Synthesis, antiproliferative, acute toxicity and assessment of antiandrogenic activities of some newly synthesized steroidal lactams

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2229-2236

  Dhingra, Neelima ^a   Bhardwaj, T R ^a,b   Mehta, Neeraj ^a   Mukhopadhyay, Tapas ^c   Kumar, Ashok ^c   Kumar, Manoj ^a  

^a PANJAB UNIVERSITY   (India)

^b ISF COLLEGE OF PHARMACY   (India)

^c PANJAB UNIVERSITY   (India)

Author keywords

17a Aza steroids; Androgen; Benign prostatic hyperplasia; Dihydrotestosterone; Five alpha reductase enzyme

Indexed keywords

17 OXO 17ALPHA AZA DEXTRO HOMO 5 ANDROSTEN 3BETA YL 4 AMINOBENZOIC ACID; 17 OXO 17ALPHA AZA DEXTRO HOMO 5 ANDROSTEN 3BETA YL 4 CHLOROBENZOIC ACID; 17 OXO 17ALPHA AZA DEXTRO HOMO 5 ANDROSTEN 3BETA YL 4 HYDROXYBENZOIC ACID; 17 OXO 17ALPHA AZA DEXTRO HOMO 5 ANDROSTEN 3BETA YL 4 METHOXYBENZOIC ACID; 17 OXO 17ALPHA AZA DEXTRO HOMO 5 ANDROSTEN 3BETA YL 4 METHYLBENZOIC ACID; 17 OXO 17ALPHA AZA DEXTRO HOMO 5 ANDROSTEN 3BETA YL 4 NITROBENZOIC ACID; 17 OXO 17ALPHA AZA DEXTRO HOMO 5 ANDROSTEN 3BETA YL BENZOIC ACID; 17 OXO 17ALPHA AZA DEXTRO HOMO 5 ANDROSTEN 3BETA YL CHLOROACETIC ACID; 17 OXO 17ALPHA AZA DEXTRO HOMO 5 ANDROSTEN 3BETA YL PHENOXYACETIC ACID; 17 OXO 17ALPHA AZA DEXTRO HOMO 5 ANDROSTEN 3BETA YL PHENYLACETIC ACID; ANDROGEN; ANTIANDROGEN; DIOSGENIN; FINASTERIDE; LACTAM; METHYLTESTOSTERONE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANDROGEN BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROSTATE CANCER; RAT; SPECTROSCOPY;

ANDROGEN ANTAGONISTS; ANDROGENS; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DISCOVERY; HUMANS; INHIBITORY CONCENTRATION 50; LACTAMS; MACROPHAGES; MALE; MICE; RATS; STEROIDS;

EID: 77950861824     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.064     Document Type: Article

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