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Volumn 27, Issue 1, 2010, Pages 1-16

Abacavir/lamivudine fixed-dose combination antiretroviral therapy for the treatment of HIV

Author keywords

Abacavir; Antiretroviral therapy; Epzicom; HIV; Lamivudine; Nucleoside reverse transcriptase inhibitor

Indexed keywords

ABACAVIR; ABACAVIR PLUS LAMIVUDINE; DIDANOSINE; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; PLACEBO; RIBAVIRIN; STAVUDINE; TENOFOVIR; ZIDOVUDINE;

EID: 77950650438     PISSN: 0741238X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12325-010-0006-9     Document Type: Review
Times cited : (12)

References (73)
  • 1
    • 84857062604 scopus 로고    scopus 로고
    • web site. Available at: Last accessed February 11
    • Report on the Global AIDS Epidemic 2008. UNAIDS web site. Available at: www.unaids.org/en/KnowledgeCentre/HIVData/GlobalReport/2008/2008-Global-report. asp. Last accessed February 11, 2010.
    • (2010) Report on the Global AIDS Epidemic 2008
  • 2
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators
    • Palella FJ Jr., Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998;338:853-860.
    • (1998) N Engl J Med. , vol.338 , pp. 853-860
    • Palella Jr., F.J.1    Delaney, K.M.2    Moorman, A.C.3
  • 3
    • 0038162585 scopus 로고    scopus 로고
    • Decline in the AIDS and death rates in the EuroSIDA study: An observational study
    • Mocroft A, Ledergerber B, Katlama C, et al. Decline in the AIDS and death rates in the EuroSIDA study: an observational study. Lancet. 2003;362:22-29.
    • (2003) Lancet , vol.362 , pp. 22-29
    • Mocroft, A.1    Ledergerber, B.2    Katlama, C.3
  • 4
    • 52749083531 scopus 로고    scopus 로고
    • British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008
    • Gazzard BG, Anderson J, Babiker A, et al. British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008. HIV Med. 2008;9:563-608.
    • (2008) HIV Med. , vol.9 , pp. 563-608
    • Gazzard, B.G.1    Anderson, J.2    Babiker, A.3
  • 5
    • 48949097660 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection 2008 recommendations of the International AIDS Society-USA panel
    • Hammer SM, Eron JJ Jr., Reiss P, et al. Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel. JAMA. 2008;300:555-570.
    • (2008) JAMA. , Issue.300 , pp. 555-570
    • Hammer, S.M.1    Eron Jr., J.J.2    Reiss, P.3
  • 6
    • 84855616052 scopus 로고    scopus 로고
    • Panel on Antiretroviral Guidelines for Adults and Adolescents, Department of Health and Human Services; December 1. Available at, Last accessed: February 11, 2010
    • Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services; December 1, 2009:1-161. Available at http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf. Last accessed: February 11, 2010.
    • (2009) Guidelines for the Use of Antiretroviral Agents in HIV-1-infected Adults and Adolescents , pp. 1-161
  • 7
    • 84868362475 scopus 로고    scopus 로고
    • Rapid advice: Antiretroviral therapy for HIV infection in adults and adolescents
    • November. Available at, Last accessed: February 11, 2010
    • Rapid advice: antiretroviral therapy for HIV infection in adults and adolescents. World Health Organization ART Guideline Review Committee; November 2009. Available at: www.who.int/hiv/pub/arv/rapid-advice-art.pdf. Last accessed: February 11, 2010.
    • (2009) World Health Organization ART Guideline Review Committee
  • 8
    • 77950678870 scopus 로고    scopus 로고
    • Epzicom (package insert). Research Triangle Park, NC: GlaxoSmithKline; 2009
    • Epzicom (package insert). Research Triangle Park, NC: GlaxoSmithKline; 2009.
  • 9
    • 68949206285 scopus 로고    scopus 로고
    • HLA-B.*5701 screening prior to abacavir prescription: Clinical and laboratory aspects
    • Nolan D. HLA-B. *5701 screening prior to abacavir prescription: clinical and laboratory aspects. Crit Rev Clin Lab Sci. 2009;46:153-165.
    • (2009) Crit Rev Clin Lab Sci. , vol.46 , pp. 153-165
    • Nolan, D.1
  • 10
    • 42649130015 scopus 로고    scopus 로고
    • Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: A multi-cohort collaboration
    • Sabin CA, Worm SW, Weber R, et al. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration. Lancet. 2008;371:1417-1426.
    • (2008) Lancet , vol.371 , pp. 1417-1426
    • Sabin, C.A.1    Worm, S.W.2    Weber, R.3
  • 11
    • 60649109560 scopus 로고    scopus 로고
    • Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients
    • Lundgren JD, Neuhaus J, Babiker A, et al. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients. AIDS. 2008;22:F17-F24.
