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Volumn 298, Issue 5, 2010, Pages

Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous system

Author keywords

Glucagon like peptide 1; Glycemia

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLUCOSE; GUANETHIDINE; HEXAMETHONIUM;

EID: 77950820188     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00464.2009     Document Type: Article
Times cited : (52)

References (43)
  • 1
    • 12244275009 scopus 로고    scopus 로고
    • GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes
    • DOI 10.1055/s-2004-826178
    • Ahren B, Schmitz O. GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes. Horm Metab Res 36: 867-876, 2004. (Pubitemid 40115912)
    • (2004) Hormone and Metabolic Research , vol.36 , Issue.11-12 , pp. 867-876
    • Ahren, B.1    Schmitz, O.2
  • 2
    • 0036257214 scopus 로고    scopus 로고
    • Exendin-4, a GLP-1 receptor agonist, modulates the effect of macronutrients on food intake by rats
    • Aziz A, Anderson GH. Exendin-4, a GLP-1 receptor agonist, modulates the effect of macronutrients on food intake by rats. J Nutr 132: 990-995, 2002.
    • (2002) J Nutr , vol.132 , pp. 990-995
    • Aziz, A.1    Anderson, G.H.2
  • 4
    • 0032714917 scopus 로고    scopus 로고
    • Neural contribution to the effect of glucagon-like peptide-1-(7-36) amide on arterial blood pressure in rats
    • Barragan JM, Eng J, Rodriguez R, Blazquez E. Neural contribution to the effect of glucagon-like peptide-1-(7-36) amide on arterial blood pressure in rats. Am J Physiol Endocrinol Metab 277: E784-E791, 1999.
    • (1999) Am J Physiol Endocrinol Metab , vol.277
    • Barragan, J.M.1    Eng, J.2    Rodriguez, R.3    Blazquez, E.4
  • 5
    • 0030583731 scopus 로고    scopus 로고
    • Interactions of exendin-(9-39) with the effects of glucagon-like peptide-1-(7-36) amide and of exendin-4 on arterial blood pressure and heart rate in rats
    • DOI 10.1016/S0167-0115(96)00113-9, PII S0167011596001139
    • Barragan JM, Rodriguez RE, Eng J, Blazquez E. Interactions of exendin-(9-39) with the effects of glucagon-like peptide-1-(7-36) amide and of exendin-4 on arterial blood pressure and heart rate in rats. Regul Pept 67: 63-68, 1996. (Pubitemid 26384196)
    • (1996) Regulatory Peptides , vol.67 , Issue.1 , pp. 63-68
    • Barragan, J.M.1    Rodriguez, R.E.2    Eng, J.3    Blazquez, E.4
  • 6
    • 73249132605 scopus 로고    scopus 로고
    • Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats
    • Barrera JG, D'Alessio DA, Drucker DJ, Woods SC, Seeley RJ. Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats. Diabetes 58: 2820-2827, 2009.
    • (2009) Diabetes , vol.58 , pp. 2820-2827
    • Barrera, J.G.1    D'Alessio, D.A.2    Drucker, D.J.3    Woods, S.C.4    Seeley, R.J.5
  • 7
    • 2442636816 scopus 로고    scopus 로고
    • Glucagon-like peptide 1: Evolution of an incretin into a treatment for diabetes
    • D'Alessio DA, Vahl TP Glucagon-like peptide 1: evolution of an incretin into a treatment for diabetes. Am J Physiol Endocrinol Metab 286: E882-E890, 2004.
    • (2004) Am J Physiol Endocrinol Metab , vol.286
    • D'Alessio, D.A.1    Vahl, T.P.2
  • 8
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab 3: 153-165, 2006.
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 9
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368: 1696-1705, 2006.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Ma, N.2
  • 11
    • 0026648961 scopus 로고
    • Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
    • Eng J, Kleinman WA, Singh L, Singh G, Raufman JP. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem 267: 7402-7405, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 7402-7405
    • Eng, J.1    Kleinman, W.A.2    Singh, L.3    Singh, G.4    Raufman, J.P.5
  • 12
    • 4644300651 scopus 로고    scopus 로고
    • Effectiveness of progressive dose-escalation of exenatide (exendin-4) in reducing dose-limiting side effects in subjects with type 2 diabetes
    • Fineman MS, Shen LZ, Taylor K, Kim DD, Baron AD. Effectiveness of progressive dose-escalation of exenatide (exendin-4) in reducing dose-limiting side effects in subjects with type 2 diabetes. Diabetes Metab Res Rev 20: 411-417, 2004.
    • (2004) Diabetes Metab Res Rev , vol.20 , pp. 411-417
    • Fineman, M.S.1    Shen, L.Z.2    Taylor, K.3    Kim, D.D.4    Baron, A.D.5
  • 13
    • 40649124452 scopus 로고    scopus 로고
    • The intravenous glucose tolerance test in cannulated Wistar rats: A robust method for the in vivo assessment of glucose-stimulated insulin secretion
