Impulsivity, gender, and the platelet serotonin transporter in healthy subjects

Neuropsychiatric Disease and Treatment

Volumn 6, Issue 1, 2010, Pages 9-15

  Marazziti, Donatella ^a   Baroni, Stefano ^a   Masala, Irene ^a   Golia, Francesca ^a   Consoli, Giorgio ^a   Massimetti, Gabriele ^a   Picchetti, Michela ^a   Dell'Osso, Mario Catena ^a   Giannaccini, Gino ^a   Betti, Laura ^a   Lucacchini, Antonio ^a   Ciapparelli, Antonio ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Barratt impulsivity scale; Gender; Impulsivity; Platelets; Serotonin transporter

Indexed keywords

PAROXETINE; SEROTONIN TRANSPORTER;

ADULT; ARTICLE; COGNITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DENSITY; DISSOCIATION CONSTANT; FEMALE; GENDER; HUMAN; HUMAN EXPERIMENT; IMPULSIVENESS; MALE; NORMAL HUMAN; PROTEIN BINDING; PROTEIN BLOOD LEVEL; QUESTIONNAIRE; SEX DIFFERENCE; THROMBOCYTE MEMBRANE;

EID: 77950829909     PISSN: 11766328     EISSN: 11782021     Source Type: Journal    
DOI: None     Document Type: Article

References (73)

