17α-hydroxyprogesterone and cortisol serum levels in neonates and young children: Influence of age, gestational age, gender and methodological procedures

Journal of Pediatric Endocrinology and Metabolism

Volumn 23, Issue 1-2, 2010, Pages 121-132

  Ballerini, María Gabriela ^a   Chiesa, Ana ^a   Scaglia, Paula ^a   Gruñeiro Papendieck, Laura ^a   Heinrich, Juan Jorge ^a   Ropelato, María Gabriela ^a  

^a HOSPITAL DE NIÑOS RICARDO GUTIÉRREZ   (Argentina)

Author keywords

17 hydroxyprogesterone; CAH; Cortisol; Preterm newborns; Reference ranges

Indexed keywords

HYDROCORTISONE; HYDROXYPROGESTERONE; DRUG DERIVATIVE; PROGESTERONE; PROGESTERONE 17 ALPHA HYDROPEROXIDE; PROGESTERONE 17 ALPHA-HYDROPEROXIDE;

ADRENAL FUNCTION; AGE; ARTICLE; BLOOD ANALYSIS; CHILD; CHRONOLOGY; CONGENITAL ADRENAL HYPERPLASIA; CONTROLLED STUDY; ENDOCRINE FUNCTION TEST; EXTRACTION; FEMALE; GENDER; GESTATIONAL AGE; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; HUMAN CELL; HYDROCORTISONE BLOOD LEVEL; HYDROXYPROGESTERONE BLOOD LEVEL; INFANT; MAJOR CLINICAL STUDY; MALE; NEWBORN; NEWBORN PERIOD; PREMATURITY; PRESCHOOL CHILD; RADIOIMMUNOASSAY; SEX DIFFERENCE; TERM BIRTH; ADRENAL GLAND; BLOOD; CLINICAL CHEMISTRY; GROWTH, DEVELOPMENT AND AGING; METHODOLOGY; PHYSIOLOGY; REFERENCE VALUE; STANDARD;

ADRENAL GLANDS; AGE FACTORS; CHEMISTRY, CLINICAL; CHILD, PRESCHOOL; FEMALE; GESTATIONAL AGE; HUMANS; HYDROCORTISONE; INFANT; INFANT, NEWBORN; INFANT, PREMATURE; MALE; PROGESTERONE; REFERENCE VALUES;

EID: 77950855106     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2010.23.1-2.121     Document Type: Article

References (33)

