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Volumn 20, Issue 9, 2010, Pages 2968-2973

The discovery and structure-activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase

Author keywords

HCV NS5B polymerase; Pyranoindoles

Indexed keywords

INDOLE DERIVATIVE; NONSTRUCTURAL PROTEIN 5B; PYRANO[3,4 BETA]INDOLE; UNCLASSIFIED DRUG;

EID: 77950867861     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.002     Document Type: Article
Times cited : (29)

References (43)
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    • note
    • The tryptophol intermediate was constructed by Fischer-Indole cyclization of the corresponding hydrazone, see Ref. 10.
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    • 1H NMR and mass spectral analyses.
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    • note
    • 2). The resulting esters were hydrolyzed using aqueous NaOH in THF/EtOH to give the desired pyranoindoles.
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    • note
    • 50's are an average of multiple experiments with the standard deviations generally within 10% of this value.
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    • note
    • 50) was the drug concentration that decreased the enzyme activity by 50% relative to control samples incubated without compound.
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    • The chiral β-ketoester derived from (S)-(+)-2-methylbutyric acid was prepared to afford diastereomeric pyranoindoles which were separated using chiral chromatography.
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    • note
    • -6 cm/s.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.