    • (2008) AIDS , vol.22
    • Lundgren, J.D.1    Neuhaus, J.2    Babiker, A.3
  • 12
    • 67649110188 scopus 로고    scopus 로고
    • Impact of specific NRTI and PI exposure on the risk of myocardial infarction: A case-control study nested within FHDH ANRS C04
    • Abstract: presented at. February 8-11; Montreal, Canada. Abstract: #43LB
    • Lang SM-KM, Cotte L, Gilquin L, et al. Impact of specific NRTI and PI exposure on the risk of myocardial infarction: a case-control study nested within FHDH ANRS C04. Abstract: presented at: 16th Conference on Retroviruses and Oppotunistic Infections. February 8-11, 2009; Montreal, Canada. Abstract: #43LB.
    • (2009) 16th Conference on Retroviruses and Oppotunistic Infections
    • Lang, S.M.-K.M.1    Cotte, L.2    Gilquin, L.3
  • 13
    • 73549088748 scopus 로고    scopus 로고
    • Abacavir and risk of myocardial infarction in HIV-infected patients on highly active antiretroviral therapy: A population-based nationwide cohort study
    • Obel N, Farkas D, Kronborg G, et al. Abacavir and risk of myocardial infarction in HIV-infected patients on highly active antiretroviral therapy: a population-based nationwide cohort study. HIV Med. 2010;11:130-136.
    • (2010) HIV Med. , vol.11 , pp. 130-136
    • Obel, N.1    Farkas, D.2    Kronborg, G.3
  • 14
    • 73349134686 scopus 로고    scopus 로고
    • Abacavirlamivudine versus tenofovir-emtricitabine for initial HIV-1 therapy
    • Sax PE, Tierney C, Collier AC, et al. Abacavirlamivudine versus tenofovir-emtricitabine for initial HIV-1 therapy. N Engl J Med. 2009;361:2230-2240.
    • (2009) N Engl J Med. , vol.361 , pp. 2230-2240
    • Sax, P.E.1    Tierney, C.2    Collier, A.C.3
  • 15
    • 12444280338 scopus 로고    scopus 로고
    • The bioequivalence and effect of food on a new oncea-day fixed-dose combination tablet of abacavir (ABC) and lamivudine (3TC)
    • Poster presented at, October 30 2004 - November 2, 2004; Washington, DC
    • Baker KL, Lou Y, Yuen G, Murray S, Stein D. The bioequivalence and effect of food on a new oncea-day fixed-dose combination tablet of abacavir (ABC) and lamivudine (3TC). Poster presented at: 44th Interscience Conference on Antimicrobial Agents and Chemotherapy. October 30, 2004 - November 2, 2004; Washington, DC.
    • 44th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Baker, K.L.1    Lou, Y.2    Yuen, G.3    Murray, S.4    Stein, D.5
  • 16
    • 0032766290 scopus 로고    scopus 로고
    • Abacavir: Absolute bioavailability, bioequivalence of three oral formulations, and effect of food
    • Chittick GE, Gillotin C, McDowell JA, et al. Abacavir: absolute bioavailability, bioequivalence of three oral formulations, and effect of food. Pharmacotherapy. 1999;19:932-942.
    • (1999) Pharmacotherapy. , vol.19 , pp. 932-942
    • Chittick, G.E.1    Gillotin, C.2    McDowell, J.A.3
  • 17
  • 18
    • 77950657743 scopus 로고    scopus 로고
    • Ziagen (package insert). Research Park Triangle, NC: GlaxoSmithKline; 2009
    • Ziagen (package insert). Research Park Triangle, NC: GlaxoSmithKline; 2009.
  • 19
    • 33645391801 scopus 로고    scopus 로고
    • Impact of pregnancy on abacavir pharmacokinetics
    • Best BM, Mirochnick M, Capparelli EV, et al. Impact of pregnancy on abacavir pharmacokinetics. AIDS. 2006;20:553-560.
    • (2006) AIDS , vol.20 , pp. 553-560
    • Best, B.M.1    Mirochnick, M.2    Capparelli, E.V.3
  • 20
    • 0034872971 scopus 로고    scopus 로고
    • Pharmacokinetics of abacavir in HIV-1-infected patients with impaired renal function
    • Izzedine H, Launay-Vacher V, Aymard G, Legrand M, Deray G. Pharmacokinetics of abacavir in HIV-1-infected patients with impaired renal function. Nephron. 2001;89:62-67.
    • (2001) Nephron. , vol.89 , pp. 62-67
    • Izzedine, H.1    Launay-Vacher, V.2    Aymard, G.3    Legrand, M.4    Deray, G.5
  • 22
    • 65649133113 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of abacavir in plasma and intracellular carbovir triphosphate following administration of abacavir at 600 milligrams once daily and 300 milligrams twice daily in human immunodeficiency virus-infected subjects
    • Moyle G, Boffito M, Fletcher C, et al. Steady-state pharmacokinetics of abacavir in plasma and intracellular carbovir triphosphate following administration of abacavir at 600 milligrams once daily and 300 milligrams twice daily in human immunodeficiency virus-infected subjects. Antimicrob Agents Chemother. 2009;53:1532-1538.