1. Evenden JL. Varieties of impulsivity. Psychopharmacology. 1999;146:348-361.
2. Olivier B. Serotonin and aggression. Ann N Y Acad Sci. 2004;1036: 382-392.
3. Linnoila M, Virkkunen M, Scheinin M, Nuutile A, Rimon R, Goodwin FK. Low cerebrospinal-fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from non-impulsive violent behavior. Life Sci. 1983;33:2609-2614.
4. Vergnes M, Depaulis A, Boehrer A. Parachlorophenylalanine-induced serotonin depletion increases offensive but not defensive aggression in male rats. Physiol Behav. 1986;36:653-658.
5. Coccaro EF, Kavoussi RJ. Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch Gen Psychiatry. 1997;54:1081-1088.
6. Harrison AA, Everitt BJ, Robbins TW. Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: interactions with dopaminergic mechanisms. Psychopharmacology. 1997;133:329-342.
7. Harrison AA, Everitt BJ, Robbins TW. Central serotonin depletion impairs both the acquisition and performance of a symmetrically reinforced go/no-go conditional visual discrimination. Behav Brain Res. 1999;100:99-112.
8. Fairbanks LA, Melega WP, Jorgensen MJ, Kaplan JR, McGuire MT. Social impulsivity inversely associated with CSF 5-HIAA and fluoxetine exposure in vervet monkeys. Neuropsychopharmacology. 2001;24: 370-378.
9. Soubrié P. Reconciling the role of central serotonin neurons in human and animal behavior. Behav Brain Sci. 1986;9:319-364.
10. Highley JD, Linnoila M. Low central nervous system serotonergic activity is trait like and correlates with impulsive behavior. Ann N Y Acad Sci. 1997;836:39-56.
11. Kalenscher T, Ohmann T, Güntürkün O. The neuroscience of impulsive and self-controlled decisions. Int J Psychophysiol. 2006;62(2):203-211.
12. Serretti A, Mandelli L, Lorenzi C, et al. Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms. Neuropsychobiology. 2006;53:9-16.
13. Pattij T, Vanderschuren LJ. The neuropharmacology of impulsive behaviour. Trends Pharmacol Sci. 2008;29(4):192-199.
14. Saudou F, Amara DA, Dierich A, et al. Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science. 1994;265(5180):1875-1878.
15. Stark KL, Oosting RS, Hen R. Inducible knockout strategies to probe the functions of 5-HT receptors. Ann N Y Acad Sci. 1998;861:57-66.
16. Korpi ER, Kleinman JE, Goodman SI, et al. Serotonin and 5-hydroxyindoleacetic acid in brains of suicide victims. Comparison in chronic schizophrenic patients with suicide as cause of death. Arch Gen Psychiatry. 1986;43(6):594-600.
17. Arango V, Underwood MD, Boldrini M, et al. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology. 2001;25(6):892-903.
18. Oquendo MA, Russo SA, Underwood MD, et al. Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide. Biol Psychiatry. 2006;59(3):235-243.
19. 3H-paroxetine binding in cerebral cortex of suicide victims is partly due to fewer high affinity, non-transporter sites. J Neural Transm. 1996;103(11):1337-1350.
20. Arango V, Underwood MD, Mann JJ. Serotonin brain circuits involved in major depression and suicide. Prog Brain Res. 2002;136:443-453.
21. Asberg M, Träskman L, Thorén P. 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry. 1976;33(10):1193-1197.
22. Mann JJ, Malone KM. Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients. Biol Psychiatry. 1997;41(2):162-171.
23. Träskman-Bendz L, Asberg M, Schalling D. Serotonergic function and suicidal behavior in personality disorders. Ann N Y Acad Sci. 1986;487:168-174.
24. Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF. Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res. 1979;1(2):131-139.
25. Brown GL, Ebert MH, Goyer PF, et al. Aggression, suicide, and serotonin: relationships to CSF amine metabolites. Am J Psychiatry. 1982;139(6):741-746.
26. Limson R, Goldman D, Roy A, et al. Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls. Arch Gen Psychiatry. 1991;48(5):437-441.
27. Virkkunen M, Goldman D, Linnoila M. Serotonin in alcoholic violent offenders. Ciba Found Symp. 1996;194:168-182.
28. Coccaro EF, Siever LJ, Klar HM, et al. Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior. Arch Gen Psychiatry. 1989;46(7):587-599.
29. Coccaro EF, Berman ME, Kavoussi RJ, Hauger RL. Relationship of prolactin response to d-fenfluramine to behavioral and questionnaire assessments of aggression in personality-disordered men. Biol Psychiatry. 1996;40(3):157-164.
30. Coccaro EF, Kavoussi RJ, Cooper TB, Hauger RL. Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects. Am J Psychiatry. 1997;154(10):1430-1435.
31. Coccaro EF, Kavoussi RJ, Trestman RL, Gabriel SM, Cooper TB, Siever LJ. Serotonin function in human subjects: intercorrelations among central 5-HT indices and aggressiveness. Psychiatry Res. 1997;73(1-2):1-14.
32. Moss HB, Yao JK, Panzak GL. Serotonergic responsivity and behavioral dimensions in antisocial personalità disorder with substance abuse. Biol Psychiatry. 1990;28(4):325-338.
33. O'Keane V, Moloney E, O'Neill H, O'Connor A, Smith C, Dinan TG. Blunted prolactin responses to d-fenfluramine in sociopathy. Evidence for subsensitivity of central serotonergic function. Br J Psychiatry. 1992;160:643-646.
34. Soloff PH, Kelly TM, Strotmeyer SJ, Malone KM, Mann JJ. Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder. Psychiatry Res. 2003;119(1-2):11-24.
35. Cloninger CR, Przybeck TR, Svrakic DM, Wetzel RD. The Temperament and Character Inventory (TCI): A guide to its development and use. St. Luise, MO: Center for Psychobiology of Personality, Washington University; 1994.
36. Cleare AJ, Bond AJ. Does central serotonergic function correlate inversely with aggression? A study using D-fenfluramine in healthy subjects. Psychiatry Res. 1997;69(2-3):89-95.
37. Evans J, Platts H, Lightman S, Nutt D. Impulsiveness and the prolactin response to d-fenfluramine. Psychopharmacology (Berl). 2000;149(2):147-152.
