Does genetic background moderate the association between parental education and school achievement?

Genes, Brain and Behavior

Volumn 9, Issue 3, 2010, Pages 318-324

  Keltikangas Jarvinen, L ^a   Jokela, M ^a   Hintsanen, M ^a   Salo, J ^a   Hintsa, T ^a   Alatupa, S ^a   Lehtimaki T ^b,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Genotype; HTR2A; Parental education; School achievement; Serotonin

Indexed keywords

CYSTEINE; SEROTONIN 2A RECEPTOR; THREONINE;

ACADEMIC ACHIEVEMENT; ADOLESCENT; ADULT; ARTICLE; CHILD; DNA POLYMORPHISM; EDUCATIONAL STATUS; ENVIRONMENTAL FACTOR; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HUMAN; INHERITANCE; INTELLIGENCE; MALE; PARENT; POPULATION GENETICS; PRIORITY JOURNAL;

ADOLESCENT; ALLELES; CHILD; EDUCATIONAL MEASUREMENT; EDUCATIONAL STATUS; FEMALE; FINLAND; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; MATERNAL AGE; PARENTS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT2A; REGRESSION ANALYSIS; SCHOOLS; STUDENTS;

EID: 77950788173     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2009.00561.x     Document Type: Article

References (40)

1. Abdolmaleky, H.M., Faraone, S.V., Glatt, S.J. & Tsuang, M.T. (2004) Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. Schizophr Res 67, 53 62.
2. Åkerblom, H.K., Uhari, M., Pesonen, E., Dahl, M., Kaprio, E.A., Nuutinen, E.M., Pietikäinen, M., Salo, M.K., Aromaa, A., Kannas, L., Keltikangas-Järvinen, L., Kuusela, V., Räsänen, L., Rönnemaa, T., Knip, M., Telama, R., Välimäki, I., Pyörälä, K. & Viikari, J. (1991) Cardiovascular risk in young Finns. Ann Med 23, 35 39.
3. Alexander, K.L., Entwisle, D.R. & Dauber, S.L. (1993) First-grade classroom behavior: its short- and long-term consequences for school performance. Child Dev 64, 801 814.
4. Bruce, K.R., Steiger, H., Joober, R., Ng Ying Kin, N.M., Israel, M. & Young, S.N. (2005) Association of the promoter polymorphism-1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa. Am J Med Genet B Neuropsychiatr Genet 137B, 40 44.
5. Ceci, S.J. & Williams, W.M. (1997) Schooling, intelligence, and income. Am Psychol 52, 1051 1058.
6. Duncan, G.J., Brooks-Gunn, J. & Klebanov, P.K. (1994) Economic deprivation and early childhood development. Child Dev 65, 296 318.
7. Friend, A., DeFries, J.C. & Olson, R.K. (2008) Parental education moderates genetic influences on reading disability. Psychol Sci 19, 1124 1130.
8. Grigorenko, E.L. & Plomin, R. (2007) Introduction to the special issue on genes and education. Mind Brain Educ 1, 151 152.
9. Harden, K.P., Turkheimer, E. & Loehlin, J.C. (2007) Genotype by environment interaction in adolescents′ cognitive aptitude. Behav Genet 37, 273 283.
10. Hollomon, H.A., Dobbins, D.R. & Scott, K.G. (1998) The effects of biological and social risk factors on special education placement: birth weight and maternal education as an example. Res Dev Disabil 19, 281 294.
11. Jokela, M., Keltikangas-Järvinen, L., Kivimäki, M., Puttonen, S., Elovainio, M., Rontu, R. & Lehtimäki, T. (2007a) Serotonin receptor 2A gene and the influence of childhood maternal nurturance on adulthood depressive symptoms. Arch Gen Psychiatry 64, 356 360. (Pubitemid 46376786)
12. Jokela, M., Lehtimäki, T. & Keltikangas-Järvinen, L. (2007b) The influence of urban/rural residency on depressive symptoms is moderated by the serotonin receptor 2A gene. Am J Med Genet B Neuropsychiatr Genet 144B, 918 922. (Pubitemid 47547994)
13. Jokela, M., Lehtimäki, T. & Keltikangas-Järvinen, L. (2007c) The serotonin receptor 2A gene moderates the influence of parental socioeconomic status on adulthood harm avoidance. Behav Genet 37, 567 574.
14. Jones, D.C., Rickel, A.U. & Smith, R.L. (1980) Maternal child-rearing practices and social problem-solving strategies among preschoolers. Dev Psychol 16, 241 242.
15. Keltikangas-Järvinen, L., Puttonen, S., Kivimäki, M., Elovainio, M., Pulkki-Råback, L., Koivu, M., Rontu, R. & Lehtimäki, T. (2008) Serotonin receptor genes 5HT1A and 5HT2A modify the relation between childhood temperament and adulthood hostility. Genes Brain Behav 7, 46 52.
16. Kuusela, J. (2002) Demograafisten tekijöiden yhteys oppimistuloksiin. In Jakku-Sihvonen, R. & Kuusela, J. (eds), Mahdollisuuksien koulutuspolitiikan tasa-arvo. Opetushallitus
17. Livak, K.J. (1999) Allelic discrimination using fluorogenic probes and the 5′ nuclease assay. Genet Anal 14, 143 149.