    • (2009) Antimicrob Agents Chemother. , vol.53 , pp. 1532-1538
    • Moyle, G.1    Boffito, M.2    Fletcher, C.3
  • 23
    • 22344455482 scopus 로고    scopus 로고
    • Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens
    • Hawkins T, Veikley W, St. Claire RL 3rd, Guyer B, Clark N, Kearney BP. Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens. J Acquir Immune Defic Syndr. 2005;39:406-411.
    • (2005) J Acquir Immune Defic Syndr. , vol.39 , pp. 406-411
    • Hawkins, T.1    Veikley, W.2    St. Claire Iii., R.L.3    Guyer, B.4    Clark, N.5    Kearney, B.P.6
  • 24
    • 0037165904 scopus 로고    scopus 로고
    • Intracellular carbovir triphosphate levels in patients taking abacavir once a day
    • Harris M, Back D, Kewn S, Jutha S, Marina R, Montaner JS. Intracellular carbovir triphosphate levels in patients taking abacavir once a day. AIDS. 2002;16:1196-1197.
    • (2002) AIDS , vol.16 , pp. 1196-1197
    • Harris, M.1    Back, D.2    Kewn, S.3    Jutha, S.4    Marina, R.5    Montaner, J.S.6
  • 25
    • 3042723210 scopus 로고    scopus 로고
    • A study examining the pharmacokinetics of abacavir and the intracellular carbovir triphosphate (GSK Protocol CNA 10905)
    • Abstract: presented at, September, Chicago, IL, USA. Abstract: A-1797
    • Piliero P, Shachoy-Clark AD, Para M, et al. A study examining the pharmacokinetics of abacavir and the intracellular carbovir triphosphate (GSK Protocol CNA 10905). Abstract: presented at: 43rd International Conference on Antimicrobial Agents and Chemotherapy. September 14-17, 2003; Chicago, IL, USA. Abstract: A-1797.
    • (2003) 43rd International Conference on Antimicrobial Agents and Chemotherapy , pp. 14-17
    • Piliero, P.1    Shachoy-Clark, A.D.2    Para, M.3
  • 26
    • 0033929197 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamic modeling of abacavir (1592U89) from a dose-ranging, double-blind, randomized monotherapy trial with human immunodeficiency virus-infected subjects
    • Weller S, Radomski KM, Lou Y, Stein DS. Population pharmacokinetics and pharmacodynamic modeling of abacavir (1592U89) from a dose-ranging, double-blind, randomized monotherapy trial with human immunodeficiency virus-infected subjects. Antimicrob Agents Chemother. 2000;44:2052-2060.
    • (2000) Antimicrob Agents Chemother. , vol.44 , pp. 2052-2060
    • Weller, S.1    Radomski, K.M.2    Lou, Y.3    Stein, D.S.4
  • 27
    • 15044341385 scopus 로고    scopus 로고
    • Abacavir once or twice daily combined with once-daily lamivudine and efavirenz for the treatment of antiretroviralnaive HIV-infected adults: Results of the Ziagen Once Daily in Antiretroviral Combination Study
    • Moyle GJ, DeJesus E, Cahn P, et al. Abacavir once or twice daily combined with once-daily lamivudine and efavirenz for the treatment of antiretroviralnaive HIV-infected adults: results of the Ziagen Once Daily in Antiretroviral Combination Study. J Acquir Immune Defic Syndr. 2005;38:417-425.
    • (2005) J Acquir Immune Defic Syndr. , vol.38 , pp. 417-425
    • Moyle, G.J.1    Dejesus, E.2    Cahn, P.3
  • 28
    • 84868347044 scopus 로고    scopus 로고
    • Viral dynamics and pharmacokinetics in vivo of tenofovir disoproxil fumarate and abacavir: Evidence of a non-additive antiviral effect
    • Goicoechea M,Jain S, Kemper C., et al editors, Poster presented at, February 8-11; Montréal, Canada. Poster no. 703.Available at
    • Goicoechea M, Jain S, Kemper C, et al., editors. Viral Dynamics and Pharmacokinetics in vivo of Tenofovir Disoproxil Fumarate and Abacavir: Evidence of a Non-additive Antiviral Effect. Poster presented at: 16th Conference on Retroviruses and Opportunistic Infections. February 8-11, 2009; Montréal, Canada. Poster no. 703.Available at: www.hivandhepatitis.com/2009icr/croi/pdf/ 3Golcoechea.pdf.
    • (2009) 16th Conference on Retroviruses and Opportunistic Infections
  • 29
    • 0033914965 scopus 로고    scopus 로고
    • Multiple-dose pharmacokinetics and pharmacodynamics of abacavir alone and in combination with zidovudine in human immunodeficiency virus-infected adults
    • McDowell JA, Lou Y, Symonds WS, Stein DS. Multiple-dose pharmacokinetics and pharmacodynamics of abacavir alone and in combination with zidovudine in human immunodeficiency virus-infected adults. Antimicrob Agents Chemother. 2000;44:2061-2067.
