In vitro gene expression analysis of nephrotoxic drugs in rat primary renal cortical tubular cells

Journal of Applied Toxicology

Volumn 28, Issue 2, 2008, Pages 237-248

  Suzuki, Hiromi ^a   Inoue, Tomoaki ^a   Matsushita, Tomochika ^a   Kobayashi, Kazuko ^a   Horii, Ikuo ^b   Hirabayashi, Yoko ^c   Inoue, Tohru ^c  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Gene expression; In vitro; Kidney; Microarray; Nephrotoxicity; Primary culture

Indexed keywords

CARBOPLATIN; CEFALORIDINE; CISPLATIN; CYCLOSPORIN A; DICLOFENAC; GENTAMICIN; PLATINUM; ZINC;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; GENE CLUSTER; GENE EXPRESSION; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CELL; KIDNEY CORTEX SLICE; NEPHROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UNINDEXED SEQUENCE;

ANIMALS; CARBOPLATIN; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CEPHALORIDINE; CISPLATIN; CLUSTER ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEASIBILITY STUDIES; GENE EXPRESSION PROFILING; GENTAMICINS; KIDNEY TUBULES; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIME FACTORS; TOXICITY TESTS; TRANSCRIPTION, GENETIC;

RATTUS;

EID: 41149169675     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1329     Document Type: Article

References (34)

