAPSE; CYTOGENETICS; GENE; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE STRUCTURE; HUMAN; IMMUNOTHERAPY; PRIORITY JOURNAL; PROGNOSIS; REVIEW; WILMS TUMOR 1 GENE; ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ARTICLE; GENETICS; MUTATION; PATHOLOGY;

EID: 77950894368     PISSN: 02780232     EISSN: 10991069     Source Type: Journal    
DOI: 10.1002/hon.931     Document Type: Review
Times cited : (42)

References (75)
  • 3
    • 0034672269 scopus 로고    scopus 로고
    • Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: A Southwest Oncology Group/ Eastern Cooperative Oncology Group Study
    • Slovak ML, Kopecky KJ, Cassileth PA, et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/ Eastern Cooperative Oncology Group Study. Blood 2000; 96: 4075-4083.
    • (2000) Blood , vol.96 , pp. 4075-4083
    • Slovak, M.L.1    Kopecky, K.J.2    Cassileth, P.A.3
  • 4
    • 52149092181 scopus 로고    scopus 로고
    • Clinical significance of the most common chromosome translocations in adult acute myeloid leukemia
    • Mrozek K, Bloomfield CD. Clinical significance of the most common chromosome translocations in adult acute myeloid leukemia. J Natl Cancer Inst Monogr 2008; 39: 52-57.
    • (2008) J Natl Cancer Inst Monogr , vol.39 , pp. 52-57
    • Mrozek, K.1    Bloomfield, C.D.2
  • 6
    • 62249103645 scopus 로고    scopus 로고
    • Impact of new prognostic markers in treatment decisions in acute myeloid leukemia
    • Schlenk RF, Dohner K. Impact of new prognostic markers in treatment decisions in acute myeloid leukemia. Curr Opin Hematol 2009; 16: 98-104.
    • (2009) Curr Opin Hematol , vol.16 , pp. 98-104
    • Schlenk, R.F.1    Dohner, K.2
  • 7
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • Vardiman JW, Thiele J, Arber DA, Brunning, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009; 114: 937-951.
    • (2009) Blood , vol.114 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3    Brunning4
  • 13
    • 67650924270 scopus 로고    scopus 로고
    • Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML
    • Tefferi A, Lim KH, Abdel-Wahab O, et al. Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML. Leukemia 2009; 23: 1343-1345.
    • (2009) Leukemia , vol.23 , pp. 1343-1345
    • Tefferi, A.1    Lim, K.H.2    Abdel-Wahab, O.3
  • 14
    • 66849124925 scopus 로고    scopus 로고
    • Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
    • Gelsi-Boyer V, Trouplin V, Adelaide J, et al. Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia. Br J Haematol 2009; 145: 788-800.
    • (2009) Br J Haematol , vol.145 , pp. 788-800
    • Gelsi-Boyer, V.1    Trouplin, V.2    Adelaide, J.3
  • 15
    • 67349203626 scopus 로고    scopus 로고
    • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
    • van Haaften G, Dalgliesh GL, Davies H, et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet 2009; 41: 521-523.
    • (2009) Nat Genet , vol.41 , pp. 521-523
    • Van Haaften, G.1    Dalgliesh, G.L.2    Davies, H.3
  • 16
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER, Ding L, Dooling DJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009.
    • (2009) N Engl J Med
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 17
    • 33749266701 scopus 로고    scopus 로고
    • Syndromes and constitutional chromosomal abnormalities associated with Wilms tumour
    • DOI 10.1136/jmg.2006.041723
    • Scott RH, Stiller CA, Walker L, Rahman N. Syndromes and constitutional chromosomal abnormalities associated with Wilms tumour. J Med Genet 2006; 43: 705-715. (Pubitemid 44483912)
    • (2006) Journal of Medical Genetics , vol.43 , Issue.9 , pp. 705-715
    • Scott, R.H.1    Stiller, C.A.2    Walker, L.3    Rahman, N.4
  • 18
    • 25444455912 scopus 로고    scopus 로고
    • Wilms' tumour: Connecting tumorigenesis and organ development in the kidney
    • Rivera MN, Haber DA. Wilms' tumour: connecting tumorigenesis and organ development in the kidney. Nat Rev Cancer 2005; 5: 699-712.