1. Speiser PW, White PC. Congenital adrenal hyperplasia. N Engl J Med 2003; 349: 776-788.
2. 2. Labarta JI, Bello E, Ruiz-Echarri M, Rueda C, Martul P, Mayayo E, Ferrandez Longas A. Childhood-onset congenital adrenal hyperplasia: long-term outcome and optimization of therapy. J Pediatr Endocrinol Metab 2004; 17 (Suppl 3): 411-422. (Pubitemid 38931041)
3. Hughes IA, Winter JS. The application of a serum 170H-progesterone radioimmunoassay to the diagnosis and management of congenital adrenal hyperplasia. J Pediatr 1976; 88: 766-773.
4. Makela SK, Ellis G. Nonspecificity of a direct 17 alpha- hydroxyprogesterone radioimmunoassay kit when used with samples from neonates. Clin Chem 1988; 34: 2070-2075.
5. Lee A, Ellis G. Serum 17 alpha-hydroxyprogesterone in infants and children as measured by a direct radioimmunoassay kit. Clin Biochem 1991; 24: 505-511.
6. Wong T, Shackleton CH, Covey TR, Ellis G. Identification of the steroids in neonatal plasma that interfere with 17 alpha-hydroxyprogesterone radioimmunoassays. Clin Chem 1992; 38: 1830-1837.
7. 7. Nahoul K. Plasma 17-hydroxyprogesterone determination with two commercial immunoassays. J Steroid Biochem Mol Biol 1994; 50: 197-203. (Pubitemid 24265234)
8. Castracane VD, Gimpel T. Comparison of three methods for 17 alpha-hydroxyprogesterone. J Clin Lab Anal 1997; 11: 179-185.
9. Mesiano S, Jaffe RB. Regulation of growth and function of human fetal adrenal. In: Saez JM, et al., eds. Cellular and Molecular Biology of the Adrenal Cortex. London: John Libby and Company, 1992; 235-245.
10. Ramayya MS. Adrenal organogenesis and steroidogenesis. Role of nuclear receptor steroidogenic factor1, DAX-1, and estrogen receptor. In: Margioris AN, Chrousos GP, eds. Adrenal Disorders. Totowa, NJ: Humana Press, 2001; 11-44.
11. Linder N, Davidovitch N, Kogan A, Barzilai A, Kuint J, Mazkeret R, Sack J. Longitudinal measurements of 17alpha-hydroxyprogesterone in premature infants during the first three months of life. Arch Dis Child Fetal Neonatal Ed 1999; 81: 175-178.
12. Taylor AE, Khoury RH, Crowley WF Jr. A comparison of 13 different immunometric assay kits for gonadotropins: implications for clinical investigation. J Clin Endocrinol Metab 1994; 79: 240-247.
13. 13. Grufieiro de Papendiek L, Prieto L, Chiesa A, Bengolea S, Bergada C. Congenital adrenal hyperplasia and early newborn screening: 17α- hydroxyprogesterone (17α-OHP) during the first days of life. J Med Screen 1998; 5: 24-26. (Pubitemid 28272354)
14. 14. Grufieiro de Papendiek L, Prieto L, Chiesa A, Bengolea S, Bossi G, Bergada C. Neonatal screening program for congenital adrenal hyperplasia: adjustments to the recall protocol. Horm Res 2001; 55: 271-277. (Pubitemid 34114173)
15. 15. Honour J, Torresani T. Evaluation of neonatal screening for congenital adrenal hyperplasia. Horm Res 2001; 55: 206-211. (Pubitemid 34701725)
16. 16. Gruñieiro-Papendieck L, Chiesa A, Mendez V, Prieto. Neonatal screening for congenital adrenal hyperplasia: experience and results in Argentina. J Pediatr Endocrinol Metab 2008; 21: 73-78. (Pubitemid 351350844)
17. Pang S. Congenital adrenal hyperplasia. Baillieres Clin Obstet Gynaecol 1997; 11: 281-306.
18. Wudy SA, Hartmann M, Svoboda M. Determination of 17-hydroxyprogesterone in plasma by stable isotope dilution/benchtop liquid chromatography-tandem mass spectrometry. Horm Res 2000; 53: 68-71.
19. 19. Turpeinen U, Itkonen O, Ahola L, Stenman UH. Determination of 17alpha-hydroxyprogesterone in serum by liquid chromatography-tandem mass spectrometry and immunoassay. Scand J Clin Lab Invest 2005; 65: 3-12. (Pubitemid 40278307)
20. Selby C. Interference in immunoassay. Ann Clin Biochem 1999; 36: 704-721.
21. al-Nuaim AR, Abdullah MA, Stevens B, Zain M. Effect of gender, birth weight and gestational age on serum 17-hydroxyprogesterone concentration and distribution among neonates in Saudi Arabia. Indian J Pediatr 1995; 62: 605-609.
22. 22. Bergadá I, Milani C, Bedecarrás P, Andreone L, Ropelato MG, Gottlieb S, Bergadá C, Campo S, Rey RA. Time course of the serum gonadotropin surge, inhibins, and anti-Mülllerian hormone in normal newborn males during the first month of life. J Clin Endocrinol Metab 2006; 91:4092-4098. (Pubitemid 44536890)
23. 23. Garagorri J, Rodriguez G, Lario-Elboj A, Olivares J, Lario-Mufioz A, Orden I. Reference levels for 17hydroxyprogesterone, 11-desoxycortisol, Cortisol, testosterone, dehydroepiandrosterone sulfate and androstenedione in infants from birth to six months of age. Eur J Pediatr 2008; 167: 647-653. (Pubitemid 351503500)
24. al Saedi S, Dean H, Dent W, Cronin C. Reference ranges for serum Cortisol and 17-hydroxyprogesterone levels in preterm infants. J Pediatr 1995; 126: 985-987.
25. Nordenström A, Wedell A, Hagenfeldt L, Marcus C, Larsson A. Neonatal screening for congenital adrenal hyperplasia. 17-Hydroxyprogesterone levels and CYP21 genotypes in preterm infants. Pediatrics 2001; 108 (Suppl 4): E68.
26. van der Kamp HJ, Oudshoorn CG, Elvers BH, van Baarle M, Otten BJ, Wit JM, Verkerk PH. Cutoff levels of 17-alpha-hydroxyprogesterone in neonatal screening for congenital adrenal hyperplasia should be based on gestational age rather than on birth weight. J Clin Endocrinol Metab 2005; 90: 3904-3907.
27. Martins PG, Procianoy RS. Cortisol and 17-alphahydroxy-progesterone levels in infants with refractory hypotension born at 30 weeks of gestation or less. Braz J Med Biol Res 2007; 40: 577-582.
28. 28. Rumsby G, Avey CJ, Conway GS, Honour JW. Genotype-phenotype analysis in late onset 21hydroxylase deficiency in comparison to the classical forms. Clin Endocrinol (Oxf) 1998; 48: 707-711. (Pubitemid 28289238)
29. 29. Lee MM, Rajagopalan L, Berg GJ, Moshang T Jr. Serum adrenal steroid concentrations in premature infants. J Clin Endocrinol Metab 1989; 69: 1133-1136. (Pubitemid 20010038)
30. Seron-Ferre M, Lawrence CC, Siiteri PK, Jaffe RB. Steroid production by definitive and fetal zones of the human fetal adrenal gland. J Clin Endocrinol Metab 1978; 47: 603-609.
31. 31. de Weerth C, Zijl R, Buitelaar J. Development of Cortisol circadian rhythm in infancy. Early Hum Dev 2003; 73: 39-52. (Pubitemid 37025684)
32. 32. Dotsch J, Hohenberger I, Riepe FG, Sippell WG, Dorr HG. Serum Cortisol and cortisone levels in newborns with congenital adrenal hyperplasia before the start of therapy. J Endocrinol Invest 2005; 28: 413-416. (Pubitemid 43162736)
33. Ng PC. Is there a "normal" range of serum Cortisol concentration for preterm infants? Pediatrics 2008; 122: 873-875.