    • (2000) Antimicrob Agents Chemother. , vol.44 , pp. 2061-2067
    • McDowell, J.A.1    Lou, Y.2    Symonds, W.S.3    Stein, D.S.4
  • 30
    • 34547224761 scopus 로고    scopus 로고
    • Evolving simplified treatment strategies for HIV infection: The role of a single-class quadruple-nucleoside/nucleotide regimen of trizivir and tenofovir
    • Mastroianni CM, d'Ettorre G, Vullo V. Evolving simplified treatment strategies for HIV infection: the role of a single-class quadruple-nucleoside/ nucleotide regimen of trizivir and tenofovir. Expert Opin Pharmacother. 2006;7:2233-2241.
    • (2006) Expert Opin Pharmacother. , vol.7 , pp. 2233-2241
    • Mastroianni, C.M.1    D'ettorre, G.2    Vullo, V.3
  • 31
    • 0037764105 scopus 로고    scopus 로고
    • Indinavir, efavirenz, and abacavir pharmacokinetics in human immunodeficiency virus-infected subjects
    • DiCenzo R, Forrest A, Squires KE, et al. Indinavir, efavirenz, and abacavir pharmacokinetics in human immunodeficiency virus-infected subjects. Antimicrob Agents Chemother. 2003;47:1929-1935.
    • (2003) Antimicrob Agents Chemother. , vol.47 , pp. 1929-1935
    • Dicenzo, R.1    Forrest, A.2    Squires, K.E.3
  • 32
    • 34547768666 scopus 로고    scopus 로고
    • Abacavir plasma pharmacokinetics in the absence and presence of atazanavir/ritonavir or lopinavir/ritonavir and vice versa in HIV-infected patients
    • Waters L, Moyle G, D'Avolio A, et al., editors
    • Waters L, Moyle G, D'Avolio A, et al., editors. Abacavir plasma pharmacokinetics in the absence and presence of atazanavir/ritonavir or lopinavir/ritonavir and vice versa in HIV-infected patients. Antivir Ther. 2007;12:825-1380
    • (2007) Antivir Ther. , vol.12 , pp. 825-1380
  • 33
    • 77950631644 scopus 로고    scopus 로고
    • Aptivus (package insert). Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc; 2009
    • Aptivus (package insert). Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc; 2009.
  • 34
    • 0034045094 scopus 로고    scopus 로고
    • Pharmacokinetic interaction of abacavir (1592U89) and ethanol in human immunodeficiency virus-infected adults
    • McDowell JA, Chittick GE, Stevens CP, Edwards KD, Stein DS. Pharmacokinetic interaction of abacavir (1592U89) and ethanol in human immunodeficiency virus-infected adults. Antimicrob Agents Chemother. 2000;44:1686-1690.
    • (2000) Antimicrob Agents Chemother. , vol.44 , pp. 1686-1690
    • McDowell, J.A.1    Chittick, G.E.2    Stevens, C.P.3    Edwards, K.D.4    Stein, D.S.5
  • 35
    • 34247624140 scopus 로고    scopus 로고
    • Early virologic failure in HIV-coinfected hepatitis C patients treated with the peginterferon-ribavirin combination does abacavir play a role?
    • Bani-Sadr F, Denoeud L, Morand P, et al. Early virologic failure in HIV-coinfected hepatitis C patients treated with the peginterferon-ribavirin combination: does abacavir play a role? J Acquir Immune Defic Syndr. 2007;45:123-125.
    • (2007) J Acquir Immune Defic Syndr. , vol.45 , pp. 123-125
    • Bani-Sadr, F.1    Denoeud, L.2    Morand, P.3
  • 37
    • 77950653520 scopus 로고    scopus 로고
    • Epivir (package insert). Research Triangle Park, NC: GlaxoSmithKline; 2009
    • Epivir (package insert). Research Triangle Park, NC: GlaxoSmithKline; 2009.
  • 39
    • 0031723646 scopus 로고    scopus 로고
    • Pharmacokinetics and antiretroviral activity of lamivudine alone or when coadministered with zidovudine in human immunodeficiency virus type 1-infected pregnant women and their offspring
    • Moodley J, Moodley D, Pillay K, et al. Pharmacokinetics and antiretroviral activity of lamivudine alone or when coadministered with zidovudine in human immunodeficiency virus type 1-infected pregnant women and their offspring. J Infect Dis. 1998;178:1327-1333.
    • (1998) J Infect Dis. , vol.178 , pp. 1327-1333
    • Moodley, J.1    Moodley, D.2    Pillay, K.3
  • 41
    • 0031818475 scopus 로고    scopus 로고
    • The pharmacokinetics of lamivudine in patients with impaired hepatic function
    • Johnson MA, Horak J, Breuel P. The pharmacokinetics of lamivudine in patients with impaired hepatic function. Eur J Clin Pharmacol. 1998;54:363-366.
    • (1998) Eur J Clin Pharmacol. , vol.54 , pp. 363-366
    • Johnson, M.A.1    Horak, J.2    Breuel, P.3
  • 42
    • 0029900659 scopus 로고    scopus 로고
    • Pharmacokinetics of lamivudine administered alone and with trimethoprim-sulfamethoxazole
    • Moore KH, Yuen GJ, Raasch RH, et al. Pharmacokinetics of lamivudine administered alone and with trimethoprim-sulfamethoxazole. Clin Pharmacol Ther. 1996;59:550-558.
