Impact of cyclin B2 and cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats

American Journal of Physiology - Renal Physiology

Volumn 298, Issue 4, 2010, Pages

  Nishihara, Kumiko ^a   Masuda, Satohiro ^a   Nakagawa, Shunsaku ^a   Yonezawa, Atsushi ^a   Ichimura, Takaharu ^b   Bonventre, Joseph V ^b   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Cell cycle; Hypertrophy; Microarray; Proximal tubule

Indexed keywords

2 CYANOETHYLALSTERPAULLONE; CYCLIN B2; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR; EVEROLIMUS; HISTONE H3; KI 67 ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE REGULATION; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; EPITHELIUM HYPERPLASIA; HISTOPATHOLOGY; KIDNEY TUBULE EPITHELIUM; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 77950834144     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00567.2009     Document Type: Article

References (46)

1. Bonventre JV. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol 14, Suppl 1: S55-S61, 2003.
2. Bottinger EP, Bitzer M. TGF-beta signaling in renal disease. J Am Soc Nephrol 13: 2600-2610, 2002.
3. Chen JK, Chen J, Neilson EG, Harris RC. Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy. J Am Soc Nephrol 16: 1384-1391, 2005.
4. Chen JK, Chen J, Thomas G, Kozma SC, Harris RC. S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy. Am J Physiol Renal Physiol 297: F585-F593, 2009.
5. Frazier KS, Paredes A, Dube P, Styer E. Connective tissue growth factor expression in the rat remnant kidney model and association with tubular epithelial cells undergoing transdifferentiation. Vet Pathol 37: 328-335, 2000.
6. Fung TK, Poon RYC. A roller coaster ride with the mitotic cyclins. Semin Cell Dev Biol 16: 335-342, 2005.
7. Fushimi K, Uchida S, Hara Y, Hirata Y, Marumo F, Sasaki S. Cloning and expression of apical membrane water channel of rat kidney collecting tubule. Nature 361: 549-552, 1993.
8. Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee WS, Hediger MA, Hebert SC. Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. J Biol Chem 269: 17713-17722, 1994.
9. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133: 1710-1715, 1984.
10. Harper JV, Brooks G. The mammalian cell cycle: an overview. Methods Mol Biol 296: 113-153, 2005.
11. Hayslett JP. Functional adaptation to reduction in renal mass. Physiol Rev 59: 137-164, 1979.
12. Hendzel MJ, Wei Y, Mancini MA, Van Hooser A, Ranalli T, Brinkley BR, Bazett-Jones DP, Allis CD. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106: 348-360, 1997.
13. Hori R, Okumura K, Kamiya A, Nihira H, Nakano H. Ampicillin and cephalexin in renal insufficiency. Clin Pharmacol Ther 34: 792-798, 1983.
14. Horiba N, Masuda S, Takeuchi A, Saito H, Okuda M, Inui K. Gene expression variance based on random sequencing in rat remnant kidney. Kidney Int 66: 29-45, 2004.
15. Hostetter TH, Olson JL, Rennke HG, Venkatachalam MA, Brenner BM. Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. Am J Physiol Renal Fluid Electrolyte Physiol 241: F85-F93, 1981.
16. Jackman M, Firth M, Pines J. Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus. EMBO J 14: 1646-1654, 1995.
17. Ji L, Masuda S, Saito H, Inui K. Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. Kidney Int 62: 514-524, 2002.
18. Kawachi H, Koike H, Kurihara H, Sakai T, Shimizu F. Cloning of rat homologue of podocin: expression in proteinuric states and in developing glomeruli. J Am Soc Nephrol 13: 46-56, 2003.
19. Kunick C, Zeng Z, Gussio R, Zaharevitz D, Leost M, Totzke F, Schachtele C, Kubbutat MH, Meijer L, Lemcke T. Structure-aided optimization of kinase inhibitors derived from alsterpaullone. Chembiochem 6: 541-549, 2005.
20. Kwon TH, Frokiaer J, Knepper MA, Nielsen S. Reduced AQP1, -2, and -3 levels in kidneys of rats with CRF induced by surgical reduction in renal mass. Am J Physiol Renal Physiol 275: F724-F741, 1998.
21. Lee CH, Inoki K, Guan KL. mTOR pathway as a target in tissue hypertrophy. Annu Rev Pharmacol Toxicol 47: 443-467, 2007.