    • Frangioudakis G, Gyte AC, Loxham SJ, Poucher SM. The intravenous glucose tolerance test in cannulated Wistar rats: a robust method for the in vivo assessment of glucose-stimulated insulin secretion. J Pharmacol Toxicol Methods 57: 106-113, 2008.
    • (2008) J Pharmacol Toxicol Methods , vol.57 , pp. 106-113
    • Frangioudakis, G.1    Gyte, A.C.2    Loxham, S.J.3    Poucher, S.M.4
  • 14
    • 42949089309 scopus 로고    scopus 로고
    • Autonomic nervous system-dependent and -independent cardiovascular effects of exendin-4 infusion in conscious rats
    • Gardiner SM, March JE, Kemp PA, Bennett T. Autonomic nervous system-dependent and -independent cardiovascular effects of exendin-4 infusion in conscious rats. Br J Pharmacol 154: 60-71, 2008.
    • (2008) Br J Pharmacol , vol.154 , pp. 60-71
    • Gardiner, S.M.1    March, J.E.2    Kemp, P.A.3    Bennett, T.4
  • 15
    • 31144446219 scopus 로고    scopus 로고
    • Mesenteric vasoconstriction and hindquarters vasodilatation accompany the pressor actions of exendin-4 in conscious rats
    • DOI 10.1124/jpet.105.093104
    • Gardiner SM, March JE, Kemp PA, Bennett T. Mesenteric vasoconstriction and hindquarters vasodilatation accompany the pressor actions of exendin-4 in conscious rats. J Pharmacol Exp Ther 316: 852-859, 2006. (Pubitemid 43131015)
    • (2006) Journal of Pharmacology and Experimental Therapeutics , vol.316 , Issue.2 , pp. 852-859
    • Gardiner, S.M.1    March, J.E.2    Kemp, P.A.3    Bennett, T.4
  • 16
    • 15444380712 scopus 로고    scopus 로고
    • Exenatide (exendin-4) improves insulin sensitivity and {beta}-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight
    • DOI 10.1210/en.2004-1349
    • Gedulin BR, Nikoulina SE, Smith PA, Gedulin G, Nielsen LL, Baron AD, Parkes DG, Young AA. Exenatide (exendin-4) improves insulin sensitivity and {beta}-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight. Endocrinology 146: 2069-2076, 2005. (Pubitemid 40396918)
    • (2005) Endocrinology , vol.146 , Issue.4 , pp. 2069-2076
    • Gedulin, B.K.1    Nikoulina, S.E.2    Smith, P.A.3    Gedulin, G.4    Nielsen, L.L.5    Baron, A.D.6    Parkes, D.G.7    Young, A.A.8
  • 17
    • 0027184119 scopus 로고
    • Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin- Secreting beta-cells
    • Göke R, Fehmann HC, Linn T, Schmidt H, Krause M, Eng J, Göke B. Exendin-4 is a high potency agonist and truncated exendin-(9 -39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. J Biol Chem 268: 19650-19655, 1993. (Pubitemid 23270754)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.26 , pp. 19650-19655
    • Goke, R.1    Fehmann, H.-C.2    Linn, T.3    Schmidt, H.4    Krause, M.5    Eng, J.6    Goke, B.7
  • 18
    • 0032932825 scopus 로고    scopus 로고
    • Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations
    • Greig NH, Holloway HW, De Ore KA, Jani D, Wang Y, Zhou J, Garant MJ, Egan JM. Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations. Diabetologia 42: 45-50, 1999.
    • (1999) Diabetologia , vol.42 , pp. 45-50
    • Greig, N.H.1    Holloway, H.W.2    De Ore, K.A.3    Jani, D.4    Wang, Y.5    Zhou, J.6    Garant, M.J.7    Egan, J.M.8
  • 19
    • 26944477362 scopus 로고    scopus 로고
    • Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: A randomized trial
    • Heine RJ, Van Gaal LF, Johns D, Mihm MJ, Widel MH, Brodows RG. Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized trial. Ann Intern Med 143: 559-569, 2005.
    • (2005) Ann Intern Med , vol.143 , pp. 559-569
    • Heine, R.J.1    Van Gaal, L.F.2    Johns, D.3    Mihm, M.J.4    Widel, M.H.5    Brodows, R.G.6
  • 20
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • Kieffer TJ, McIntosh CH, Pederson RA. Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 136: 3585-3596, 1995.
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.2    Pederson, R.A.3
  • 22
    • 0036896243 scopus 로고    scopus 로고
    • The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness
    • Kinzig KP, D'Alessio DA, Seeley RJ. The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness. J Neurosci 22: 10470-10476, 2002.
    • (2002) J Neurosci , vol.22 , pp. 10470-10476
    • Kinzig, K.P.1    D'Alessio, D.A.2    Seeley, R.J.3
  • 26
    • 38449111196 scopus 로고    scopus 로고
    • Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice
    • Lamont BJ, Drucker DJ. Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice. Diabetes 57: 190-198, 2008.
    • (2008) Diabetes , vol.57 , pp. 190-198
    • Lamont, B.J.1    Drucker, D.J.2
  • 27
    • 52449129375 scopus 로고    scopus 로고