    • (1996) Clin Pharmacol Ther. , vol.59 , pp. 550-558
    • Moore, K.H.1    Yuen, G.J.2    Raasch, R.H.3
  • 43
    • 0001024860 scopus 로고    scopus 로고
    • The pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells from patients infected with HIV-1
    • Moore KH, Barrett JE, Shaw S, et al. The pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells from patients infected with HIV-1. AIDS. 1999;13:2239-2250.
    • (1999) AIDS , vol.13 , pp. 2239-2250
    • Moore, K.H.1    Barrett, J.E.2    Shaw, S.3
  • 44
    • 0034793648 scopus 로고    scopus 로고
    • Comparison of the plasma pharmacokinetics of lamivudine during twice and once daily administration in patients with HIV
    • Bruno R, Regazzi MB, Ciappina V, et al. Comparison of the plasma pharmacokinetics of lamivudine during twice and once daily administration in patients with HIV. Clin Pharmacokinet. 2001; 40:695-700.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 695-700
    • Bruno, R.1    Regazzi, M.B.2    Ciappina, V.3
  • 45
    • 0347992034 scopus 로고    scopus 로고
    • Equivalent steady-state pharmacokinetics of lamivudine in plasma and lamivudine triphosphate within cells following administration of lamivudine at 300 milligrams once daily and 150 milligrams twice daily
    • Yuen GJ, Lou Y, Bumgarner NF, et al. Equivalent steady-state pharmacokinetics of lamivudine in plasma and lamivudine triphosphate within cells following administration of lamivudine at 300 milligrams once daily and 150 milligrams twice daily. Antimicrob Agents Chemother. 2004;48:176-182.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 176-182
    • Yuen, G.J.1    Lou, Y.2    Bumgarner, N.F.3
  • 46
    • 3943101413 scopus 로고    scopus 로고
    • Once-daily versus twice-daily lamivudine, in combination with zidovudine and efavirenz, for the treatment of antiretroviral-naive adults with HIV infection: A randomized equivalence trial
    • DeJesus E, McCarty D, Farthing CF, et al. Once-daily versus twice-daily lamivudine, in combination with zidovudine and efavirenz, for the treatment of antiretroviral-naive adults with HIV infection: a randomized equivalence trial. Clin Infect Dis. 2004;39:411-418.
    • (2004) Clin Infect Dis. , vol.39 , pp. 411-418
    • Dejesus, E.1    McCarty, D.2    Farthing, C.F.3
  • 47
    • 66149147423 scopus 로고    scopus 로고
    • Pilot pharmacokinetic study of human immunodeficiency virus-infected patients receiving tenofovir disoproxil fumarate (TDF): Investigation of systemic and intracellular interactions between TDF and abacavir, lamivudine, or lopinavir-ritonavir
    • Pruvost A, Negredo E, Theodoro F, et al. Pilot pharmacokinetic study of human immunodeficiency virus-infected patients receiving tenofovir disoproxil fumarate (TDF): investigation of systemic and intracellular interactions between TDF and abacavir, lamivudine, or lopinavir-ritonavir. Antimicrob Agents Chemother. 2009;53:1937-1943.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 1937-1943
    • Pruvost, A.1    Negredo, E.2    Theodoro, F.3
  • 48
    • 0035126997 scopus 로고    scopus 로고
    • Abacavir/lamivudine/zidovudine as a combined formulation tablet: Bioequivalence compared with each component administered concurrently and the effect of food on absorption
    • Yuen GJ, Lou Y, Thompson NF, et al. Abacavir/lamivudine/zidovudine as a combined formulation tablet: bioequivalence compared with each component administered concurrently and the effect of food on absorption. J Clin Pharmacol. 2001;41:277-288.
    • (2001) J Clin Pharmacol. , vol.41 , pp. 277-288
    • Yuen, G.J.1    Lou, Y.2    Thompson, N.F.3
  • 49
    • 25844464986 scopus 로고    scopus 로고
    • Effect of ribavirin on intracellular and plasma pharmacokinetics of nucleoside reverse transcriptase inhibitors in patients with human immunodeficiency virus-hepatitis C virus coinfection: Results of a randomized clinical study
    • Rodriguez-Torres M, Torriani FJ, Soriano V, et al. Effect of ribavirin on intracellular and plasma pharmacokinetics of nucleoside reverse transcriptase inhibitors in patients with human immunodeficiency virus-hepatitis C virus coinfection: results of a randomized clinical study. Antimicrob Agents Chemother. 2005;49:3997-4008.
