Development of granules from Phyllanthus niruri spray-dried extract

Brazilian Journal of Pharmaceutical Sciences

Volumn 45, Issue 4, 2009, Pages 669-675

  De Souza, Tatiane Pereira ^a,c   Gómez Amoza, José Luiz ^b   Pacheco, Ramón Martínez ^b   Petrovick, Pedro Ros ^c  

^a FEDERAL UNIVERSITY OF AMAZONAS   (Brazil)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Dry granulation; Granules production; Phyllantus nururi pharmacotechnics; Spray dried extract; Wet granulation

Indexed keywords

EUDRAGIT; GALLIC ACID; PHYLLANTHUS NIRURI EXTRACT;

ARTICLE; BULK DENSITY; CONTROLLED STUDY; DRUG FORMULATION; DRUG GRANULATION; DRUG GRANULE; HARDNESS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMIDITY; NONHUMAN; PARTICLE SIZE; QUANTITATIVE ANALYSIS; SPRAY DRYING; TABLET DISINTEGRATION TIME; TABLET FRIABILITY; TABLET HARDNESS; TABLET THICKNESS; WETTABILITY;

EID: 77950666152     PISSN: 19848250     EISSN: 21759790     Source Type: Journal    
DOI: 10.1590/S1984-82502009000400009     Document Type: Article

References (24)