1. nd, Curtiss S, Naciff JM, Cunningham M, Tennant R, Stevens J, Car B, Bertram TA, Afshari CA. 2004. Identification of putative gene based markers of renal toxicity. Environ. Health Perspect. 112: 465-479.
2. Arany I, Megyesi JK, Kaneto H, Price PM, Safirstein RL. 2004. Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells. Am. J. Physiol. Renal Physiol. 287: F543-F549.
3. Asher G, Lotem J, Sachs L, Kahana C, Shaul Y. 2002. Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1. Proc. Natl Acad. Sci. USA 99: 13125-13130.
4. Borch RF, Pleasants ME. 1979. Inhibition of cis-platinum nephrotoxicity by diethyldithiocarbamate rescue in a rat model. Proc. Natl Acad. Sci. USA 76: 6611-6614.
5. Busauschina A, Schnuelle P, van der Woude FJ. 2004. Cyclosporine nephrotoxicity. Transplant Proc. 36(2 Suppl): 229S-233S.
6. Demeule M, Brossard M, Beliveau R. 1999. Cisplatin induces renal expression of P-glycoprotein and canalicular multispecific organic anion transporter. Am. J. Physiol. 277(6 Pt 2): F832-F840.
7. Durnam DM, Hoffman JS, Quaife CJ, Benditt EP, Chen HY, Brinster RL, Palmiter RD. 1984. Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones. Proc. Natl Acad. Sci. USA 81: 1053-1056.
8. Elliget KA, Trump BF. 1991. Primary cultures of normal rat kidney proximal tubule epithelial cells for studies of renal cell injury. In Vitro Cell. Dev. Biol. 27A: 739-748.
9. Francescato HD, Coimbra TM, Costa RS, Bianchi Mde L. 2004. Protective effect of quercetin on the evolution of cisplatin-induced acute tubular necrosis. Kidney Blood Press. Res. 27: 148-158.
10. Hickey EJ, Raje RR, Reid VE, Gross SM, Ray SD. 2001. Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death. Free Radic. Biol. Med. 31: 139-152.
11. Huang Q, Dunn RT, 2nd, Jayadev S, DiSorbo O, Pack FD, Farr SB, Stoll RE, Blanchard KT. 2001. Assessment of cisplatin-induced nephrotoxicity by microarray technology. Toxicol. Sci. 63: 196-207.
12. Husbeck B, Powis G. 2002. The redox protein thioredoxin-1 regulates the constitutive and inducible expression of the estrogen metabolizing cytochromes P450 1B1 and 1A1 in MCF-7 human breast cancer cells. Carcinogenesis 23: 1625-1630.
13. Jones DP, Sundby GB, Ormstad K, Orrenius S. 1979. Use of isolated kidney cells for study of drug metabolism. Biochem. Pharmacol. 28: 929-935.
14. Kawashima A, Lu Y, Horii I. 2001. High throughput in vitro toxicity testing using rat or monkey renal cortical epithelial cells - effects of cisplatin and carboplatin. The 39th Congress of the EUROTOX, Istanbul, Turkey. Elsevier: Amsterdam.
15. Klaassen CD (ed.). 2004. Casarett & Doull's Toxicology, 6th edn. McGraw-Hill Companies, Inc., Japanese translation through UNI Agency Tokyo; 968.
16. Lash LH, Tokarz JJ. 1989. Isolation of two distinct populations of cells from rat kidney cortex and their use in the study of chemical-induced toxicity. Anal. Biochem. 182: 271-279.
17. Luft FC, Patel V, Yum MN, Patel B, Kleit SA. 1975. Experimental aminoglycoside nephrotoxicity. J. Lab. Clin. Med. 86: 213-220.
18. Megyesi J, Udvarhelyi N, Safirstein RL, Price PM. 1996. The p53-independent activation of transcription of p21 WAF1/CIP1/SDI1 after acute renal failure. Am. J. Physiol. 271(6 Pt 2): F1211-F1216.
19. Moritz F, Marouillat S, Monteil C, Baudelot A, Fillastre JP, Bonmarchand G, Morin JP. 1995. Impact of cephaloridine on glutathione and related enzymes: comparison of in vivo and in vitro rat models. Arch. Toxicol. 70: 104-111.
20. Murray MD, Brater DC. 1993. Renal toxicity of the nonsteroidal antiinflammatory drugs. Annu. Rev. Pharmacol. Toxicol. 33: 435-465.
21. Perazella MA. 2002. COX-2 selective inhibitors: analysis of the renal effects. Expert Opin. Drug Saf. 1: 53-64.
22. Perazella MA. 2005. Drug-induced nephropathy: an update. Expert Opin. Drug Saf. 4: 689-706.
23. Price PM, Safirstein RL, Megyesi J. 2004. Protection of renal cells from cisplatin toxicity by cell cycle inhibitors. Am. J. Physiol. Renal Physiol. 286: F378-F384.
24. Rodilla V, Miles AT, Jenner W, Hawksworth GM. 1998. Exposure of cultured human proximal tubular cells to cadmium, mercury, zinc and bismuth: toxicity and metallothionein induction. Chem. Biol. Interact. 115: 71-83.
25. Saeed AI, Sharov V, White J, Li J, Liang W, Bhagabati N, Braisted J, Klapa M, Currier T, Thiagarajan M, Sturn A, Snuffin M, Rezantsev A, Popov D, Ryltsov A, Kostukovich E, Borisovsky I, Liu Z, Vinsavich A, Trush V, Quackenbush J. 2003. TM4: a free, open-source system for microarray data management and analysis. Biotechniques 34: 374-378.
26. Schaaf GJ, Maas RF, de Groene EM, Fink-Gremmels J. 2002. Management of oxidative stress by heme oxygenase-1 in cisplatin-induced toxicity in renal tubular cells. Free Radic. Res. 36: 835-843.
27. Shi L, Reid LH, Jones WD, Shippy R, Warrington JA, Baker SC, Collins PJ, de Longueville F, Kawasaki ES, Lee KY, Baker SC, et al. 2006. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat. Biotechnol. 24: 1151-1161.
28. Smets FN, Chen Y, Wang LJ, Soriano HE. 2002. Loss of cell anchorage triggers apoptosis (anoikis) in primary mouse hepatocytes. Mol. Genet. Metab. 75: 344-352.
29. Thompson KL, Afshari CA, Amin RP, Bertram TA, Car B, Cunningham M, Kind C, Kramer JA, Lawton M, Mirsky M, Naciff JM, Oreffo V, Pine PS, Sistare FD. 2004. Identification of platform-independent gene expression markers of cisplatin nephrotoxicity. Environ. Health Perspect. 112: 488-494.
30. Tune BM. 1997. Nephrotoxicity of beta-lactam antibiotics: mechanisms and strategies for prevention. Pediatr. Nephrol. 11: 768-772.
31. Wachsmuth ED. 1981. Nephrotoxicity of cefotiam (CGP 14221/E) in rats and rabbits. Arch. Toxicol. 48: 135-156.
32. Walker PD, Barri Y, Shah SV. 1999. Oxidant mechanisms in gentamicin nephrotoxicity. Ren. Fail. 21: 433-442.
33. Wolfgang GH, Dominick MA, Walsh KM, Hoeschele JD, Pegg DG. 1994. Comparative nephrotoxicity of a novel platinum compound, cisplatin, and carboplatin in male Wistar rats. Fundam. Appl. Toxicol. 22: 73-79.
34. Zhou H, Kato A, Yasuda H, Miyaji T, Fujigaki Y, Yamamoto T, Yonemura K, Hishida A. 2004. The induction of cell cycle regulatory and DNA repair proteins in cisplatin-induced acute renal failure. Toxicol. Appl. Pharmacol. 200: 111-120.