    • Exenatide prevents fat-induced insulin resistance and raises adiponectin expression and plasma levels
    • Li L, Yang G, Li Q, Tan X, Liu H, Tang Y, Boden G. Exenatide prevents fat-induced insulin resistance and raises adiponectin expression and plasma levels. Diabetes Obes Metab 10: 921-930, 2008.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 921-930
    • Li, L.1    Yang, G.2    Li, Q.3    Tan, X.4    Liu, H.5    Tang, Y.6    Boden, G.7
  • 28
    • 2542428084 scopus 로고    scopus 로고
    • Prolonged exendin-4 administration stimulates pituitary-adrenocortical axis of normal and streptozotocin-induced diabetic rats
    • Malendowicz LK, Neri G, Nussdorfer GG, Nowak KW, Zyterska A, Ziolkowska A. Prolonged exendin-4 administration stimulates pituitary-adrenocortical axis of normal and streptozotocin-induced diabetic rats. Int J Mol Med 12: 593-596, 2003.
    • (2003) Int J Mol Med , vol.12 , pp. 593-596
    • Malendowicz, L.K.1    Neri, G.2    Nussdorfer, G.G.3    Nowak, K.W.4    Zyterska, A.5    Ziolkowska, A.6
  • 29
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 214: 829-835, 1993.
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 30
    • 10244241840 scopus 로고    scopus 로고
    • Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: Evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake
    • Navarro M, Rodriquez de Fonseca F, Alvarez E, Chowen JA, Zueco JA, Gomez R, Eng J, Blázquez E. Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. J Neurochem 67: 1982-1991, 1996.
    • (1996) J Neurochem , vol.67 , pp. 1982-1991
    • Navarro, M.1    Rodriquez De Fonseca, F.2    Alvarez, E.3    Chowen, J.A.4    Zueco, J.A.5    Gomez, R.6    Eng, J.7    Blázquez, E.8
  • 31
    • 0035340019 scopus 로고    scopus 로고
    • Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro
    • Parkes DG, Pittner R, Jodka C, Smith P, Young A. Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro. Metabolism 50: 583-589, 2001.
    • (2001) Metabolism , vol.50 , pp. 583-589
    • Parkes, D.G.1    Pittner, R.2    Jodka, C.3    Smith, P.4    Young, A.5
  • 33
    • 0014040284 scopus 로고
    • A receptor mechanism for the inhibition of insulin release by epinephrine in man
    • Porte D Jr. A receptor mechanism for the inhibition of insulin release by epinephrine in man. J Clin Invest 46: 86-94, 1967.
    • (1967) J Clin Invest , vol.46 , pp. 86-94
    • Porte Jr., D.1
  • 34
    • 50949094723 scopus 로고    scopus 로고
    • Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake
    • Sandoval DA, Bagnol D, Woods SC, D'Alessio DA, Seeley RJ. Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. Diabetes 57: 2046-2054, 2008.
    • (2008) Diabetes , vol.57 , pp. 2046-2054
    • Sandoval, D.A.1    Bagnol, D.2    Woods, S.C.3    D'Alessio, D.A.4    Seeley, R.J.5
  • 35
    • 0034652302 scopus 로고    scopus 로고
    • The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride
    • Seeley RJ, Blake K, Rushing PA, Benoit S, Eng J, Woods SC, D'Alessio D. The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride. J Neurosci 20: 1616-1621, 2000.
    • (2000) J Neurosci , vol.20 , pp. 1616-1621
    • Seeley, R.J.1    Blake, K.2    Rushing, P.A.3    Benoit, S.4    Eng, J.5    Woods, S.C.6    D'Alessio, D.7
  • 39
    • 0036381989 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice
    • Wang Q, Brubaker PL. Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice. Diabetologia 45: 1263-1273, 2002.
    • (2002) Diabetologia , vol.45 , pp. 1263-1273
    • Wang, Q.1    Brubaker, P.L.2
  • 40
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF, Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48: 2270-2276, 1999.
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 41
    • 0345726358 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites
    • Yamamoto H, Kishi T, Lee CE, Choi BJ, Fang H, Hollenberg AN, Drucker DJ, Elmquist JK. Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci 23: 2939-2946, 2003.
    • (2003) J Neurosci , vol.23 , pp. 2939-2946
    • Yamamoto, H.1    Kishi, T.2    Lee, C.E.3    Choi, B.J.4    Fang, H.5    Hollenberg, A.N.6    Drucker, D.J.7    Elmquist, J.K.8
  • 43
    • 0032908654 scopus 로고    scopus 로고
    • Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    • Young AA, Gedulin BR, Bhavsar S, Bodkin N, Jodka C, Hansen B, Denaro M. Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes 48: 1026-1034, 1999.
    • (1999) Diabetes , vol.48 , pp. 1026-1034
    • Young, A.A.1    Gedulin, B.R.2    Bhavsar, S.3    Bodkin, N.4    Jodka, C.5    Hansen, B.6    Denaro, M.7


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