    • (2005) Antimicrob Agents Chemother. , vol.49 , pp. 3997-4008
    • Rodriguez-Torres, M.1    Torriani, F.J.2    Soriano, V.3
  • 50
    • 40149097939 scopus 로고    scopus 로고
    • Shortterm safety and tolerability of a once-daily fixeddose abacavir-lamivudine combination versus twice-daily dosing of abacavir and lamivudine as separate components: Findings from the ALOHA study
    • Cohen CJ, Kubota M, Brachman PS, et al. Shortterm safety and tolerability of a once-daily fixeddose abacavir-lamivudine combination versus twice-daily dosing of abacavir and lamivudine as separate components: findings from the ALOHA study. Pharmacotherapy. 2008;28:314-322.
    • (2008) Pharmacotherapy , vol.28 , pp. 314-322
    • Cohen, C.J.1    Kubota, M.2    Brachman, P.S.3
  • 51
    • 21744446593 scopus 로고    scopus 로고
    • Once-daily abacavir in place of twice-daily administration
    • Goedken AM, Herman RA. Once-daily abacavir in place of twice-daily administration. Ann Pharmacother. 2005;39:1302-1308.
    • (2005) Ann Pharmacother , vol.39 , pp. 1302-1308
    • Goedken, A.M.1    Herman, R.A.2
  • 52
    • 67651056237 scopus 로고    scopus 로고
    • A simplification trial switching from nucleoside reverse transcriptase inhibitors to once-daily fixed-dose abacavir/lamivudine or tenofovir/ emtricitabine in HIV-1-infected patients with virological suppression
    • Martinez E, Arranz JA, Podzamczer D, et al. A simplification trial switching from nucleoside reverse transcriptase inhibitors to once-daily fixed-dose abacavir/lamivudine or tenofovir/emtricitabine in HIV-1-infected patients with virological suppression. J Acquir Immune Defic Syndr. 2009;51:290-297.
    • (2009) J Acquir Immune Defic Syndr. , vol.51 , pp. 290-297
    • Martinez, E.1    Arranz, J.A.2    Podzamczer, D.3
  • 53
    • 68649086238 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment
    • Smith KY, Patel P, Fine D, et al. Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment. AIDS. 2009;23:1547-1556.
    • (2009) AIDS , vol.23 , pp. 1547-1556
    • Smith, K.Y.1    Patel, P.2    Fine, D.3
  • 54
    • 27944438845 scopus 로고    scopus 로고
    • Abacavir and lamivudine fixed-dose combination tablet once daily compared with abacavir and lamivudine twice daily in HIV-infected patients over 48 weeks (ESS30008, SEAL)
    • Sosa N, Hill-Zabala C, Dejesus E, et al. Abacavir and lamivudine fixed-dose combination tablet once daily compared with abacavir and lamivudine twice daily in HIV-infected patients over 48 weeks (ESS30008, SEAL). J Acquir Immune Defic Syndr. 2005;40:422-427.
    • (2005) J Acquir Immune Defic Syndr. , vol.40 , pp. 422-427
    • Sosa, N.1    Hill-Zabala, C.2    Dejesus, E.3
  • 55
    • 32644472009 scopus 로고    scopus 로고
    • Once daily administration of abacavir is not a clinical risk factor for suspected hypersensitivity reactions in clinical trials and rash is not sufficient to diagnose the reaction
    • Poster presented at, Boston, USA. February 23. Poster 836
    • Brothers CCA, Zhao H, Edwards M, Fleming J, Scott T. Once daily administration of abacavir is not a clinical risk factor for suspected hypersensitivity reactions in clinical trials and rash is not sufficient to diagnose the reaction. Poster presented at: 12th Conference on Retroviruses and Opportunistic Infections, Boston, USA. February 23, 2005. Poster 836.
    • (2005) 12th Conference on Retroviruses and Opportunistic Infections
    • Brothers, C.C.A.1    Zhao, H.2    Edwards, M.3    Fleming, J.4    Scott, T.5
  • 56
    • 0037006623 scopus 로고    scopus 로고
    • Association between presence of HLA-B*5701 HLA-DR7 and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    • Mallal S, Nolan D, Witt C, et al. Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet. 2002;359:727-732.
    • (2002) Lancet , vol.359 , pp. 727-732
    • Mallal, S.1    Nolan, D.2    Witt, C.3
  • 57
    • 0037197044 scopus 로고    scopus 로고
    • Genetic variations in HLA-B region and hypersensitivity reactions to abacavir
    • Hetherington S, Hughes AR, Mosteller M, et al. Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. Lancet. 2002;359:1121-1122.
    • (2002) Lancet , vol.359 , pp. 1121-1122
    • Hetherington, S.1    Hughes, A.R.2    Mosteller, M.3
  • 58
    • 38949196447 scopus 로고    scopus 로고
    • HLAB* 5701 screening for hypersensitivity to abacavir
    • Mallal S, Phillips E, Carosi G, et al. HLAB* 5701 screening for hypersensitivity to abacavir. N Engl J Med. 2008;358:568-579.
