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Volumn 9, Issue 2, 2007, Pages 109-122

Immunomodulation and antitumor activity of a mushroom product, proflamin, isolated from Flammulina velutipes (W. Curt.: Fr.) singer (agaricomycetideae)

Author keywords

Antitumor effect; Cellular immunity; Combination therapy; EA6; Flammulina velutipes; Humoral immunity; Immunopotentiator; Macrophage; Medicinal mushrooms; Proflamin; Protein bound polysaccharide

Indexed keywords

ALANINE; AMINO ACID; ANTINEOPLASTIC AGENT; ARGININE; ASPARTIC ACID; CANCER VACCINE; CARBOHYDRATE; CONCANAVALIN A; GLUTAMIC ACID; GLUTARALDEHYDE; GLYCINE; GLYCOPROTEIN; HISTIDINE; ISOLEUCINE; LEUCINE; LYSINE; LYSOZYME; METHIONINE; PHENYLALANINE; PLANT EXTRACT; POLYSACCHARIDE; PROFLAMIN; PROLINE; SERINE; THREONINE; THYROXINE; UNCLASSIFIED DRUG; VALINE;

EID: 34347328146     PISSN: 15219437     EISSN: None     Source Type: Journal    
DOI: 10.1615/IntJMedMushr.v9.i2.20     Document Type: Article
Times cited : (18)