    • (2005) Nat Rev Cancer , vol.5 , pp. 699-712
    • Rivera, M.N.1    Haber, D.A.2
  • 20
    • 34247579714 scopus 로고    scopus 로고
    • A tumor suppressor and oncogene: The WT1 story
    • DOI 10.1038/sj.leu.2404624, PII 2404624
    • Yang L, Han Y, Suarez Saiz F, Minden MD. A tumor suppressor and oncogene: the WT1 story. Leukemia 2007; 21: 868-876. (Pubitemid 46672061)
    • (2007) Leukemia , vol.21 , Issue.5 , pp. 868-876
    • Yang, L.1    Han, Y.2    Saurez Saiz, F.3    Minden, M.D.4
  • 22
    • 0028903902 scopus 로고
    • WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins
    • Reddy JC, Morris JC, Wang J, English, et al. WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins. J Biol Chem 1995; 270: 10878-10884.
    • (1995) J Biol Chem , vol.270 , pp. 10878-10884
    • Reddy, J.C.1    Morris, J.C.2    Wang, J.3    English4
  • 23
    • 33745143094 scopus 로고    scopus 로고
    • The Wilms tumour suppressor protein WT1 (+KTS isoform) binds alpha-actinin 1 mRNA via its zinc-finger domain
    • DOI 10.1139/O06-065
    • Morrison AA, Venables JP, Dellaire G, Ladomery MR. The Wilms tumour suppressor protein WT1 (+KTS isoform) binds alpha-actinin 1 mRNA via its zinc-finger domain. Biochem Cell Biol 2006; 84: 789-798. (Pubitemid 46121604)
    • (2006) Biochemistry and Cell Biology , vol.84 , Issue.5 , pp. 789-798
    • Morrison, A.A.1    Venables, J.P.2    Dellaire, G.3    Ladomery, M.R.4
  • 24
    • 77951099028 scopus 로고    scopus 로고
    • High expression of WT1 gene in acute myeloid leukemias with more predominant WT1+17AA isoforms at relapse
    • May 2 [Epub]
    • Gu W, Hu S, Chen Z, et al. High expression of WT1 gene in acute myeloid leukemias with more predominant WT1+17AA isoforms at relapse. Leuk Res 2009 May 2 [Epub].
    • (2009) Leuk Res
    • Gu, W.1    Hu, S.2    Chen, Z.3
  • 25
    • 33748806802 scopus 로고    scopus 로고
    • N-terminally truncated WT1 protein with oncogenic properties overexpressed in leukemia
    • DOI 10.1074/jbc.M512391200
    • Hossain A, Nixon M, Kuo MT, Saunders GF. N-terminally truncated WT1 protein with oncogenic properties overexpressed in leukemia. J Biol Chem 2006; 281: 28122-28130. (Pubitemid 44414526)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.38 , pp. 28122-28130
    • Hossain, A.1    Nixon, M.2    Kuo, M.T.3    Saunders, G.F.4
  • 26
    • 34250784012 scopus 로고    scopus 로고
    • The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis
    • DOI 10.1017/S1462399407000336, PII S1462399407000336
    • Ariyaratana S, Loeb DM. The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis. Expert Rev Mol Med 2007; 9: 1-17. (Pubitemid 46965072)
    • (2007) Expert Reviews in Molecular Medicine , vol.9 , Issue.14 , pp. 1-17
    • Ariyaratana, S.1    Loeb, D.M.2
  • 27
    • 0026751042 scopus 로고
    • Expression of the Wilms' tumor gene (WT1) in human leukemias
    • Miwa H, Beran M, Saunders GF. Expression of the Wilms' tumor gene (WT1) in human leukemias. Leukemia 1992; 6: 405-409.
    • (1992) Leukemia , vol.6 , pp. 405-409
    • Miwa, H.1    Beran, M.2    Saunders, G.F.3
  • 28
    • 0029069227 scopus 로고
    • Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias
    • Menssen HD, Renkl HJ, Rodeck U, et al. Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. Leukemia 1995; 9: 1060-1067.
