Synthesis and biological activity of 2H-quinolizin-2-one based p38α MAP kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 2765-2769

  Tynebor, Robert M ^a   Chen, Meng Hsin ^a   Natarajan, Swaminathan R ^a   O'Neill, Edward A ^a   Thompson, James E ^a   Fitzgerald, Catherine E ^a   O'Keefe, Stephen J ^a   Doherty, James B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

MAP kinase; p38 inhibitors

Indexed keywords

2H QUINOLIZIN 2 ONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; QUINOLIZINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG ACTIVITY; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MONKEY; NONHUMAN; RAT; SUBSTITUTION REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; DOGS; HAPLORHINI; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; QUINOLIZINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77950864469     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.069     Document Type: Article

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