References (29)
  • 1
    • 0015077745 scopus 로고
    • Prospects for cryo-immunotherapy in cases of metastasizing carcinoma of the prostate
    • Ablin R. J., Soanes W. A., and Gonder M. J. 1971. Prospects for cryo-immunotherapy in cases of metastasizing carcinoma of the prostate. Cryobiology, 8, 271-279.
    • (1971) Cryobiology , vol.8 , pp. 271-279
    • Ablin, R.J.1    Soanes, W.A.2    Gonder, M.J.3
  • 3
    • 0023909810 scopus 로고
    • Current status and possible future of antitumor drugs with special reference to pharmacology of oriental medicine
    • Chihara G. 1988. Current status and possible future of antitumor drugs with special reference to pharmacology of oriental medicine. Yakugaku Zasshi, 108, 171-186.
    • (1988) Yakugaku Zasshi , vol.108 , pp. 171-186
    • Chihara, G.1
  • 4
    • 0014276973 scopus 로고
    • Further improvements in the plaque technique for detecting single antibody-forming cells
    • Cunningham A. J. and Szenberg A. 1968. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology, 14, 599-601.
    • (1968) Immunology , vol.14 , pp. 599-601
    • Cunningham, A.J.1    Szenberg, A.2
  • 5
    • 34347327373 scopus 로고
    • BCG immunotherapy: Efficacy on BCG-induced tumor immunity in guinea pigs with regional tumor and/or visceral micrometastases
    • Hersh, E, ed, Raven Press, New York, pp
    • Hanna M. G. and Peters L. C. 1978. BCG immunotherapy: efficacy on BCG-induced tumor immunity in guinea pigs with regional tumor and/or visceral micrometastases. In: Immunotherapy of Human Cancer, Hersh, E., ed., Raven Press, New York, pp. 111-129.
    • (1978) Immunotherapy of Human Cancer , pp. 111-129
    • Hanna, M.G.1    Peters, L.C.2
  • 6
    • 34347331527 scopus 로고    scopus 로고
    • An epidemiological study on relationship between decrease of cancer death rate and agricultural products
    • Hara M. and Hanaoka T. 2005. An epidemiological study on relationship between decrease of cancer death rate and agricultural products. Noukouken Tsushin, 1, 2-6.
    • (2005) Noukouken Tsushin , vol.1 , pp. 2-6
    • Hara, M.1    Hanaoka, T.2
  • 8
    • 0033659980 scopus 로고    scopus 로고
    • On biological activity of mushrooms
    • Ikekawa T. 2000. On biological activity of mushrooms. Biotherapy, 14, 945-951.
    • (2000) Biotherapy , vol.14 , pp. 945-951
    • Ikekawa, T.1
  • 9
    • 0000717250 scopus 로고    scopus 로고
    • Beneficial effects of edible and medicinal mushrooms on health care
    • Ikekawa T. 2001. Beneficial effects of edible and medicinal mushrooms on health care. Int J Med Mushr, 3, 291-298.
    • (2001) Int J Med Mushr , vol.3 , pp. 291-298
    • Ikekawa, T.1
  • 10
    • 34347338986 scopus 로고    scopus 로고
    • Ikekawa T. 2005. Cancer risk reduction by intake of mushrooms and clinical studies on EEM. Presented at 3rd International Medicinal Mushrooms Conference, Port Townsend, WA, Oct. 12-17. Int J Med Mushr, 7, 347.
    • Ikekawa T. 2005. Cancer risk reduction by intake of mushrooms and clinical studies on EEM. Presented at 3rd International Medicinal Mushrooms Conference, Port Townsend, WA, Oct. 12-17. Int J Med Mushr, 7, 347.
  • 11
    • 0020405291 scopus 로고
    • Studies on antitumor polysaccharides of Flammulina velutipes (Curt. ex Fr.) Sing. II. The structure of EA3 and further purification of EA5
    • Ikekawa T., Ikeda Y., Yoshioka Y., Nakanishi K., Yokoyama E., and Yamazaki E. 1982. Studies on antitumor polysaccharides of Flammulina velutipes (Curt. ex Fr.) Sing. II. The structure of EA3 and further purification of EA5. J Pharmacobiogyn, 5, 576-581.
    • (1982) J Pharmacobiogyn , vol.5 , pp. 576-581
    • Ikekawa, T.1    Ikeda, Y.2    Yoshioka, Y.3    Nakanishi, K.4    Yokoyama, E.5    Yamazaki, E.6
  • 13
    • 34347350432 scopus 로고    scopus 로고
    • Antitumor activity and immunopotentiation of EA6 isolated from Flammulina velutipes
    • 454 pp
    • Ikekawa T., Maruyama H., Sayama K., and Yoshida M. 2002. Antitumor activity and immunopotentiation of EA6 isolated from Flammulina velutipes. Jpn J Cancer Res, 93 (Suppl.), 454 pp.
    • (2002) Jpn J Cancer Res , vol.93 , Issue.SUPPL.
    • Ikekawa, T.1    Maruyama, H.2    Sayama, K.3    Yoshida, M.4
  • 15
  • 16
    • 0015576515 scopus 로고
    • Studies on antitumor activity of polysaccharides from Flammulina velutipes (Curt. ex Fr.) Sing
    • Ikekawa T., Yosioka Y., Emori M., Sano T., and Fukuoka F. 1973. Studies on antitumor activity of polysaccharides from Flammulina velutipes (Curt. ex Fr.) Sing. Cancer Chemother Rep (Part 1), 57, 85-86.
    • (1973) Cancer Chemother Rep , vol.57 , Issue.PART 1 , pp. 85-86
    • Ikekawa, T.1    Yosioka, Y.2    Emori, M.3    Sano, T.4    Fukuoka, F.5
  • 17
    • 33645504600 scopus 로고    scopus 로고
    • Antitumor effect of combination therapy of proflamin with cryosurgery of Meth-A fibrosarcoma in BALB/c mice
    • Maruyama H. and Ikekawa T. 2005a. Antitumor effect of combination therapy of proflamin with cryosurgery of Meth-A fibrosarcoma in BALB/c mice. Int J Med Mushr, 7, 561-567.
    • (2005) Int J Med Mushr , vol.7 , pp. 561-567
    • Maruyama, H.1    Ikekawa, T.2
  • 18
    • 20844459329 scopus 로고    scopus 로고