    • (1995) Leukemia , vol.9 , pp. 1060-1067
    • Menssen, H.D.1    Renkl, H.J.2    Rodeck, U.3
  • 29
    • 2942597447 scopus 로고    scopus 로고
    • WT1 gene expression: An excellent tool for monitoring minimal residual disease in 70% of acute myeloid leukaemia patients - Results from a single-centre study
    • DOI 10.1111/j.1365-2141.2004.04952.x
    • Ostergaard M, Olesen LH, Hasle H, Kjeldsen E, Hokland P. WT1 gene expression: an excellent tool for monitoring minimal residual disease in 70% of acute myeloid leukaemia patients - results from a single-centre study. Br J Haematol 2004; 125: 590-600. (Pubitemid 38747961)
    • (2004) British Journal of Haematology , vol.125 , Issue.5 , pp. 590-600
    • Ostergaard, M.1    Olesen, L.H.2    Hasle, H.3    Kjeldsen, E.4    Hokland, P.5
  • 30
    • 0028606895 scopus 로고
    • The expression of the Wilms' tumor gene in acute myelocytic leukemias as a possible marker for leukemic blast cells
    • Brieger J, Weidmann E, Fenchel K, Mitrou PS, Hoelzer D, Bergmann L. The expression of the Wilms' tumor gene in acute myelocytic leukemias as a possible marker for leukemic blast cells. Leukemia 1994; 8: 2138-2143.
    • (1994) Leukemia , vol.8 , pp. 2138-2143
    • Brieger, J.1    Weidmann, E.2    Fenchel, K.3    Mitrou, P.S.4    Hoelzer, D.5    Bergmann, L.6
  • 33
    • 23844458023 scopus 로고    scopus 로고
    • Prognostic impact of RT-PCR-based quantification WT1 gene expression during MRD monitoring of acute myeloid leukemia
    • DOI 10.1038/sj.leu.2403809
    • Weisser M, Kern W, Rauhut S, et al. Prognostic impact of RTPCR-based quantification of WT1 gene expression during MRD monitoring of acute myeloid leukemia. Leukemia 2005; 19: 1416-1423. (Pubitemid 41148947)
    • (2005) Leukemia , vol.19 , Issue.8 , pp. 1416-1423
    • Weisser, M.1    Kern, W.2    Rauhut, S.3    Schoch, C.4    Hiddemann, W.5    Haferlach, T.6    Schittger, S.7
  • 37
    • 44249108579 scopus 로고    scopus 로고
    • Relapse prediction in acute myeloid leukaemia patients in complete remission using WT1 as a molecular marker: Development of a mathematical model to predict time from molecular to clinical relapse and define optimal sampling intervals
    • DOI 10.1111/j.1365-2141.2008.07132.x
    • Ommen HB, Nyvold CG, Braendstrup K, et al. Relapse prediction in acute myeloid leukaemia patients in complete remission using WT1 as a molecular marker: development of a mathematical model to predict time from molecular to clinical relapse and define optimal sampling intervals. Br J Haematol 2008; 141: 782-791. (Pubitemid 351724866)
    • (2008) British Journal of Haematology , vol.141 , Issue.6 , pp. 782-791
    • Ommen, H.B.1    Nyvold, C.G.2    Braendstrup, K.3    Andersen, B.L.4    Ommen, I.B.5    Hasle, H.6    Hokland, P.7    Ostergaard, M.8
  • 38
    • 57649155053 scopus 로고    scopus 로고
    • Quantitative assessment of WT1 gene expression after allogeneic stem cell transplantation is a useful tool for monitoring minimal residual disease in acute myeloid leukemia
    • Candoni A, Tiribelli M, Toffoletti E, et al. Quantitative assessment of WT1 gene expression after allogeneic stem cell transplantation is a useful tool for monitoring minimal residual disease in acute myeloid leukemia. Eur J Haematol 2009; 82: 61-68.