    • (2008) N Engl J Med. , vol.358 , pp. 568-579
    • Mallal, S.1    Phillips, E.2    Carosi, G.3
  • 59
    • 75649093029 scopus 로고    scopus 로고
    • Risk of myocardial infarction in patients with HIV infection exposed to specific individual antiretroviral drugs from the 3 major drug classes: The data collection on adverse events of anti-hiv drugs (D:A:D) study
    • Worm SW, Sabin C, Weber R, et al. Risk of myocardial infarction in patients with HIV infection exposed to specific individual antiretroviral drugs from the 3 major drug classes: the data collection on adverse events of anti-hiv drugs (D:A:D) study. J Infect Dis. 2010;201:318-330.
    • (2010) J Infect Dis. , vol.201 , pp. 318-330
    • Worm, S.W.1    Sabin, C.2    Weber, R.3
  • 60
    • 70349213594 scopus 로고    scopus 로고
    • Efficacy and safety of atazanavir-ritonavir plus abacavirlamivudine or tenofovir-emtricitabine in patients with hyperlipidaemia switched from a stable protease inhibitor-based regimen including one thymidine analogue
    • Calza L, Manfredi R, Colangeli V, et al. Efficacy and safety of atazanavir-ritonavir plus abacavirlamivudine or tenofovir-emtricitabine in patients with hyperlipidaemia switched from a stable protease inhibitor-based regimen including one thymidine analogue. AIDS Patient Care STDS. 2009;23:691-697.
    • (2009) AIDS Patient Care STDS. , vol.23 , pp. 691-697
    • Calza, L.1    Manfredi, R.2    Colangeli, V.3
  • 61
    • 33645988818 scopus 로고    scopus 로고
    • A prospective, 96-week study of the impact of Trizivir, Combivir/nelfinavir, and lamivudine/ stavudine/nelfinavir on lipids, metabolic parameters and efficacy in antiretroviral-naive patients: Effect of sex and ethnicity
    • Kumar PN, Rodriguez-French A, Thompson MA, et al. A prospective, 96-week study of the impact of Trizivir, Combivir/nelfinavir, and lamivudine/ stavudine/nelfinavir on lipids, metabolic parameters and efficacy in antiretroviral-naive patients: effect of sex and ethnicity. HIV Med. 2006;7:85-98.
    • (2006) HIV Med. , vol.7 , pp. 85-98
    • Kumar, P.N.1    Rodriguez-French, A.2    Thompson, M.A.3
  • 62
    • 34247144465 scopus 로고    scopus 로고
    • Metabolic effects of protease inhibitor-sparing antiretroviral regimens given as initial treatment of HIV-1 Infection (AIDS Clinical Trials Group Study A5095)
    • Shikuma CM, Yang Y, Glesby MJ, et al. Metabolic effects of protease inhibitor-sparing antiretroviral regimens given as initial treatment of HIV-1 Infection (AIDS Clinical Trials Group Study A5095). J Acquir Immune Defic Syndr. 2007;44:540-550.
    • (2007) J Acquir Immune Defic Syndr. , vol.44 , pp. 540-550
    • Shikuma, C.M.1    Yang, Y.2    Glesby, M.J.3
  • 63
    • 67651167085 scopus 로고    scopus 로고
    • Risk of myocardial infarction and abacavir therapy: No increased risk across 52 GlaxoSmithKlinesponsored clinical trials in adult subjects
    • Brothers CH, Hernandez JE, Cutrell AG, et al. Risk of myocardial infarction and abacavir therapy: no increased risk across 52 GlaxoSmithKlinesponsored clinical trials in adult subjects. J Acquir Immune Defic Syndr. 2009;51:20-28.
    • (2009) J Acquir Immune Defic Syndr. , vol.51 , pp. 20-28
    • Brothers, C.H.1    Hernandez, J.E.2    Cutrell, A.G.3
  • 64
    • 67649120904 scopus 로고    scopus 로고
    • No association of abacavir use with risk of myocardial infarction or severe cardiovascular disease events: Results from ACTG A5001
    • Abstract: presented at. February 8-11; Montreal, Canada. Abstract: #
    • Benson CRH, Zheng E, Koletar S, et al. No association of abacavir use with risk of myocardial infarction or severe cardiovascular disease events: results from ACTG A5001. Abstract: presented at: 16th Conference on Retroviruses and Opportunistic Infections. February 8-11, 2009; Montreal, Canada. Abstract: #721.
    • (2009) 16th Conference on Retroviruses and Opportunistic Infections , pp. 721
    • Benson, C.R.H.1    Zheng, E.2    Koletar, S.3
  • 65
    • 77950645341 scopus 로고    scopus 로고
    • Relation between use of nucleoside reverse transcriptase inhibitors (NRTI) and risk of myocardial infarction (MI): A nested case control study using Quebec's public health insurance database (QPHID)
    • Abstract: presented at. July 19-22; Cape Town, South Africa. Abstract: #TUPEB175
    • Durand MSO, Baril JA. Relation between use of nucleoside reverse transcriptase inhibitors (NRTI) and risk of myocardial infarction (MI): a nested case control study using Quebec's public health insurance database (QPHID). Abstract: presented at: 5th IAS Conference on HIV Pathogenesis, Treatment, and Prevention. July 19-22, 2009; Cape Town, South Africa. Abstract: #TUPEB175.
