Determination of 17-hydroxyprogesterone in plasma by stable isotope dilution/benchtop liquid chromatography-tandem mass spectrometry

Hormone Research

Volumn 53, Issue 2, 2000, Pages 68-71

  Wudy, Stefan A ^a   Hartmann, Michaela ^a   Svoboda, Michal ^b  

^a UNIVERSITY OF ULM   (Germany)

^b PE Biosystems   (Germany)

Author keywords

17 Hydroxyprogesterone; Mass spectrometry; Stable isotope; Steroid; Tandem mass spectrometry

Indexed keywords

HYDROXYPROGESTERONE; STEROID 21 MONOOXYGENASE;

ACCURACY; ADULT; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; HORMONE DETERMINATION; HUMAN; ISOTOPE DILUTION ASSAY; LIQUID CHROMATOGRAPHY; NEWBORN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; STEROID 21 MONOOXYGENASE DEFICIENCY; TANDEM MASS SPECTROMETRY; URINALYSIS;

EID: 0033818514     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000023516     Document Type: Article

References (11)

1. New MI, White PC, Pang S, Dupont B, Speiser PW: The adrenal hyperplasias; in Scriver CR, Beaudet AL, Sly WS, Valle D (eds): The Metabolic Basis of Inherited Disease. New York, McGraw-Hill, 1989, pp 1881-1917.
2. Middle JG: The quality assessment of steroid hormone assays; in Makin HLJ, Gower DB, Kirk DN (eds): Steroid Analysis. London, Blackie Academic & Professional, 1995, pp 647-696.
3. Wudy SA, Wachter UA, Homoki J, Teller WM: 17α-Hydroxyprogesterone, 4-androstenedione and testosterone profiled by routine stable isotope dilution/gas chromatography-mass spectrometry in plasma of children. Pediatr Res 1995;38:76-80.
4. Millington DM, Chace DH, Hillman SL, Kodo N, Terada N: Diagnosis of metabolic disease; in Matsuo T, Caprioli RM, Gross ML, Seyama Y (eds): Biological Mass Spectrometry: Present and Future. New York, McGraw-Hill, 1995, pp 1239-1277.
5. Levy H: Newborn screening by tandem mass spectrometry: A new era. Clin Chem 1998;44: 2401-2402.
6. Shimizu K, Yamaga N, Kohara H: Synthesis of deuterium-labeled 17-hydroxyprogesterone suitable as an internal standard for isotope dilution mass spectrometry. Steroids 1988;51: 283-297.
7. Wudy SA, Wachter UA, Homoki J, Teller WM, Shackleton CHL: Androgen metabolism assessment by routine gas chromatography/mass spectrometry profiling of plasma steroids. I. Unconjugated steroids. Steroids 1992;57:319-324.
8. Nimkarn S, Cerame BI, Wie JQ, Dumic M, Zuned R, Brkljacic L, Skrabic V, New M, Wilson R: Congenital adrenal hyperplasia (21-hydroxylase deficiency) without demonstrable genetic mutations. J Clin Endocrinol Metab 1999;84:378-381.
9. Rizea Savu S, Silvestro L, Haag A, Sörgel F: A confirmatory HPLC-MS/MS method for ten synthetic corticosteroids in bovine urines. J Mass Spectrom 1996;31:1351-1363.
10. Chang YS, Jang JS, Chung BC: Fast analysis of anabolic steroids in urine samples by electrospray ionization tandem mass spectrometry. Anal Lett 1996;29:1389-1397.
11. Bean KA, Henion JD: Direct determination of anabolic steroid conjugates in human urine by combined high-performance liquid chromatography and tandem mass spectrometry. J Chromatogr B Biomed Sci Appl 1997;690:65-75.