    • (2009) Eur J Haematol , vol.82 , pp. 61-68
    • Candoni, A.1    Tiribelli, M.2    Toffoletti, E.3
  • 42
    • 71049194464 scopus 로고    scopus 로고
    • WT1 expression at diagnosis does not predict survival in pediatric aml: A report from the Children's Oncology Group
    • Noronha SA, Farrar JE, Alonzo TA, et al. WT1 expression at diagnosis does not predict survival in pediatric aml: A report from the Children's Oncology Group. Pediatr Blood Cancer 2009; 53: 1136-1139.
    • (2009) Pediatr Blood Cancer , vol.53 , pp. 1136-1139
    • Noronha, S.A.1    Farrar, J.E.2    Alonzo, T.A.3
  • 43
    • 0032795913 scopus 로고    scopus 로고
    • Wilms' tumour gene (wt1) expression at diagnosis has no prognostic relevance in childhood acute lymphoblastic leukaemia treated by an intensive chemotherapy protocol
    • Gaiger A, Linnerth B, Mann G, et al. Wilms' tumour gene (wt1) expression at diagnosis has no prognostic relevance in childhood acute lymphoblastic leukaemia treated by an intensive chemotherapy protocol. Eur J Haematol 1999; 63: 86-93.
    • (1999) Eur J Haematol , vol.63 , pp. 86-93
    • Gaiger, A.1    Linnerth, B.2    Mann, G.3
  • 44
    • 70350292724 scopus 로고    scopus 로고
    • Wilms' tumor gene 1 (WT1) expression in subtypes of acute lymphoblastic leukemia (ALL) of adults and impact on clinical outcome
    • Busse A, Gokbuget N, Siehl JM, et al. Wilms' tumor gene 1 (WT1) expression in subtypes of acute lymphoblastic leukemia (ALL) of adults and impact on clinical outcome. Ann Hematol 2009; 88: 1199-1205.
    • (2009) Ann Hematol , vol.88 , pp. 1199-1205
    • Busse, A.1    Gokbuget, N.2    Siehl, J.M.3
  • 45
    • 31444452790 scopus 로고    scopus 로고
    • Wilms' tumor gene 1 (WT1) expression in childhood acute lymphoblastic leukemia: A wide range of WT1 expression levels, its impact on prognosis and minimal residual disease monitoring
    • Boublikova L, Kalinova M, Ryan J, et al. Wilms' tumor gene 1 (WT1) expression in childhood acute lymphoblastic leukemia: a wide range of WT1 expression levels, its impact on prognosis and minimal residual disease monitoring. Leukemia 2006; 20: 254-263.
    • (2006) Leukemia , vol.20 , pp. 254-263
    • Boublikova, L.1    Kalinova, M.2    Ryan, J.3
  • 46
    • 70349232830 scopus 로고    scopus 로고
    • WT1 mutations in TALL
    • Tosello V, Mansour MR, Barnes K, et al. WT1 mutations in TALL. Blood 2009; 114: 1038-1045.
    • (2009) Blood , vol.114 , pp. 1038-1045
    • Tosello, V.1    Mansour, M.R.2    Barnes, K.3
  • 47
    • 0029880547 scopus 로고    scopus 로고
    • A WT1 antisense oligonucleotide inhibits proliferation and induces apoptosis in myeloid leukaemia cell lines
    • Algar EM. A WT1 antisense oligonucleotide inhibits proliferation and induces apoptosis in myeloid leukaemia cell lines. Oncogene 1996; 12: 1005-1014.
    • (1996) Oncogene , vol.12 , pp. 1005-1014
    • Algar, E.M.1
  • 48
    • 4644289323 scopus 로고    scopus 로고
    • Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression
    • Oka Y, Tsuboi A, Taguchi T, et al. Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression. Proc Natl Acad Sci USA 2004; 101: 13885-13890.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13885-13890
    • Oka, Y.1    Tsuboi, A.2    Taguchi, T.3
  • 49
    • 38049188363 scopus 로고    scopus 로고
    • Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies
    • Rezvani K, Yong AS, Mielke S, et al. Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood 2008; 111: 236-242.