    • (2009) 5th IAS Conference on HIV Pathogenesis, Treatment, and Prevention
    • Durand, M.S.O.1    Baril, J.A.2
  • 66
    • 77949558089 scopus 로고    scopus 로고
    • Abacavir use and risk of acute myocardial infarction and cerebrovascular disease in the HAART era
    • Abstract: presented at. July 19-22; Cape Town, South Africa. Abstract: #MOAB202
    • Bedimo RWA, Dreschler H, Tebas P. Abacavir use and risk of acute myocardial infarction and cerebrovascular disease in the HAART era. Abstract: presented at: 5th IAS Conference on HIV Pathogenesis, Treatment, and Prevention. July 19-22, 2009; Cape Town, South Africa. Abstract: #MOAB202.
    • (2009) 5th IAS Conference on HIV Pathogenesis Treatment and Prevention
    • Bedimo, R.W.A.1    Dreschler, H.2    Tebas, P.3
  • 67
    • 50649101127 scopus 로고    scopus 로고
    • Abacavir and increased risk of myocardial infarction
    • author reply 4-5
    • Post FA, Campbell LJ. Abacavir and increased risk of myocardial infarction. Lancet. 2008;372:803; author reply 4-5.
    • (2008) Lancet , vol.372 , pp. 803
    • Post, F.A.1    Campbell, L.J.2
  • 68
    • 71049130451 scopus 로고    scopus 로고
    • Inflammatory markers among abacavir and non-abacavir recipients in the Womens' Interagency HIV study and the Multicenter AIDS cohort study
    • Abstract: presented at. February 8-11; Montreal, Canada. Abstract: #150LB
    • Palella FGS, Elion R, Benning L, et al. Inflammatory markers among abacavir and non-abacavir recipients in the Womens' Interagency HIV study and the Multicenter AIDS cohort study. Abstract: presented at: 16th Conference on Retroviruses and Opportunistic Infections. February 8-11, 2009; Montreal, Canada. Abstract: #150LB.
    • (2009) 16th Conference on Retroviruses and Opportunistic Infections
    • Palella, F.G.S.1    Elion, R.2    Benning, L.3
  • 69
    • 77949559871 scopus 로고    scopus 로고
    • No evidence for recent abacavir/lamivudine use in promoting inflammation, endothelial dysfunction, hypercoaguability, or insulin resistance in virologically suppressed HIV-infected patients: A substudy of the BICOMBO randomized clinical trial
    • July 19-22; Cape Town, South Africa. Abstract: #MOAB203
    • Martinez ELM, Perez I. No evidence for recent abacavir/lamivudine use in promoting inflammation, endothelial dysfunction, hypercoaguability, or insulin resistance in virologically suppressed HIV-infected patients: a substudy of the BICOMBO randomized clinical trial. 5th IAS Conference on HIV Pathogenesis, Treatment, and Prevention. July 19-22, 2009; Cape Town, South Africa. Abstract: #MOAB203.
    • (2009) 5th IAS Conference on HIV Pathogenesis, Treatment, and Prevention
    • Martinez, E.L.M.1    Perez, I.2
  • 70
    • 70349769521 scopus 로고    scopus 로고
    • Association of abacavir and impaired endothelial function in treated and suppressed HIV-infected patients
    • Hsue PY, Hunt PW, Wu Y, et al. Association of abacavir and impaired endothelial function in treated and suppressed HIV-infected patients. AIDS. 2009;23:2021-2027.
    • (2009) AIDS , vol.23 , pp. 2021-2027
    • Hsue, P.Y.1    Hunt, P.W.2    Wu, Y.3
  • 72
    • 20844462378 scopus 로고    scopus 로고
    • Abacavir versus zidovudine combined with lamivudine and efavirenz, for the treatment of antiretroviral-naive HIV-infected adults
    • DeJesus E, Herrera G, Teofilo E, et al. Abacavir versus zidovudine combined with lamivudine and efavirenz, for the treatment of antiretroviral-naive HIV-infected adults. Clin Infect Dis. 2004;39:1038-1046.
    • (2004) Clin Infect Dis. , vol.39 , pp. 1038-1046
    • Dejesus, E.1    Herrera, G.2    Teofilo, E.3
  • 73
    • 33646755880 scopus 로고    scopus 로고
    • Efficacy and safety of a once-daily fixed-dose combination of abacavir/lamivudine compared with abacavir twice daily and lamivudine once daily as separate entities in antiretroviral-experienced HIV-1-infected patients (CAL30001 Study)
    • Lamarca A, Clumeck N, Plettenberg A, et al. Efficacy and safety of a once-daily fixed-dose combination of abacavir/lamivudine compared with abacavir twice daily and lamivudine once daily as separate entities in antiretroviral-experienced HIV-1-infected patients (CAL30001 Study). J Acquir Immune Defic Syndr. 2006;41:598-606.
    • (2006) J Acquir Immune Defic Syndr. , vol.41 , pp. 598-606
    • Lamarca, A.1    Clumeck, N.2    Plettenberg, A.3


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