Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 2987-2990

  Young, Sherri ^a   Fabio, Karine ^a   Guillon, Christophe ^a   Mohanta, Pramod ^a   Halton, Timothy A ^a   Heck, Diane E ^b   Flowers II, Robert A ^a   Laskin, Jeffrey D ^c   Heindel, Ned D ^a  

^a LEHIGH UNIVERSITY   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c Environmental and Occupational Health Sciences Institute   (United States)

Author keywords

Acetylcholinesterase inhibitors; Noncompetitive inhibitor; NSAIDs; Prodrugs

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; DICLOFENAC; GALANTAMINE; NONSTEROID ANTIINFLAMMATORY AGENT; TACRINE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHOLINERGIC ACTIVITY; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG DETERMINATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; IC 50; IN VIVO CULTURE; INFLAMMATION; LIPOPHILICITY; UPREGULATION;

ACETYLCHOLINESTERASE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHOLINERGIC AGENTS; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HUMANS; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77950866259     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.102     Document Type: Article

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