    • (2008) Blood , vol.111 , pp. 236-242
    • Rezvani, K.1    Yong, A.S.2    Mielke, S.3
  • 50
    • 69249220181 scopus 로고    scopus 로고
    • A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS
    • Keilholz U, Letsch A, Busse A, et al. A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS. Blood 2009; 113: 6541-6548.
    • (2009) Blood , vol.113 , pp. 6541-6548
    • Keilholz, U.1    Letsch, A.2    Busse, A.3
  • 51
    • 0028133507 scopus 로고
    • The Wilms tumour (WT1) gene is mutated in a secondary leukaemia in a WAGR patient
    • Pritchard-Jones K, Renshaw J, King-Underwood L. The Wilms tumour (WT1) gene is mutated in a secondary leukaemia in a WAGR patient. Hum Mol Genet 1994; 3: 1633-1637.
    • (1994) Hum Mol Genet , vol.3 , pp. 1633-1637
    • Pritchard-Jones, K.1    Renshaw, J.2    King-Underwood, L.3
  • 52
    • 0032522974 scopus 로고    scopus 로고
    • Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance
    • King-Underwood L, Pritchard-Jones K. Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance. Blood 1998; 91: 2961-2968.
    • (1998) Blood , vol.91 , pp. 2961-2968
    • King-Underwood, L.1    Pritchard-Jones, K.2
  • 53
    • 12544257171 scopus 로고    scopus 로고
    • Genome-wide single nucleotide polymorphism analysis reveals frequent partial uniparental disomy due to somatic recombination in acute myeloid leukemias
    • Raghavan M, Lillington DM, Skoulakis S, et al. Genome-wide single nucleotide polymorphism analysis reveals frequent partial uniparental disomy due to somatic recombination in acute myeloid leukemias. Cancer Res 2005; 65: 375-378.
    • (2005) Cancer Res , vol.65 , pp. 375-378
    • Raghavan, M.1    Lillington, D.M.2    Skoulakis, S.3
  • 54
    • 27144478643 scopus 로고    scopus 로고
    • Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias
    • Fitzgibbon J, Smith LL, Raghavan M, et al. Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias. Cancer Res 2005; 65: 9152-9154.
    • (2005) Cancer Res , vol.65 , pp. 9152-9154
    • Fitzgibbon, J.1    Smith, L.L.2    Raghavan, M.3
  • 55
    • 33847238455 scopus 로고    scopus 로고
    • Wilms' tumour 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML
    • author reply 552
    • Summers K, Stevens J, Kakkas I, et al. Wilms' tumour 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML. Leukemia 2007; 21: 550-551 author reply 552.
    • (2007) Leukemia , vol.21 , pp. 550-551
    • Summers, K.1    Stevens, J.2    Kakkas, I.3
  • 56
    • 0029921478 scopus 로고    scopus 로고
    • Mutations in the Wilms' tumor gene WT1 in leukemias
    • King-Underwood L, Renshaw J, Pritchard-Jones K. Mutations in the Wilms' tumor gene WT1 in leukemias. Blood 1996; 87: 2171-2179.
    • (1996) Blood , vol.87 , pp. 2171-2179
    • King-Underwood, L.1    Renshaw, J.2    Pritchard-Jones, K.3
  • 57
    • 56749098118 scopus 로고    scopus 로고
    • Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: The United Kingdom Medical Research Council Adult Leukaemia Working Party
    • Virappane P, Gale R, Hills R, Kakkas, et al. Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party. J Clin Oncol 2008; 26: 5429-5435.
    • (2008) J Clin Oncol , vol.26 , pp. 5429-5435
    • Virappane, P.1    Gale, R.2    Hills, R.3    Kakkas4
  • 58
    • 53749101166 scopus 로고    scopus 로고
    • Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: A cancer and leukemia group B study
    • Paschka P, Marcucci G, Ruppert AS, Whitman, et al. Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol 2008; 26: 4595-4602.