1. AULTON, M. E. Pharmaceutics, the science of dosage form design. 2.ed. London: Churcill Livingstone, 2002. 675 p.
2. BONATI, A. Problems relating to the preparation and use of extracts from medicinal plants. Fitoterapia, v.1, n.1, p.5-12, 1980.
3. BOZIC, D. Z.; DREU, R.; VRECER, F. Influence of dry granulation on compactibility and capping tendency of macrolide antibiotic formulation. Int. J. Pharm., v.357, n.1, p.44-54, 2008.
4. COUTO, A. G. Desenvolvimento e avaliação tecnológica de granulados contendo produto seco nebulizado de Phyllanthus niruri L. - Euphorbiaceae (quebra-pedra). Porto Alegre, 2000. 179p. [Dissertaçã o de Mestrado. Faculdade de Farmácia. Universidade Federal do Rio Grande do Sul].
5. CRIPPA, F. Problems of pharmaceutical technics with plant extracts. Fitoterapia, v.49, n.2, p.257-263, 1978.
6. DÍAZ, L. M.; SOUTO, C.; CONCHEIRO, A.; GÓMEZ-AMOZA, J. L.; MARTÍNEZ-PACHECO. Evaluation of Eudragit E as major excipient in tablets of dry plant extracts. S.T.P. Pharma Sci., v.6, n.1, p.105-109, 1996. (Pubitemid 26174932)
7. ERIKSSON, M.; ALDERBORN, G. The effect of particle fragmentation and deformation on the interparticulate bond formation process during powder compaction. Pharm. Res., v.12, n.7, p.1031-1039, 1995.
8. FARMACOPÉIA Brasileira. 4.ed. São Paulo: Atheneu, 1988. p.V.1.3.1,V.1.3.2,V.1.4.1
9. GUYOT, J. C.; ARNAUD, P.; BECOURT, P.; CASSIERE, J. P.; CHULIA, D.; DUCHÊNE, D.; FERRAND, D.; GOUAIHARDOU, J.; LANGLOIS, C.; LEQUIEN, C.; MALFROID, F.; POURCELOT, Y.; RENOUX, R.; SERGOT, S.; TOURE, P. Commentaires relatifs aux méthodes générales d'analyse des formes orales solides récemment introduites dans les pharmacopées française et européenne. Rapport d'une commission SFSTP. S.T.P. Pharm. Prat., v.5, n.6, p.482-494, 1995.
10. HERTING, M. G.; KLEINEBUDDE, P. Roll compaction/dry granulation: Effect of raw material particle size on granule and tablet properties. Int. J. Pharm., v.338, n.1/2, p.110-118, 2007.
11. HUBERT-DROZ, P.; MORDIER, D.; DOELKER, E. Rapid method of determination of compression behavior for preformulations studies. Pharm. Acta Helv., v.57, p.136-143, 1982.
12. LANTZ Jr., R. J. Size Reduction In: LIBERMAN, H.A.; LACHMAN, I.; SCHWARTZ, J.B. (Eds.). Pharmaceutical dosage forms: tablets. 2.ed. New York: Marcel Dekker, 1989. v.2, cap.3, p.107-199.
13. LIST, P. H.; SCHIMDT, P. C. Phytopharmaceutical technology. Boca Raton: CRC, 1989. 552 p.
14. MARTÍNEZ-PACHECO, R.; GÓMEZ-AMOZA, J. L.;VILA JATO, J. L. Diseño de un sistema de registro de presión en máquinas de comprimir excéntrica. Cienc. Ind. Farm., v.4, n.2, p.207-211, 1985.
15. NYQVIST, H. Saturated salt solutions for maintaining specified relative humidities. Int. J. Pharm. Tech. Prod. Manuf., v.4, n.2, p.47-78, 1983.
16. ONUNKWO, G. C.; UDEALA, O. K. Studies on Rauwolfia vomitoria root III. flow properties of R. vomitora Granulations. S.T.P. Pharm. Sci., v.5, n.4, p.296-301, 1995.
17. PETEREIT, H. U.; WEIBSBROD, W. Formulation and process considerations affecting the stability of solid dosage forms formulated with methacrylate copolymers. Eur. J. Pharm. Biopharm., v.47, n.2, p.15-25, 1999.
18. SOARES, L. A. L. Padronização de extrato aquoso e desenvolvimento de produto seco por aspersão de Phyllantus niruri L. Euphorbiaceae (Quebra-pedra). Porto Alegre, 1997. 169p. [Dissertaçã o de Mestrado. Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul.].
19. SOARES, L. A. L.; GEORGE GONZÁLEZ, O.; PETROVICK, P. R.; SCHMIDT, P. C. Dry granulation and compression of spray-dried plant extracts. AAPS Pharm. Sci. Tech., v.6, n.3, p.E359-E366, 2005.
20. SOUZA, K. C. B.; PETROVICK, P. R.; BASSANI, V. L.; GONZÁLEZ ORTEGA, G. The adjuvants aerosil 200 and Gelita-Sol-P influence on the technological characteristics of spray-dried powders from Passiflora edulis var. flavicarpa. Drug Dev. Ind. Pharm., v.26, n.3, p.331-336, 2000.
21. SOUZA, T. P.; GÓMEZ-AMOZA, J. L.; MARTÍNEZ-PACHECO, R.; PETROVICK, P. R. Compression behavior of formulations from Phyllanthus niruri spray dried extract. Pharmazie, v.61, n.3, p.213-217, 2006.
22. SOUZA, T. P.; MARTÍNEZ-PACHECO, R.; GÓMEZ-AMOZA, J. L.; PETROVICK, P. R. Eudragit E as excipient for production of granules and tablets from Phyllanthus niruri L spray-dried extract. AAPS Pharm. Sci. Tech., v.8, n.2, p.E1-E7, 2007.
23. SOUZA, T. P.; GONZÁLEZ ORTEGA, G.; BASSANI, V. L.; PETROVICK, P. R. Avaliação da viabilidade de compressão direta de formulações contendo alto teor de produto seco nebulizado de Maytenus ilicifolia. Acta. Farm. Bonaer., v.19, n.1, p.53-60, 2000.
24. SOUZA, T. P.; HOLZSCHUH, M. H.; LIONÇO, M. I.; GONZÁLEZ ORTEGA, G.; PETROVICK, P. R. Validation of a LC method for the analysis of phenolic compounds from aqueous extract of Phyllanthus niruri aerial parts. J. Pharm. Biom. Anal., v.30, n.2, p.351-356, 2002.