    • Combination therapy of transplanted Meth-A fibrosarcoma in BALB/c mice with protein-bound polysaccharide EA6 isolated from enokitake mushroom Flammulina velutipes (W. Curt.: Fr.) Singer and surgical excision
    • Maruyama H. and Ikekawa T. 2005b. Combination therapy of transplanted Meth-A fibrosarcoma in BALB/c mice with protein-bound polysaccharide EA6 isolated from enokitake mushroom Flammulina velutipes (W. Curt.: Fr.) Singer and surgical excision. Int J Med Mushr, 7, 213-220.
    • (2005) Int J Med Mushr , vol.7 , pp. 213-220
    • Maruyama, H.1    Ikekawa, T.2
  • 21
    • 0020415521 scopus 로고
    • Augmentation of antitumor activity by combined cryo-destruction of Sarcoma 180 and protein-bound polysaccharide, EA6, isolated from Flammulina velutipes (Curt. ex Fr.) Sing. in ICR mice
    • Ohkuma T., Otagiri K., Ikekawa T., and Tanaka S. 1982. Augmentation of antitumor activity by combined cryo-destruction of Sarcoma 180 and protein-bound polysaccharide, EA6, isolated from Flammulina velutipes (Curt. ex Fr.) Sing. in ICR mice. J Pharmacobiodyn, 5, 439-444.
    • (1982) J Pharmacobiodyn , vol.5 , pp. 439-444
    • Ohkuma, T.1    Otagiri, K.2    Ikekawa, T.3    Tanaka, S.4
  • 22
    • 0020609229 scopus 로고
    • Augmentation of host's immunity by combined cryodestruction of Sarcoma 180 and administration of protein-bound polysaccharide, EA6, isolated from Flammulina velutipes (Curt. ex Fr.) Sing. in ICR mice
    • Ohkuma T., Tanaka S., and Ikekawa T. 1983. Augmentation of host's immunity by combined cryodestruction of Sarcoma 180 and administration of protein-bound polysaccharide, EA6, isolated from Flammulina velutipes (Curt. ex Fr.) Sing. in ICR mice. J Pharmacobiodyn, 6, 88-95.
    • (1983) J Pharmacobiodyn , vol.6 , pp. 88-95
    • Ohkuma, T.1    Tanaka, S.2    Ikekawa, T.3
  • 23
    • 34347355715 scopus 로고
    • Immunomodulation of a new antitumor agent, proflamin (PRF). Proceedings of the Japanese Cancer Association
    • 125 pp
    • Okura A., Sawasaki Y., Naito K., Yoshida E., Arakawa H., and Ikekawa T. 1983. Immunomodulation of a new antitumor agent, proflamin (PRF). Proceedings of the Japanese Cancer Association. The 42nd Annual Meeting, 125 pp.
    • (1983) The 42nd Annual Meeting
    • Okura, A.1    Sawasaki, Y.2    Naito, K.3    Yoshida, E.4    Arakawa, H.5    Ikekawa, T.6
  • 24
    • 34347354586 scopus 로고    scopus 로고
    • Otagiri K. 1989a. Twenty-year study on antitumor activities of mushrooms. In: Immunomodification of EA6 and PRF. Nagano Prefecture Agricultural Technology Institute, ed., Nagano, Japan, pp. 51-52.
    • Otagiri K. 1989a. Twenty-year study on antitumor activities of mushrooms. In: Immunomodification of EA6 and PRF. Nagano Prefecture Agricultural Technology Institute, ed., Nagano, Japan, pp. 51-52.
  • 25
    • 34347360872 scopus 로고    scopus 로고
    • Otagiri K. 1989b. Twenty-year study on antitumor activities of mushrooms. In: Epidemiological Study on intake of Flammulina velutipes, Nagano Prefecture Agricultural Technology Institute, ed., Nagano, Japan, pp. 56-63.
    • Otagiri K. 1989b. Twenty-year study on antitumor activities of mushrooms. In: Epidemiological Study on intake of Flammulina velutipes, Nagano Prefecture Agricultural Technology Institute, ed., Nagano, Japan, pp. 56-63.
  • 26
    • 34347364898 scopus 로고    scopus 로고
    • Otagiri K. 1989c. Twenty-year study on antitumor activities of mushrooms. In: Studies on Prevention of Carcinogenesis of Flammulina velutipes (I). Decrease of Cancer Death Rate by Intake of Flammulina velutipes, Nagano Prefecture Agricultural Technology Institute, ed., Nagano, Japan, pp. 75-79.
    • Otagiri K. 1989c. Twenty-year study on antitumor activities of mushrooms. In: Studies on Prevention of Carcinogenesis of Flammulina velutipes (I). Decrease of Cancer Death Rate by Intake of Flammulina velutipes, Nagano Prefecture Agricultural Technology Institute, ed., Nagano, Japan, pp. 75-79.
  • 27
    • 0020563621 scopus 로고
    • Intensification of antitumor-immunity by protein-bound polysaccharide, EA6, derived from Flammulina velutipes (Curt. ex Fr.) Sing. combined with murine Leukemia L1210 vaccine in animal experiments
    • Otagiri K., Ohkuma T., Ikekawa T., and Tanaka S. 1983. Intensification of antitumor-immunity by protein-bound polysaccharide, EA6, derived from Flammulina velutipes (Curt. ex Fr.) Sing. combined with murine Leukemia L1210 vaccine in animal experiments. J Pharmacobiodyn, 6, 96-104.
    • (1983) J Pharmacobiodyn , vol.6 , pp. 96-104
    • Otagiri, K.1    Ohkuma, T.2    Ikekawa, T.3    Tanaka, S.4
  • 28
    • 0019990129 scopus 로고
    • Immunological aspects of cryosurgery in general surgery
    • Tanaka S. 1982. Immunological aspects of cryosurgery in general surgery. Cryobiology, 19, 257-272.
    • (1982) Cryobiology , vol.19 , pp. 257-272
    • Tanaka, S.1
  • 29
    • 0015854815 scopus 로고
    • Studies on antitumor polysaccharides of Flammulina velutipes (Curt. ex Fr.) Sing. I
    • Yoshioka Y., Sano T., and Ikekawa T. 1973. Studies on antitumor polysaccharides of Flammulina velutipes (Curt. ex Fr.) Sing. I. Chem Pharm Bull, 21, 1772-1776.
    • (1973) Chem Pharm Bull , vol.21 , pp. 1772-1776
    • Yoshioka, Y.1    Sano, T.2    Ikekawa, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.