    • (2008) J Clin Oncol , vol.26 , pp. 4595-4602
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3    Whitman4
  • 59
    • 66549116716 scopus 로고    scopus 로고
    • Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: A study of the German-Austrian AML Study Group
    • Gaidzik VI, Schlenk RF, Moschny S, et al. Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group. Blood 2009; 113: 4505-4511.
    • (2009) Blood , vol.113 , pp. 4505-4511
    • Gaidzik, V.I.1    Schlenk, R.F.2    Moschny, S.3
  • 60
    • 68549132617 scopus 로고    scopus 로고
    • Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: A study from the Acute Leukemia French Association
    • Renneville A, Boissel N, Zurawski V, et al. Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: a study from the Acute Leukemia French Association. Cancer 2009; 115: 3719-3727.
    • (2009) Cancer , vol.115 , pp. 3719-3727
    • Renneville, A.1    Boissel, N.2    Zurawski, V.3
  • 61
    • 77951111366 scopus 로고    scopus 로고
    • Mutations in the WT1 transcription factor are associated with inferior overall survival - An analysis in 368 AML patients with normal karyotype under 60 years treated in the AML96 protocol of the DSIL
    • abstract
    • Thiede C, Illmer T, Soucek S, Schaich M, Ehninger G. Mutations in the WT1 transcription factor are associated with inferior overall survival - an analysis in 368 AML patients with normal karyotype under 60 years treated in the AML96 protocol of the DSIL. Haematologica 2008; 93: 62 [abstract].
    • (2008) Haematologica , vol.93 , pp. 62
    • Thiede, C.1    Illmer, T.2    Soucek, S.3    Schaich, M.4    Ehninger, G.5
  • 62
    • 79955075293 scopus 로고    scopus 로고
    • Prognostic signifiance of molecular markers in normal karyotype-AML: A single centre experience
    • abstract
    • Spinelli O, Tosi M, Guerini V, et al. Prognostic signifiance of molecular markers in normal karyotype-AML: a single centre experience. Haematologica 2008; 91: 206 [abstract].
    • (2008) Haematologica , vol.91 , pp. 206
    • Spinelli, O.1    Tosi, M.2    Guerini, V.3
  • 63
    • 67651096058 scopus 로고    scopus 로고
    • Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia
    • Hollink IH, van den Heuvel-Eibrink MM, Zimmermann M, et al. Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia. Blood 2009; 113: 5951-5960.
    • (2009) Blood , vol.113 , pp. 5951-5960
    • Hollink, I.H.1    Van Den Heuvel-Eibrink, M.M.2    Zimmermann, M.3
  • 64
    • 77951098233 scopus 로고    scopus 로고
    • Mutant Wilms' Tumor 1 (WT1) mRNA with premature termination codons is sensitive to nonsense-mediated RNA decay in Acute Myeloid Leukemia (AML)
    • abstract
    • Abbas S, Erpelinck C, Goudswaard C, Lowenberg B, Valk P. Mutant Wilms' Tumor 1 (WT1) mRNA with premature termination codons is sensitive to nonsense-mediated RNA decay in Acute Myeloid Leukemia (AML). Blood 2008; 112: 2538 [abstract].
    • (2008) Blood , vol.112 , pp. 2538
    • Abbas, S.1    Erpelinck, C.2    Goudswaard, C.3    Lowenberg, B.4    Valk, P.5
  • 65
    • 67650886013 scopus 로고    scopus 로고
    • Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: Comparative analysis of 493 adult patients
    • Chou WC, Chen CY, Hou HA, et al. Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients. Leukemia 2009; 23: 1303-1310.
    • (2009) Leukemia , vol.23 , pp. 1303-1310
    • Chou, W.C.1    Chen, C.Y.2    Hou, H.A.3
  • 66
    • 3242789449 scopus 로고    scopus 로고
    • Prevalence of WT1 mutations in a large cohort of patients with steroid-resistant and steroid-sensitive nephrotic syndrome
    • Ruf RG, Schultheiss M, Lichtenberger A, et al. Prevalence of WT1 mutations in a large cohort of patients with steroid-resistant and steroid-sensitive nephrotic syndrome. Kidney Int 2004; 66: 564-570.
