Cholinesterase inhibitors improve survival in experimental sepsis: A new way to activate the cholinergic anti-inflammatory pathway

Critical Care Medicine

Volumn 36, Issue 2, 2008, Pages 622-623

  Fodale, Vincenzo ^a   Santamaria, Letterio B ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

Cholinergic anti inflammatory pathway; Cholinesterase inhibitors; Neostigmine; Nicotine; Physostigmine; Sepsis

Indexed keywords

CHOLINESTERASE INHIBITOR; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; NEOSTIGMINE; PHYSOSTIGMINE; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; CHOLINERGIC ACTIVITY; CYTOKINE PRODUCTION; DRUG MECHANISM; EDITORIAL; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SEPSIS; SURVIVAL; VAGUS NERVE;

EID: 38549179278     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCM.0B013E31816297CE     Document Type: Editorial

References (12)

1. Andersson J: The inflammatory reflex-introduction. J Intern Med 2005; 257:122-125
2. Gallowitsch-Puerta M, Pavlov VA: Neuroimmune interactions via the cholinergic anti-inflammatory pathway. Life Sci 2007; 80:2325-2329
3. Oke SL, Tracey KJ: The inflammatory reflex and the role of complementary and alternative medical therapies. Ann N Y Acad Sci 2007 September 28; [Epub ahead of print]
4. Giebelen IA, van Westerloo DJ, LaRosa GJ, et al: Stimulation of alpha7 cholinergic receptors inhibits lipopolysaccharide-induced neutrophil recruitment by a tumor necrosis factor alpha-independent mechanism. Shock 2007; 27:443-447
5. Huston JM, Puerta MG, Ochani M, et al: Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis. Crit Care Med 2007; 35:2762-2768
6. Pavlov VA, Tracey KJ: Controlling inflammation: The cholinergic anti-inflammatory pathway. Biochem Soc Trans 2006; 34:1037-1040
7. Czura CJ, Tracey KJ: Autonomic neural regulation of immunity. J Intern Med 2005; 257:156-166
8. Wittebole X, Hahm S, Coyle SM, et al: Nicotine exposure alters in vivo human responses to endotoxin. Clin Exp Immunol 2007; 147:28-34
9. Hofer S, Eisenbach C, Lukic IK, et al: Pharmacologic cholinesterase inhibition improves survival in experimental sepsis. Crit Care Med 2008; 36:404-408
10. van Westerloo DJ, Giebelen IA, Florquin S, et al: The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis. J Infect Dis 2005; 191:2138-2148
11. Akinci SB, Ulu N, Yondem OZ, et al: Effect of neostigmine on organ injury in murine endotoxemia: Missing facts about the cholinergic antiinflammatory pathway. World J Surg 2005; 29:1483-1489
12. Wang H, Liao H, Ochani M, et al: Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med 2004; 10:1216-1221