38. Gerra G, Zaimovic A, Timpano M, Zambelli U, Delsignore R, Brambilla F. Neuroendocrine correlates of temperamental traits in humans. Psychoneuroendocrinology. 2000;25(5):479-496.
39. Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol. 1995;51(6):768-774.
40. Coccaro EF, Bergeman CS, McClearn GE. Heritability of irritable impulsiveness: a study of twins reared together and apart. Psychiatry Res. 1993;48(3):229-242.
41. Livesley WJ, Jang KL, Vernon PA. Phenotypic and genetic structure of traits delineating personality disorder. Arch Gen Psychiatry. 1998;55(10):941-948.
42. Lesch KP, Wolozin BL, Murphy DL, Reiderer P. Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem. 1993;60(6):2319-2322.
43. Qian Y, Melikian HE, Rye DB, Levey AI, Blakely RD. Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. J Neurosci. 1995;15(2):1261-1274.
44. Coccaro EF, Kavoussi RJ, Sheline YI, Lish JD, Csernansky JG. Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet. Arch Gen Psychiatry. 1996;53(6):531-536.
45. 3H]paroxetine binding sites in suicide attempters. Psychiatry Res. 2001;103(2-3):125-131.
46. Reist C, Mazzanti C, Vu R, Tran D, Goldman D. Serotonin transporter promoter polymorphism is associated with attenuated prolactin response to fenfluramine. Am J Med Genet. 2001;105(4):363-368.
47. Mazzanti CM, Lappalainen J, Long JC, et al. Role of the serotonin transporter promoter polymorphism in anxiety-related traits. Arch Gen Psychiatry. 1998;55(10):936-940.
48. Lesch KP, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274(5292):1527-1531.
49. Greenberg BD, Li Q, Lucas FR, et al. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet. 2000;96(2): 202-216.
50. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition (SCID-I P, Version 2.0, 4 97 revision). New York, NY: Biometrics Research, New York State Psychiatric Institute; 1997.
51. Fossati A, di Ceglie A, Acquarini E, Barratt ES. Psychometric properties of an Italian version of the Barratt Impulsiveness Scale-11 (BIS-11) in nonclinical subjects. J Clin Psychol. 2001;57(6):815-828.
52. 3H-paroxetine binding in obsessive-compulsive patients. Neuropsychobiology. 1996;34:184-187.
53. Peterson GL. A simplification of the protein assay method of Lowry et al which is more generally applicable. Anal Biochem. 1977;83:356-366.
54. White JL, Moffitt TE, Caspi A, Bartusch DJ, Needles DJ, Stouthamer-Loeber M. Measuring impulsivity and examining its relationship to delinquency. J Abnorm Psychol. 1994;103(2):192-205.
55. Lane S, Cherek DR, Rhodes HM, Pietras CJ, Techeremissine OV. Relationships among laboratory and psychometric measures of impulsivity: implications in substance abuse and dependence. Addict Disord Their Treat. 2003;2:33-40.
56. Reynolds B, Ortengren A, Richards JB, de Wit H. Dimensions of impulsive behaviour: personality and behavioural measures. Pers Indiv Dif. 2006;40:305-315.
57. Feingold A. Gender differences in personality: a meta-analysis. Psychol Bull. 1994;116(3):429-456.
58. Stoltenberg SF, Batien BD, Birgenheir DG. Does gender moderate associations among impulsivity and health-risk behaviors? Addict Behav. 2008;33(2):252-265.
59. Waldeck TL, Miller LS. Gender and impulsivity differences in licit substance use. J Subst Abuse. 1997;9:269-275.
60. Granö N, Keltikangas-Järvinen L, Kouvonen A, et al. Impulsivity as a predictor of newly diagnosed depression. Scand J Psychol. 2007;48(2):173-179.
61. Caspi A, Begg D, Dickson N, et al. Personality differences predict health-risk behaviors in young adulthood: evidence from a longitudinal study. J Pers Soc Psychol. 1997;73(5):1052-1063.
62. Gerald MS, Higley JD. Evolutionary underpinnings of excessive alcohol consumption. Addiction. 2002;97(4):415-425.
63. Oades RD, Slusarek M, Velling S, Bondy B. Serotonin platelet-transporter measures in childhood attention-deficit/hyperactivity disorder (ADHD): clinical versus experimental measures of impulsivity. World J Biol Psychiatry. 2002;3(2):96-100.
64. Hollander E, Stein DJ, DeCaria CM, et al. Serotonergic sensitivity in borderline personality disorder: preliminary findings. Am J Psychiatry. 1994;151(2):277-280.
65. Stein DJ, Hollander E, DeCaria CM, Simeon D, Cohen L, Aronowitz B. m-Chlorophenylpiperazine challenge in borderline personality disorder: relationship of neuroendocrine response, behavioral response, and clinical measures. Biol Psychiatry. 1996;40(6):508-513.
66. Martial J, Paris J, Leyton M, et al. Neuroendocrine study of serotonin function in female borderline personalità disorder patients: a pilot study. Biol Psychiatry. 1997;42(8):737-739.
67. New AS, Trestman RL, Mitropoulou V, et al. Serotonergic function and self-injurious behavior in personality disorder patients. Psychiatry Res. 1997;69(1):17-26.
68. Ruegg RG, Gilmore J, Ekstrom RD, et al. Clomipramine challenge responses covary with Tridimensional Personality Questionnaire scores in healthy subjects. Biol Psychiatry. 1997;42(12):1123-1129.
69. Manuck SB, Flory JD, McCaffery JM, Matthews KA, Mann JJ, Muldoon MF. Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. Neuropsychopharmacology. 1998;19(4):287-299.
70. Askenazy F, Caci H, Myquel M, Darcourt G, Lecrubier Y. Relationship between impulsivity and platelet serotonin content in adolescents. Psychiatry Res. 2000;94(1):19-28.
71. Paaver M, Kurrikoff T, Nordquist N, Oreland L, Harro J. The effect of 5-HTT gene promoter polymorphism on impulsivity depends on family relations in girls. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(5):1263-1268.
72. Walderhaug E, Lunde H, Nordvik JE, Landrø NI, Refsum H, Magnusson A. Lowering of serotonin by rapid tryptophan depletion increases impulsiveness in normal individuals. Psychopharmacology (Berl). 2002;164(4):385-391.
73. Walderhaug E, Magnusson A, Neumeister A, et al. Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people. Biol Psychiatry. 2007;62(6):593-599.