18. Mintun, M.A., Sheline, Y.I., Moerlein, S.M., Vlassenko, A.G., Huang, Y. & Snyder, A.Z. (2004) Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography. Biol Psychiatry 55, 217 224.
19. Moresco, F.M., Dieci, M., Vita, A., Messa, C., Gobbo, C., Galli, L., Rizzo, G., Panzacchi, A., De Peri, L., Invernizzi, G. & Fazio, F. (2002) In vivo serotonin 5HT(2A) receptor binding and personality traits in healthy subjects: a positron emission tomography study. Neuroimage 17, 1470 1478.
20. Nagoshi, C.T. & Johnson, R.C. (2005) Socioeconomic status does not moderate the familiality of cognitive abilities in the Hawaii family study of cognition. J Biosoc Sci 37, 773 781.
21. van den Oord, E.J.C.G. & Rowe, D.C. (1997) An examination of genotype-environment interactions for academic achievement in an US national longitudinal survey. Intelligence 25, 205 228.
22. Patterson, C.J., Kupersmidt, J.B. & Vaden, N.A. (1990) Income level, gender, ethnicity, and household composition as predictors of children′s school-based competence. Child Dev 61, 485 494.
23. Petrill, S.A. & Justice, L.M. (2007) Bridging the gap between genomics and education. Mind Brain Educ 1, 153 161.
24. Petrill, S.A. & Wilkerson, B. (2000) Intelligence and achievement: a behavioral genetic perspective. Educ Psychol Rev 12, 185 199.
25. Plomin, R., Kovas, Y. & Haworth, C.M.A. (2007) Generalist genes: genetic links between brain, mind, and education. Mind Brain Educ 1, 11 19.
26. Plomin, R., Fulker, D.W., Corley, R. & DeFries, J.C. (1997) Nature, nurture, and cognitive development from 1 to 16 years: a parent-offspring adoption study. Psychol Sci 8, 442 447.
27. Polesskaya, O.O. & Sokolov, B.P. (2002) Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. J Neurosci Res 67, 812 822.
28. de Quervain, D.J., Henke, K., Aerni, A., Coluccia, D., Wollmer, M.A., Hock, C., Nitsch, R.M. & Papassotiropoulos, A. (2003) A functional genetic variation of the 5-HT2a receptor affects human memory. Nat Neurosci 6, 1141 1142.
29. Rowe, D.C. & Rodgers, J.L. (1997) Poverty and behavior: are environmental measures nature and nurture? Dev Rev 17, 358 375.
30. Rowe, D.C., Jacobson, K.C. & van den Oord, E.J. (1999) Genetic and environmental influences on vocabulary IQ: parental education level as moderator. Child Dev 70, 1151 1162.
31. Scarr, S. (1993) Biological and cultural diversity: the legacy of Darwin for development. Child Dev 64, 1333 1353.
32. Singhammer, J. & Mittelmark, M.B. (2006) Associations between mother′s level of education and offspring′s smoking and alcohol use in adulthood: a 28-year longitudinal follow-up study. J Public Health 14, 132 138.
33. Sirin, S.R. (2005) Socioeconomic status and academic achievement: a meta-analytic review of research. Rev Educ Res 75, 417 453.
34. Sparkes, R.S., Lan, N., Klisak, I., Mohandas, T., Diep, A., Kojis, T., Heinzmann, C. & Shih, J.C. (1991) Assignment of a serotonin 5HT-2 receptor gene (HTR2) to human chromosome 13q14-q21 and mouse chromosome 14. Genomics 9, 461 465.
35. Steinberg, L., Lamborn, S.D., Dornbusch, S.M. & Darling, N. (1992) Impact of parenting practices on adolescent achievement: authoritative parenting, school involvement, and encouragement to succeed. Child Dev 63, 1266 1281.
36. Teachman, J.D. (1987) Family background, educational resources, and educational attainment. Am Soc Rev 52, 548 557.
37. Thompson, L.A., Detterman, D.K. & Plomin, R. (1991) Associations between cognitive abilities and scholastic achievement: genetic overlap but environmental differences. Psychol Sci 2, 158 165.
38. Turecki, G., Briere, R., Dewar, K., Antonetti, T., Lesage, A.D., Seguin, M., Chawky, N., Vanier, C., Alda, M., Joober, R., Benkelfat, C. & Rouleau, G.A. (1999) Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. Am J Psychiatry 156, 1456 1458.
39. Turkheimer, E., Haley, A., Waldron, M., D′Onofrio, B. & Gottesman, II (2003) Socioeconomic status modifies heritability of IQ in young children. Psychol Sci 14, 623 628.
40. Unschuld, P.G., Ising, M., Erhardt, A., Lucae, S., Kloiber, S., Kohli, M., Salyakina, D., Welt, T., Kern, N., Lieb, R., Uhr, M., Binder, E.B., Muller-Myhsok, B., Holsboer, F. & Keck, M.E. (2007) Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder. Am J Med Genet B Neuropsychiatr Genet 144B, 424 429.