Conformationally restricted analogues of 1N,14N-bisethylhomospermine (BE-4-4-4): Synthesis and growth inhibitory effects on human prostate cancer cells

Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2001, Pages 390-403

  Valasinas, A ^a   Sarkar, A ^a   Reddy, V K ^a   Marton, L J ^a   Basu, H S ^a   Frydman, B ^a  

^a SLIL Biomedical Corp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,8,13,18 TETRAAZA 10,11 [1,2 CYCLOBUTYL] 3,8,13,18 EICOSANE; 3,8,13,18 TETRAAZA 10,11 [1,2 CYCLOPROPYL]EICOSANE; 3,8,13,18 TETRAAZA 5 ENE; ANTINEOPLASTIC AGENT; BE 444; CYCLOPROPANE; N1,N14 DIETHYLHOMOSPERMINE; PUTRESCINE; SPERMIDINE; SPERMINE DERIVATIVE; TETRAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CHEMOTHERAPY; CELL GROWTH; CHEMICAL BOND; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; ISOMERISM; PROSTATE CANCER;

ANTINEOPLASTIC AGENTS; CELL DIVISION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PROSTATIC NEOPLASMS; SPERMINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035254215     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000309t     Document Type: Article

References (41)

1. Polyamines as targets for therapeutic interactions
2. 12-Bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content and excretion in human colon tumor cells
3. 11-Bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action
4. Regulatory and antiproliferative effects of N-Alkylated polyamine analogues in human and hamster pancreatic adenocarcinoma cell lines
5. Effects of polyamine analogues BE-3-7-3, 3-8-3, and BE-3-8-3 on human brain tumor cell growth and survival
6. Effects of the polyamine analogues BE-4-4-4-4, BE-3-7-3, and BE-3-3-3 on the proliferation of three prostate cancer cell lines
7. Effects of polyamine analogues on prostatic adenocarcinoma cells in vitro and in vivo
8. Polyamine-Based chemotherapy of cancer
9. Synthesis and evaluation of hydroxylated polyamine analogues as anti-proliferatives
10. 12N-bisethylspermine: Synthesis and growth inhibitory effects of on human tumor cell lines
11. Cis-Unsaturated analogues of 3,6,13,18,23 pentaazapentacosane (BE-4-4-4-4): Synthesis and growth inhibitory effects on human prostate cancer cell lines
12. Effect of structural variations of spermine on its interaction with DNA
13. Implications and concepts of polyamine-nucleic acid interactions
14. A stopped-Flow H-D exchange kinetic study of spermine-polynucleotide interaction
15. Recognition of Z-RNA and Z-DNA determinants by polyamines in solution: Experimental and theoretical studies
16. Differential effects of spermine and its analogues on the structures of polynucleotides complexed with ethidium bromide
17. The interaction of spermine and pentamines with DNA
18. Interaction of a polyamine analogue, 1,19-Bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4), with DNA and effect on growth, survival, and polyamine levels in seven human brain tumor cell lines
19. 15N NMR study
20. 13C NMR study of [5,8-13C2]spermidine binding to t-RNA and to Escherichia coli macromolecules
21. Interactions of polyamines with ion channels
22. Modulation of channel functions by polyamines
23. Polyamine analogue regulation of NMDA MK-801 binding: A structure-Activity study
24. Synthesis and assay of hybrid analogues of argiotoxin-636 and philantotexin-433: Glutamate receptor antagonist
25. Role of methylene backbone in the antiproliferative activity of polyamine analogues on L1210 cells
26. Control of ornithine decarboxylase activity in α-Difluoromethylornithine resistant L1210 cells by polyamines and synthetic analogues
27. 12-Bis(ethyl)spermine
28. 1-acetyltransferase activity by spermine analogues and their relationship to polyamine depletion and growth inhibition in L1210 cells
29. 1-Acetyltransferase activity, polyamine pool depletion and growth inhibition in human melnoma cell lines
30. Effect of bis(ethyl)-homospermine on the growth Of U-87 Mg, and SF-126 human brain tumor cells
31. Correlation between effects of polyamine analogues on DNA conformation and cell growth
32. Antiproliferative properties of polyamine analogues: A structure-activity study
33. Induction of programmed cell death in human breast cancer cells by an asymmetrically alkylated polyamine analogue
34. Antitumor activity of N, N-Bisethylspermine homolgues against human MALME3 melanoma xenografts
35. 14-Diethylhomospermine
36. A comparison of structure-activity relationships between spermidine and spermine analogue antineoplastics
37. Solid-phase extraction and determination of dansyl derivatives of unconjugated and acetylated polyamines by reversed-phased liquid chromatography