22. Leonard MO, Cottell DC, Godson C, Brady HR, Taylor CT. The role of HIF-1alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia. J Biol Chem 278: 40296-40304, 2003.
23. Liu B, Preisig PA. Compensatory renal hypertrophy is mediated by a cell cycle-dependent mechanism. Kidney Int 62: 1650-1658, 2002.
24. Lloberas N, Cruzado JM, Franquesa M, Herrero-Fresneda I, Torras J, Alperovich G, Rama I, Vidal A, Grinyo JM. Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats. J Am Soc Nephrol 17: 1395-1404, 2006.
25. Martin SG, Berthelot-Grosjean M. Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle. Nature 459: 852-856, 2009.
26. Masuda S, Saito H, Nonoguchi H, Tomita K, Inui K. mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules. FEBS Lett 407: 127-131, 1997.
27. WAF1/CIP1 gene ameliorates progression to chronic renal failure. Proc Natl Acad Sci USA 96: 10830-10835, 1999.
28. Moseley JB, Mayeux A, Paoletti A, Nurse P. A spatial gradient coordinates cell size and mitotic entry in fission yeast. Nature 459: 857-860, 2009.
29. Nakagawa S, Masuda S, Nishihara K, Inui K. mTOR inhibitor everolimus ameliorates progressive tubular dysfunction in chronic renal failure rats. Biochem Pharmacol 79: 67-76, 2010.
30. Nishihara K, Masuda S, Ji L, Katsura T, Inui K. Pharmacokinetic significance of luminal multidrug and toxin extrusion 1 in chronic renal failure rats. Biochem Pharmacol 73: 1482-1490, 2007.
31. Price PM, Safirstein RL, Megyesi J. The cell cycle and acute kidney injury. Kidney Int 76: 604-613, 2009.
32. Satyanarayana A, Kaldis P. Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms. Oncogene 28: 2925-2939, 2009.
33. Shankland SJ, Wolf G. Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis. Am J Physiol Renal Physiol 278: F515-F529, 2000.
34. Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T. The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci USA 103: 5466-5471, 2006.
35. Shimamura T, Morrison AB. A progressive glomerulosclerosis occurring in partial five-sixths nephrectomized rats. Am J Pathol 79: 95-106, 1975.
36. Suzuki H, Inoue T, Matsushita T, Kobayashi K, Horii I, Hirabayashi Y, Inoue T. In vitro gene expression analysis of nephrotoxic drugs in rat primary renal cortical tubular cells. J Appl Toxicol 28: 237-248, 2008.
37. Taal MW, Zandi-Nejad K, Weening B, Shahsafaei A, Kato S, Lee KW, Ziai F, Jiang T, Brenner BM, MacKenzie HS. Proinflammatory gene expression and macrophage recruitment in the rat remnant kidney. Kidney Int 58: 1664-1676, 2000.
38. Takeuchi A, Masuda S, Saito H, Doi T, Inui K. Role of kidney-specific organic anion transporters in the urinary excretion of methotrexate. Kidney Int 60: 1058-1068, 2001.
39. Tao Y, Kim J, Schrier RW, Edelstein CL. Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease. J Am Soc Nephrol 16: 46-51, 2005.
40. Tsuji M, Monkawa T, Yoshino J, Asai M, Fukuda S, Kawachi H, Shimizu F, Hayashi M, Saruta T. Microarray analysis of a reversible model and an irreversible model of anti-Thy-1 nephritis. Kidney Int 69: 996-1004, 2006.
41. Weiland C, Ahr HJ, Vohr HW, Ellinger-Ziegelbauer H. Characterization of primary rat proximal tubular cells by gene expression analysis. Toxicol In Vitro 21: 466-491, 2007.
42. Kip1. Kidney Int 50: 2112-2119, 1996.
43. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. p21 is a universal inhibitor of cyclin kinases. Nature 366: 701-704, 1993.
44. Yamada M, Katsuma S, Adachi T, Hirasawa A, Shiojima S, Kadowaki T, Okuno Y, Koshimizu T, Fujii S, Sekiya Y, Miyamoto Y, Tamura M, Yumura W, Nihei H, Kobayashi M, Tsujimoto G. Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis. Proc Natl Acad Sci USA 102: 7736-7741, 2005.
45. Yang Y, Wang J, Qin L, Shou Z, Zhao J, Wang H, Chen Y, Chen J. Rapamycin prevents early steps of the development of diabetic nephropathy in rats. Am J Nephrol 27: 495-502, 2007.
46. +-coupled glucose transporters in adult and embryonic rat kidney. J Biol Chem 270: 29365-29371, 1995.