Nucleocytoplasmic shuttling of hexokinase II in a cancer cell

Biochemical and Biophysical Research Communications

Volumn 394, Issue 4, 2010, Pages 1075-1081

  Neary, Catherine L ^a   Pastorino, John G ^a  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

2 Deoxyglucose; Exportin; Hexokinase 2; Nucleocytoplasmic transport

Indexed keywords

CYTOKINE RESPONSE MODIFIER A; DEOXYGLUCOSE; GLUCOSE; HEXOKINASE; HEXOKINASE ISOENZYME; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL FRACTIONATION; CYTOPLASM; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; NUCLEAR LOCALIZATION SIGNAL; NUCLEOCYTOPLASMIC TRANSPORT; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL NUCLEUS; CYTOPLASM; DEOXYGLUCOSE; FATTY ACIDS, UNSATURATED; GLUCOSE; HELA CELLS; HEXOKINASE; HUMANS; KARYOPHERINS; NEOPLASMS; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

MAMMALIA;

EID: 77950861581     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.03.129     Document Type: Article

References (29)

1. Gatenby R.A., and Gillies R.J. Why do cancers have high aerobic glycolysis?. Nat. Rev. Cancer 4 (2004) 891-899
2. 18F]FDG to predict tumor behavior in experimental colorectal cancer. Neoplasia 3 (2001) 189-195
3. 18fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. J. Clin. Oncol. 20 (2002) 379-387
4. Wilson J.E. Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. J. Exp. Biol. 206 (2003) 2049-2057
5. Wilson J.E., and Felgner P.L. An inverse relationship between mitochondrial hexokinase content and phosphoglucomutase activity of rat tissues. Mol. Cell. Biochem. 18 (1977) 39-47
6. Sebastian S., Horton J.D., and Wilson J.E. Anabolic function of the type II isozyme of hexokinase in hepatic lipid synthesis. Biochem. Biophys. Res. Commun. 270 (2000) 886-891
7. Kaselonis G.L., McCabe E.R., and Gray S.M. Expression of hexokinase 1 and hexokinase 2 in mammary tissue of nonlactating and lactating rats: evaluation by RT-PCR. Mol. Genet. Metab. 68 (1999) 371-374
8. Preller A., and Wilson J.E. Localization of the type III isozyme of hexokinase at the nuclear periphery. Arch. Biochem. Biophys. 294 (1992) 482-492
9. Postic C., Shiota M., and Magnuson M.A. Cell-specific roles of glucokinase in glucose homeostasis. Recent Prog. Horm. Res. 56 (2001) 195-217
10. Meglasson M.D., and Matschinsky F.M. New perspectives on pancreatic islet glucokinase. Am. J. Physiol. 246 (1984) E1-E13
11. Girard J., Ferre P., and Foufelle F. Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes. Annu. Rev. Nutr. 17 (1997) 325-352
12. de la Iglesia N., Veiga-da-Cunha M., Van Schaftingen E., Guinovart J.J., and Ferrer J.C. Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase. FEBS Lett. 456 (1999) 332-338
13. Shiota C., Coffey J., Grimsby J., Grippo J.F., and Magnuson M.A. Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase. J. Biol. Chem. 274 (1999) 37125-37130
14. Bednenko J., Cingolani G., and Gerace L. Nucleocytoplasmic transport: navigating the channel. Traffic 4 (2003) 127-135
15. Gorlich D., and Kutay U. Transport between the cell nucleus and the cytoplasm. Annu. Rev. Cell Dev. Biol. 15 (1999) 607-660
16. Fukuda M., Asano S., Nakamura T., Adachi M., Yoshida M., Yanagida M., and Nishida E. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 390 (1997) 308-311
17. Mathupala S.P., Rempel A., and Pedersen P.L. Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase. J. Bioenerg. Biomembr. 29 (1997) 339-343
18. Pastorino J.G., and Hoek J.B. Regulation of hexokinase binding to VDAC. J. Bioenerg. Biomembr. 40 (2008) 171-182
19. Pastorino J.G., Shulga N., and Hoek J.B. Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis. J. Biol. Chem. 277 (2002) 7610-7618
20. Pastorino J.G., Hoek J.B., and Shulga N. Activation of glycogen synthase kinase 3β disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Cancer Res. 65 (2005) 10546
21. Niederacher D., and Entian K.-D. Characterization of Hex2 protein, a negative regulatory element necessary for glucose repression in yeast. Eur. J. Biochem. 200 (1991) 311-319
22. Ahuatzi D., Herrero P., de la Cera T., and Moreno F. The glucose-regulated nuclear localization of hexokinase 2 in Saccharomyces cerevisiae is Mig1-dependent. J. Biol. Chem. 279 (2004) 14440-14446
23. Ahuatzi D., Riera A., Pelaez R., Herrero P., and Moreno F. Hxk2 regulates the phosphorylation state of Mig1 and therefore its nucleocytoplasmic distribution. J. Biol. Chem. 282 (2007) 4485-4493
24. Pelaez R., Herrero P., and Moreno F. Nuclear export of the yeast hexokinase 2 protein requires the Xpo1 (Crm1)-dependent pathway. J. Biol. Chem. 284 (2009) 20548-20555
25. Kudo N., Wolff B., Sekimoto T., Schreiner E.P., Yoneda Y., Yanagida M., Horinouchi S., and Yoshida M. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242 (1998) 540-547
26. Herrero P., Martinez-Campa C., and Moreno F. The hexokinase 2 protein participates in regulatory DNA-protein complexes necessary for glucose repression of the SUC2 gene in Saccharomyces cerevisiae. FEBS Lett. 434 (1998) 71-76
27. Deeb S.S., Malkki M., and Laakso M. Human hexokinase II: sequence and homology to other hexokinases. Biochem. Biophys. Res. Commun. 197 (1993) 68-74
28. Reitzer L., Wice B., and Kennel D. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J. Biol. Chem. 254 (1979) 2669-2676
29. Pedersen P.L., Mathupala S., Rempel A., Geschwind J.F., and Ko Y.H. Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention. Biochim. Biophys. Acta 1555 (2002) 14-20