A concise total synthesis of (+)-tetrabenazine and (+)-α- dihydrotetrabenazine

Chemistry - A European Journal

Volumn 16, Issue 15, 2010, Pages 4623-4628

  Paek, Seung Mann ^a   Kim, Nam Jung ^a   Shin, Dongyun ^b   Jung, Jae Kyung ^c   Jung, Jong Wha ^a   Chang, Dong Jo ^a   Moon, Hyunyoung ^a   Suh, Young Ger ^a  

^a Seoul National University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c Chungbuk National University   (South Korea)

Author keywords

Bentazines; Claisen rearrangement; Rearrangement; Total synthesis

Indexed keywords

ACTIVE METABOLITES; ASYMMETRIC TOTAL SYNTHESIS; AZA-CLAISEN REARRANGEMENT; CARBON FRAMEWORK; CLAISEN REARRANGEMENT; DIHYDROTETRABENAZINE; HUNTINGTON'S DISEASE; STEREOGENIC CENTERS; SYNTHETIC ROUTES; TOTAL SYNTHESIS;

ETHERS;

SYNTHESIS (CHEMICAL);

DIHYDROTETRABENAZINE; DRUG DERIVATIVE; TETRABENAZINE;

ARTICLE; BENTAZINES; CHEMICAL STRUCTURE; CHEMISTRY; CHOLERA; CLAISEN REARRANGEMENT; HUNTINGTON CHOREA; REARRANGEMENT; STEREOISOMERISM; SYNTHESIS; TOTAL SYNTHESIS;

BENTAZINES; CLAISEN REARRANGEMENT; REARRANGEMENT; TOTAL SYNTHESIS;

CHOLERA; HUNTINGTON DISEASE; MOLECULAR STRUCTURE; STEREOISOMERISM; TETRABENAZINE;

EID: 77950818724     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200902591     Document Type: Article

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53. Two TBZ molecules were co-crystallized and one TBZ molecule is shown. For details see the Supporting Information.