Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: Novel heterocyclic templates for butyrylcholinesterase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 2946-2949

  Schulze, Maria ^a   Siol, Oliver ^a   Decker, Michael ^a   Lehmann, Jochen ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Acetylcholinesterase; Bivalent inhibitor; Butyrylcholinesterase; Cytotoxicity

Indexed keywords

(3 METHOXY 5,8,9,13B TETRAHYDRO 6H ISOQUINO [1,2 A]ISOQUINOLINE); 3 METHOXY 5,8,9,13B TETRATETRAHYDRO 6H ISOQUINO [1,2 A]ISOQUINOLINE; 3 METHOXY 7 METHYL 5,6,7,8,9,14 HEXAHYDRODIBENZO[D,G]AZECINE; 5,8,9,13B TETRAHYDRO 6H ISOQUINO[1,2 A]ISOQUINOLINE DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; GALANTAMINE; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; DRUG ACTIVITY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50;

BUTYRYLCHOLINESTERASE; CELL LINE; CHOLINESTERASE INHIBITORS; HETEROCYCLIC COMPOUNDS; HUMANS; ISOQUINOLINES; QUATERNARY AMMONIUM COMPOUNDS;

EID: 77950863140     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.011     Document Type: Article

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