    • (2004) Kidney Int , vol.66 , pp. 564-570
    • Ruf, R.G.1    Schultheiss, M.2    Lichtenberger, A.3
  • 67
    • 0029832887 scopus 로고    scopus 로고
    • Effects of Denys-Drash syndrome point mutations on the DNA binding activity of the Wilms' tumor suppressor protein WT1
    • Borel F, Barilla KC, Hamilton TB, Iskandar M, Romaniuk PJ. Effects of Denys-Drash syndrome point mutations on the DNA binding activity of the Wilms' tumor suppressor protein WT1. Biochemistry 1996; 35: 12070-12076.
    • (1996) Biochemistry , vol.35 , pp. 12070-12076
    • Borel, F.1    Barilla, K.C.2    Hamilton, T.B.3    Iskandar, M.4    Romaniuk, P.J.5
  • 68
    • 0033050457 scopus 로고    scopus 로고
    • Myelodysplastic syndrome, juvenile myelomonocytic leukemia, and acute myeloid leukemia associated with complete or partial monosomy 7
    • European Working Group on MDS in Childhood (EWOGMDS)
    • Hasle H, Arico M, Basso G, Biondi, et al. Myelodysplastic syndrome, juvenile myelomonocytic leukemia, and acute myeloid leukemia associated with complete or partial monosomy 7. European Working Group on MDS in Childhood (EWOGMDS). Leukemia 1999; 13: 376-385.
    • (1999) Leukemia , vol.13 , pp. 376-385
    • Hasle, H.1    Arico, M.2    Basso, G.3    Biondi4
  • 69
    • 13044266382 scopus 로고    scopus 로고
    • A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome
    • Patek CE, Little MH, Fleming S, et al. A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome. Proc Natl Acad Sci USA 1999; 96: 2931-2936.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2931-2936
    • Patek, C.E.1    Little, M.H.2    Fleming, S.3
  • 70
    • 7644239147 scopus 로고    scopus 로고
    • The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome
    • Gao F, Maiti S, Sun G, et al. The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome. Mol Cell Biol 2004; 24: 9899-9910.
    • (2004) Mol Cell Biol , vol.24 , pp. 9899-9910
    • Gao, F.1    Maiti, S.2    Sun, G.3
  • 71
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Gale RE, Green C, Allen C, et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 2008; 111: 2776-2784.
    • (2008) Blood , vol.111 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3
  • 73
    • 68749092656 scopus 로고    scopus 로고
    • Standardization of WT1 mRNA quantitation for minimal residual disease monitoring in childhood AML and implications of WT1 gene mutations: A European multicenter study
    • Willasch AM, Gruhn B, Coliva T, et al. Standardization of WT1 mRNA quantitation for minimal residual disease monitoring in childhood AML and implications of WT1 gene mutations: a European multicenter study. Leukemia 2009; 23: 1472-1479.
    • (2009) Leukemia , vol.23 , pp. 1472-1479
    • Willasch, A.M.1    Gruhn, B.2    Coliva, T.3
  • 74
    • 68749122290 scopus 로고    scopus 로고
    • Prevalence and prognostic implications of WT1 mutations in pediatric AML: A report from the children's Oncology Group
    • abstract
    • Pollard J, Zeng R, Ho P, et al. Prevalence and prognostic implications of WT1 mutations in pediatric AML: a report from the children's Oncology Group. Blood 2008; 112: 143 [abstract].
    • (2008) Blood , vol.112 , pp. 143
    • Pollard, J.1    Zeng, R.2    Ho, P.3
  • 75
    • 33750295930 scopus 로고    scopus 로고
    • Wilms' tumor 1 mutation accumulated during therapy in acute myeloid leukemia: Biological and clinical implications
    • Nyvold CG, Stentoft J, Braendstrup K, et al. Wilms' tumor 1 mutation accumulated during therapy in acute myeloid leukemia: biological and clinical implications. Leukemia 2006; 20: 2051-2054.
    • (2006) Leukemia , vol.20 , pp. 2051-2054
    • Nyvold, C.G.1    Stentoft, J.2    Braendstrup, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.